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| {{Infobox_Disease |
| | __NOTOC__ |
| Name = {{PAGENAME}} |
| | {{Renal artery stenosis}} |
| Image = Kidney PioM.png |
| | {| class="infobox" style="float:right;" |
| Caption = [[Renal artery]] is #3 |
| | |} |
| DiseasesDB = 11255 |
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| ICD10 = |
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| ICD9 = {{ICD9|440.1}} |
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| ICDO = |
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| OMIM = |
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| MedlinePlus = 001273 |
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| eMedicineSubj = med |
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| eMedicineTopic = 2001 |
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| }}
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| {{SI}}
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| {{CMG}} | | {{CMG}}; '''Associate Editor-In-Chief:''' {{Shivam Singla}} |
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| {{Editor Join}} | | {{SK}} RAS; renovascular hypertension; atherosclerotic renal artery stenosis; ARAS |
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| '''Renal artery stenosis''' is the narrowing of the [[renal artery]], most often caused by [[atherosclerosis]] or [[fibromuscular dysplasia]]. This narrowing of the renal artery can impede blood flow to the target kidney. Hypertension and atrophy of the affected [[kidney]] may result from renal artery stenosis, ultimately leading to [[renal failure]] if not treated.
| | ==[[Renal artery stenosis overview|Overview]]== |
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| ==Signs and symptoms== | | ==[[Renal artery stenosis pathophysiology|Pathophysiology]]== |
| Most cases of renal artery stenosis are asymptomatic, and the main problem is high blood pressure that cannot be controlled with medication. Deterioration in [[renal function]] may develop if both kidneys are poorly supplied, or when treatment with an [[ACE inhibitor]] is initiated. Some patients present with episodes of [[flash pulmonary edema]] (sudden left ventricular heart failure).<ref>{{cite journal |author=Pickering TG, Herman L, Devereux RB, ''et al'' |title=Recurrent pulmonary oedema in hypertension due to bilateral renal artery stenosis: treatment by angioplasty or surgical revascularisation |journal=Lancet |volume=2 |issue=8610 |pages=551-2 |year=1988 |pmid=2900930 |doi=}}</ref>
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| ==Diagnosis== | | ==[[Renal artery stenosis causes|Causes]]== |
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| A [[clinical prediction rule]] is available to guide diagnosis.<ref name="pmid9841602">{{cite journal|author=Krijnen P, van Jaarsveld BC, Steyerberg EW, Man in 't Veld AJ, Schalekamp MA, Habbema JD|title=A clinical prediction rule for renal artery stenosis|journal=Ann. Intern. Med.|volume=129|issue=9|pages=705–11|year=1998|pmid=9841602}}</ref>
| | ==[[Renal artery stenosis classification|Classification]]== |
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| * refractory [[hypertension]] - high blood pressure that can not be controlled adequately with [[antihypertensives]]
| | ==[[Renal artery stenosis epidemiology and demographics|Epidemiology and Demographics]]== |
| * [[auscultation]] (with [[stethoscope]]) - [[bruit]] ("rushing" sound) on affected side, inferior of the [[costal margin]]
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| * [[captopril challenge test]]
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| * captopril test dose effect on the differential renal function as measured by [[MAG3 scan]].<ref name="pmid9351069">{{cite journal|author=Roccatello D, Picciotto G|title=Captopril-enhanced scintigraphy using the method of the expected renogram: improved detection of patients with renin-dependent hypertension due to functionally significant renal artery stenosis|journal=Nephrol. Dial. Transplant.|volume=12|issue=10|pages=2081–6|year=1997|pmid=9351069|doi= 10.1093/ndt/12.10.2081|url=http://ndt.oxfordjournals.org/cgi/reprint/12/10/2081.pdf|format=PDF}}</ref>
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| * renal artery [[angiogram|arteriogram]]
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| ==Etiology== | | ==[[Renal artery stenosis risk factors|Risk Factors]]== |
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| Atherosclerosis is the predominant cause of renal artery stenosis in the majority of patients, usually those with a sudden onset of hypertension at age 50 or older. Fibromuscular dysplasia is the predominant cause in young patients, usually females under 40 years of age. A variety of other causes exist. These include [[arteritis]], [[aneurysm|renal artery aneurysm]], extrinsic compression (eg. [[neoplasm]]s), neurofibromatosis, and fibrous bands.
