Acute retinal necrosis laboratory findings: Difference between revisions
No edit summary |
m (Bot: Removing from Primary care) |
||
(9 intermediate revisions by 4 users not shown) | |||
Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
Laboratory findings associated with | Laboratory findings associated with acute [[retinal]] [[necrosis]] are those used to confirm the presence of the [[viral]] pathogen, including [[Polymerase chain reaction|PCR]] test results, [[viral culture|viral cultures]], [[immunoflourescence]] results, and the detection of [[antibodies]] indicative of sources of acute [[retinal]] [[necrosis]] via the Goldmann-Witmer coefficient. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Laboratory findings associated with | Laboratory findings associated with acute [[retinal]] [[necrosis]] are those used to confirm the presence of the [[viral]] pathogen, obtained from [[aqueous humor]] or the [[vitreous]].<ref name="pmid25356955">{{cite journal |vauthors=Brydak-Godowska J, Borkowski P, Szczepanik S, Moneta-Wielgoś J, Kęcik D |title=Clinical manifestation of self-limiting acute retinal necrosis |journal=Med. Sci. Monit. |volume=20 |issue= |pages=2088–96 |year=2014 |pmid=25356955 |pmc=4226315 |doi=10.12659/MSM.890469 |url=}}</ref><ref name="pmid18584564">{{cite journal| author=Usui Y, Goto H| title=Overview and diagnosis of acute retinal necrosis syndrome. | journal=Semin Ophthalmol | year= 2008 | volume= 23 | issue= 4 | pages= 275-83 | pmid=18584564 | doi=10.1080/08820530802111325 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18584564 }} </ref><ref name="pmid17264500">{{cite journal| author=Kezuka T, Atherton SS| title=Acute retinal necrosis. | journal=Chem Immunol Allergy | year= 2007 | volume= 92 | issue= | pages= 244-53 | pmid=17264500 | doi=10.1159/000099275 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17264500 }} </ref><ref name="pmid16282149">{{cite journal| author=Bonfioli AA, Eller AW| title=Acute retinal necrosis. | journal=Semin Ophthalmol | year= 2005 | volume= 20 | issue= 3 | pages= 155-60 | pmid=16282149 | doi=10.1080/08820530500232027 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16282149 }} </ref><ref name="ARNopth">{{cite journal| author=Chun HL, Missotten T, Salzmann J, Lightman SL | title=Acute Retinal Necrosis: Features, Management, and Outcomes | journal=Opthalmology | year=2007 | volume=114 | Issue=4 | pages=756-762 | url=http://www.sciencedirect.com/science/article/pii/S0161642006012073 }}</ref> | ||
*Qualitative and | *Qualitative and real-time [[Polymerase chain reaction]]<ref name="pmid25356955">{{cite journal |vauthors=Brydak-Godowska J, Borkowski P, Szczepanik S, Moneta-Wielgoś J, Kęcik D |title=Clinical manifestation of self-limiting acute retinal necrosis |journal=Med. Sci. Monit. |volume=20 |issue= |pages=2088–96 |year=2014 |pmid=25356955 |pmc=4226315 |doi=10.12659/MSM.890469 |url=}}</ref> | ||
**PCR | **PCR tests for acute [[retinal]] [[necrosis]] patients will produce [[genomic]] evidence of the causative [[virus]] | ||
** | **Preferred due to 90% specificity in detecting [[Herpes simplex virus]] (HSV), [[Varicella-zoster virus]] (VZV), and [[Cytomegalovirus]] (CMV) | ||
*Viral cultures may reveal positive results for HSV-1, HSV-2, VZV, or CMV | *Viral cultures may reveal positive results for HSV-1, HSV-2, VZV, or CMV<ref name="pmid23052715">{{cite journal |vauthors=Silva RA, Berrocal AM, Moshfeghi DM, Blumenkranz MS, Sanislo S, Davis JL |title=Herpes simplex virus type 2 mediated acute retinal necrosis in a pediatric population: case series and review |journal=Graefes Arch. Clin. Exp. Ophthalmol. |volume=251 |issue=2 |pages=559–66 |year=2013 |pmid=23052715 |doi=10.1007/s00417-012-2164-8 |url=}}</ref> | ||
*[[Immunoflourescence]] may reveal [[antibodies]] indicative of | *[[Immunoflourescence]] may reveal [[antibodies]] indicative of ARN pathogens<ref name="pmid18159535">{{cite journal |vauthors=Singh A, Preiksaitis J, Ferenczy A, Romanowski B |title=The laboratory diagnosis of herpes simplex virus infections |journal=Can J Infect Dis Med Microbiol |volume=16 |issue=2 |pages=92–8 |year=2005 |pmid=18159535 |pmc=2095011 |doi= |url=}}</ref> | ||
*Detection of indicative [[antibodies]] via Goldmann-witmer coefficient | *Detection of indicative [[antibodies]] via Goldmann-witmer coefficient<ref name="pmid16458686">{{cite journal |vauthors=De Groot-Mijnes JD, Rothova A, Van Loon AM, Schuller M, Ten Dam-Van Loon NH, De Boer JH, Schuurman R, Weersink AJ |title=Polymerase chain reaction and Goldmann-Witmer coefficient analysis are complimentary for the diagnosis of infectious uveitis |journal=Am. J. Ophthalmol. |volume=141 |issue=2 |pages=313–8 |year=2006 |pmid=16458686 |doi=10.1016/j.ajo.2005.09.017 |url=}}</ref> | ||
==References== | ==References== | ||
Line 20: | Line 20: | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Disease]] | |||
[[Category:Ophthalmology]] | [[Category:Ophthalmology]] | ||
[[Category:Up-To-Date]] | |||
[[Category:Emergency medicine]] | |||
[[Category:Infectious disease]] |
Latest revision as of 20:16, 29 July 2020
Acute retinal necrosis Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Acute retinal necrosis laboratory findings On the Web |
American Roentgen Ray Society Images of Acute retinal necrosis laboratory findings |
Risk calculators and risk factors for Acute retinal necrosis laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.
