Ureaplasma urealyticum epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
[[Urogenital tract|Genital tract]] colonization by Ureaplasma occur in over 40% of healthy women.<ref name="pmid8399903">{{cite journal| author=Waites KB, Crouse DT, Cassell GH| title=Systemic neonatal infection due to Ureaplasma urealyticum. | journal=Clin Infect Dis | year= 1993 | volume= 17 Suppl 1 | issue= | pages= S131-5 | pmid=8399903 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8399903 }} </ref><ref name="pmid26518581" /><ref name="pmid21258263">{{cite journal| author=Okogbule-Wonodi AC, Gross GW, Sun CC, Agthe AG, Xiao L, Waites KB et al.| title=Necrotizing enterocolitis is associated with ureaplasma colonization in preterm infants. | journal=Pediatr Res | year= 2011 | volume= 69 | issue= 5 Pt 1 | pages= 442-7 | pmid=21258263 | doi=10.1203/PDR.0b013e3182111827 | pmc=3968774 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21258263 }} </ref><ref name="pmid18596706">{{cite journal| author=Viscardi RM, Hashmi N, Gross GW, Sun CC, Rodriguez A, Fairchild KD| title=Incidence of invasive ureaplasma in VLBW infants: relationship to severe intraventricular hemorrhage. | journal=J Perinatol | year= 2008 | volume= 28 | issue= 11 | pages= 759-65 | pmid=18596706 | doi=10.1038/jp.2008.98 | pmc=5334544 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18596706 }} </ref> Ureaplasma species are the most common pathogen identified in VLBW infants.<ref name="pmid18596706" /> [[Respiratory tract]] colonization by Ureaplasma is more common in preterm VLBW infants compared to term infants.<ref name="pmid16223956">{{cite journal| author=Waites KB, Katz B, Schelonka RL| title=Mycoplasmas and ureaplasmas as neonatal pathogens. | journal=Clin Microbiol Rev | year= 2005 | volume= 18 | issue= 4 | pages= 757-89 | pmid=16223956 | doi=10.1128/CMR.18.4.757-789.2005 | pmc=1265909 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16223956 }} </ref><ref name="pmid9576388">{{cite journal| author=Patterson AM, Taciak V, Lovchik J, Fox RE, Campbell AB, Viscardi RM| title=Ureaplasma urealyticum respiratory tract colonization is associated with an increase in interleukin 1-beta and tumor necrosis factor alpha relative to interleukin 6 in tracheal aspirates of preterm infants. | journal=Pediatr Infect Dis J | year= 1998 | volume= 17 | issue= 4 | pages= 321-8 | pmid=9576388 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9576388 }} </ref> 20-45% of VLBW infants have Ureaplasma colonization of the [[respiratory tract]].<ref name="pmid26518581">{{cite journal| author=Resch B, Gutmann C, Reiterer F, Luxner J, Urlesberger B| title=Neonatal Ureaplasma urealyticum colonization increases pulmonary and cerebral morbidity despite treatment with macrolide antibiotics. | journal=Infection | year= 2016 | volume= 44 | issue= 3 | pages= 323-7 | pmid=26518581 | doi=10.1007/s15010-015-0858-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26518581 }} </ref> | |||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
===Prevalence=== | |||
Ureaplasma species are commensal organisms in the female [[Urogenital tract|genital tract]], colonizing 40-80% of the [[Urogenital tract|genital tract]] of healthy women.<ref name="pmid8399903" /> <ref name="pmid26518581" /><ref name="pmid21258263" /><ref name="pmid18596706" /> The prevalence of vaginal colonization with ''U. urealyticum'' in pregnant women is 29-42%.<ref name="pmid16817073">{{cite journal| author=Vogel I, Thorsen P, Hogan VK, Schieve LA, Jacobsson B, Ferre CD| title=The joint effect of vaginal Ureaplasma urealyticum and bacterial vaginosis on adverse pregnancy outcomes. | journal=Acta Obstet Gynecol Scand | year= 2006 | volume= 85 | issue= 7 | pages= 778-85 | pmid=16817073 | doi=10.1080/00016340500442423 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16817073 }} </ref> Ureaplasma species are the most common pathogen identified in VLBW infants.<ref name="pmid18596706" /> Ureaplasma colonization of the [[respiratory tract]] is more common in preterm VLBW infants compared to term infants.