Lymphangitis laboratory findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Lymphangitis}} | {{Lymphangitis}} | ||
{{CMG}} | {{CMG}}{{AE}}{{VD}} | ||
==Overview== | ==Overview== | ||
There are no diagnostic lab findings associated with lymphangitis. The presence of certain non-specific laboratory findings, in the presence of lymphangitis, may be suggestive of certain underlying causes. Examples of tests that may demonstrate abnormal findings include [[CBC]], [[ESR]], [[CRP]], and serology titers.<ref name=lymphangitis>lymphanitis Mandell, GERALD L. "Mandell, Douglas, and Bennett's." Principles and practice of infectious diseases 7 (1995) Accessed on October 12,2016</ref> | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
*[[ | There are no diagnostic lab findings associated with lymphangitis The presence of certain non-specific laboratory findings, in the presence of lymphangitis, may be suggestive of certain underlying causes. Routine laboratory studies should be correlated with a carefully collected history and a precise physical examination. Routine laboratory tests that may be ordered and their respective findings include:<ref name="lymphangitis2">lymphanitis Mandell, GERALD L. "Mandell, Douglas, and Bennett's." Principles and practice of infectious diseases 7 (1995) Accessed on October 12,2016</ref><ref name="pmid8480962">{{cite journal| author=Kostman JR, DiNubile MJ| title=Nodular lymphangitis: a distinctive but often unrecognized syndrome. | journal=Ann Intern Med | year= 1993 | volume= 118 | issue= 11 | pages= 883-8 | pmid=8480962 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8480962 }}</ref><ref name="pmid18317034">{{cite journal| author=Schubach A, Barros MB, Wanke B| title=Epidemic sporotrichosis. | journal=Curr Opin Infect Dis | year= 2008 | volume= 21 | issue= 2 | pages= 129-33 | pmid=18317034 | doi=10.1097/QCO.0b013e3282f44c52 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18317034 }}</ref><ref name="pmid27051706">{{cite journal| author=Chung E, Pulitzer MP, Papadopoulos EB, Papanicolaou GA, Babady NE, Marchetti MA| title=Lymphangitic papules caused by Nocardia takedensis. | journal=JAAD Case Rep | year= 2015 | volume= 1 | issue= 3 | pages= 126-8 | pmid=27051706 | doi=10.1016/j.jdcr.2015.03.001 | pmc=4808715 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27051706 }}</ref><ref name="pmid11472559">{{cite journal| author=Taylor MJ, Cross HF, Ford L, Makunde WH, Prasad GB, Bilo K| title=Wolbachia bacteria in filarial immunity and disease. | journal=Parasite Immunol | year= 2001 | volume= 23 | issue= 7 | pages= 401-9 | pmid=11472559 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11472559 }}</ref><ref name="pmid20739055">{{cite journal| author=Taylor MJ, Hoerauf A, Bockarie M| title=Lymphatic filariasis and onchocerciasis. | journal=Lancet | year= 2010 | volume= 376 | issue= 9747 | pages= 1175-85 | pmid=20739055 | doi=10.1016/S0140-6736(10)60586-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20739055 }}</ref><ref name="harrison">lymphanitis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on October 12,2016</ref><ref name="pmid8930034">{{cite journal| author=Bruce DM, Heys SD, Eremin O| title=Lymphangitis carcinomatosa: a literature review. | journal=J R Coll Surg Edinb | year= 1996 | volume= 41 | issue= 1 | pages= 7-13 | pmid=8930034 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8930034 }}</ref> | ||
===Complete Blood Count with Differentials and Peripheral Blood Smear=== | |||
*[[Eosinophilia]] may be suggestive of underlying [[parasitic]] infections. | |||
*Elevated [[white blood cells]] with a [[left shift]] may be suggestive of an underlying infection. | |||
*Microfilariae on giemsa stained, thin and thick blood film smears, are considered gold standard in diagnosis for filariasis | |||
===Laboratory Findings of severe disease <small><small><small><small>'''Adapted from the 2005 IDSA Practice guidelines for the diagnosis and management of skin and soft-tissue infections.'''<ref name="pmid16231249">{{cite journal| author=Stevens DL, Bisno AL, Chambers HF, Everett ED, Dellinger P, Goldstein EJ et al.| title=Practice guidelines for the diagnosis and management of skin and soft-tissue infections. | journal=Clin Infect Dis | year= 2005 | volume= 41 | issue= 10 | pages= 1373-406 | pmid=16231249 | doi=10.1086/497143 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16231249 }} </ref></small></small></small></small>=== | |||
*[[C reactive protein]] over 13 mg/L | |||
*[[CBC]] with marked [[left shift]] | |||
*Elevated [[creatinine]] level | |||
*2 to 3 times the upper level of normal [[creatinine phosphokinase]] | |||
*Low [[bicarbonate]] level | |||
===ESR and CRP=== | |||
*Elevated [[ESR]] and [[CRP]] may be suggestive of an underlying infection or [[Autoimmune|inflammatory condition]] | |||