| | ==Diagnosis== |
| | | [[Renal artery stenosis diagnostic criteria|Diagnostic Criteria]] | [[Renal artery stenosis history and symptoms|History and Symptoms]] | [[Renal artery stenosis physical examination|Physical Examination]] | [[Renal artery stenosis x ray|X Ray]] | [[Renal artery stenosis CT|CT]] | [[Renal artery stenosis MRI|MRI]] | [[Renal artery stenosis ultrasound|Echocardiography or Ultrasound]] |
| ==Pathophysiology==
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| The [[macula densa]] of the kidney senses a decreased systemic blood pressure due to the pressure drop over the stenosis. The response of the kidney to this decreased blood pressure is activation of the [[renin-angiotension aldosterone system]], which normally counteracts low blood pressure, but in this case lead to hypertension (high blood pressure). The decreased perfusion pressure (caused by the stenosis) leads to decreased blood flow ([[hypoperfusion]]) to the kidney and a decrease in the [[Glomerular filtration rate|GFR]]. If the stenosis is long standing and severe the GFR in the affected kidneys never increases again and (pre-renal) [[renal failure]] is the result.
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| ==Treatment== | | ==Treatment== |
| When high-grade renal artery stenosis is documented and blood pressure cannot be controlled with medication, or if renal function deteriorates, renal artery stenosis is often treated invasively. Renal artery stenosis is most commonly treated by endovascular techniques (i.e. [[angioplasty]] with or without [[stent]]ing). A 2003 [[meta-analysis]] found that angioplasty was safe and effective in this context.<ref>{{cite journal |author=Nordmann AJ, Woo K, Parkes R, Logan AG |title=Balloon angioplasty or medical therapy for hypertensive patients with atherosclerotic renal artery stenosis? A meta-analysis of randomized controlled trials |journal=Am. J. Med. |volume=114 |issue=1 |pages=44-50 |year=2003 |pmid=12557864 |doi=}}</ref> There are ongoing clinical trials to compare medical management and angioplasty with stenting to medical management alone. These include CORAL and ASTRAL, both scheduled to report results in 2010. In addition to endovascular treatment, surgical resection and anastomosis is a rarely-used option.
| | [[Renal artery stenosis medical therapy|Medical Therapy]] | [[Renal artery stenosis angioplasty and stenting|Angioplasty and Stenting]] | [[Renal artery stenosis surgery|Surgery]] |
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| ==See also==
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| * [[Renovascular hypertension]]
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| ==Examples of Renal Artery Stenosis== | | ==Case Studies== |
| | [[Renal artery stenosis case study one|Case #1]] |
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| <youtube v=xeV3lmYi1Hk/>
| | ==References== |
| | | {{Reflist|2}} |
| * Right Renal Artery Stenosis
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| <youtube v=4UzLFatOg1Q/>
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| * Aortogram of Bilateral Renal Artery Stenosis
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| <youtube v=cL1TQFUU2Iw/>
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| ==Reference== | |
| <references/>
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| {{Circulatory system pathology}}
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| {{Nephrology}}
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| {{SIB}} | |
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| [[Category:Kidney diseases]] | | [[Category:Kidney diseases]] |
| [[Category:Nephrology]] | | [[Category:Nephrology]] |
| [[Category:Cardiology]] | | [[Category:Cardiology]] |
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| [[de:Nierenarterienstenose]]
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| [[nl:Nierarteriestenose]]
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