Liposarcoma natural history: Difference between revisions
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==Overview== | ==Overview== | ||
The natural history of liposarcoma depends on the [[Histopathology|histopathological]] sub-type and location of the [[tumor]]. If left untreated, liposarcomas may remain silent for a long time, especially if they are located in the [[retroperitoneum]]. Liposarcoma may [[Metastasis|metastasize]] to other [[Organ (anatomy)|organs]]. [[Lung]] is the most common location for [[metastatic disease]]. [[Retroperitoneum|Retroperitoneal]] liposarcomas may affect adjacent [[Organ (anatomy)|organs]] and structures, that can lead to [[kidney disease]] or [[vascular]] compression. The [[prognosis]] of liposarcoma will depend on the [[Histopathology|histopathological]] sub-type. Atypical lipomatous neoplasm/well-differentiated liposarcoma has a low [[metastasis]] risk, but may recur locally. The [[prognosis]] for this sub-type is better than for other sub-types of liposarcoma. The 5-year disease free [[survival rate]] for liposarcoma located in the [[Limb (anatomy)|extremities]] is 74%. | |||
==Natural History | ==Natural History, Complications, and Prognosis== | ||
*The | === Natural History === | ||
*The natural history of liposarcoma depends on the [[Histopathology|histopathological]] sub-type and location of the [[tumor]]. | |||
* | *If left untreated, liposarcomas may remain silent for a long time, especially if they are located in the [[retroperitoneum]].<ref name="PetersonKransdorf2003">{{cite journal|last1=Peterson|first1=Jeffrey J.|last2=Kransdorf|first2=Mark J.|last3=Bancroft|first3=Laura W.|last4=O'Connor|first4=Mary I.|title=Malignant fatty tumors: classification, clinical course, imaging appearance and treatment|journal=Skeletal Radiology|volume=32|issue=9|year=2003|pages=493–503|issn=0364-2348|doi=10.1007/s00256-003-0647-8}}</ref> | ||
* | *The most common presentation of a liposarcoma located in the [[Limb (anatomy)|extremities]] is a painless growing [[mass]] without additional [[Symptom|symptoms]]. | ||
| | |||
==Complications== | ===Complications=== | ||
*Liposarcoma may | *Liposarcoma may [[Metastasis|metastasize]] to other [[Organ (anatomy)|organs]]. | ||
*A myxoid liposarcoma | *[[Lung]] is the most common location for [[metastatic disease]]. | ||
*Retroperitoneal liposarcomas may affect adjacent organs and structures, that | *A myxoid liposarcoma [[Metastasis|metastasizes]] more commonly to extrapulmonary locations, such as [[retroperitoneum]], [[pericardium]], [[chest wall]], [[pleura]], and [[Pelvis|pelvic]] [[soft tissue]].<ref name="PetersonKransdorf2003">{{cite journal|last1=Peterson|first1=Jeffrey J.|last2=Kransdorf|first2=Mark J.|last3=Bancroft|first3=Laura W.|last4=O'Connor|first4=Mary I.|title=Malignant fatty tumors: classification, clinical course, imaging appearance and treatment|journal=Skeletal Radiology|volume=32|issue=9|year=2003|pages=493–503|issn=0364-2348|doi=10.1007/s00256-003-0647-8}}</ref> | ||
*[[Retroperitoneum|Retroperitoneal]] liposarcomas may affect adjacent [[Organ (anatomy)|organs]] and structures, that can lead to [[kidney disease]] or [[vascular]] compression.<ref>{{Cite journal | |||
| author = [[Amit Gupta]], [[Omar Pacha]], [[Rony Skaria]], [[Tam Huynh]], [[Luan Truong]] & [[Abdul Abdellatif]] | | author = [[Amit Gupta]], [[Omar Pacha]], [[Rony Skaria]], [[Tam Huynh]], [[Luan Truong]] & [[Abdul Abdellatif]] | ||
| title = Retroperitoneal sarcoma presenting as acute renal failure, secondary to bilateral renal artery invasion | | title = Retroperitoneal sarcoma presenting as acute renal failure, secondary to bilateral renal artery invasion | ||
| Line 48: | Line 28: | ||
| pmid = 22790462 | | pmid = 22790462 | ||
}}</ref> | }}</ref> | ||
*A case of [[pancreatitis]] has been reported due to a dedifferentiated retroperitoneal liposarcoma. <ref>{{Cite journal | *A case of [[pancreatitis]] has been reported due to a dedifferentiated retroperitoneal liposarcoma.<ref>{{Cite journal | ||
| author = [[Yusuke Arakawa]], [[Kazuo Yoshioka]], [[Hitomi Kamo]], [[Koichiro Kawano]], [[Takeshi Yamaguchi]], [[Yuko Sumise]], [[Natsu Okitsu]], [[Shizuo Ikeyama]], [[Kojiro Morimoto]], [[Yoshihiro Nakai]] & [[Seiki Tashiro]] | | author = [[Yusuke Arakawa]], [[Kazuo Yoshioka]], [[Hitomi Kamo]], [[Koichiro Kawano]], [[Takeshi Yamaguchi]], [[Yuko Sumise]], [[Natsu Okitsu]], [[Shizuo Ikeyama]], [[Kojiro Morimoto]], [[Yoshihiro Nakai]] & [[Seiki Tashiro]] | ||
| title = Huge retroperitoneal dedifferentiated liposarcoma presented as acute pancreatitis: report of a case | | title = Huge retroperitoneal dedifferentiated liposarcoma presented as acute pancreatitis: report of a case | ||
