Liposarcoma laboratory findings: Difference between revisions

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==Overview==
==Overview==
There are no specific [[Medical laboratory|laboratory]] [[Test|tests]] for the [[diagnosis]] of liposarcoma. [[Patient|Patients]] with [[ureteral]] or [[renal]] involvement can have an elevated [[creatinine]]. [[Anemia]] and [[BUN|elevated BUN]] may be present in [[Patient|patients]] with liposarcoma assoicated with [[gastrointestinal bleeding]]. Elevated [[D-dimer]] level.


==Laboratory Findings==
==Laboratory Findings==
 
*There are no specific [[Medical laboratory|laboratory]] [[Test|tests]] for the [[diagnosis]] of liposarcoma.  
===Biopsy===
*[[Patient|Patients]] with [[ureteral]] or [[renal]] involvement can have an elevated [[creatinine]].<ref>{{Cite journal
Although imaging assists in the diagnosis of liposarcoma, a biopsy is needed to confirm the disease and determine the histopathological subtype of liposarcoma.  
| author = [[Kazim Duman]], [[Mustafa Girgin]] & [[Gokhan Artas]]
 
  | title = A case report: Giant intra-abdominal liposarcoma presenting acute renal failure
{| style="border: 0px; font-size: 90%; margin: 3px; width: 700px" align=center
| journal = [[Annals of medicine and surgery (2012)]]
|valign=top|
| volume = 12
|+
| pages = 90–93
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Subtype}}
| year = 2016
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Findings}}
  | month = December
|-
| doi = 10.1016/j.amsu.2016.09.005
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Atypical Lipomatous Neoplasm (ALN)/Well-Differentiated Liposarcoma (WDL)
| pmid = 27942382
| style="padding: 5px 5px; background: #F5F5F5;" | 4 subtypes: lipoma-like, sclerosing, spindle cell and inflammatory. Multivacuolated lipoblasts and spindle cells with a hyperchromatic nuclei. Fibrotic areas and atypical stroma cells may be observed.
}}</ref>
|-
*[[Anemia]] and [[BUN|elevated BUN]] may be present in [[Patient|patients]] with liposarcoma assoicated with [[gastrointestinal bleeding]].<ref name="NennstielMollenhauer2014">{{cite journal|last1=Nennstiel|first1=Simon|last2=Mollenhauer|first2=Martin|last3=Schlag|first3=Christoph|last4=Becker|first4=Valentin|last5=Neu|first5=Bruno|last6=Hüser|first6=Norbert|last7=Gertler|first7=Ralf|last8=Schmid|first8=Roland M.|last9=von Delius|first9=Stefan|title=Small Bowel Pleomorphic Liposarcoma: A Rare Cause of Gastrointestinal Bleeding|journal=Case Reports in Gastrointestinal Medicine|volume=2014|year=2014|pages=1–4|issn=2090-6528|doi=10.1155/2014/391871}}</ref>
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Dedifferentiated Liposarcoma
*Elevated [[D-dimer]] level.<ref>{{Cite journal
| style="padding: 5px 5px; background: #F5F5F5;" | Abrupt transition from a low-grade to a high-grade differentiation within the same mass of well-differentiated liposarcoma.
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Myxoid Liposarcoma
| style="padding: 5px 5px; background: #F5F5F5;" |Multinodular mass with round cells, hyaluronic acid matrix. High cellularity at the periphery and low cellularity inside the mass. Mitotic activity is normal and the nuclei is normochromatic.
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Pleomorphic Liposarcoma
| style="padding: 5px 5px; background: #F5F5F5;" | Pleomorphic lipoblasts with hyperchromatic nuclei, acidophilic cytoplasm and eosinophilic hyaline globules; spinde cells and multinucleated giant cells may be observed.
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Mixed-type Liposarcoma
| style="padding: 5px 5px; background: #F5F5F5;" | Mixed features of myxoid, pleomorphic and well-differentiated liposarcoma.  
|-
| style="padding: 5px 5px; background: #F5F5F5;" colspan=2| <small>Table adapted from Fletcher C.D.M., Unni K.K., Mertens F. (Eds.): WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone<ref>{{cite book | last = Fletcher | first = Christopher | title = Pathology and genetics of tumours of soft tissue and bone | publisher = IARC Press | location = Lyon | year = 2002 | isbn = 9283224132 }}</ref> and Enzinger and Weiss's Soft Tissue Tumors , 6th Edition <ref>{{cite book | last = Goldblum | first = John | title = Enzinger and Weiss's soft tissue tumors | publisher = Saunders/Elsevier | location = Philadelphia, PA | year = 2014 | isbn = 978-0-323-08834-3 }}</ref> </small>
|-
|}
 
