Liposarcoma laboratory findings: Difference between revisions

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==Overview==
==Overview==
The definitive diagnosis of liposarcoma is made by biopsy, which also provides histopathological classification of the liposarcoma's subtype. Other pertinent laboratory findings include anemia and elevated BUN due to GI bleeding and elevated creatinine among patients with obstructive nephropathy.
There are no specific [[Medical laboratory|laboratory]] [[Test|tests]] for the [[diagnosis]] of liposarcoma. [[Patient|Patients]] with [[ureteral]] or [[renal]] involvement can have an elevated [[creatinine]]. [[Anemia]] and [[BUN|elevated BUN]] may be present in [[Patient|patients]] with liposarcoma assoicated with [[gastrointestinal bleeding]]. Elevated [[D-dimer]] level.


==Laboratory findings==
==Laboratory Findings==
*There are no specific laboratory tests for the diagnosis of liposarcoma.  
*There are no specific [[Medical laboratory|laboratory]] [[Test|tests]] for the [[diagnosis]] of liposarcoma.  
*Patients with [[ureteral]] or [[renal]] involvement, an elevated [[creatinine]] may be observed.
*[[Patient|Patients]] with [[ureteral]] or [[renal]] involvement can have an elevated [[creatinine]].<ref>{{Cite journal
*[[Anemia]] and [[BUN|elevated BUN]] may be present among patients with liposarcoma assoicated with GI bleeding.<ref name="NennstielMollenhauer2014">{{cite journal|last1=Nennstiel|first1=Simon|last2=Mollenhauer|first2=Martin|last3=Schlag|first3=Christoph|last4=Becker|first4=Valentin|last5=Neu|first5=Bruno|last6=Hüser|first6=Norbert|last7=Gertler|first7=Ralf|last8=Schmid|first8=Roland M.|last9=von Delius|first9=Stefan|title=Small Bowel Pleomorphic Liposarcoma: A Rare Cause of Gastrointestinal Bleeding|journal=Case Reports in Gastrointestinal Medicine|volume=2014|year=2014|pages=1–4|issn=2090-6528|doi=10.1155/2014/391871}}</ref>
| author = [[Kazim Duman]], [[Mustafa Girgin]] & [[Gokhan Artas]]
*The level of [[D-dimer]] has been studied as a marker for the differential diagnosis of [[lipoma]] and well-differentiated liposarcoma. Results have demonstrated that liposarcoma may have increased levels of D-dimer compared to lipoma.<ref>{{Cite journal
| title = A case report: Giant intra-abdominal liposarcoma presenting acute renal failure
| journal = [[Annals of medicine and surgery (2012)]]
| volume = 12
| pages = 90–93
| year = 2016
| month = December
| doi = 10.1016/j.amsu.2016.09.005
| pmid = 27942382
}}</ref>
*[[Anemia]] and [[BUN|elevated BUN]] may be present in [[Patient|patients]] with liposarcoma assoicated with [[gastrointestinal bleeding]].<ref name="NennstielMollenhauer2014">{{cite journal|last1=Nennstiel|first1=Simon|last2=Mollenhauer|first2=Martin|last3=Schlag|first3=Christoph|last4=Becker|first4=Valentin|last5=Neu|first5=Bruno|last6=Hüser|first6=Norbert|last7=Gertler|first7=Ralf|last8=Schmid|first8=Roland M.|last9=von Delius|first9=Stefan|title=Small Bowel Pleomorphic Liposarcoma: A Rare Cause of Gastrointestinal Bleeding|journal=Case Reports in Gastrointestinal Medicine|volume=2014|year=2014|pages=1–4|issn=2090-6528|doi=10.1155/2014/391871}}</ref>
*Elevated [[D-dimer]] level.<ref>{{Cite journal
| author = [[Akira Yoshiyama]], [[Takeshi Morii]], [[Takashi Tajima]], [[Takayuki Aoyagi]], [[Keita Honya]], [[Kazuo Mochizuki]], [[Kazuhiko Satomi]] & [[Shoichi Ichimura]]
| author = [[Akira Yoshiyama]], [[Takeshi Morii]], [[Takashi Tajima]], [[Takayuki Aoyagi]], [[Keita Honya]], [[Kazuo Mochizuki]], [[Kazuhiko Satomi]] & [[Shoichi Ichimura]]
  | title = D-dimer Levels in the Differential Diagnosis Between Lipoma and Well-differentiated Liposarcoma
  | title = D-dimer Levels in the Differential Diagnosis Between Lipoma and Well-differentiated Liposarcoma
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  | pmid = 25202112
  | pmid = 25202112
}}</ref>
}}</ref>
===Biopsy===
Although imaging may be helpful in the diagnosis of liposarcoma, the optimal method for diagnosis of liposarcoma is by biopsy. A biopsy also provides important histopathological information requires to identify the subtype of the liposarcoma.
{| style="border: 0px; font-size: 90%; margin: 3px; width: 700px" align=center
|valign=top|
|+
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Subtype}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Findings}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Atypical Lipomatous Neoplasm (ALN)/Well-Differentiated Liposarcoma (WDL)
| style="padding: 5px 5px; background: #F5F5F5;" | 4 subtypes:<br>
*Lipoma-like<br>
*Sclerosing<br>
*Spindle cell<br>
*Inflammatory<br>
Multivacuolated lipoblasts and spindle cells with hyperchromatic nuclei are often observed.<br>Other findings include fibrotic areas and atypical stroma cells.
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | De-differentiated Liposarcoma
| style="padding: 5px 5px; background: #F5F5F5;" | Abrupt transition from a low-grade to a high-grade differentiation within the same mass of a well-differentiated liposarcoma.
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Myxoid liposarcoma
| style="padding: 5px 5px; background: #F5F5F5;" |Multinodular mass with round cells and hyaluronic acid matrix.<br>High cellularity at the periphery and low cellularity at the center of the mass. Mitotic activity is normal and the nuclei are normochromatic.
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Pleomorphic liposarcoma
| style="padding: 5px 5px; background: #F5F5F5;" | Pleomorphic lipoblasts with hyperchromatic nuclei, acidophilic cytoplasm, and eosinophilic hyaline globules.<br>Spindle cells and multinucleated giant cells may be observed.
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Mixed-type Liposarcoma
| style="padding: 5px 5px; background: #F5F5F5;" | Mixed features of myxoid, pleomorphic, and well-differentiated liposarcoma.
|-
| style="padding: 5px 5px; background: #F5F5F5;" colspan=2| <small>Table adapted from Fletcher CDM, Unni KK, Mertens F, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Geneva:IARC Press; 2002<ref>{{cite book | last = Fletcher | first = Christopher | title = Pathology and genetics of tumours of soft tissue and bone | publisher = IARC Press | location = Lyon | year = 2002 | isbn = 9283224132 }}</ref> and Enzinger and Weiss's Soft Tissue Tumors , 6th Edition <ref>{{cite book | last = Goldblum | first = John | title = Enzinger and Weiss's soft tissue tumors | publisher = Saunders/Elsevier | location = Philadelphia, PA | year = 2014 | isbn = 978-0-323-08834-3 }}</ref> </small>
|-
|}
{|
|[[File:Well Differentiated Liposarcoma.jpg|thumb|250px|Well-differentiated liposarcoma.<br>Retrieved from Wikimedia Commons. Original image courtesy of Panoraia Paraskeva, Paraskevas Katsaronis, Eleftherios D Spartalis, et al. Giant liposarcoma of the back with 4 types of histopathology: a case report. Cases Journal. 2009; 2:9339(Open Access)]]
|[[File:Dedifferentiated Liposarcoma.jpg|thumb|250px|De-differentiated liposarcoma.<br>Retrieved from Wikimedia Commons. Image by user: Nephron, licensed under GNU Free Documentation License]]
|[[File:Dedifferentiated Liposarcoma 2.jpg|thumb|250px|De-differentiated liposarcoma.<br>Retrieved from Wikimedia Commons. Image by user: Nephron, licensed under GNU Free Documentation License]]
|-
|[[File:Dedifferentiated Liposarcoma 3.jpg|thumb|250px|De-differentiated liposarcoma.<br>Retrieved from Wikimedia Commons. Image by user: Nephron, licensed under GNU Free Documentation License]]
|[[File:Dedifferentiated Liposarcoma 4.jpg|thumb|250px|De-differentiated liposarcoma.<br>Retrieved from Wikimedia Commons. Image by user: Nephron, licensed under GNU Free Documentation License]]
|}


