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__NOTOC__ | __NOTOC__ | ||
{{VIPoma}} | {{VIPoma}} | ||
{{CMG}}{{AE}}{{MSI}}{{PSD}} | {{CMG}}{{AE}}{{MSI}}{{PSD}}{{Homa}} | ||
==Overview== | ==Overview== | ||
The hallmark of | The [[hallmark]] of Vipoma is [[watery diarrhea]]. A positive [[History and Physical examination|history]] of [[abdominal pain]], [[weight loss]], [[numbness]], and [[weakness]] is suggestive of VIPoma . The most common [[symptoms]] of VIPoma include [[watery diarrhea]] like [[cholera]], [[Dehydration |dehydration,]] [[lethargy]], [[muscle weakness]], [[weight loss]], [[numbness]], and [[flushing]]. | ||
==History and Symptoms== | |||
==Symptoms== | *The [[hallmark]] of Vipoma is [[watery diarrhea]]. A positive [[History and Physical examination|history]] of [[abdominal pain]], [[weight loss]], [[numbness]], and [[weakness]] is suggestive of VIPoma . The most common [[symptoms]] of VIPoma include [[watery diarrhea]] like [[cholera]], [[Dehydration |dehydration,]] [[lethargy]], [[muscle weakness]], [[weight loss]], [[numbness]], and [[flushing]]. | ||
Symptoms of VIPoma may include any of the following:<ref name="sss">VIPoma. U.S. National Library of Medicine. Accessed on October 23, 2015. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm </ref><ref name="pmid16357627 | |||
===History=== | |||
[[Patients]] with VIPoma may have a positive [[History and Physical examination|history]] of: | |||
*[[Diarrhea|Watery diarrhea]] | |||
*[[Abdominal pain]] | |||
*[[Muscle weakness|Weakness]] | |||
===Common Symptoms=== | |||
[[Symptoms]] of VIPoma usually arise when [[tumor]] reaches certain size. Most tumors are > 2cm and [[metastatic]] by the time [[symptoms]] arise. Common [[symptoms]] may include any of the following:<ref name="sss">VIPoma. U.S. National Library of Medicine. Accessed on October 23, 2015. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm </ref><ref name="pmid16357627">{{cite journal| author=Remme CA, de Groot GH, Schrijver G| title=Diagnosis and treatment of VIPoma in a female patient. | journal=Eur J Gastroenterol Hepatol | year= 2006 | volume= 18 | issue= 1 | pages= 93-9 | pmid=16357627 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16357627 }} </ref><ref name="pmid17510774">{{cite journal| author=Ghaferi AA, Chojnacki KA, Long WD, Cameron JL, Yeo CJ| title=Pancreatic VIPomas: subject review and one institutional experience. | journal=J Gastrointest Surg | year= 2008 | volume= 12 | issue= 2 | pages= 382-93 | pmid=17510774 | doi=10.1007/s11605-007-0177-0 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17510774 }} </ref><ref name="pmid235829162">{{cite journal| author=Ito T, Igarashi H, Jensen RT| title=Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances. | journal=Best Pract Res Clin Gastroenterol | year= 2012 | volume= 26 | issue= 6 | pages= 737-53 | pmid=23582916 | doi=10.1016/j.bpg.2012.12.003 | pmc=3627221 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23582916 }}</ref> | |||
*[[Watery diarrhea]] like [[cholera]] | |||
**[[Volume]] ranges from 750ml to more than 3 liters. | |||
**Secretory [[diarrhea]] persists even on fasting for 48 hours and is odorless. | |||
**The [[stool]] [[Appearance|appears]] like [[Diluted|dilute]] tea in color, is [[blood]] and [[mucus]] free. | |||
*[[Dehydration ]] ([[thirst]], [[dry skin]], [[dry mouth]], [[tiredness]], [[headaches]], and [[dizziness]]) | *[[Dehydration ]] ([[thirst]], [[dry skin]], [[dry mouth]], [[tiredness]], [[headaches]], and [[dizziness]]) | ||
*[[Lethargy]] | *[[Lethargy]] | ||
*[[Muscle weakness]] | *[[Muscle weakness]] | ||
*[[Weight loss]] | *[[Weight loss]] | ||
*[[Numbness]] caused due to [[hypokalaemia]] | *[[Numbness]] caused due to [[hypokalaemia]] | ||
*[[Flushing]] | *[[Flushing]] | ||
===Less Common Symptoms=== | |||
*[[Abdominal cramps|Crampy]] [[abdominal pain]] | |||
*[[Nausea]] | |||
*[[Vomiting]] | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
[[Category:Medicine]] | |||
[[Category:Oncology]] | [[Category:Oncology]] | ||
[[Category: | [[Category:Up-To-Date]] | ||
[[Category:Endocrinology]] | |||
[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
Latest revision as of 00:40, 30 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]Parminder Dhingra, M.D. [3] Homa Najafi, M.D.[4]
Overview
The hallmark of Vipoma is watery diarrhea. A positive history of abdominal pain, weight loss, numbness, and weakness is suggestive of VIPoma . The most common symptoms of VIPoma include watery diarrhea like cholera, dehydration, lethargy, muscle weakness, weight loss, numbness, and flushing.
History and Symptoms
- The hallmark of Vipoma is watery diarrhea. A positive history of abdominal pain, weight loss, numbness, and weakness is suggestive of VIPoma . The most common symptoms of VIPoma include watery diarrhea like cholera, dehydration, lethargy, muscle weakness, weight loss, numbness, and flushing.
History
Patients with VIPoma may have a positive history of:
Common Symptoms
Symptoms of VIPoma usually arise when tumor reaches certain size. Most tumors are > 2cm and metastatic by the time symptoms arise. Common symptoms may include any of the following:[1][2][3][4]
- Watery diarrhea like cholera
- Dehydration (thirst, dry skin, dry mouth, tiredness, headaches, and dizziness)
- Lethargy
- Muscle weakness
- Weight loss
- Numbness caused due to hypokalaemia
- Flushing
Less Common Symptoms
References
- ↑ VIPoma. U.S. National Library of Medicine. Accessed on October 23, 2015. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm
- ↑ Remme CA, de Groot GH, Schrijver G (2006). "Diagnosis and treatment of VIPoma in a female patient". Eur J Gastroenterol Hepatol. 18 (1): 93–9. PMID 16357627.
- ↑ Ghaferi AA, Chojnacki KA, Long WD, Cameron JL, Yeo CJ (2008). "Pancreatic VIPomas: subject review and one institutional experience". J Gastrointest Surg. 12 (2): 382–93. doi:10.1007/s11605-007-0177-0. PMID 17510774.
- ↑ Ito T, Igarashi H, Jensen RT (2012). "Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances". Best Pract Res Clin Gastroenterol. 26 (6): 737–53. doi:10.1016/j.bpg.2012.12.003. PMC 3627221. PMID 23582916.