Neuroblastoma history and symptoms: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Neuroblastoma}} | {{Neuroblastoma}} | ||
{{CMG}} {{AE}}{{HL}} | {{CMG}} {{AE}}{{ZAS}}{{HL}} | ||
==Overview== | ==Overview== | ||
A detailed history of presenting [[symptoms]], [[family history]] and other associated [[Symptom|symptoms]] should be undertaken when evaluating a [[patient]] of neuroblastoma. General neuroblastoma symptoms include; [[fever]], [[irritability]], [[fatigue]], [[loss of appetite]] and [[weight loss]]. Other [[symptoms]] depending upon the [[anatomical]] location of neuroblastoma include [[abdominal pain]], [[distension]] and [[constipation]] ([[abdomen]]), [[Dyspnea|shortness of breath]], [[chronic cough]] & [[difficulty swallowing]] ([[posterior mediastinum]]), [[weakness]], [[numbness]], [[paralysis]] ([[retroperitoneum]]), visual defects, facial bruising ([[Head and neck anatomy|head & neck]]) and [[pallor]], [[bone pain]] ([[bone marrow]] [[Metastasis|metastases]]). | |||
==History== | ==History== | ||
* | * A detailed history of presenting [[symptoms]] (duration, onset, progression), a thorough [[family history]] and a review of other other associated [[symptoms]] should be undertaken when evaluating a [[patient]] of neuroblastoma. When obtaining the history focus on possible associated [[Syndrome|syndromes]] as well, such as:<ref>{{Cite journal | ||
| author = [[Sidharth Mahapatra]] & [[Kishore B.. Challagundla]] | |||
| title = Cancer, Neuroblastoma | |||
| year = 2018 | |||
| month = January | |||
| pmid = 28846355 | |||
}}</ref><ref>{{Cite journal | |||
| author = [[John M. Maris]] | |||
| title = Recent advances in neuroblastoma | |||
| journal = [[The New England journal of medicine]] | |||
| volume = 362 | |||
| issue = 23 | |||
| pages = 2202–2211 | |||
| year = 2010 | |||
| month = June | |||
| doi = 10.1056/NEJMra0804577 | |||
| pmid = 20558371 | |||
}}</ref> | |||
:* [[Neurofibromatosis type 1]] ([[von Recklinghausen disease]]) | :* [[Neurofibromatosis type 1]] ([[von Recklinghausen disease]]) | ||
:* [[Beckwith-Wiedemann syndrome]] | :* [[Beckwith-Wiedemann syndrome]] | ||
| Line 16: | Line 33: | ||
==Symptoms== | ==Symptoms== | ||
* General symptoms of neuroblastoma include: | * General [[symptoms]] of neuroblastoma include:<ref>{{Cite journal | ||
| author = [[J. W. Duckett]] & [[C. E. Koop]] | |||
| title = Neuroblastoma | |||
| journal = [[The Urologic clinics of North America]] | |||
| volume = 4 | |||
| issue = 2 | |||
| pages = 285–295 | |||
| year = 1977 | |||
| month = June | |||
| pmid = 331618 | |||
}}</ref><ref>{{Cite journal | |||
| author = [[Nadja C. Colon]] & [[Dai H. Chung]] | |||
| title = Neuroblastoma | |||
| journal = [[Advances in pediatrics]] | |||
| volume = 58 | |||
| issue = 1 | |||
| pages = 297–311 | |||
| year = 2011 | |||
| month = | |||
| doi = 10.1016/j.yapd.2011.03.011 | |||
| pmid = 21736987 | |||
}}</ref> | |||
:* [[Fever]] | :* [[Fever]] | ||
:* [[Irritability]] | :* [[Irritability]] | ||
| Line 23: | Line 61: | ||
:* [[Weight loss]] | :* [[Weight loss]] | ||
* However, the specific clinical presentation of neuroblastoma is determined by the exact anatomical location of the tumor: | * However, the specific clinical presentation of neuroblastoma is determined by the exact [[anatomical]] location of the [[tumor]] such as:<ref name="O">Neuroblastoma Childhood: Symptoms and Signs. Cancer.net http://www.cancer.net/cancer-types/neuroblastoma-childhood/symptoms-and-signs Accessed on October, 7 2015</ref><ref name="pmid21736987">{{cite journal| author=Colon NC, Chung DH| title=Neuroblastoma. | journal=Adv Pediatr | year= 2011 | volume= 58 | issue= 1 | pages= 297-311 | pmid=21736987 | doi=10.1016/j.yapd.2011.03.011 | pmc=PMC3668791 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21736987 }} </ref><ref>{{Cite journal | ||
| author = [[Titilope A. Ishola]] & [[Dai H. Chung]] | |||
| title = Neuroblastoma | |||
| journal = [[Surgical oncology]] | |||
