Hemophilia A classification: Difference between revisions
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{{Hemophilia A}} | {{Hemophilia A}} | ||
{{CMG}} {{FNY}} | {{CMG}}{{AE}}{{FNY}} | ||
==Overview== | ==Overview== | ||
Hemophilia A may be classified according to the amount of Factor VIII present, resulting in either a mild, moderate, or severe form of the disease. <ref>How is Hemophilia Diagnosed? – NHLBI, NIH. Available at http://www.nhlbi.nih.gov/health/health-topics/topics/hemophilia/diagnosis. Accessed on July 30, 2016 </ref> | [[Hemophilia A]] and [[Hemophilia B|B]] an C may be classified according to the amount of [[Factor VIII]]/ [[Factor IX|IX]]/ [[Factor XI|XI]] present respectively, resulting in either a mild, moderate, or severe form of the disease.<ref>How is Hemophilia Diagnosed? – NHLBI, NIH. Available at http://www.nhlbi.nih.gov/health/health-topics/topics/hemophilia/diagnosis. Accessed on July 30, 2016 </ref> | ||
==Classification== | ==Classification== | ||
Hemophilia A may be classified according to the amount of Factor VIII present, resulting in either a mild, moderate, or severe form of the disease. | [[Hemophilia A]] and [[Hemophilia B|B]] an C may be classified according to the amount of [[Factor VIII]]/ [[Factor IX|IX]]/ [[Factor XI|XI]] present respectively, resulting in either a mild, moderate, or severe form of the disease. | ||
*Mild hemophilia – 5-40% of normal factor VIII activity in the blood | *Mild hemophilia – 5-40% of normal factor [[Factor VIII|VIII]]/ [[Factor IX|IX]] activity in the blood | ||
*Moderate hemophilia – 1-5% of normal factor VIII activity in the blood | *Moderate hemophilia – 1-5% of normal factor [[Factor VIII|VIII]]/ [[Factor IX|IX]] activity in the blood | ||
*Severe hemophilia – less than 1% of normal factor VIII activity in the blood | *Severe hemophilia – less than 1% of normal factor [[Factor VIII|VIII]]/ [[Factor IX|IX]] activity in the blood | ||
Hemophilia C severity classification is different from A and B and severe Hemophilia C is defined when plasma [[factor XI]] concentration is less than 20 IU/dL<ref name="pmid23929304">{{cite journal| author=Duga S, Salomon O| title=Congenital factor XI deficiency: an update. | journal=Semin Thromb Hemost | year= 2013 | volume= 39 | issue= 6 | pages= 621-31 | pmid=23929304 | doi=10.1055/s-0033-1353420 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23929304 }}</ref>. | |||
==References== | ==References== | ||
Latest revision as of 18:39, 28 October 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fahd Yunus, M.D. [2]
Overview
Hemophilia A and B an C may be classified according to the amount of Factor VIII/ IX/ XI present respectively, resulting in either a mild, moderate, or severe form of the disease.[1]
Classification
Hemophilia A and B an C may be classified according to the amount of Factor VIII/ IX/ XI present respectively, resulting in either a mild, moderate, or severe form of the disease.
- Mild hemophilia – 5-40% of normal factor VIII/ IX activity in the blood
- Moderate hemophilia – 1-5% of normal factor VIII/ IX activity in the blood
- Severe hemophilia – less than 1% of normal factor VIII/ IX activity in the blood
Hemophilia C severity classification is different from A and B and severe Hemophilia C is defined when plasma factor XI concentration is less than 20 IU/dL[2].
References
- ↑ How is Hemophilia Diagnosed? – NHLBI, NIH. Available at http://www.nhlbi.nih.gov/health/health-topics/topics/hemophilia/diagnosis. Accessed on July 30, 2016
- ↑ Duga S, Salomon O (2013). "Congenital factor XI deficiency: an update". Semin Thromb Hemost. 39 (6): 621–31. doi:10.1055/s-0033-1353420. PMID 23929304.