Postpartum thyroiditis causes: Difference between revisions
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{{Postpartum thyroiditis}} | {{Postpartum thyroiditis}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}}{{SKA}} | ||
==Overview== | ==Overview== | ||
[[Postpartum thyroiditis|Postpartum thyroiditis (PPT)]] is a type of subacute [[Lymphocyte|lymphocytic]] [[thyroiditis]] that occurs due to [[Autoimmunity|autoimmune]] response towards thyroid gland in [[postpartum]] period, [[miscarriage]], or [[abortion]]. [[Postpartum thyroiditis|PPT]] is an [[autoimmune]] disorder. [[Postpartum thyroiditis|PPT]] is caused by a [[mutation]] in the G-allele of CD60 CTLA-4 [[gene]], [[HLA-DR3]], [[HLA-DR4]], and [[HLA-DR5]] gene. To review details about various risk factors that contribute to the development of [[Postpartum thyroiditis|PPT]], [[Postpartum thyroiditis risk factors|'''click here.''']] | |||
==Causes== | ==Causes== | ||
[[Postpartum thyroiditis|Postpartum thyroiditis (PPT)]] is a type of subacute [[Lymphocyte|lymphocytic]] [[thyroiditis]] that occurs due to [[Autoimmunity|autoimmune]] response towards [[thyroid gland]] in [[postpartum]] period, [[miscarriage]], or abortion.<ref name="pmid10634366">{{cite journal| author=Premawardhana LD, Parkes AB, Ammari F, John R, Darke C, Adams H et al.| title=Postpartum thyroiditis and long-term thyroid status: prognostic influence of thyroid peroxidase antibodies and ultrasound echogenicity. | journal=J Clin Endocrinol Metab | year= 2000 | volume= 85 | issue= 1 | pages= 71-5 | pmid=10634366 | doi=10.1210/jcem.85.1.6227 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10634366 }}</ref> | |||
===Genetic Causes=== | ===Genetic Causes=== | ||
[[Postpartum thyroiditis|Postpartum thyroiditis (PPT)]] is caused by a [[mutation]] in the G-allele of the following:<ref name="pmid22312089">{{cite journal| author=Stagnaro-Green A| title=Approach to the patient with postpartum thyroiditis. | journal=J Clin Endocrinol Metab | year= 2012 | volume= 97 | issue= 2 | pages= 334-42 | pmid=22312089 | doi=10.1210/jc.2011-2576 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22312089 }} </ref> | |||
* CD60 CTLA-4 [[gene]] | |||
* [[HLA-DR3|HLA-DR3 gene]] | |||
* [[HLA-DR4|HLA-DR4 gene]] | |||
* [[HLA-DR5|HLA-DR5 gene]] | |||
===Causes in Alphabetical Order=== | ===Causes in Alphabetical Order=== | ||
Following is a list of the various causes of the postpartum thyroididtis in alphabetical order: | |||
{{columns-list | {{columns-list| | ||
* | * CD60 CTLA-4 [[gene]] | ||
* [[HLA-DR3|HLA-DR3 gene]] | |||
* [[HLA-DR4|HLA-DR4 gene]] | |||
* [[HLA-DR5|HLA-DR5 gene]] | |||
* | |||
* | |||
* | |||
}} | }} | ||
Latest revision as of 22:30, 10 January 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sunny Kumar MD [2]
Overview
Postpartum thyroiditis (PPT) is a type of subacute lymphocytic thyroiditis that occurs due to autoimmune response towards thyroid gland in postpartum period, miscarriage, or abortion. PPT is an autoimmune disorder. PPT is caused by a mutation in the G-allele of CD60 CTLA-4 gene, HLA-DR3, HLA-DR4, and HLA-DR5 gene. To review details about various risk factors that contribute to the development of PPT, click here.
Causes
Postpartum thyroiditis (PPT) is a type of subacute lymphocytic thyroiditis that occurs due to autoimmune response towards thyroid gland in postpartum period, miscarriage, or abortion.[1]
Genetic Causes
Postpartum thyroiditis (PPT) is caused by a mutation in the G-allele of the following:[2]
- CD60 CTLA-4 gene
- HLA-DR3 gene
- HLA-DR4 gene
- HLA-DR5 gene
Causes in Alphabetical Order
Following is a list of the various causes of the postpartum thyroididtis in alphabetical order:
- CD60 CTLA-4 gene
- HLA-DR3 gene
- HLA-DR4 gene
- HLA-DR5 gene
References
- ↑ Premawardhana LD, Parkes AB, Ammari F, John R, Darke C, Adams H; et al. (2000). "Postpartum thyroiditis and long-term thyroid status: prognostic influence of thyroid peroxidase antibodies and ultrasound echogenicity". J Clin Endocrinol Metab. 85 (1): 71–5. doi:10.1210/jcem.85.1.6227. PMID 10634366.
- ↑ Stagnaro-Green A (2012). "Approach to the patient with postpartum thyroiditis". J Clin Endocrinol Metab. 97 (2): 334–42. doi:10.1210/jc.2011-2576. PMID 22312089.