<ref name="pmid16223956">{{cite journal| author=Waites KB, Katz B, Schelonka RL| title=Mycoplasmas and ureaplasmas as neonatal pathogens. | journal=Clin Microbiol Rev | year= 2005 | volume= 18 | issue= 4 | pages= 757-89 | pmid=16223956 | doi=10.1128/CMR.18.4.757-789.2005 | pmc=1265909 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16223956 }} </ref><ref name="pmid9576388">{{cite journal| author=Patterson AM, Taciak V, Lovchik J, Fox RE, Campbell AB, Viscardi RM| title=Ureaplasma urealyticum respiratory tract colonization is associated with an increase in interleukin 1-beta and tumor necrosis factor alpha relative to interleukin 6 in tracheal aspirates of preterm infants. | journal=Pediatr Infect Dis J | year= 1998 | volume= 17 | issue= 4 | pages= 321-8 | pmid=9576388 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9576388 }} </ref> 20-45% of VLBW infants have Ureaplasma colonization of the [[respiratory tract]].<ref name="pmid26518581">{{cite journal| author=Resch B, Gutmann C, Reiterer F, Luxner J, Urlesberger B| title=Neonatal Ureaplasma urealyticum colonization increases pulmonary and cerebral morbidity despite treatment with macrolide antibiotics. | journal=Infection | year= 2016 | volume= 44 | issue= 3 | pages= 323-7 | pmid=26518581 | doi=10.1007/s15010-015-0858-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26518581 }} </ref> The incidence of Ureaplasma species in [[cord blood]] cultures of VLBW neonates was found to be 17%.<ref name="pmid18166302">{{cite journal| author=Goldenberg RL, Andrews WW, Goepfert AR, Faye-Petersen O, Cliver SP, Carlo WA et al.| title=The Alabama Preterm Birth Study: umbilical cord blood Ureaplasma urealyticum and Mycoplasma hominis cultures in very preterm newborn infants. | journal=Am J Obstet Gynecol | year= 2008 | volume= 198 | issue= 1 | pages= 43.e1-5 | pmid=18166302 | doi=10.1016/j.ajog.2007.07.033 | pmc=2278008 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18166302 }} </ref> Ureaplasma species have also been shown to invade the [[bloodstream]] and cross the [[blood–brain barrier]] in 23% of VLBW infants in another study.<ref name="pmid18596706" /> The prevalence of Ureaplasma positive [[CSF]] culture from preterm infants investigated for suspected [[meningitis]] was 8%.<ref name="pmid2891889">{{cite journal| author=Waites KB, Rudd PT, Crouse DT, Canupp KC, Nelson KG, Ramsey C et al.| title=Chronic Ureaplasma urealyticum and Mycoplasma hominis infections of central nervous system in preterm infants. | journal=Lancet | year= 1988 | volume= 1 | issue= 8575-6 | pages= 17-21 | pmid=2891889 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2891889 }} </ref> | |||
===Age=== | |||
Colonization by Ureaplasma species can be seen in both the pediatric and adult population. [[Urogenital tract|Genital tract]] of adult men and women are the main reservoirs of Ureaplasma species.<ref name="pmid26518581" /><ref name="pmid15076934">{{cite journal| author=Deguchi T, Yoshida T, Miyazawa T, Yasuda M, Tamaki M, Ishiko H et al.| title=Association of Ureaplasma urealyticum (biovar 2) with nongonococcal urethritis. | journal=Sex Transm Dis | year= 2004 | volume= 31 | issue= 3 | pages= 192-5 | pmid=15076934 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15076934 }} </ref> However, symptomatic Ureaplasma infection is seen more often in preterm neonates.<ref name="pmid18596706" /> Colonization of neonates by ''U. urealyticum'' increases with decreasing gestational age and birth weight.<ref name="pmid11036807">{{cite journal| author=Agarwal P, Rajadurai VS, Pradeepkumar VK, Tan KW| title=Ureaplasma urealyticum and its association with chronic lung disease in Asian neonates. | journal=J Paediatr Child Health | year= 2000 | volume= 36 | issue= 5 | pages= 487-90 | pmid=11036807 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11036807 }} </ref> | |||
===Gender=== | |||
There is no known gender predilection for Ureaplasma infection. | |||
===Race=== | |||
