Hamartoma classification: Difference between revisions

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Latest revision as of 04:17, 5 April 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2] Vamsikrishna Gunnam M.B.B.S [3]

Overview

Hamartomas may be classified into different types based on their location, such as lung (most common), heart, hypothalamus, kidneys, or spleen. Other classification method considers lesion class, dividing hamartomas into 4 different categories, such as bone-forming, cartilage-forming, fiber-forming, and benign non–matrix-forming.

Classification

Location

Based on the location, hamartomas can be classified into the following types:^[1]^[2]


Location	Type
CNS	Hypothalamic hamartoma Neurofibromatosis in von Recklinghausen disease Neuroepithelial cells in tuberous sclerosis
Hypopharynx	Hypopharyngeal rhabdomyomatous
Eyelid	Rhabdomyomatous mesenchymal hamartoma
Lung	Endobronchial pulmonary hamartoma Parenchymal pulmonary hamartoma Bronchial hamartoma
Heart	Rhabdomyoma
Bowel	Peutz-Jeghers polyp Polyp of the large bowel
Kidneys	Angiomyolipoma
Spleen	Splenic hamartoma
Skin	Melanocytic nevi

Lesion class

Based on the lesion class, hamartomas may be classified into the following types:^[3]


Lesion class	Tumors type
Cartilage-forming	Enchondromatosis Epiphyseal osteochondroma Multiple osteochondroma Osteochondroma
Fiber-forming	Nonossifying fibroma Fibrous dysplasia
Bone-forming	Osteopathia striata Melorheostosis Osteopoikilosis Bone island
Benign non-matrix-forming	Skeletal hemangiomatosis Hemangioma of bone

References

↑ Patterson HC, Dickerson GR, Pilch BZ, Bentkover SH (December 1981). "Hamartoma of the hypopharynx". Arch Otolaryngol. 107 (12): 767–72. PMID 7316862.
↑ Read RW, Burnstine M, Rowland JM, Zamir E, Rao NA (April 2001). "Rhabdomyomatous mesenchymal hamartoma of the eyelid: report of a case and literature review". Ophthalmology. 108 (4): 798–804. PMID 11297501.
↑ Kumar V, Abbas AK, Aster JC. Robbins Basic Pathology. Elsevier Health Sciences; 2012.

Template:WikiDoc Sources

[pmid7316862-1] Patterson HC, Dickerson GR, Pilch BZ, Bentkover SH (December 1981). "Hamartoma of the hypopharynx". Arch Otolaryngol. 107 (12): 767–72. PMID 7316862.

[pmid11297501-2] Read RW, Burnstine M, Rowland JM, Zamir E, Rao NA (April 2001). "Rhabdomyomatous mesenchymal hamartoma of the eyelid: report of a case and literature review". Ophthalmology. 108 (4): 798–804. PMID 11297501.

[kumar-3] Kumar V, Abbas AK, Aster JC. Robbins Basic Pathology. Elsevier Health Sciences; 2012.

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[2]

