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{{Microangiopathic hemolytic anemia}} | {{Microangiopathic hemolytic anemia}} {{MSJ}} | ||
==Classification== | |||
[[Microangiopathic hemolytic anemia]] may be classified into primary subtype based on the [[genetic]] mutations and no known underlying [[disease]] and secondary subtype due to known underlying cause<ref name="pmid27754896">{{cite journal| author=Arnold DM, Patriquin CJ, Nazy I| title=Thrombotic microangiopathies: a general approach to diagnosis and management. | journal=CMAJ | year= 2017 | volume= 189 | issue= 4 | pages= E153-E159 | pmid=27754896 | doi=10.1503/cmaj.160142 | pmc=5266569 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27754896 }} </ref>. | |||
* Primary: | |||
** [[Thrombotic thrombocytopenic purpura]] | |||
*** [[Congenital]] | |||
*** [[Acquired]] | |||
** [[Hemolytic Uremic Syndrome]] | |||
*** Shiga [[toxin]] [[E-coli]] | |||
*** Atypical | |||
*Secondary: | |||
** [[Malignant hypertension]] | |||
** [[Pregnancy]] | |||
*** [[Pre-eclampsia]], [[Eclampsia]] | |||
*** [[Thrombotic microangiopathy]] | |||
*** [[Hemolysis]], elevated [[liver]] [[enzymes]], low [[platelet]] count (HELLP [[syndrome]]) | |||
** [[Drug]] or [[toxin]] mediated: | |||
*** [[calcineurin inhibitor]]s, [[quinine]] | |||
** [[Viral]] [[infections]]: | |||
*** [[Epstein-Barr virus]] | |||
*** [[Influenza]] | |||
*** [[HIV]] | |||
** [[Cancer]] | |||
** [[Disseminated intravascular coagulation]] | |||
** Solid [[organ]] or [[bone marrow]] [[transplantation]] | |||
** [[Nutrition]]al deficiency: [[Vitamin B12]] or [[vitamin C]] deficiency | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Latest revision as of 22:47, 21 January 2021
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Classification
Microangiopathic hemolytic anemia may be classified into primary subtype based on the genetic mutations and no known underlying disease and secondary subtype due to known underlying cause[1].
- Primary:
- Secondary:
- Malignant hypertension
- Pregnancy
- Pre-eclampsia, Eclampsia
- Thrombotic microangiopathy
- Hemolysis, elevated liver enzymes, low platelet count (HELLP syndrome)
- Drug or toxin mediated:
- Viral infections:
- Cancer
- Disseminated intravascular coagulation
- Solid organ or bone marrow transplantation
- Nutritional deficiency: Vitamin B12 or vitamin C deficiency
References
- ↑ Arnold DM, Patriquin CJ, Nazy I (2017). "Thrombotic microangiopathies: a general approach to diagnosis and management". CMAJ. 189 (4): E153–E159. doi:10.1503/cmaj.160142. PMC 5266569. PMID 27754896.