Chemokine (C-C motif) ligand 17 (CCL17) (also known as TARC) is a small cytokine belonging to the CC chemokine family is also known as thymus and activation regulated chemokine (TARC). CCL17 is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells.[1] This chemokine specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4.[1][2] The gene for CCL17 is located on chromosome 16, in humans, along with other chemokines called CCL22 and CX3CL1.[3][4]
References
↑ 1.01.1Imai T, Yoshida T, Baba M, Nishimura M, Kakizaki M, Yoshie O (1996). "Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector". J. Biol. Chem. 271 (35): 21514–21. doi:10.1074/jbc.271.35.21514. PMID8702936.
↑Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". J. Biol. Chem. 272 (23): 15036–42. doi:10.1074/jbc.272.23.15036. PMID9169480.
↑Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1997). "Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13". Genomics. 40 (1): 211–3. doi:10.1006/geno.1996.4552. PMID9070951.
↑Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13". Cytogenet. Cell Genet. 81 (1): 10–1. doi:10.1159/000015000. PMID9691168.
Saeki H, Tamaki K (2006). "Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases". J. Dermatol. Sci. 43 (2): 75–84. doi:10.1016/j.jdermsci.2006.06.002. PMID16859899.
Imai T, Yoshida T, Baba M, et al. (1996). "Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector". J. Biol. Chem. 271 (35): 21514–21. doi:10.1074/jbc.271.35.21514. PMID8702936.
Nomiyama H, Imai T, Kusuda J, et al. (1997). "Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13". Genomics. 40 (1): 211–3. doi:10.1006/geno.1996.4552. PMID9070951.
Imai T, Baba M, Nishimura M, et al. (1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". J. Biol. Chem. 272 (23): 15036–42. doi:10.1074/jbc.272.23.15036. PMID9169480.
Imai T, Chantry D, Raport CJ, et al. (1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4". J. Biol. Chem. 273 (3): 1764–8. doi:10.1074/jbc.273.3.1764. PMID9430724.
Nomiyama H, Imai T, Kusuda J, et al. (1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13". Cytogenet. Cell Genet. 81 (1): 10–1. doi:10.1159/000015000. PMID9691168.
Struyf S, Proost P, Sozzani S, et al. (1998). "Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor". J. Immunol. 161 (6): 2672–5. PMID9743322.
Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID10493829.
Ghia P, Transidico P, Veiga JP, et al. (2001). "Chemoattractants MDC and TARC are secreted by malignant B-cell precursors following CD40 ligation and support the migration of leukemia-specific T cells". Blood. 98 (3): 533–40. doi:10.1182/blood.V98.3.533. PMID11468146.
Morita A, Kikuoka S, Horikawa T, et al. (2002). "Evaluation of human thymus and activation-regulated chemokine concentrations in blood using a new sandwich ELISA based on monoclonal antibodies". Clin. Chim. Acta. 322 (1–2): 67–75. doi:10.1016/S0009-8981(02)00131-6. PMID12104083.
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Zheng X, Nakamura K, Tojo M, et al. (2003). "TGF-beta1-mediated regulation of thymus and activation-regulated chemokine (TARC/CCL17) synthesis and secretion by HaCaT cells co-stimulated with TNF-alpha and IFN-gamma". J. Dermatol. Sci. 30 (2): 154–60. doi:10.1016/S0923-1811(02)00071-3. PMID12413771.
Kakinuma T, Nakamura K, Wakugawa M, et al. (2003). "IL-4, but not IL-13, modulates TARC (thymus and activation-regulated chemokine)/CCL17 and IP-10 (interferon-induced protein of 10kDA)/CXCL10 release by TNF-alpha and IFN-gamma in HaCaT cell line". Cytokine. 20 (1): 1–6. doi:10.1006/cyto.2002.1965. PMID12441140.
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Jones, K (Feb 1, 2013). "Serum CD163 and TARC as disease response biomarkers in classical Hodgkin lymphoma". Clin Cancer Res. 19 (3): 731–42. doi:10.1158/1078-0432.CCR-12-2693. PMID23224400.