==References==
==References==
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Latest revision as of 18:29, 28 May 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]

Overview

There are no specific laboratory tests for the diagnosis of liposarcoma. Patients with ureteral or renal involvement can have an elevated creatinine. Anemia and elevated BUN may be present in patients with liposarcoma assoicated with gastrointestinal bleeding. Elevated D-dimer level.

Laboratory Findings

References

  1. ↑ Kazim Duman, Mustafa Girgin & Gokhan Artas (2016). "A case report: Giant intra-abdominal liposarcoma presenting acute renal failure". Annals of medicine and surgery (2012). 12: 90–93. doi:10.1016/j.amsu.2016.09.005. PMID 27942382. Unknown parameter |month= ignored (help)
  2. ↑ Nennstiel, Simon; Mollenhauer, Martin; Schlag, Christoph; Becker, Valentin; Neu, Bruno; Hüser, Norbert; Gertler, Ralf; Schmid, Roland M.; von Delius, Stefan (2014). "Small Bowel Pleomorphic Liposarcoma: A Rare Cause of Gastrointestinal Bleeding". Case Reports in Gastrointestinal Medicine. 2014: 1–4. doi:10.1155/2014/391871. ISSN 2090-6528.
  3. ↑ Akira Yoshiyama, Takeshi Morii, Takashi Tajima, Takayuki Aoyagi, Keita Honya, Kazuo Mochizuki, Kazuhiko Satomi & Shoichi Ichimura (2014). "D-dimer Levels in the Differential Diagnosis Between Lipoma and Well-differentiated Liposarcoma". Anticancer research. 34 (9): 5181–5185. PMID 25202112. Unknown parameter |month= ignored (help)


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