A study conducted in the United States in the 1980's in 13,747 women of low socioeconomic status from four different ethnic groups revealed that women of black ethnicity were more likely to have genital tract colonization with potentially pathogenic organisms such as ''U. urealyticum ''<ref name="pmid28140029">{{cite journal| author=Goldenberg RL, Klebanoff MA, Nugent R, Krohn MA, Hillier S, Andrews WW et al.| title=Bacterial colonization of the vagina during pregnancy in four ethnic groups. | journal=Am J Obstet Gynecol | year= 1996 | volume= 174 | issue= 5 | pages= 1618-1621 | pmid=28140029 | doi=10.1016/S0002-9378(96)70617-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28140029 }} </ref> Another study was carried out by Doh et al. in healthy pregnant women from different ethnic groups, and it revealed no racial predilection for Ureaplasma colonization.<ref name="pmid15739821">{{cite journal| author=Doh K, Barton PT, Korneeva I, Perni SC, Bongiovanni AM, Tuttle SL et al.| title=Differential vaginal expression of interleukin-1 system cytokines in the presence of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women. | journal=Infect Dis Obstet Gynecol | year= 2004 | volume= 12 | issue= 2 | pages= 79-85 | pmid=15739821 | doi=10.1080/10647440400003667 | pmc=1784593 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15739821 }} </ref> | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Emergency mdicine]] | |||
[[Category:Disease]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Infectious disease]] | |||
[[Category:Nephrology]] | |||
[[Category:Pulmonology]] | |||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fatimo Biobaku M.B.B.S [2]
Overview
Genital tract colonization by Ureaplasma occur in over 40% of healthy women.[1][2][3][4] Ureaplasma species are the most common pathogen identified in VLBW infants.[4] Respiratory tract colonization by Ureaplasma is more common in preterm VLBW infants compared to term infants.[5][6] 20-45% of VLBW infants have Ureaplasma colonization of the respiratory tract.[2]
Epidemiology and Demographics
Prevalence
Ureaplasma species are commensal organisms in the female genital tract, colonizing 40-80% of the genital tract of healthy women.[1] [2][3][4] The prevalence of vaginal colonization with U. urealyticum in pregnant women is 29-42%.[7] Ureaplasma species are the most common pathogen identified in VLBW infants.[4] Ureaplasma colonization of the respiratory tract is more common in preterm VLBW infants compared to term infants.[5][6] 20-45% of VLBW infants have Ureaplasma colonization of the respiratory tract.[2] The incidence of Ureaplasma species in cord blood cultures of VLBW neonates was found to be 17%.[8] Ureaplasma species have also been shown to invade the bloodstream and cross the blood–brain barrier in 23% of VLBW infants in another study.[4] The prevalence of Ureaplasma positive CSF culture from preterm infants investigated for suspected meningitis was 8%.[9]
Age
Colonization by Ureaplasma species can be seen in both the pediatric and adult population. Genital tract of adult men and women are the main reservoirs of Ureaplasma species.[2][10] However, symptomatic Ureaplasma infection is seen more often in preterm neonates.[4] Colonization of neonates by U. urealyticum increases with decreasing gestational age and birth weight.[11]
Gender
There is no known gender predilection for Ureaplasma infection.
Race
A study conducted in the United States in the 1980's in 13,747 women of low socioeconomic status from four different ethnic groups revealed that women of black ethnicity were more likely to have genital tract colonization with potentially pathogenic organisms such as U. urealyticum [12] Another study was carried out by Doh et al. in healthy pregnant women from different ethnic groups, and it revealed no racial predilection for Ureaplasma colonization.[13]
References
- ↑ 1.0 1.1 Waites KB, Crouse DT, Cassell GH (1993). "Systemic neonatal infection due to Ureaplasma urealyticum". Clin Infect Dis. 17 Suppl 1: S131–5. PMID 8399903.
