VIPoma laboratory findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{VIPoma}} | {{VIPoma}} | ||
{{CMG}}{{AE}}{{ | {{CMG}}{{AE}}{{MSI}}{{Homa}} | ||
==Overview== | ==Overview== | ||
Laboratory | [[Laboratory]] [[Test|tests]] used in the [[diagnosis]] of VIPoma include [[serum]] [[Vasoactive intestinal peptide|vasoactive intestinal polypeptide]] ([[VIP]]) levels, basal [[gastric acid]] output, and [[Comprehensive metabolic panel|CMP]] for [[potassium]], [[bicarbonate]], [[magnesium]], and [[calcium]] levels. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
* | [[Laboratory]] findings consistent with the [[diagnosis]] of VIPoma include:<ref name="pmid23582916">{{cite journal| author=Ito T, Igarashi H, Jensen RT| title=Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances. | journal=Best Pract Res Clin Gastroenterol | year= 2012 | volume= 26 | issue= 6 | pages= 737-53 | pmid=23582916 | doi=10.1016/j.bpg.2012.12.003 | pmc=3627221 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23582916 }}</ref><ref name="pmid27583474">{{cite journal| author=Nilubol N, Freedman EM, Quezado MM, Patel D, Kebebew E| title=Pancreatic Neuroendocrine Tumor Secreting Vasoactive Intestinal Peptide and Dopamine With Pulmonary Emboli: A Case Report. | journal=J Clin Endocrinol Metab | year= 2016 | volume= 101 | issue= 10 | pages= 3564-3567 | pmid=27583474 | doi=10.1210/jc.2016-2051 | pmc=5052354 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27583474 }}</ref> | ||
* | *Elevated [[serum]] [[vasoactive intestinal polypeptide]] ([[VIP]]) levels: | ||
*Low serum [[potassium]], [[bicarbonate]], [[ | **Normal fasting [[serum]] [[Vasoactive intestinal peptide|VIP]] level is generally < 75 pg/ml | ||
*Low basal gastric acid output | **In VIPomas levels of [[Vasoactive intestinal peptide|VIP]] is generally > 500 pg/ml. | ||
**[[Vasoactive intestinal peptide|VIP]] level > 200pg/ml is strongly suggestive of VIPoma. | |||
**<nowiki/>[[Hormone]] [[measurement]] taken at the time of [[diarrhea]]<nowiki/>l episode has the highest yield as [[VIP]] [[secretion]] during [[period]] of [[diarrhea]] and has short t1/2 (approx. 2 mins in blood). | |||
**Single [[measurement]] should be confirmed by repeat <nowiki/>testing. | |||
*Elevated [[pancreatic polypeptide]] levels (Normal < 312 pg/ml) and [[neurotensin]] levels. | |||
*Low [[serum]] [[potassium]], [[bicarbonate]], and [[magnesium]] levels secondary to [[fecal]] loss. | |||
*[[Hypercalcaemia|High calcium]] levels secondary to [[fecal]] loss. | |||
*Low basal [[gastric acid]] output. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
[[Category:Medicine]] | |||
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[[Category:Endocrinology]] | |||
[[Category:Gastroenterology]] | |||
Latest revision as of 00:40, 30 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2] Homa Najafi, M.D.[3]
Overview
Laboratory tests used in the diagnosis of VIPoma include serum vasoactive intestinal polypeptide (VIP) levels, basal gastric acid output, and CMP for potassium, bicarbonate, magnesium, and calcium levels.
Laboratory Findings
Laboratory findings consistent with the diagnosis of VIPoma include:[1][2]
- Elevated serum vasoactive intestinal polypeptide (VIP) levels:
- Normal fasting serum VIP level is generally < 75 pg/ml
- In VIPomas levels of VIP is generally > 500 pg/ml.
- VIP level > 200pg/ml is strongly suggestive of VIPoma.
- Hormone measurement taken at the time of diarrheal episode has the highest yield as VIP secretion during period of diarrhea and has short t1/2 (approx. 2 mins in blood).
- Single measurement should be confirmed by repeat testing.
- Elevated pancreatic polypeptide levels (Normal < 312 pg/ml) and neurotensin levels.
- Low serum potassium, bicarbonate, and magnesium levels secondary to fecal loss.
- High calcium levels secondary to fecal loss.
- Low basal gastric acid output.
References
- ↑ Ito T, Igarashi H, Jensen RT (2012). "Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances". Best Pract Res Clin Gastroenterol. 26 (6): 737–53. doi:10.1016/j.bpg.2012.12.003. PMC 3627221. PMID 23582916.
- ↑ Nilubol N, Freedman EM, Quezado MM, Patel D, Kebebew E (2016). "Pancreatic Neuroendocrine Tumor Secreting Vasoactive Intestinal Peptide and Dopamine With Pulmonary Emboli: A Case Report". J Clin Endocrinol Metab. 101 (10): 3564–3567. doi:10.1210/jc.2016-2051. PMC 5052354. PMID 27583474.