Liposarcoma natural history: Difference between revisions

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==Overview==
==Overview==
The natural history of liposarcoma depends on the [[Histopathology|histopathological]] sub-type and location of the [[tumor]]. If left untreated, liposarcomas may remain silent for a long time, especially if they are located in the [[retroperitoneum]]. Liposarcoma may [[Metastasis|metastasize]] to other [[Organ (anatomy)|organs]]. [[Lung]] is the most common location for [[metastatic disease]]. [[Retroperitoneum|Retroperitoneal]] liposarcomas may affect adjacent [[Organ (anatomy)|organs]] and structures, that can lead to [[kidney disease]] or [[vascular]] compression. The [[prognosis]] of liposarcoma will depend on the [[Histopathology|histopathological]] sub-type. Atypical lipomatous neoplasm/well-differentiated liposarcoma has a low [[metastasis]] risk, but may recur locally. The [[prognosis]] for this sub-type is better than for other sub-types of liposarcoma. The 5-year disease free [[survival rate]] for liposarcoma located in the [[Limb (anatomy)|extremities]] is 74%.


==Natural History==
==Natural History, Complications, and Prognosis==
*The natural history of liposarcoma would depend on the histopathological subtype and location.
*Liposarcomas may remain asymptomatic for a long time, specially if they are located in the retroperitoneum. 
*The common presentation for a liposarcoma located in the soft tissue of the skin is a painless growing mass without other symptoms.
*The lower extremities are the most common location of liposarcomas. <ref name="PetersonKransdorf2003">{{cite journal|last1=Peterson|first1=Jeffrey J.|last2=Kransdorf|first2=Mark J.|last3=Bancroft|first3=Laura W.|last4=O'Connor|first4=Mary I.|title=Malignant fatty tumors: classification, clinical course, imaging appearance and treatment|journal=Skeletal Radiology|volume=32|issue=9|year=2003|pages=493–503|issn=0364-2348|doi=10.1007/s00256-003-0647-8}}</ref>
*Between 10 and 15% of patients may present with pain in the affected region. <ref name="PetersonKransdorf2003">{{cite journal|last1=Peterson|first1=Jeffrey J.|last2=Kransdorf|first2=Mark J.|last3=Bancroft|first3=Laura W.|last4=O'Connor|first4=Mary I.|title=Malignant fatty tumors: classification, clinical course, imaging appearance and treatment|journal=Skeletal Radiology|volume=32|issue=9|year=2003|pages=493–503|issn=0364-2348|doi=10.1007/s00256-003-0647-8}}</ref>
*Retroperitoneal liposarcomas may present as a dull abdominal pain, weight loss and increase abdominal girth.


==Complications==
=== Natural History ===
*Liposarcoma may cause metastasis to other organs and the lung is the most common location for metastatic disease.
*The natural history of liposarcoma depends on the [[Histopathology|histopathological]] sub-type and location of the [[tumor]].
*If left untreated, liposarcomas may remain silent for a long time, especially if they are located in the [[retroperitoneum]].<ref name="PetersonKransdorf2003">{{cite journal|last1=Peterson|first1=Jeffrey J.|last2=Kransdorf|first2=Mark J.|last3=Bancroft|first3=Laura W.|last4=O'Connor|first4=Mary I.|title=Malignant fatty tumors: classification, clinical course, imaging appearance and treatment|journal=Skeletal Radiology|volume=32|issue=9|year=2003|pages=493–503|issn=0364-2348|doi=10.1007/s00256-003-0647-8}}</ref>
*The most common presentation of a liposarcoma located in the [[Limb (anatomy)|extremities]] is a painless growing [[mass]] without additional [[Symptom|symptoms]].