- ↑ 2.0 2.1 2.2 2.3 2.4 Resch B, Gutmann C, Reiterer F, Luxner J, Urlesberger B (2016). "Neonatal Ureaplasma urealyticum colonization increases pulmonary and cerebral morbidity despite treatment with macrolide antibiotics". Infection. 44 (3): 323–7. doi:10.1007/s15010-015-0858-7. PMID 26518581.
- ↑ 3.0 3.1 Okogbule-Wonodi AC, Gross GW, Sun CC, Agthe AG, Xiao L, Waites KB; et al. (2011). "Necrotizing enterocolitis is associated with ureaplasma colonization in preterm infants". Pediatr Res. 69 (5 Pt 1): 442–7. doi:10.1203/PDR.0b013e3182111827. PMC 3968774. PMID 21258263.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Viscardi RM, Hashmi N, Gross GW, Sun CC, Rodriguez A, Fairchild KD (2008). "Incidence of invasive ureaplasma in VLBW infants: relationship to severe intraventricular hemorrhage". J Perinatol. 28 (11): 759–65. doi:10.1038/jp.2008.98. PMC 5334544. PMID 18596706.
- ↑ 5.0 5.1 Waites KB, Katz B, Schelonka RL (2005). "Mycoplasmas and ureaplasmas as neonatal pathogens". Clin Microbiol Rev. 18 (4): 757–89. doi:10.1128/CMR.18.4.757-789.2005. PMC 1265909. PMID 16223956.
- ↑ 6.0 6.1 Patterson AM, Taciak V, Lovchik J, Fox RE, Campbell AB, Viscardi RM (1998). "Ureaplasma urealyticum respiratory tract colonization is associated with an increase in interleukin 1-beta and tumor necrosis factor alpha relative to interleukin 6 in tracheal aspirates of preterm infants". Pediatr Infect Dis J. 17 (4): 321–8. PMID 9576388.
- ↑ Vogel I, Thorsen P, Hogan VK, Schieve LA, Jacobsson B, Ferre CD (2006). "The joint effect of vaginal Ureaplasma urealyticum and bacterial vaginosis on adverse pregnancy outcomes". Acta Obstet Gynecol Scand. 85 (7): 778–85. doi:10.1080/00016340500442423. PMID 16817073.
- ↑ Goldenberg RL, Andrews WW, Goepfert AR, Faye-Petersen O, Cliver SP, Carlo WA; et al. (2008). "The Alabama Preterm Birth Study: umbilical cord blood Ureaplasma urealyticum and Mycoplasma hominis cultures in very preterm newborn infants". Am J Obstet Gynecol. 198 (1): 43.e1–5. doi:10.1016/j.ajog.2007.07.033. PMC 2278008. PMID 18166302.
- ↑ Waites KB, Rudd PT, Crouse DT, Canupp KC, Nelson KG, Ramsey C; et al. (1988). "Chronic Ureaplasma urealyticum and Mycoplasma hominis infections of central nervous system in preterm infants". Lancet. 1 (8575–6): 17–21. PMID 2891889.
- ↑ Deguchi T, Yoshida T, Miyazawa T, Yasuda M, Tamaki M, Ishiko H; et al. (2004). "Association of Ureaplasma urealyticum (biovar 2) with nongonococcal urethritis". Sex Transm Dis. 31 (3): 192–5. PMID 15076934.
- ↑ Agarwal P, Rajadurai VS, Pradeepkumar VK, Tan KW (2000). "Ureaplasma urealyticum and its association with chronic lung disease in Asian neonates". J Paediatr Child Health. 36 (5): 487–90. PMID 11036807.
- ↑ Goldenberg RL, Klebanoff MA, Nugent R, Krohn MA, Hillier S, Andrews WW; et al. (1996). "Bacterial colonization of the vagina during pregnancy in four ethnic groups". Am J Obstet Gynecol. 174 (5): 1618–1621. doi:10.1016/S0002-9378(96)70617-8. PMID 28140029.
- ↑ Doh K, Barton PT, Korneeva I, Perni SC, Bongiovanni AM, Tuttle SL; et al. (2004). "Differential vaginal expression of interleukin-1 system cytokines in the presence of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women". Infect Dis Obstet Gynecol. 12 (2): 79–85. doi:10.1080/10647440400003667. PMC 1784593. PMID 15739821.