| Line 59: | Line 39: | ||
| pmid = 23614927 | | pmid = 23614927 | ||
}}</ref> | }}</ref> | ||
*Other [[Complication (medicine)|complications]] can include: | |||
:*[[Bowel obstruction|Intestinal obstruction]], [[Bowel ischemia|ischemia]], and/or [[Intestinal perforation|perforation]]<ref>{{Cite journal | |||
| author = [[Kazim Duman]], [[Mustafa Girgin]] & [[Gokhan Artas]] | |||
| title = A case report: Giant intra-abdominal liposarcoma presenting acute renal failure | |||
| journal = [[Annals of medicine and surgery (2012)]] | |||
| volume = 12 | |||
| pages = 90–93 | |||
| year = 2016 | |||
| month = December | |||
| doi = 10.1016/j.amsu.2016.09.005 | |||
| pmid = 27942382 | |||
}}</ref> | |||
:*[[Hydronephrosis]]<ref>{{Cite journal | |||
| author = [[Kazim Duman]], [[Mustafa Girgin]] & [[Gokhan Artas]] | |||
| title = A case report: Giant intra-abdominal liposarcoma presenting acute renal failure | |||
| journal = [[Annals of medicine and surgery (2012)]] | |||
| volume = 12 | |||
| pages = 90–93 | |||
| year = 2016 | |||
| month = December | |||
| doi = 10.1016/j.amsu.2016.09.005 | |||
| pmid = 27942382 | |||
}}</ref> | |||
:*[[Ureter|Ureteric]] [[fistula]] | |||
:*[[Aortic rupture]] | |||
==Prognosis== | ===Prognosis=== | ||
*The prognosis of liposarcoma will depend on the histopathological | *The [[prognosis]] of liposarcoma will depend on the [[Histopathology|histopathological]] sub-type. | ||
*Atypical lipomatous neoplasm/well-differentiated liposarcoma has a low metastasis risk, but may recur locally. | *Atypical lipomatous neoplasm/well-differentiated liposarcoma has a low [[metastasis]] risk, but may recur locally. The [[prognosis]] for this sub-type is better than for other sub-types of liposarcoma.<ref name="PetersonKransdorf2003">{{cite journal|last1=Peterson|first1=Jeffrey J.|last2=Kransdorf|first2=Mark J.|last3=Bancroft|first3=Laura W.|last4=O'Connor|first4=Mary I.|title=Malignant fatty tumors: classification, clinical course, imaging appearance and treatment|journal=Skeletal Radiology|volume=32|issue=9|year=2003|pages=493–503|issn=0364-2348|doi=10.1007/s00256-003-0647-8}}</ref> | ||
*The pleomorphic liposarcoma has a high metastasis potential and a high recurrence. | *The [[Pleomorphism|pleomorphic]] liposarcoma has a high [[metastasis]] potential and a high recurrence rate. The 5-year disease free [[survival rate]] for pleomorphic liposarcoma is 40%.<ref>{{Cite journal | ||
| author = [[A. M. Oliveira]] & [[A. G. Nascimento]] | | author = [[A. M. Oliveira]] & [[A. G. Nascimento]] | ||
| title = Pleomorphic liposarcoma | | title = Pleomorphic liposarcoma | ||
| Line 74: | Line 79: | ||
| pmid = 11757868 | | pmid = 11757868 | ||
}}</ref> | }}</ref> | ||
*The 5-year disease free survival rate for liposarcoma located in the extremities is 74%.<ref>{{Cite journal | *The 5-year disease free [[survival rate]] for liposarcoma located in the [[Limb (anatomy)|extremities]] is 74%.<ref>{{Cite journal | ||
| author = [[D. B. Pearlstone]], [[P. W. Pisters]], [[R. J. Bold]], [[B. W. Feig]], [[K. K. Hunt]], [[A. W. Yasko]], [[S. Patel]], [[A. Pollack]], [[R. S. Benjamin]] & [[R. E. Pollock]] | | author = [[D. B. Pearlstone]], [[P. W. Pisters]], [[R. J. Bold]], [[B. W. Feig]], [[K. K. Hunt]], [[A. W. Yasko]], [[S. Patel]], [[A. Pollack]], [[R. S. Benjamin]] & [[R. E. Pollock]] | ||
| title = Patterns of recurrence in extremity liposarcoma: implications for staging and follow-up | | title = Patterns of recurrence in extremity liposarcoma: implications for staging and follow-up | ||
| Line 91: | Line 96: | ||
[[Category:Disease]] | [[Category:Disease]] | ||
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Latest revision as of 16:33, 28 May 2019
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Liposarcoma natural history On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]
Overview
The natural history of liposarcoma depends on the histopathological sub-type and location of the tumor. If left untreated, liposarcomas may remain silent for a long time, especially if they are located in the retroperitoneum. Liposarcoma may metastasize to other organs. Lung is the most common location for metastatic disease. Retroperitoneal liposarcomas may affect adjacent organs and structures, that can lead to kidney disease or vascular compression. The prognosis of liposarcoma will depend on the histopathological sub-type. Atypical lipomatous neoplasm/well-differentiated liposarcoma has a low metastasis risk, but may recur locally. The prognosis for this sub-type is better than for other sub-types of liposarcoma. The 5-year disease free survival rate for liposarcoma located in the extremities is 74%.