[3]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Hamartoma}}
-{{CMG}}{AE}}{{MV}}
+{{CMG}}{{AE}}{{MV}} {{VKG}}
 ==Overview==
-Hamartomas may be classified into different types based on their location, such as; [[lung]] (most common), [[heart]], [[hypothalamus]], [[kidneys]], or [[spleen]]. Other classifications can consider lesion class, dividing hamartomas into 4 different categories, such as; Bone-forming, cartilage-forming, fiber-forming and benign non–matrix-forming.
+Hamartomas may be classified into different types based on their location, such as [[lung]] (most common), [[heart]], [[hypothalamus]], [[kidneys]], or [[spleen]]. Other classification method considers lesion class, dividing [[hamartomas]] into 4 different categories, such as [[bone]]-forming, [[cartilage]]-forming, [[fiber]]-forming, and [[benign]] non–matrix-forming.
 ==Classification==
+===Location===
+Based on the location, [[hamartomas]] can be classified into the following types:<ref name="pmid7316862">{{cite journal |vauthors=Patterson HC, Dickerson GR, Pilch BZ, Bentkover SH |title=Hamartoma of the hypopharynx |journal=Arch Otolaryngol |volume=107 |issue=12 |pages=767–72 |date=December 1981 |pmid=7316862 |doi= |url=}}</ref><ref name="pmid11297501">{{cite journal |vauthors=Read RW, Burnstine M, Rowland JM, Zamir E, Rao NA |title=Rhabdomyomatous mesenchymal hamartoma of the eyelid: report of a case and literature review |journal=Ophthalmology |volume=108 |issue=4 |pages=798–804 |date=April 2001 |pmid=11297501 |doi= |url=}}</ref>
+{| class="wikitable"
+|+
+!Location
+!Type
+|-
+|[[CNS]]
+|
+* [[Hypothalamic hamartoma]]
-Based on the genetic mutations, hereditary hamartomatous syndromes carry different gene mutations.
+* [[Neurofibromatosis]] in [[von Recklinghausen disease]]
+* Neuroepithelial cells in [[tuberous sclerosis]]
-===Familial inheritance===
+|-
+|[[Hypopharynx]]
-All the syndromes are inherited in the autosomal dominant manner and are conditioned by mutations in four genes, which are: BMPR1A, SMAD4, PTEN and STK11.
+|
+* Hypopharyngeal rhabdomyomatous
+|-
+|[[Eyelid]]
+|
+* [[Rhabdomyomatous mesenchymal hamartomas|Rhabdomyomatous mesenchymal hamartoma]]
+|-
+|[[Lung]]
+|
+* Endobronchial pulmonary [[hamartoma]]
-* [[Juvenile polyposis syndrome]]
+* Parenchymal [[pulmonary]] [[hamartoma]]
-* [[Peutz-Jeghers syndrome]]
+* [[Bronchial]] [[hamartoma]]
-* Hereditary mixed polyposis syndrome
+|-
-* PTEN hamartoma tumour syndrome
+|[[Heart]]
-* [[Cowden syndrome]]
+|
-* Bannayan-Riley-Ruvalcaba syndrome
+* [[Rhabdomyoma]]
-* Proteus’es syndrome
+|-
+|[[Bowel]]
+|
+* Peutz-Jeghers [[polyp]]
+* [[Polyp]] of the large bowel
+|-
+|[[Kidneys]]
+|
+* [[Angiomyolipoma]]
+|-
+|[[Spleen]]
+|
+* [[Splenic]] [[hamartoma]]
+|-
+|Skin
+|
+*[[Melanocytic naevi|Melanocytic]] nevi
+|}
-===Location===
+===Lesion class===
-Based on the location, hamartomas can be classified into the following types:
-* Bone-forming tumors
+Based on the lesion class, hamartomas may be classified into the following types:<ref name="kumar">Kumar V, Abbas AK, Aster JC. Robbins Basic Pathology. Elsevier Health Sciences; 2012.</ref>
-* Cartilage-forming tumors
+{| class="wikitable"
+|+
-* Fiber-forming tumors
+!Lesion class
-**Nonossifying fibroma
+!Tumors type
-**Fibrous dysplasia
+|-
-**Mazabraud syndrome
+|[[Cartilage]]-forming
+|
-* Benign non–matrix-forming tumors
+* [[Enchondroma|Enchondromatosis]]
+* [[Epiphyseal]] [[osteochondroma]]
+* Multiple [[osteochondroma]]
+* [[Osteochondroma]]
+|-
+|[[Fiber]]-forming
+|
+* [[Nonossifying fibroma]]
+* [[Fibrous dysplasia]]
+|-
+|[[Bone]]-forming
+|
+* Osteopathia striata
+* [[Melorheostosis]]
+* [[Osteopoikilosis]]
+* [[Bone island]]
+|-
+|[[Benign]] non-matrix-forming
+|
+* [[Skeletal]] hemangiomatosis
+* [[Hemangioma]] of [[bone]]
+|}
+*
 ==References==
-{{reflist|2}}
+{{reflist|1}}
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 [[Category:Types of cancer]]
-[[Category:Pulmonology]]
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+[[Category:Oncology]]
+[[Category:Medicine]]
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