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==Overview==
==Overview==
Familial adenomatous polyposis is a rare disease that affects individuals worldwide. The [[incidence]] and [[prevalence]] of familial adenomatous polyposis is approximately 3 to 20 and 12 per 100,000 individuals, respectively. Surgical [[mortality rate]] is approximately 4400 per 100,000 individuals (4.4%) in Sweden. Patients usually develop familial adenomatous polyposis in their first and second decades of life. Familial adenomatous polyposis affects men and women equally and there is no racial predilection. All of the patients with familial adenomatous polyposis without treatment, will develop [[colorectal cancer]] by age of 39.


==Epidemiology and Demographics==
==Epidemiology and Demographics==
===Incidence===
===The epidemiology and demographicsIncidence===
*The incidence familial adenomatous polyposis is approximately 12 per 100,000 births in the Europe.<ref name="HalfBercovich2009">{{cite journal|last1=Half|first1=Elizabeth|last2=Bercovich|first2=Dani|last3=Rozen|first3=Paul|title=Familial adenomatous polyposis|journal=Orphanet Journal of Rare Diseases|volume=4|issue=1|year=2009|pages=22|issn=1750-1172|doi=10.1186/1750-1172-4-22}}</ref>
*The [[incidence]] of familial adenomatous polyposis is approximately 12 per 100,000 births in the Europe.<ref name="HalfBercovich2009">{{cite journal|last1=Half|first1=Elizabeth|last2=Bercovich|first2=Dani|last3=Rozen|first3=Paul|title=Familial adenomatous polyposis|journal=Orphanet Journal of Rare Diseases|volume=4|issue=1|year=2009|pages=22|issn=1750-1172|doi=10.1186/1750-1172-4-22}}</ref>
*


===Prevalence===
===Prevalence===
*The prevalence of familial adenomatous polyposis is approximately 2.5-8.5 per 100,000 individuals in the Europe.
*The [[prevalence]] of familial adenomatous polyposis is approximately 10 to 20 per 100,000 individuals in the United States.<ref name="NieuwenhuisVasen2007">{{cite journal|last1=Nieuwenhuis|first1=M.H.|last2=Vasen|first2=H.F.A.|title=Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): A review of the literature|journal=Critical Reviews in Oncology/Hematology|volume=61|issue=2|year=2007|pages=153–161|issn=10408428|doi=10.1016/j.critrevonc.2006.07.004}}</ref>
*In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.
*The [[prevalence]] of familial adenomatous polyposis is approximately 3 to 10 per 100,000 individuals in the Europe.<ref name="HalfBercovich2009">{{cite journal|last1=Half|first1=Elizabeth|last2=Bercovich|first2=Dani|last3=Rozen|first3=Paul|title=Familial adenomatous polyposis|journal=Orphanet Journal of Rare Diseases|volume=4|issue=1|year=2009|pages=22|issn=1750-1172|doi=10.1186/1750-1172-4-22}}</ref>
*The prevalence of [disease/malignancy] is estimated to be [number] cases annually.


===Case-fatality rate/Mortality rate===
===Case-fatality rate/Mortality rate===
*In [year], the incidence of [disease name] is approximately [number range] per 100,000 individuals with a case-fatality rate/mortality rate of [number range]%.
*In 1975, the incidence of familial adenomatous polyposis is approximately 13 per 100,000 individuals with a surgical [[mortality rate]] of 4400 per 100,000 individuals (4.4%) in Sweden.<ref name="pmid">{{cite journal |vauthors=Alm T |title=Surgical treatment of hereditary adenomatosis of the colon and rectum in Sweden during the last 20 years. Part II. Patients with prophylactic operations, primary and late results. Discussion and summary |journal=Acta Chir Scand |volume=141 |issue=3 |pages=228–37 |year=1975 |pmid= |doi= |url=}}</ref>
*The case-fatality rate/mortality rate of [disease name] is approximately [number range].
 
===Age===
===Age===
*Patients of all age groups may develop [disease name].
*The mean age for developing [[colon polyps]] in patients with familial adenomatous polyposis is 13 years.<ref name="KennedyPotter2014">{{cite journal|last1=Kennedy|first1=Raelene D.|last2=Potter|first2=D. Dean|last3=Moir|first3=Christopher R.|last4=El-Youssef|first4=Mounif|title=The natural history of familial adenomatous polyposis syndrome: A 24year review of a single center experience in screening, diagnosis, and outcomes|journal=Journal of Pediatric Surgery|volume=49|issue=1|year=2014|pages=82–86|issn=00223468|doi=10.1016/j.jpedsurg.2013.09.033}}</ref>
*The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.
*Patients in their first and second decades usually develop familial adenomatous polyposis.
*[Disease name] commonly affects individuals younger than/older than [number of years] years of age.  
*All the patients with familial adenomatous polyposis without treatment will develop [[colorectal cancer]] by age of 39.<ref name="pmid11446392">{{cite journal |vauthors=Beech D, Pontius A, Muni N, Long WP |title=Familial adenomatous polyposis: a case report and review of the literature |journal=J Natl Med Assoc |volume=93 |issue=6 |pages=208–13 |year=2001 |pmid=11446392 |pmc=2594024 |doi= |url=}}</ref>
*[Chronic disease name] is usually first diagnosed among [age group].
*[Acute disease name] commonly affects [age group].


