| IL-24 is a [[cytokine]] belonging to the [[Interleukin 10|IL-10]] family of cytokines that signals through two [[heterodimer]]ic receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 ('''mda-7''') due to its discovery as a [[tumour]] suppressing protein. IL-24 appears to control in cell survival and [[cell growth|proliferation]] by inducing rapid activation of particular [[transcription factor]]s called [[STAT1]] and [[STAT3]]. This cytokine is predominantly released by activated [[monocyte]]s, [[macrophages]] and [[helper T cells|T helper 2]] (Th2) cells<ref name="pmid16000394">{{cite journal |vauthors=Poindexter NJ, Walch ET, Chada S, Grimm EA | title = Cytokine induction of interleukin-24 in human peripheral blood mononuclear cells | journal = J. Leukoc. Biol. | volume = 78 | issue = 3 | pages = 745–52 |date=September 2005 | pmid = 16000394 | doi = 10.1189/jlb.0205116 }}</ref> and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, arthritis, [[psoriasis]] and [[cancer]].<ref name="pmid15667561">{{cite journal |vauthors=Wang M, Liang P | title = Interleukin-24 and its receptors | journal = Immunology | volume = 114 | issue = 2 | pages = 166–70 |date=February 2005 | pmid = 15667561 | pmc = 1782067 | doi = 10.1111/j.1365-2567.2005.02094.x }}</ref><ref>{{cite journal|last1=Kragstrup|first1=TW|last2=Otkjaer|first2=K|last3=Holm|first3=C|last4=Jørgensen|first4=A|last5=Hokland|first5=M|last6=Iversen|first6=L|last7=Deleuran|first7=B|title=The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy.|journal=Cytokine|date=January 2008|volume=41|issue=1|pages=16–23|pmid=18061474}}</ref><ref>{{cite journal|last1=Kragstrup|first1=Tue Wenzel|last2=Greisen|first2=Stinne Ravn|last3=Nielsen|first3=Morten Aagaard|last4=Rhodes|first4=Christopher|last5=Stengaard-Pedersen|first5=Kristian|last6=Hetland|first6=Merete Lund|last7=Hørslev-Petersen|first7=Kim|last8=Junker|first8=Peter|last9=Østergaard|first9=Mikkel|last10=Hvid|first10=Malene|last11=Vorup-Jensen|first11=Thomas|last12=Robinson|first12=William H.|last13=Sokolove|first13=Jeremy|last14=Deleuran|first14=Bent|title=The interleukin-20 receptor axis in early rheumatoid arthritis: novel links between disease-associated autoantibodies and radiographic progression|journal=Arthritis Research & Therapy|date=11 March 2016|volume=18|issue=1|doi=10.1186/s13075-016-0964-7}}</ref> Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24.<ref name="pmid14508078">{{cite journal |vauthors=Fisher PB, Gopalkrishnan RV, Chada S, Ramesh R, Grimm EA, Rosenfeld MR, Curiel DT, Dent P | title = mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic | journal = Cancer Biol. Ther. | volume = 2 | issue = 4 Suppl 1 | pages = S23–37 | year = 2003 | pmid = 14508078 | doi = }}</ref><ref name="pmid15126330">{{cite journal |vauthors=Sauane M, Lebedeva IV, Su ZZ, Choo HT, Randolph A, Valerie K, Dent P, Gopalkrishnan RV, Fisher PB | title = Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways | journal = Cancer Res. | volume = 64 | issue = 9 | pages = 2988–93 |date=May 2004 | pmid = 15126330 | doi =10.1158/0008-5472.CAN-04-0200 }}</ref> The gene for IL-24 is located on chromosome 1 in humans.<ref>[http://www.genecards.org/cgi-bin/carddisp.pl?gene=IL24 IL24 GeneCard<!-- Bot generated title -->]</ref> | | IL-24 is a [[cytokine]] belonging to the [[Interleukin 10|IL-10]] family of cytokines that signals through two [[heterodimer]]ic receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 ('''mda-7''') due to its discovery as a [[tumour]] suppressing protein. IL-24 appears to control in cell survival and [[cell growth|proliferation]] by inducing rapid activation of particular [[transcription factor]]s called [[STAT1]] and [[STAT3]]. This cytokine is predominantly released by activated [[monocyte]]s, [[macrophages]] and [[helper T cells|T helper 2]] (Th2) cells<ref name="pmid16000394">{{cite journal |vauthors=Poindexter NJ, Walch ET, Chada S, Grimm EA | title = Cytokine induction of interleukin-24 in human peripheral blood mononuclear cells | journal = J. Leukoc. Biol. | volume = 78 | issue = 3 | pages = 745–52 |date=September 2005 | pmid = 16000394 | doi = 10.1189/jlb.0205116 }}</ref> and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, arthritis, [[psoriasis]] and [[cancer]].<ref name="pmid15667561">{{cite journal |vauthors=Wang M, Liang P | title = Interleukin-24 and its receptors | journal = Immunology | volume = 114 | issue = 2 | pages = 166–70 |date=February 2005 | pmid = 15667561 | pmc = 1782067 | doi = 10.1111/j.1365-2567.2005.02094.x }}</ref><ref>{{cite journal|last1=Kragstrup|first1=TW|last2=Otkjaer|first2=K|last3=Holm|first3=C|last4=Jørgensen|first4=A|last5=Hokland|first5=M|last6=Iversen|first6=L|last7=Deleuran|first7=B|title=The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy.|journal=Cytokine|date=January 2008|volume=41|issue=1|pages=16–23|pmid=18061474|doi=10.1016/j.cyto.2007.10.004}}</ref><ref>{{cite journal|last1=Kragstrup|first1=Tue Wenzel|last2=Greisen|first2=Stinne Ravn|last3=Nielsen|first3=Morten Aagaard|last4=Rhodes|first4=Christopher|last5=Stengaard-Pedersen|first5=Kristian|last6=Hetland|first6=Merete Lund|last7=Hørslev-Petersen|first7=Kim|last8=Junker|first8=Peter|last9=Østergaard|first9=Mikkel|last10=Hvid|first10=Malene|last11=Vorup-Jensen|first11=Thomas|last12=Robinson|first12=William H.|last13=Sokolove|first13=Jeremy|last14=Deleuran|first14=Bent|title=The interleukin-20 receptor axis in early rheumatoid arthritis: novel links between disease-associated autoantibodies and radiographic progression|journal=Arthritis Research & Therapy|date=11 March 2016|volume=18|issue=1|doi=10.1186/s13075-016-0964-7}}</ref> Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24.<ref name="pmid14508078">{{cite journal |vauthors=Fisher PB, Gopalkrishnan RV, Chada S, Ramesh R, Grimm EA, Rosenfeld MR, Curiel DT, Dent P | title = mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic | journal = Cancer Biol. Ther. | volume = 2 | issue = 4 Suppl 1 | pages = S23–37 | year = 2003 | pmid = 14508078 | doi = }}</ref><ref name="pmid15126330">{{cite journal |vauthors=Sauane M, Lebedeva IV, Su ZZ, Choo HT, Randolph A, Valerie K, Dent P, Gopalkrishnan RV, Fisher PB | title = Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways | journal = Cancer Res. | volume = 64 | issue = 9 | pages = 2988–93 |date=May 2004 | pmid = 15126330 | doi =10.1158/0008-5472.CAN-04-0200 }}</ref> The gene for IL-24 is located on chromosome 1 in humans.<ref>[https://www.genecards.org/cgi-bin/carddisp.pl?gene=IL24 IL24 GeneCard<!-- Bot generated title -->]</ref> |
