Polymyalgia rheumatica laboratory findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{CMG}} | |||
{{CMG}}; {{AE}} {{Rim}} | |||
{{Polymyalgia rheumatica}} | {{Polymyalgia rheumatica}} | ||
==Overview== | ==Overview== | ||
Polymyalgia rheumatica is a clinical diagnosis that is supported by laboratory tests. | Polymyalgia rheumatica (PMR) is a clinical diagnosis that is supported by laboratory tests. Elevation of [[C-reactive protein]] (CRP) and/or [[erythrocyte sedimentation rate]] (ESR) is essential for the diagnosis of PMR. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
The following laboratory findings are characteristic of PMR:<ref name="pmid22388996">{{cite journal| author=Dasgupta B, Cimmino MA, Maradit-Kremers H, Schmidt WA, Schirmer M, Salvarani C et al.| title=2012 provisional classification criteria for polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. | journal=Ann Rheum Dis | year= 2012 | volume= 71 | issue= 4 | pages= 484-92 | pmid=22388996 | doi=10.1136/annrheumdis-2011-200329 | pmc=PMC3298664 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22388996 }} </ref> | * The following laboratory findings are characteristic of PMR:<ref name="pmid22388996">{{cite journal| author=Dasgupta B, Cimmino MA, Maradit-Kremers H, Schmidt WA, Schirmer M, Salvarani C et al.| title=2012 provisional classification criteria for polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. | journal=Ann Rheum Dis | year= 2012 | volume= 71 | issue= 4 | pages= 484-92 | pmid=22388996 | doi=10.1136/annrheumdis-2011-200329 | pmc=PMC3298664 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22388996 }} </ref> | ||
* Elevated [[C-reactive protein]] (CRP) | ** Elevated [[C-reactive protein]] (CRP) | ||
* Elevated [[erythrocyte sedimentation rate]] (ESR) | ** Elevated [[erythrocyte sedimentation rate]] (ESR) | ||
* Absence of [[rheumatoid factor]] (RF) | ** Absence of [[rheumatoid factor]] (RF) | ||
* Absence of [[anti-citrullinated protein antibody]] (ACPA) | ** Absence of [[anti-citrullinated protein antibody]] (ACPA) | ||
* Other supporting laboratory findings are:<ref name="pmid1807822">{{cite journal |author=Kyle V |title=Laboratory investigations including liver in polymyalgia rheumatica/giant cell arteritis |journal=Baillieres Clin Rheumatol |volume=5 |issue=3 |pages=475–84 |year=1991 |month=December |pmid=1807822 |doi= |url=}}</ref> | |||
** Mild normochromic, normocytic [[anemia]] (during active phase) | |||
** Normal [[white blood cell]] ([[WBC]]) | |||
** Elevated [[platelet count]] | |||
** Negative [[antinuclear antibody]] (ANA) | |||
** Elevated [[alkaline phosphatase]] (detected in one third to half of patients with [[PMR]] associated with [[GCA]]) | |||
** Normal [[creatine kinase]] (CK) | |||
** Normal [[aldolase]] | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Medicine]] | |||
[[Category: | |||
[[Category:Rheumatology]] | [[Category:Rheumatology]] | ||
[[Category:Up-To-Date]] | |||
Latest revision as of 23:47, 29 July 2020
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]
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Overview
Polymyalgia rheumatica (PMR) is a clinical diagnosis that is supported by laboratory tests. Elevation of C-reactive protein (CRP) and/or erythrocyte sedimentation rate (ESR) is essential for the diagnosis of PMR.
Laboratory Findings
- The following laboratory findings are characteristic of PMR:[1]
- Elevated C-reactive protein (CRP)
- Elevated erythrocyte sedimentation rate (ESR)
- Absence of rheumatoid factor (RF)
- Absence of anti-citrullinated protein antibody (ACPA)
- Other supporting laboratory findings are:[2]
- Mild normochromic, normocytic anemia (during active phase)
- Normal white blood cell (WBC)
- Elevated platelet count
- Negative antinuclear antibody (ANA)
- Elevated alkaline phosphatase (detected in one third to half of patients with PMR associated with GCA)
- Normal creatine kinase (CK)
- Normal aldolase
References
- ↑ Dasgupta B, Cimmino MA, Maradit-Kremers H, Schmidt WA, Schirmer M, Salvarani C; et al. (2012). "2012 provisional classification criteria for polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative". Ann Rheum Dis. 71 (4): 484–92. doi:10.1136/annrheumdis-2011-200329. PMC 3298664. PMID 22388996.
- ↑ Kyle V (1991). "Laboratory investigations including liver in polymyalgia rheumatica/giant cell arteritis". Baillieres Clin Rheumatol. 5 (3): 475–84. PMID 1807822. Unknown parameter
|month=ignored (help)