 
{|
|[[File:Well Differentiated Liposarcoma.jpg|thumb|250px|Well Differentiated Liposarcoma.  Image courtesy of Wikimedia Commons.]]
|[[File:Dedifferentiated Liposarcoma.jpg|thumb|250px|Dedifferentiated Liposarcoma.  Image courtesy of Wikimedia Commons.]]
|[[File:Dedifferentiated Liposarcoma 2.jpg|thumb|250px|Dedifferentiated Liposarcoma.  Image courtesy of Wikimedia Commons.]]
|-
|[[File:Dedifferentiated Liposarcoma 3.jpg|thumb|250px|Dedifferentiated Liposarcoma.  Image courtesy of Wikimedia Commons.]]
|[[File:Dedifferentiated Liposarcoma 4.jpg|thumb|250px|Dedifferentiated Liposarcoma.  Image courtesy of Wikimedia Commons.]]
|}
 
===Laboratory Tests===
*There are no specific laboratory test findings for the diagnosis of liposarcoma.
*In cases of [[ureter]] or [[kidney]] involvement, an elevated [[creatinine]] and [[BUN]] may be seen.
*[[Anemia]] may be present, specially if there is [[bleeding]] associated with the liposarcoma. <ref name="NennstielMollenhauer2014">{{cite journal|last1=Nennstiel|first1=Simon|last2=Mollenhauer|first2=Martin|last3=Schlag|first3=Christoph|last4=Becker|first4=Valentin|last5=Neu|first5=Bruno|last6=Hüser|first6=Norbert|last7=Gertler|first7=Ralf|last8=Schmid|first8=Roland M.|last9=von Delius|first9=Stefan|title=Small Bowel Pleomorphic Liposarcoma: A Rare Cause of Gastrointestinal Bleeding|journal=Case Reports in Gastrointestinal Medicine|volume=2014|year=2014|pages=1–4|issn=2090-6528|doi=10.1155/2014/391871}}</ref>
* The level of D-dimer has been studied as a marker for the differential diagnosis of lipoma and well-differentiated liposarcoma, the latter having higher levels of D=dimer.<ref>{{Cite journal
| author = [[Akira Yoshiyama]], [[Takeshi Morii]], [[Takashi Tajima]], [[Takayuki Aoyagi]], [[Keita Honya]], [[Kazuo Mochizuki]], [[Kazuhiko Satomi]] & [[Shoichi Ichimura]]
| author = [[Akira Yoshiyama]], [[Takeshi Morii]], [[Takashi Tajima]], [[Takayuki Aoyagi]], [[Keita Honya]], [[Kazuo Mochizuki]], [[Kazuhiko Satomi]] & [[Shoichi Ichimura]]
  | title = D-dimer Levels in the Differential Diagnosis Between Lipoma and Well-differentiated Liposarcoma
  | title = D-dimer Levels in the Differential Diagnosis Between Lipoma and Well-differentiated Liposarcoma
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Latest revision as of 18:29, 28 May 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]

Overview

There are no specific laboratory tests for the diagnosis of liposarcoma. Patients with ureteral or renal involvement can have an elevated creatinine. Anemia and elevated BUN may be present in patients with liposarcoma assoicated with gastrointestinal bleeding. Elevated D-dimer level.

Laboratory Findings

References

  1. ↑ Kazim Duman, Mustafa Girgin & Gokhan Artas (2016). "A case report: Giant intra-abdominal liposarcoma presenting acute renal failure". Annals of medicine and surgery (2012). 12: 90–93. doi:10.1016/j.amsu.2016.09.005. PMID 27942382. Unknown parameter |month= ignored (help)
  2. ↑ Nennstiel, Simon; Mollenhauer, Martin; Schlag, Christoph; Becker, Valentin; Neu, Bruno; Hüser, Norbert; Gertler, Ralf; Schmid, Roland M.; von Delius, Stefan (2014). "Small Bowel Pleomorphic Liposarcoma: A Rare Cause of Gastrointestinal Bleeding". Case Reports in Gastrointestinal Medicine. 2014: 1–4. doi:10.1155/2014/391871. ISSN 2090-6528.
  3. ↑ Akira Yoshiyama, Takeshi Morii, Takashi Tajima, Takayuki Aoyagi, Keita Honya, Kazuo Mochizuki, Kazuhiko Satomi & Shoichi Ichimura (2014). "D-dimer Levels in the Differential Diagnosis Between Lipoma and Well-differentiated Liposarcoma". Anticancer research. 34 (9): 5181–5185. PMID 25202112. Unknown parameter |month= ignored (help)


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