==Prognosis==
===Complications===
*The prognosis of liposarcoma will depend on the histopathological subtype.   
*Liposarcoma may [[Metastasis|metastasize]] to other [[Organ (anatomy)|organs]].
*Atypical lipomatous neoplasm/well-differentiated liposarcoma has a low metastasis risk, but may recur locally. The prognosis for this subtype is better than for other subtypes of liposarcoma.<ref name="PetersonKransdorf2003">{{cite journal|last1=Peterson|first1=Jeffrey J.|last2=Kransdorf|first2=Mark J.|last3=Bancroft|first3=Laura W.|last4=O'Connor|first4=Mary I.|title=Malignant fatty tumors: classification, clinical course, imaging appearance and treatment|journal=Skeletal Radiology|volume=32|issue=9|year=2003|pages=493–503|issn=0364-2348|doi=10.1007/s00256-003-0647-8}}</ref>
*[[Lung]] is the most common location for [[metastatic disease]].
*The pleomorphic liposarcoma has a high metastasis potential and a high recurrence.
*A myxoid liposarcoma [[Metastasis|metastasizes]] more commonly to extrapulmonary locations, such as [[retroperitoneum]], [[pericardium]], [[chest wall]], [[pleura]], and [[Pelvis|pelvic]] [[soft tissue]].<ref name="PetersonKransdorf2003">{{cite journal|last1=Peterson|first1=Jeffrey J.|last2=Kransdorf|first2=Mark J.|last3=Bancroft|first3=Laura W.|last4=O'Connor|first4=Mary I.|title=Malignant fatty tumors: classification, clinical course, imaging appearance and treatment|journal=Skeletal Radiology|volume=32|issue=9|year=2003|pages=493–503|issn=0364-2348|doi=10.1007/s00256-003-0647-8}}</ref>
*The 5-year disease free survival rate for liposarcoma located in the extremities is 74%.<ref>{{Cite journal
*[[Retroperitoneum|Retroperitoneal]] liposarcomas may affect adjacent [[Organ (anatomy)|organs]] and structures, that can lead to [[kidney disease]] or [[vascular]] compression.<ref>{{Cite journal
| author = [[Amit Gupta]], [[Omar Pacha]], [[Rony Skaria]], [[Tam Huynh]], [[Luan Truong]] & [[Abdul Abdellatif]]
| title = Retroperitoneal sarcoma presenting as acute renal failure, secondary to bilateral renal artery invasion
| journal = [[Clinical nephrology]]
| volume = 78
| issue = 2
| pages = 164–168
| year = 2012
| month = August
| pmid = 22790462
}}</ref>
*A case of [[pancreatitis]] has been reported due to a dedifferentiated retroperitoneal liposarcoma.<ref>{{Cite journal
| author = [[Yusuke Arakawa]], [[Kazuo Yoshioka]], [[Hitomi Kamo]], [[Koichiro Kawano]], [[Takeshi Yamaguchi]], [[Yuko Sumise]], [[Natsu Okitsu]], [[Shizuo Ikeyama]], [[Kojiro Morimoto]], [[Yoshihiro Nakai]] & [[Seiki Tashiro]]
| title = Huge retroperitoneal dedifferentiated liposarcoma presented as acute pancreatitis: report of a case
| journal = [[The journal of medical investigation : JMI]]
| volume = 60
| issue = 1-2
| pages = 164–168
| year = 2013
| month =
| pmid = 23614927
}}</ref>
*Other [[Complication (medicine)|complications]] can include:
:*[[Bowel obstruction|Intestinal obstruction]], [[Bowel ischemia|ischemia]], and/or [[Intestinal perforation|perforation]]<ref>{{Cite journal
| author = [[Kazim Duman]], [[Mustafa Girgin]] & [[Gokhan Artas]]
| title = A case report: Giant intra-abdominal liposarcoma presenting acute renal failure
| journal = [[Annals of medicine and surgery (2012)]]
| volume = 12
| pages = 90–93
| year = 2016
| month = December
| doi = 10.1016/j.amsu.2016.09.005
| pmid = 27942382
}}</ref>
:*[[Hydronephrosis]]<ref>{{Cite journal
| author = [[Kazim Duman]], [[Mustafa Girgin]] & [[Gokhan Artas]]
| title = A case report: Giant intra-abdominal liposarcoma presenting acute renal failure
| journal = [[Annals of medicine and surgery (2012)]]
| volume = 12
| pages = 90–93
| year = 2016
| month = December
| doi = 10.1016/j.amsu.2016.09.005
| pmid = 27942382
}}</ref>
:*[[Ureter|Ureteric]] [[fistula]]
:*[[Aortic rupture]]
 
===Prognosis===
*The [[prognosis]] of liposarcoma will depend on the [[Histopathology|histopathological]] sub-type.   
*Atypical lipomatous neoplasm/well-differentiated liposarcoma has a low [[metastasis]] risk, but may recur locally. The [[prognosis]] for this sub-type is better than for other sub-types of liposarcoma.<ref name="PetersonKransdorf2003">{{cite journal|last1=Peterson|first1=Jeffrey J.|last2=Kransdorf|first2=Mark J.|last3=Bancroft|first3=Laura W.|last4=O'Connor|first4=Mary I.|title=Malignant fatty tumors: classification, clinical course, imaging appearance and treatment|journal=Skeletal Radiology|volume=32|issue=9|year=2003|pages=493–503|issn=0364-2348|doi=10.1007/s00256-003-0647-8}}</ref>  
*The [[Pleomorphism|pleomorphic]] liposarcoma has a high [[metastasis]] potential and a high recurrence rate. The 5-year disease free [[survival rate]] for pleomorphic liposarcoma is 40%.<ref>{{Cite journal
| author = [[A. M. Oliveira]] & [[A. G. Nascimento]]
| title = Pleomorphic liposarcoma
| journal = [[Seminars in diagnostic pathology]]
| volume = 18
| issue = 4
| pages = 274–285
| year = 2001
| month = November
| pmid = 11757868
}}</ref>
*The 5-year disease free [[survival rate]] for liposarcoma located in the [[Limb (anatomy)|extremities]] is 74%.<ref>{{Cite journal
| author = [[D. B. Pearlstone]], [[P. W. Pisters]], [[R. J. Bold]], [[B. W. Feig]], [[K. K. Hunt]], [[A. W. Yasko]], [[S. Patel]], [[A. Pollack]], [[R. S. Benjamin]] & [[R. E. Pollock]]
| author = [[D. B. Pearlstone]], [[P. W. Pisters]], [[R. J. Bold]], [[B. W. Feig]], [[K. K. Hunt]], [[A. W. Yasko]], [[S. Patel]], [[A. Pollack]], [[R. S. Benjamin]] & [[R. E. Pollock]]
  | title = Patterns of recurrence in extremity liposarcoma: implications for staging and follow-up
  | title = Patterns of recurrence in extremity liposarcoma: implications for staging and follow-up
Line 31: Line 90:
  | pmid = 9921978
  | pmid = 9921978
}}</ref>
}}</ref>


