Lymphotoxin: Difference between revisions
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'''Lymphotoxin''' (previously known as '''[[Tumor necrosis factors|tumor necrosis factor]]-beta''') is a [[lymphokine]] [[cytokine]]. | '''Lymphotoxin''' (previously known as '''[[Tumor necrosis factors|tumor necrosis factor]]-beta''') is a [[lymphokine]] [[cytokine]]. | ||
It is a [[protein]] that is produced by Th1 type T-cells and induces vascular endothelial cells to change their surface adhesion molecules to allow phagocytic cells to bind to them.<ref name="isbn0-8153-4093-1">{{cite book | author = Parham, Peter | authorlink = | editor = | others = | title = The immune system | edition = 2nd | language = | publisher = Garland Science | location = New York | year = 2005 | chapter = Chapter 6: T-cell mediated immunity | page = 172 | quote = | isbn = 0-8153-4093-1 | oclc = | doi = | url = | accessdate = }}</ref> It is also known to be required for normal development of [[Peyer's patches]].<ref name="robbins">{{cite book | author = Kumar | editor = Kumar | title = Robbins and Cotran Pathologic Basis of Disease, Professional Edition | chapter = Chapter 13 – Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus | edition = 8th | It is a [[protein]] that is produced by Th1 type T-cells and induces vascular endothelial cells to change their surface adhesion molecules to allow phagocytic cells to bind to them.<ref name="isbn0-8153-4093-1">{{cite book | author = Parham, Peter | authorlink = | editor = | others = | title = The immune system | edition = 2nd | language = | publisher = Garland Science | location = New York | year = 2005 | chapter = Chapter 6: T-cell mediated immunity | page = 172 | quote = | isbn = 0-8153-4093-1 | oclc = | doi = | url = | accessdate = }}</ref> It is also known to be required for normal development of [[Peyer's patches]].<ref name="robbins">{{cite book | author = Kumar | editor = Kumar | title = Robbins and Cotran Pathologic Basis of Disease, Professional Edition | chapter = Chapter 13 – Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus | edition = 8th }}</ref> | ||
Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is [[paracrine]] due to the small amounts produced. | Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is [[paracrine]] due to the small amounts produced. | ||
Latest revision as of 14:41, 4 May 2018
| lymphotoxin alpha (TNF superfamily, member 1) | |
|---|---|
| Identifiers | |
| Symbol | LTA |
| Alt. symbols | TNFB |
| Entrez | 4049 |
| HUGO | 6709 |
| OMIM | 153440 |
| RefSeq | NM_000595 |
| UniProt | P01374 |
| Other data | |
| Locus | Chr. 6 p21.3 |
| lymphotoxin beta (TNF superfamily, member 3) | |
|---|---|
| Identifiers | |
| Symbol | LTB |
| Alt. symbols | TNFC |
| Entrez | 4050 |
| HUGO | 6711 |
| OMIM | 600978 |
| RefSeq | NM_002341 |
| UniProt | Q06643 |
| Other data | |
| Locus | Chr. 6 p21.3 |
Lymphotoxin (previously known as tumor necrosis factor-beta) is a lymphokine cytokine.
It is a protein that is produced by Th1 type T-cells and induces vascular endothelial cells to change their surface adhesion molecules to allow phagocytic cells to bind to them.[1] It is also known to be required for normal development of Peyer's patches.[2]
Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts produced. The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs.
See also
References
- ↑ Parham, Peter (2005). "Chapter 6: T-cell mediated immunity". The immune system (2nd ed.). New York: Garland Science. p. 172. ISBN 0-8153-4093-1.
- ↑ Kumar. "Chapter 13 – Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus". In Kumar. Robbins and Cotran Pathologic Basis of Disease, Professional Edition (8th ed.).
External links
- Lymphotoxin at the US National Library of Medicine Medical Subject Headings (MeSH)
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