Natural History, Complications, and Prognosis
Natural History
- The natural history of liposarcoma depends on the histopathological sub-type and location of the tumor.
- If left untreated, liposarcomas may remain silent for a long time, especially if they are located in the retroperitoneum.[1]
- The most common presentation of a liposarcoma located in the extremities is a painless growing mass without additional symptoms.
Complications
- Liposarcoma may metastasize to other organs.
- Lung is the most common location for metastatic disease.
- A myxoid liposarcoma metastasizes more commonly to extrapulmonary locations, such as retroperitoneum, pericardium, chest wall, pleura, and pelvic soft tissue.[1]
- Retroperitoneal liposarcomas may affect adjacent organs and structures, that can lead to kidney disease or vascular compression.[2]
- A case of pancreatitis has been reported due to a dedifferentiated retroperitoneal liposarcoma.[3]
- Other complications can include:
Prognosis
- The prognosis of liposarcoma will depend on the histopathological sub-type.
- Atypical lipomatous neoplasm/well-differentiated liposarcoma has a low metastasis risk, but may recur locally. The prognosis for this sub-type is better than for other sub-types of liposarcoma.[1]
- The pleomorphic liposarcoma has a high metastasis potential and a high recurrence rate. The 5-year disease free survival rate for pleomorphic liposarcoma is 40%.[6]
- The 5-year disease free survival rate for liposarcoma located in the extremities is 74%.[7]
References
- ↑ 1.0 1.1 1.2 Peterson, Jeffrey J.; Kransdorf, Mark J.; Bancroft, Laura W.; O'Connor, Mary I. (2003). "Malignant fatty tumors: classification, clinical course, imaging appearance and treatment". Skeletal Radiology. 32 (9): 493–503. doi:10.1007/s00256-003-0647-8. ISSN 0364-2348.
- ↑ Amit Gupta, Omar Pacha, Rony Skaria, Tam Huynh, Luan Truong & Abdul Abdellatif (2012). "Retroperitoneal sarcoma presenting as acute renal failure, secondary to bilateral renal artery invasion". Clinical nephrology. 78 (2): 164–168. PMID 22790462. Unknown parameter
|month=ignored (help) - ↑ Yusuke Arakawa, Kazuo Yoshioka, Hitomi Kamo, Koichiro Kawano, Takeshi Yamaguchi, Yuko Sumise, Natsu Okitsu, Shizuo Ikeyama, Kojiro Morimoto, Yoshihiro Nakai & Seiki Tashiro (2013). "Huge retroperitoneal dedifferentiated liposarcoma presented as acute pancreatitis: report of a case". The journal of medical investigation : JMI. 60 (1–2): 164–168. PMID 23614927.
- ↑ Kazim Duman, Mustafa Girgin & Gokhan Artas (2016). "A case report: Giant intra-abdominal liposarcoma presenting acute renal failure". Annals of medicine and surgery (2012). 12: 90–93. doi:10.1016/j.amsu.2016.09.005. PMID 27942382. Unknown parameter
|month=ignored (help) - ↑ Kazim Duman, Mustafa Girgin & Gokhan Artas (2016). "A case report: Giant intra-abdominal liposarcoma presenting acute renal failure". Annals of medicine and surgery (2012). 12: 90–93. doi:10.1016/j.amsu.2016.09.005. PMID 27942382. Unknown parameter
|month=ignored (help) - ↑ A. M. Oliveira & A. G. Nascimento (2001). "Pleomorphic liposarcoma". Seminars in diagnostic pathology. 18 (4): 274–285. PMID 11757868. Unknown parameter
|month=ignored (help) - ↑ D. B. Pearlstone, P. W. Pisters, R. J. Bold, B. W. Feig, K. K. Hunt, A. W. Yasko, S. Patel, A. Pollack, R. S. Benjamin & R. E. Pollock (1999). "Patterns of recurrence in extremity liposarcoma: implications for staging and follow-up". Cancer. 85 (1): 85–92. PMID 9921978. Unknown parameter
|month=ignored (help)