Milk-alkali syndrome epidemiology and demographics: Difference between revisions
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{{Milk-alkali syndrome}} | {{Milk-alkali syndrome}} | ||
{{CMG}} {{AE}} {{SHA}} | |||
== Overview == | |||
The exact [[incidence]] and [[prevalence]]<nowiki/>f of milk-alkali syndrome is not known. With the introduction of [[Histamine antagonist|histamine antagonists]] and decrease in [[antacid]] consumption since the 1970s, the incidence of milk-alkali syndrome has decreased significantly. However, since the 1990s, there has been an increase in milk-alkali syndrome due to an increase in [[calcium]] and [[vitamin D]] consumption in postmenopausal women for [[osteoporosis]] prevention. Milk-alkali syndrome is the third most common cause of [[hypercalcemia]] in hospitalized patients after primary [[hyperparathyroidism]] and [[Cancer|malignancies]]. | |||
== Epidemiology and Demographics == | |||
=== Incidence === | |||
* The exact [[incidence]] of milk-alkali syndrome is not known.<ref name="pmid24288027">{{cite journal| author=Patel AM, Adeseun GA, Goldfarb S| title=Calcium-alkali syndrome in the modern era. | journal=Nutrients | year= 2013 | volume= 5 | issue= 12 | pages= 4880-93 | pmid=24288027 | doi=10.3390/nu5124880 | pmc=3875933 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24288027 }} </ref> | |||
* With the introduction of [[Histamine antagonist|histamine antagonists]] and decrease in [[antacid]] consumption since the 1970s, the incidence of milk-alkali syndrome has decreased significantly. However, since the 1990s, there has been an increase in milk-alkali syndrome due to increase in [[calcium]] and [[vitamin D]] consumption in postmenopausal women for [[osteoporosis]] prevention.<ref name="pmid19252114">{{cite journal| author=Medarov BI| title=Milk-alkali syndrome. | journal=Mayo Clin Proc | year= 2009 | volume= 84 | issue= 3 | pages= 261-7 | pmid=19252114 | doi=10.1016/S0025-6196(11)61144-0 | pmc=2664604 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19252114 }} </ref><ref name="pmid23543983">{{cite journal| author=Arroyo M, Fenves AZ, Emmett M| title=The calcium-alkali syndrome. | journal=Proc (Bayl Univ Med Cent) | year= 2013 | volume= 26 | issue= 2 | pages= 179-81 | pmid=23543983 | doi=10.1080/08998280.2013.11928954 | pmc=3603742 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23543983 }} </ref><ref name="pmid17699269">{{cite journal| author=Felsenfeld AJ, Levine BS| title=Milk alkali syndrome and the dynamics of calcium homeostasis. | journal=Clin J Am Soc Nephrol | year= 2006 | volume= 1 | issue= 4 | pages= 641-54 | pmid=17699269 | doi=10.2215/CJN.01451005 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17699269 }} </ref> | |||
=== Prevalence === | |||
* The exact [[prevalence]] of milk-alkali syndrome is not known. | |||
* Milk-alkali syndrome is the third most common cause of [[hypercalcemia]] in hospitalized patients after primary [[hyperparathyroidism]] and [[Cancer|malignancies]]. <ref name="pmid7891547">{{cite journal| author=Beall DP, Scofield RH| title=Milk-alkali syndrome associated with calcium carbonate consumption. Report of 7 patients with parathyroid hormone levels and an estimate of prevalence among patients hospitalized with hypercalcemia. | journal=Medicine (Baltimore) | year= 1995 | volume= 74 | issue= 2 | pages= 89-96 | pmid=7891547 | doi=10.1097/00005792-199503000-00004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7891547 }} </ref> | |||
=== Age === | |||
* Currently, the 'modern' milk-alkali syndrome mostly affects postmenopausal women who consume [[calcium]] supplements for [[osteoporosis]] prevention. <ref name="pmid16702792">{{cite journal| author=Beall DP, Henslee HB, Webb HR, Scofield RH| title=Milk-alkali syndrome: a historical review and description of the modern version of the syndrome. | journal=Am J Med Sci | year= 2006 | volume= 331 | issue= 5 | pages= 233-42 | pmid=16702792 | doi=10.1097/00000441-200605000-00001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16702792 }} </ref><ref name="pmid19252114">{{cite journal| author=Medarov BI| title=Milk-alkali syndrome. | journal=Mayo Clin Proc | year= 2009 | volume= 84 | issue= 3 | pages= 261-7 | pmid=19252114 | doi=10.1016/S0025-6196(11)61144-0 | pmc=2664604 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19252114 }} </ref> | |||