| volume = 16 | |||
| issue = 3 | |||
| pages = 149–156 | |||
| year = 2007 | |||
| month = November | |||
| doi = 10.1016/j.suronc.2007.09.005 | |||
| pmid = 17976976 | |||
}}</ref> | |||
:* ''' | :* '''Abdominal neuroblastoma symptoms:''' | ||
::* [[Abdominal pain]] | ::* [[Abdominal pain]] | ||
::* [[Abdominal distension]] | ::* [[Abdominal distension]] | ||
::* [[Constipation]] | ::* [[Constipation]] | ||
:* ''' | :* '''Posterior mediastinum neuroblastoma symptoms:''' | ||
::* [[Shortness of breath]] | ::* [[Shortness of breath]] | ||
::* | ::* [[Chronic cough]] | ||
::* Difficulty swallowing | ::* [[Difficulty swallowing]] | ||
::* Difficulty breathing | ::* [[Difficulty breathing]] | ||
:* ''' | :* '''Retroperitoneal neuroblastoma symptoms:''' | ||
::* [[Weakness]] | ::* [[Weakness]] | ||
::* [[Numbness]] | ::* [[Numbness]] | ||
::* [[Paralysis]] | ::* [[Paralysis]] | ||
:* ''' | :* '''Head & neck neuroblastoma symptoms:''' | ||
::* Visual defects | ::* Visual defects | ||
::* [[Facial]] [[bruising]] | ::* [[Facial]] [[bruising]] | ||
::* [[Facial]] [[swelling]] | ::* [[Facial]] [[swelling]] | ||
:* '''Metastatic neuroblastomas lesions located in the bone marrow symptoms:''' | |||
::* [[Pallor]] | |||
::* [[Bone pain]] | |||
==References== | ==References== | ||
| Line 58: | Line 107: | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Pediatrics]] | [[Category:Pediatrics]] | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Neurology]] | |||
[[Category:Neurosurgery]] | |||
Latest revision as of 15:19, 6 March 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]Haytham Allaham, M.D. [3]
Overview
A detailed history of presenting symptoms, family history and other associated symptoms should be undertaken when evaluating a patient of neuroblastoma. General neuroblastoma symptoms include; fever, irritability, fatigue, loss of appetite and weight loss. Other symptoms depending upon the anatomical location of neuroblastoma include abdominal pain, distension and constipation (abdomen), shortness of breath, chronic cough & difficulty swallowing (posterior mediastinum), weakness, numbness, paralysis (retroperitoneum), visual defects, facial bruising (head & neck) and pallor, bone pain (bone marrow metastases).
History
- A detailed history of presenting symptoms (duration, onset, progression), a thorough family history and a review of other other associated symptoms should be undertaken when evaluating a patient of neuroblastoma. When obtaining the history focus on possible associated syndromes as well, such as:[1][2]
Symptoms
- However, the specific clinical presentation of neuroblastoma is determined by the exact anatomical location of the tumor such as:[5][6][7]
- Abdominal neuroblastoma symptoms:
- Posterior mediastinum neuroblastoma symptoms:
References
- ↑ Sidharth Mahapatra & Kishore B.. Challagundla (2018). "Cancer, Neuroblastoma". PMID 28846355. Unknown parameter
|month=ignored (help) - ↑ John M. Maris (2010). "Recent advances in neuroblastoma". The New England journal of medicine. 362 (23): 2202–2211. doi:10.1056/NEJMra0804577. PMID 20558371. Unknown parameter
|month=ignored (help) - ↑ J. W. Duckett & C. E. Koop (1977). "Neuroblastoma". The Urologic clinics of North America. 4 (2): 285–295. PMID 331618. Unknown parameter
|month=ignored (help) - ↑ Nadja C. Colon & Dai H. Chung (2011). "Neuroblastoma". Advances in pediatrics. 58 (1): 297–311. doi:10.1016/j.yapd.2011.03.011. PMID 21736987.
- ↑ Neuroblastoma Childhood: Symptoms and Signs. Cancer.net http://www.cancer.net/cancer-types/neuroblastoma-childhood/symptoms-and-signs Accessed on October, 7 2015
- ↑ Colon NC, Chung DH (2011). "Neuroblastoma". Adv Pediatr. 58 (1): 297–311. doi:10.1016/j.yapd.2011.03.011. PMC 3668791. PMID 21736987.
- ↑ Titilope A. Ishola & Dai H. Chung (2007). "Neuroblastoma". Surgical oncology. 16 (3): 149–156. doi:10.1016/j.suronc.2007.09.005. PMID 17976976. Unknown parameter
|month=ignored (help)