===Serology tests=== | |||
*F. tularensis titre | |||
*Histoplasma titre | |||
===Microbiological investigations=== | |||
*Swab and aspirate taken from the primary site, should be sent for microscopy, as well as cultural and sensitivity. | |||
*Microbiological investigations not only helps us to identify causative infectious organism, but also act as a guide to select appropriate antimicrobial | |||
===Other Laboratory Findings=== | |||
*Rarely, polymerase chain reaction(PCR) can be used in diagnosis of Nocardia, Tularemia, and Leshmania. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Inflammations]] | [[Category:Inflammations]] | ||
[[Category:Disease]] | |||
[[Category:Emergency mdicine]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Infectious disease]] | [[Category:Infectious disease]] | ||
[[Category: | [[Category:Vascular medicine]] | ||
Latest revision as of 22:36, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Vishal Devarkonda, M.B.B.S[2]
Overview
There are no diagnostic lab findings associated with lymphangitis. The presence of certain non-specific laboratory findings, in the presence of lymphangitis, may be suggestive of certain underlying causes. Examples of tests that may demonstrate abnormal findings include CBC, ESR, CRP, and serology titers.[1]
Laboratory Findings
There are no diagnostic lab findings associated with lymphangitis The presence of certain non-specific laboratory findings, in the presence of lymphangitis, may be suggestive of certain underlying causes. Routine laboratory studies should be correlated with a carefully collected history and a precise physical examination. Routine laboratory tests that may be ordered and their respective findings include:[2][3][4][5][6][7][8][9]
Complete Blood Count with Differentials and Peripheral Blood Smear
- Eosinophilia may be suggestive of underlying parasitic infections.
- Elevated white blood cells with a left shift may be suggestive of an underlying infection.
- Microfilariae on giemsa stained, thin and thick blood film smears, are considered gold standard in diagnosis for filariasis
Laboratory Findings of severe disease Adapted from the 2005 IDSA Practice guidelines for the diagnosis and management of skin and soft-tissue infections.[10]
- C reactive protein over 13 mg/L
- CBC with marked left shift
- Elevated creatinine level
- 2 to 3 times the upper level of normal creatinine phosphokinase
- Low bicarbonate level
ESR and CRP
- Elevated ESR and CRP may be suggestive of an underlying infection or inflammatory condition
Serology tests
- F. tularensis titre
- Histoplasma titre
Microbiological investigations
- Swab and aspirate taken from the primary site, should be sent for microscopy, as well as cultural and sensitivity.
- Microbiological investigations not only helps us to identify causative infectious organism, but also act as a guide to select appropriate antimicrobial
Other Laboratory Findings
- Rarely, polymerase chain reaction(PCR) can be used in diagnosis of Nocardia, Tularemia, and Leshmania.
References
- ↑ lymphanitis Mandell, GERALD L. "Mandell, Douglas, and Bennett's." Principles and practice of infectious diseases 7 (1995) Accessed on October 12,2016
- ↑ lymphanitis Mandell, GERALD L. "Mandell, Douglas, and Bennett's." Principles and practice of infectious diseases 7 (1995) Accessed on October 12,2016
- ↑ Kostman JR, DiNubile MJ (1993). "Nodular lymphangitis: a distinctive but often unrecognized syndrome". Ann Intern Med. 118 (11): 883–8. PMID 8480962.
- ↑ Schubach A, Barros MB, Wanke B (2008). "Epidemic sporotrichosis". Curr Opin Infect Dis. 21 (2): 129–33. doi:10.1097/QCO.0b013e3282f44c52. PMID 18317034.
- ↑ Chung E, Pulitzer MP, Papadopoulos EB, Papanicolaou GA, Babady NE, Marchetti MA (2015). "Lymphangitic papules caused by Nocardia takedensis". JAAD Case Rep. 1 (3): 126–8. doi:10.1016/j.jdcr.2015.03.001. PMC 4808715. PMID 27051706.
- ↑ Taylor MJ, Cross HF, Ford L, Makunde WH, Prasad GB, Bilo K (2001). "Wolbachia bacteria in filarial immunity and disease". Parasite Immunol. 23 (7): 401–9. PMID 11472559.
- ↑ Taylor MJ, Hoerauf A, Bockarie M (2010). "Lymphatic filariasis and onchocerciasis". Lancet. 376 (9747): 1175–85. doi:10.1016/S0140-6736(10)60586-7. PMID 20739055.
- ↑ lymphanitis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on October 12,2016
- ↑ Bruce DM, Heys SD, Eremin O (1996). "Lymphangitis carcinomatosa: a literature review". J R Coll Surg Edinb. 41 (1): 7–13. PMID 8930034.
- ↑ Stevens DL, Bisno AL, Chambers HF, Everett ED, Dellinger P, Goldstein EJ; et al. (2005). "Practice guidelines for the diagnosis and management of skin and soft-tissue infections". Clin Infect Dis. 41 (10): 1373–406. doi:10.1086/497143. PMID 16231249.