* The 'classic' milk-alkali syndrome mostly affected middle aged men who consumed the 'Sippy Powder' for [[Peptic ulcer|peptic ulcer disease]], and has disappeared with the introduction of [[H2 antagonist|histamine-2 blockers]] and [[Proton pump inhibitor|proton pump inhibitors (PPIs)]] in 1976 and 1989, respectively.<ref name="pmid16702792">{{cite journal| author=Beall DP, Henslee HB, Webb HR, Scofield RH| title=Milk-alkali syndrome: a historical review and description of the modern version of the syndrome. | journal=Am J Med Sci | year= 2006 | volume= 331 | issue= 5 | pages= 233-42 | pmid=16702792 | doi=10.1097/00000441-200605000-00001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16702792 }} </ref><ref name="pmid19252114">{{cite journal| author=Medarov BI| title=Milk-alkali syndrome. | journal=Mayo Clin Proc | year= 2009 | volume= 84 | issue= 3 | pages= 261-7 | pmid=19252114 | doi=10.1016/S0025-6196(11)61144-0 | pmc=2664604 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19252114 }} </ref><ref name="pmid23543983">{{cite journal| author=Arroyo M, Fenves AZ, Emmett M| title=The calcium-alkali syndrome. | journal=Proc (Bayl Univ Med Cent) | year= 2013 | volume= 26 | issue= 2 | pages= 179-81 | pmid=23543983 | doi=10.1080/08998280.2013.11928954 | pmc=3603742 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23543983 }} </ref> | |||
=== Gender === | |||
* Currently, the 'modern' milk-alkali syndrome mostly affects postmenopausal women who consume [[calcium]] supplements for [[osteoporosis]] prevention.<ref name="pmid16702792">{{cite journal| author=Beall DP, Henslee HB, Webb HR, Scofield RH| title=Milk-alkali syndrome: a historical review and description of the modern version of the syndrome. | journal=Am J Med Sci | year= 2006 | volume= 331 | issue= 5 | pages= 233-42 | pmid=16702792 | doi=10.1097/00000441-200605000-00001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16702792 }} </ref><ref name="pmid19252114">{{cite journal| author=Medarov BI| title=Milk-alkali syndrome. | journal=Mayo Clin Proc | year= 2009 | volume= 84 | issue= 3 | pages= 261-7 | pmid=19252114 | doi=10.1016/S0025-6196(11)61144-0 | pmc=2664604 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19252114 }} </ref> | |||
* The 'classic' milk-alkali syndrome mostly affected middle aged men who consumed the 'Sippy Powder' for [[Peptic ulcer|peptic ulcer disease]], and has disappeared with the introduction of [[H2 antagonist|histamine-2 blockers]] and [[Proton pump inhibitor|proton pump inhibitors (PPIs)]] in 1976 and 1989, respectively.<ref name="pmid16702792">{{cite journal| author=Beall DP, Henslee HB, Webb HR, Scofield RH| title=Milk-alkali syndrome: a historical review and description of the modern version of the syndrome. | journal=Am J Med Sci | year= 2006 | volume= 331 | issue= 5 | pages= 233-42 | pmid=16702792 | doi=10.1097/00000441-200605000-00001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16702792 }} </ref><ref name="pmid19252114">{{cite journal| author=Medarov BI| title=Milk-alkali syndrome. | journal=Mayo Clin Proc | year= 2009 | volume= 84 | issue= 3 | pages= 261-7 | pmid=19252114 | doi=10.1016/S0025-6196(11)61144-0 | pmc=2664604 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19252114 }} </ref><ref name="pmid23543983">{{cite journal| author=Arroyo M, Fenves AZ, Emmett M| title=The calcium-alkali syndrome. | journal=Proc (Bayl Univ Med Cent) | year= 2013 | volume= 26 | issue= 2 | pages= 179-81 | pmid=23543983 | doi=10.1080/08998280.2013.11928954 | pmc=3603742 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23543983 }} </ref> | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Latest revision as of 13:05, 16 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]
Overview
The exact incidence and prevalencef of milk-alkali syndrome is not known. With the introduction of histamine antagonists and decrease in antacid consumption since the 1970s, the incidence of milk-alkali syndrome has decreased significantly. However, since the 1990s, there has been an increase in milk-alkali syndrome due to an increase in calcium and vitamin D consumption in postmenopausal women for osteoporosis prevention. Milk-alkali syndrome is the third most common cause of hypercalcemia in hospitalized patients after primary hyperparathyroidism and malignancies.
