Familial adenomatous polyposis classification: Difference between revisions
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* [[FAP (gene)|''FAP'' gene]] associated familial adenomatous polyposis | * [[FAP (gene)|''FAP'' gene]] associated familial adenomatous polyposis | ||
* ''[[MUTYH]]''-associated polyposis (MAP) | * ''[[MUTYH]]''-associated polyposis (MAP) | ||
Familial adenomatous polyposis may be classified according to severity into three subtypes:<ref name="NieuwenhuisVasen2007">{{cite journal|last1=Nieuwenhuis|first1=M.H.|last2=Vasen|first2=H.F.A.|title=Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): A review of the literature|journal=Critical Reviews in Oncology/Hematology|volume=61|issue=2|year=2007|pages=153–161|issn=10408428|doi=10.1016/j.critrevonc.2006.07.004}}</ref> | Familial adenomatous polyposis may also be classified according to severity into three subtypes:<ref name="NieuwenhuisVasen2007">{{cite journal|last1=Nieuwenhuis|first1=M.H.|last2=Vasen|first2=H.F.A.|title=Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): A review of the literature|journal=Critical Reviews in Oncology/Hematology|volume=61|issue=2|year=2007|pages=153–161|issn=10408428|doi=10.1016/j.critrevonc.2006.07.004}}</ref> | ||
*Profuse | *Profuse FAP | ||
*Intermediate | *Intermediate FAP | ||
*Attenuated | *Attenuated FAP | ||
{| class="wikitable" | {| class="wikitable" | ||
!Type | !Type | ||
| Line 34: | Line 34: | ||
|55-60 | |55-60 | ||
|} | |} | ||
===Variants=== | |||
Familial adenomatous polyposis has less severe variants, including: | Familial adenomatous polyposis has less severe variants, including: | ||
*[[Gardner's syndrome]] | *[[Gardner's syndrome]] | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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[[Category:Medicine]] | |||
[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
[[Category:Oncology]] | [[Category:Oncology]] | ||
[[Category:Up-To-Date | [[Category:Up-To-Date]] | ||
Latest revision as of 21:43, 29 July 2020
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Familial adenomatous polyposis Microchapters |
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Differentiating Familial adenomatous polyposis from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Familial adenomatous polyposis classification On the Web |
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American Roentgen Ray Society Images of Familial adenomatous polyposis classification |
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Directions to Hospitals Treating Familial adenomatous polyposis |
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Risk calculators and risk factors for Familial adenomatous polyposis classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2], Mohamad Alkateb, MBBCh [3]
Overview
Familial adenomatous polyposis (FAP) may be classified according to the affected gene into two subtypes including FAP gene and MYH gene associated familial adenomatous polyposis. Familial adenomatous polyposis may be classified according to severity into three subtypes including profuse, intermediate, and attenuated. Familial adenomatous polyposis has less severe variants, including gardner's syndrome and turcot syndrome.
Classification
Familial adenomatous polyposis may be classified according to the affected genes into two subtypes:[1][2]
Familial adenomatous polyposis may also be classified according to severity into three subtypes:[3]
- Profuse FAP
- Intermediate FAP
- Attenuated FAP
| Type | Characteristics | Age of onset for polyp | Age of onset for cancer |
|---|---|---|---|
| Profuse | Thousands of polyps | 15-20 | 35-40 |
| Intermediate | Hundreds to thousands of polyps | 25-30 | 45-50 |
| Attenuated | Less than 100 polyps | 35-40 | 55-60 |
Variants
Familial adenomatous polyposis has less severe variants, including:
References
- ↑ Iaquinto, Gaetano; Fornasarig, Mara; Quaia, Michele; Giardullo, Nicola; D'Onofrio, Vittorio; Iaquinto, Salvatore; Di Bella, Simone; Cannizzaro, Renato (2008). "Capsule endoscopy is useful and safe for small-bowel surveillance in familial adenomatous polyposis". Gastrointestinal Endoscopy. 67 (1): 61–67. doi:10.1016/j.gie.2007.07.048. ISSN 0016-5107.
- ↑ King, John E.; Dozois, Roger R.; Lindor, Noralane M.; Ahlquist, David A. (2000). "Care of Patients and Their Families With Familial Adenomatous Polyposis". Mayo Clinic Proceedings. 75 (1): 57–67. doi:10.4065/75.1.57. ISSN 0025-6196.
- ↑ Nieuwenhuis, M.H.; Vasen, H.F.A. (2007). "Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): A review of the literature". Critical Reviews in Oncology/Hematology. 61 (2): 153–161. doi:10.1016/j.critrevonc.2006.07.004. ISSN 1040-8428.