===Race===
===Race===
*There is no racial predilection to [disease name].
*There is no racial predilection to familial adenomatous polyposis.
*[Disease name] usually affects individuals of the [race 1] race. [Race 2] individuals are less likely to develop [disease name].
===Gender===
===Gender===
*Familial adenomatous polyposis affects men and women equally.<ref name="HalfBercovich2009">{{cite journal|last1=Half|first1=Elizabeth|last2=Bercovich|first2=Dani|last3=Rozen|first3=Paul|title=Familial adenomatous polyposis|journal=Orphanet Journal of Rare Diseases|volume=4|issue=1|year=2009|pages=22|issn=1750-1172|doi=10.1186/1750-1172-4-22}}</ref>
*Familial adenomatous polyposis affects men and women equally.<ref name="HalfBercovich2009">{{cite journal|last1=Half|first1=Elizabeth|last2=Bercovich|first2=Dani|last3=Rozen|first3=Paul|title=Familial adenomatous polyposis|journal=Orphanet Journal of Rare Diseases|volume=4|issue=1|year=2009|pages=22|issn=1750-1172|doi=10.1186/1750-1172-4-22}}</ref>
===Region===
===Region===
*Familial adenomatous polyposis is a rare disease that is worldwide.  
*Familial adenomatous polyposis is a rare disease that tends to affect individuals worldwide.<ref name="pmid20301519">{{cite journal |vauthors=Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, Jasperson KW, Patel SG, Ahnen DJ |title=APC-Associated Polyposis Conditions. |journal= |volume= |issue= |pages= |year= |pmid=20301519 |doi= |url=}}</ref>
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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[[Category:Medicine]]
[[Category:Gastroenterology]]
[[Category:Oncology]]
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Latest revision as of 21:43, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2], Mohamad Alkateb, MBBCh [3]

Overview

Familial adenomatous polyposis is a rare disease that affects individuals worldwide. The incidence and prevalence of familial adenomatous polyposis is approximately 3 to 20 and 12 per 100,000 individuals, respectively. Surgical mortality rate is approximately 4400 per 100,000 individuals (4.4%) in Sweden. Patients usually develop familial adenomatous polyposis in their first and second decades of life. Familial adenomatous polyposis affects men and women equally and there is no racial predilection. All of the patients with familial adenomatous polyposis without treatment, will develop colorectal cancer by age of 39.

Epidemiology and Demographics

The epidemiology and demographicsIncidence

  • The incidence of familial adenomatous polyposis is approximately 12 per 100,000 births in the Europe.[1]

Prevalence

  • The prevalence of familial adenomatous polyposis is approximately 10 to 20 per 100,000 individuals in the United States.[2]
  • The prevalence of familial adenomatous polyposis is approximately 3 to 10 per 100,000 individuals in the Europe.[1]

Case-fatality rate/Mortality rate

  • In 1975, the incidence of familial adenomatous polyposis is approximately 13 per 100,000 individuals with a surgical mortality rate of 4400 per 100,000 individuals (4.4%) in Sweden.[3]

Age

  • The mean age for developing colon polyps in patients with familial adenomatous polyposis is 13 years.[4]
  • Patients in their first and second decades usually develop familial adenomatous polyposis.
  • All the patients with familial adenomatous polyposis without treatment will develop colorectal cancer by age of 39.[5]

Race

  • There is no racial predilection to familial adenomatous polyposis.

Gender

  • Familial adenomatous polyposis affects men and women equally.[1]

Region

  • Familial adenomatous polyposis is a rare disease that tends to affect individuals worldwide.[6]

References

  1. ↑ 1.0 1.1 1.2 Half, Elizabeth; Bercovich, Dani; Rozen, Paul (2009). "Familial adenomatous polyposis". Orphanet Journal of Rare Diseases. 4 (1): 22. doi:10.1186/1750-1172-4-22. ISSN 1750-1172.
  2. ↑ Nieuwenhuis, M.H.; Vasen, H.F.A. (2007). "Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): A review of the literature". Critical Reviews in Oncology/Hematology. 61 (2): 153–161. doi:10.1016/j.critrevonc.2006.07.004. ISSN 1040-8428.
  3. ↑ Alm T (1975). "Surgical treatment of hereditary adenomatosis of the colon and rectum in Sweden during the last 20 years. Part II. Patients with prophylactic operations, primary and late results. Discussion and summary". Acta Chir Scand. 141 (3): 228–37.
  4. ↑ Kennedy, Raelene D.; Potter, D. Dean; Moir, Christopher R.; El-Youssef, Mounif (2014). "The natural history of familial adenomatous polyposis syndrome: A 24year review of a single center experience in screening, diagnosis, and outcomes". Journal of Pediatric Surgery. 49 (1): 82–86. doi:10.1016/j.jpedsurg.2013.09.033. ISSN 0022-3468.
  5. ↑ Beech D, Pontius A, Muni N, Long WP (2001). "Familial adenomatous polyposis: a case report and review of the literature". J Natl Med Assoc. 93 (6): 208–13. PMC 2594024. PMID 11446392.
  6. ↑ Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean L, Stephens K, Amemiya A, Jasperson KW, Patel SG, Ahnen DJ. "APC-Associated Polyposis Conditions". PMID 20301519. Vancouver style error: initials (help)

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