Overview
Laboratory findings associated with acute retinal necrosis are those used to confirm the presence of the viral pathogen, including PCR test results, viral cultures, immunoflourescence results, and the detection of antibodies indicative of sources of acute retinal necrosis via the Goldmann-Witmer coefficient.
Laboratory Findings
Laboratory findings associated with acute retinal necrosis are those used to confirm the presence of the viral pathogen, obtained from aqueous humor or the vitreous.[1][2][3][4][5]
- Qualitative and real-time Polymerase chain reaction[1]
- PCR tests for acute retinal necrosis patients will produce genomic evidence of the causative virus
- Preferred due to 90% specificity in detecting Herpes simplex virus (HSV), Varicella-zoster virus (VZV), and Cytomegalovirus (CMV)
- Viral cultures may reveal positive results for HSV-1, HSV-2, VZV, or CMV[6]
- Immunoflourescence may reveal antibodies indicative of ARN pathogens[7]
- Detection of indicative antibodies via Goldmann-witmer coefficient[8]
References
- ↑ 1.0 1.1 Brydak-Godowska J, Borkowski P, Szczepanik S, Moneta-Wielgoś J, Kęcik D (2014). "Clinical manifestation of self-limiting acute retinal necrosis". Med. Sci. Monit. 20: 2088–96. doi:10.12659/MSM.890469. PMC 4226315. PMID 25356955.
- ↑ Usui Y, Goto H (2008). "Overview and diagnosis of acute retinal necrosis syndrome". Semin Ophthalmol. 23 (4): 275–83. doi:10.1080/08820530802111325. PMID 18584564.
- ↑ Kezuka T, Atherton SS (2007). "Acute retinal necrosis". Chem Immunol Allergy. 92: 244–53. doi:10.1159/000099275. PMID 17264500.
- ↑ Bonfioli AA, Eller AW (2005). "Acute retinal necrosis". Semin Ophthalmol. 20 (3): 155–60. doi:10.1080/08820530500232027. PMID 16282149.
- ↑ Chun HL, Missotten T, Salzmann J, Lightman SL (2007). "Acute Retinal Necrosis: Features, Management, and Outcomes". Opthalmology. 114: 756–762. Unknown parameter
|Issue=
ignored (|issue=
suggested) (help) - ↑ Silva RA, Berrocal AM, Moshfeghi DM, Blumenkranz MS, Sanislo S, Davis JL (2013). "Herpes simplex virus type 2 mediated acute retinal necrosis in a pediatric population: case series and review". Graefes Arch. Clin. Exp. Ophthalmol. 251 (2): 559–66. doi:10.1007/s00417-012-2164-8. PMID 23052715.
- ↑ Singh A, Preiksaitis J, Ferenczy A, Romanowski B (2005). "The laboratory diagnosis of herpes simplex virus infections". Can J Infect Dis Med Microbiol. 16 (2): 92–8. PMC 2095011. PMID 18159535.
- ↑ De Groot-Mijnes JD, Rothova A, Van Loon AM, Schuller M, Ten Dam-Van Loon NH, De Boer JH, Schuurman R, Weersink AJ (2006). "Polymerase chain reaction and Goldmann-Witmer coefficient analysis are complimentary for the diagnosis of infectious uveitis". Am. J. Ophthalmol. 141 (2): 313–8. doi:10.1016/j.ajo.2005.09.017. PMID 16458686.