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{{Renal artery stenosis}}
{{Renal artery stenosis}}
{{CMG}}
{{CMG}} {{AE}} {{Shivam Singla}}


==Overview==
==Overview==
[[Renal artery stenosis]] is most commonly caused by the development of [[atherosclerotic]] [[plaque]] in the [[renal arteries]] (termed atherosclerotic renal artery stenosis). Less frequently, it is caused by [[fibromuscular dysplasia]].


==Causes==
==Causes==
Atherosclerosis is the predominant cause of renal artery stenosis in the majority of patients, usually those with a sudden onset of hypertension at age 50 or older. Fibromuscular dysplasia is the predominant cause in young patients, usually females under 40 years of age. A variety of other causes exist. These include:
*[[Arteritis]]
*[[Aneurysm|renal artery aneurysm]]
*Extrinsic compression (eg. [[neoplasm]]s)
*Neurofibromatosis
*Fibrous bands.


==References==
Unilateral [[Renal artery stenosis]] has two major causes:
 
1) Atherosclerosis<ref name="urlRenal artery stenosis - Symptoms and causes - Mayo Clinic">{{cite web |url=https://www.mayoclinic.org/diseases-conditions/renal-artery-stenosis/symptoms-causes/syc-20352777 |title=Renal artery stenosis - Symptoms and causes - Mayo Clinic |format= |work= |accessdate=}}</ref>: Most common cause seen in almost 60-90 percent of the cases associated with [[renal artery stenosis]]. [[Atherosclerosis]] mostly affects men over the age of 45 years and mainly involves the proximal part of the main [[renal artery]]. Although this condition is also commonly seen as an isolated lesion even in patients not having the underlying [[atherosclerotic]] [[disease]]. The [[risk factors]] associated with [[atherosclerosis]] are [[dyslipidemia]], [[cigarette smoking]], [[virus]] [[infection]], [[immune]] damage, and elevated concentrations of [[homocysteine]].
 
2) Fibromuscular dysplasia<ref name="pmid28613469">{{cite journal |vauthors=Bokhari MR, Bokhari SRA |title= |journal= |volume= |issue= |pages= |date= |pmid=28613469 |doi= |url=}}</ref><ref name="urlRenal Artery Stenosis - StatPearls - NCBI Bookshelf">{{cite web |url=https://www.ncbi.nlm.nih.gov/books/NBK430718/#article-28335.s2 |title=Renal Artery Stenosis - StatPearls - NCBI Bookshelf |format= |work= |accessdate=}}</ref>: This is responsible for causing [[renal artery stenosis]] in the remaining 10-30 percent of cases. This is most commonly seen in women under the age of 50 years and mainly involves middle and distal [[renal arteries]] and typically involves the middle and distal main [[renal artery]] or the [[intrarenal]] branches.
 
3) In, Less than 10 percent of the [[patient population]] other less common factors play a role like
- [[Thromboembolic]] [[disease]]
 
- [[Aortic aneurysm|Aortic aneurysms]]
 
- [[Takayasu arteritis]]


{{Reflist|2}}
- [[Polyarteritis nodosa]]


[[Category:Kidney diseases]]
- [[Retroperitoneal fibrosis]].
[[Category:Nephrology]]
[[Category:Cardiology]]


{{WH}}
==References==
{{WS}}
<references />

Latest revision as of 21:52, 12 December 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shivam Singla, M.D.[2]

Overview

Renal artery stenosis is most commonly caused by the development of atherosclerotic plaque in the renal arteries (termed atherosclerotic renal artery stenosis). Less frequently, it is caused by fibromuscular dysplasia.

Causes

Unilateral Renal artery stenosis has two major causes:

1) Atherosclerosis[1]: Most common cause seen in almost 60-90 percent of the cases associated with renal artery stenosis. Atherosclerosis mostly affects men over the age of 45 years and mainly involves the proximal part of the main renal artery. Although this condition is also commonly seen as an isolated lesion even in patients not having the underlying atherosclerotic disease. The risk factors associated with atherosclerosis are dyslipidemia, cigarette smoking, virus infection, immune damage, and elevated concentrations of homocysteine.

2) Fibromuscular dysplasia[2][3]: This is responsible for causing renal artery stenosis in the remaining 10-30 percent of cases. This is most commonly seen in women under the age of 50 years and mainly involves middle and distal renal arteries and typically involves the middle and distal main renal artery or the intrarenal branches.

3) In, Less than 10 percent of the patient population other less common factors play a role like

- Thromboembolic disease

- Aortic aneurysms

- Takayasu arteritis

- Polyarteritis nodosa

- Retroperitoneal fibrosis.

References

  1. "Renal artery stenosis - Symptoms and causes - Mayo Clinic".
  2. Bokhari MR, Bokhari S. PMID 28613469. Vancouver style error: initials (help); Missing or empty |title= (help)
  3. "Renal Artery Stenosis - StatPearls - NCBI Bookshelf".