Epidemiology and Demographics
Incidence
- With the introduction of histamine antagonists and decrease in antacid consumption since the 1970s, the incidence of milk-alkali syndrome has decreased significantly. However, since the 1990s, there has been an increase in milk-alkali syndrome due to increase in calcium and vitamin D consumption in postmenopausal women for osteoporosis prevention.[2][3][4]
Prevalence
- The exact prevalence of milk-alkali syndrome is not known.
- Milk-alkali syndrome is the third most common cause of hypercalcemia in hospitalized patients after primary hyperparathyroidism and malignancies. [5]
Age
- Currently, the 'modern' milk-alkali syndrome mostly affects postmenopausal women who consume calcium supplements for osteoporosis prevention. [6][2]
- The 'classic' milk-alkali syndrome mostly affected middle aged men who consumed the 'Sippy Powder' for peptic ulcer disease, and has disappeared with the introduction of histamine-2 blockers and proton pump inhibitors (PPIs) in 1976 and 1989, respectively.[6][2][3]
Gender
- Currently, the 'modern' milk-alkali syndrome mostly affects postmenopausal women who consume calcium supplements for osteoporosis prevention.[6][2]
- The 'classic' milk-alkali syndrome mostly affected middle aged men who consumed the 'Sippy Powder' for peptic ulcer disease, and has disappeared with the introduction of histamine-2 blockers and proton pump inhibitors (PPIs) in 1976 and 1989, respectively.[6][2][3]
References
- ↑ Patel AM, Adeseun GA, Goldfarb S (2013). "Calcium-alkali syndrome in the modern era". Nutrients. 5 (12): 4880–93. doi:10.3390/nu5124880. PMC 3875933. PMID 24288027.
- ↑ 2.0 2.1 2.2 2.3 2.4 Medarov BI (2009). "Milk-alkali syndrome". Mayo Clin Proc. 84 (3): 261–7. doi:10.1016/S0025-6196(11)61144-0. PMC 2664604. PMID 19252114.
- ↑ 3.0 3.1 3.2 Arroyo M, Fenves AZ, Emmett M (2013). "The calcium-alkali syndrome". Proc (Bayl Univ Med Cent). 26 (2): 179–81. doi:10.1080/08998280.2013.11928954. PMC 3603742. PMID 23543983.
- ↑ Felsenfeld AJ, Levine BS (2006). "Milk alkali syndrome and the dynamics of calcium homeostasis". Clin J Am Soc Nephrol. 1 (4): 641–54. doi:10.2215/CJN.01451005. PMID 17699269.
- ↑ Beall DP, Scofield RH (1995). "Milk-alkali syndrome associated with calcium carbonate consumption. Report of 7 patients with parathyroid hormone levels and an estimate of prevalence among patients hospitalized with hypercalcemia". Medicine (Baltimore). 74 (2): 89–96. doi:10.1097/00005792-199503000-00004. PMID 7891547.
- ↑ 6.0 6.1 6.2 6.3 Beall DP, Henslee HB, Webb HR, Scofield RH (2006). "Milk-alkali syndrome: a historical review and description of the modern version of the syndrome". Am J Med Sci. 331 (5): 233–42. doi:10.1097/00000441-200605000-00001. PMID 16702792.