==References==
==References==
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Latest revision as of 16:33, 28 May 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]

Overview

The natural history of liposarcoma depends on the histopathological sub-type and location of the tumor. If left untreated, liposarcomas may remain silent for a long time, especially if they are located in the retroperitoneum. Liposarcoma may metastasize to other organs. Lung is the most common location for metastatic disease. Retroperitoneal liposarcomas may affect adjacent organs and structures, that can lead to kidney disease or vascular compression. The prognosis of liposarcoma will depend on the histopathological sub-type. Atypical lipomatous neoplasm/well-differentiated liposarcoma has a low metastasis risk, but may recur locally. The prognosis for this sub-type is better than for other sub-types of liposarcoma. The 5-year disease free survival rate for liposarcoma located in the extremities is 74%.

Natural History, Complications, and Prognosis

Natural History

  • The natural history of liposarcoma depends on the histopathological sub-type and location of the tumor.
  • If left untreated, liposarcomas may remain silent for a long time, especially if they are located in the retroperitoneum.[1]
  • The most common presentation of a liposarcoma located in the extremities is a painless growing mass without additional symptoms.

Complications

Prognosis

References

  1. ↑ 1.0 1.1 1.2 Peterson, Jeffrey J.; Kransdorf, Mark J.; Bancroft, Laura W.; O'Connor, Mary I. (2003). "Malignant fatty tumors: classification, clinical course, imaging appearance and treatment". Skeletal Radiology. 32 (9): 493–503. doi:10.1007/s00256-003-0647-8. ISSN 0364-2348.
  2. ↑ Amit Gupta, Omar Pacha, Rony Skaria, Tam Huynh, Luan Truong & Abdul Abdellatif (2012). "Retroperitoneal sarcoma presenting as acute renal failure, secondary to bilateral renal artery invasion". Clinical nephrology. 78 (2): 164–168. PMID 22790462. Unknown parameter |month= ignored (help)
  3. ↑ Yusuke Arakawa, Kazuo Yoshioka, Hitomi Kamo, Koichiro Kawano, Takeshi Yamaguchi, Yuko Sumise, Natsu Okitsu, Shizuo Ikeyama, Kojiro Morimoto, Yoshihiro Nakai & Seiki Tashiro (2013). "Huge retroperitoneal dedifferentiated liposarcoma presented as acute pancreatitis: report of a case". The journal of medical investigation : JMI. 60 (1–2): 164–168. PMID 23614927.
  4. ↑ Kazim Duman, Mustafa Girgin & Gokhan Artas (2016). "A case report: Giant intra-abdominal liposarcoma presenting acute renal failure". Annals of medicine and surgery (2012). 12: 90–93. doi:10.1016/j.amsu.2016.09.005. PMID 27942382. Unknown parameter |month= ignored (help)
  5. ↑ Kazim Duman, Mustafa Girgin & Gokhan Artas (2016). "A case report: Giant intra-abdominal liposarcoma presenting acute renal failure". Annals of medicine and surgery (2012). 12: 90–93. doi:10.1016/j.amsu.2016.09.005. PMID 27942382. Unknown parameter |month= ignored (help)
  6. ↑ A. M. Oliveira & A. G. Nascimento (2001). "Pleomorphic liposarcoma". Seminars in diagnostic pathology. 18 (4): 274–285. PMID 11757868. Unknown parameter |month= ignored (help)
  7. ↑ D. B. Pearlstone, P. W. Pisters, R. J. Bold, B. W. Feig, K. K. Hunt, A. W. Yasko, S. Patel, A. Pollack, R. S. Benjamin & R. E. Pollock (1999). "Patterns of recurrence in extremity liposarcoma: implications for staging and follow-up". Cancer. 85 (1): 85–92. PMID 9921978. Unknown parameter |month= ignored (help)


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