Ureaplasma urealyticum medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
Antibiotics are the mainstay of treatment for Ureaplasma infection, and antibiotic susceptibility testing is advised prior to treatment due to geographical differences in antibiotic resistance pattern. [[Doxycycline]] is recommended as the drug of first choice in non-pregnant women and adults. [[Josamycin]] is often recommended for neonates and pregnant women, especially when mixed infection is present. [[Clarithromycin]] and [[pristinamycin]] are also effective for treating Ureaplasma infection.<ref name="pmid23192735">{{cite journal| author=De Francesco MA, Caracciolo S, Bonfanti C, Manca N| title=Incidence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum isolated in Brescia, Italy, over 7 years. | journal=J Infect Chemother | year= 2013 | volume= 19 | issue= 4 | pages= 621-7 | pmid=23192735 | doi=10.1007/s10156-012-0527-z | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23192735 }} </ref><ref name="pmid26518581">{{cite journal| author=Resch B, Gutmann C, Reiterer F, Luxner J, Urlesberger B| title=Neonatal Ureaplasma urealyticum colonization increases pulmonary and cerebral morbidity despite treatment with macrolide antibiotics. | journal=Infection | year= 2016 | volume= 44 | issue= 3 | pages= 323-7 | pmid=26518581 | doi=10.1007/s15010-015-0858-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26518581 }} </ref><ref name="pmid27401661">{{cite journal| author=Lee MY, Kim MH, Lee WI, Kang SY, Jeon YL| title=Prevalence and Antibiotic Susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in Pregnant Women. | journal=Yonsei Med J | year= 2016 | volume= 57 | issue= 5 | pages= 1271-5 | pmid=27401661 | doi=10.3349/ymj.2016.57.5.1271 | pmc=4960396 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27401661 }} </ref> | |||
==Medical Therapy== | ==Medical Therapy== | ||
Antibiotics are the mainstay of treatment for Ureaplasma infection | Antibiotics are the mainstay of treatment for Ureaplasma infection. Antibiotic susceptibility testing should be done to avoid treatment failure because of the geographical differences in antibiotic resistance. | ||
'''Recommended antibiotics'''<ref name="pmid23192735">{{cite journal| author=De Francesco MA, Caracciolo S, Bonfanti C, Manca N| title=Incidence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum isolated in Brescia, Italy, over 7 years. | journal=J Infect Chemother | year= 2013 | volume= 19 | issue= 4 | pages= 621-7 | pmid=23192735 | doi=10.1007/s10156-012-0527-z | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23192735 }} </ref><ref name="pmid26518581"/><ref name="pmid27401661">{{cite journal| author=Lee MY, Kim MH, Lee WI, Kang SY, Jeon YL| title=Prevalence and Antibiotic Susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in Pregnant Women. | journal=Yonsei Med J | year= 2016 | volume= 57 | issue= 5 | pages= 1271-5 | pmid=27401661 | doi=10.3349/ymj.2016.57.5.1271 | pmc=4960396 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27401661 }} </ref> | |||
* [[Doxycycline]] | |||
# This is the drug of first choice. | |||
# It is the most active [[tetracycline]] for [[Mycoplasma]] and Ureaplasma infection. | |||
# It should be avoided in pregnant women and young children. | |||
* [[Macrolides]] | |||
# [[Josamycin]] and [[clarithromycin]] are the most effective macrolides against Ureaplasma infection. | |||
# [[Josamycin]] is often recommended for neonates and pregnant women, especially when mixed infection is present. | |||
# [[Pristinamycin]] can be used as an alternative to [[Josamycin]] in pregnant women. | |||
# [[Erythromycin]] has a low efficacy against ''Ureaplasma urealyticum''. | |||
* [[Fluoroquinolones]]: They have a low efficacy against urogenital [[Mycoplasma]] and Ureaplasma infection. | |||
* [[Clindamycin]]: This has also been demonstrated to have a low efficacy against Ureaplasma species. | |||
==References== | ==References== | ||
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{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Emergency mdicine]] | |||
[[Category:Disease]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Infectious disease]] | |||
[[Category:Nephrology]] | |||
[[Category:Pulmonology]] | |||
Latest revision as of 00:35, 30 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fatimo Biobaku M.B.B.S [2]
Overview
Antibiotics are the mainstay of treatment for Ureaplasma infection, and antibiotic susceptibility testing is advised prior to treatment due to geographical differences in antibiotic resistance pattern. Doxycycline is recommended as the drug of first choice in non-pregnant women and adults. Josamycin is often recommended for neonates and pregnant women, especially when mixed infection is present. Clarithromycin and pristinamycin are also effective for treating Ureaplasma infection.[1][2][3]
Medical Therapy
Antibiotics are the mainstay of treatment for Ureaplasma infection. Antibiotic susceptibility testing should be done to avoid treatment failure because of the geographical differences in antibiotic resistance.
Recommended antibiotics[1][2][3]
- This is the drug of first choice.
- It is the most active tetracycline for Mycoplasma and Ureaplasma infection.
- It should be avoided in pregnant women and young children.
- Josamycin and clarithromycin are the most effective macrolides against Ureaplasma infection.
- Josamycin is often recommended for neonates and pregnant women, especially when mixed infection is present.
- Pristinamycin can be used as an alternative to Josamycin in pregnant women.
- Erythromycin has a low efficacy against Ureaplasma urealyticum.
- Fluoroquinolones: They have a low efficacy against urogenital Mycoplasma and Ureaplasma infection.
- Clindamycin: This has also been demonstrated to have a low efficacy against Ureaplasma species.
References
- ↑ 1.0 1.1 De Francesco MA, Caracciolo S, Bonfanti C, Manca N (2013). "Incidence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum isolated in Brescia, Italy, over 7 years". J Infect Chemother. 19 (4): 621–7. doi:10.1007/s10156-012-0527-z. PMID 23192735.
- ↑ 2.0 2.1 Resch B, Gutmann C, Reiterer F, Luxner J, Urlesberger B (2016). "Neonatal Ureaplasma urealyticum colonization increases pulmonary and cerebral morbidity despite treatment with macrolide antibiotics". Infection. 44 (3): 323–7. doi:10.1007/s15010-015-0858-7. PMID 26518581.
- ↑ 3.0 3.1 Lee MY, Kim MH, Lee WI, Kang SY, Jeon YL (2016). "Prevalence and Antibiotic Susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in Pregnant Women". Yonsei Med J. 57 (5): 1271–5. doi:10.3349/ymj.2016.57.5.1271. PMC 4960396. PMID 27401661.