Hemophilia A risk factors: Difference between revisions
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{{Hemophilia A}} | {{Hemophilia A}} | ||
{{CMG}}{{AE}}{{FNY}} | {{CMG}}{{AE}}{{FNY}} {{VE}} | ||
==Overview== | ==Overview== | ||
Risk factors for development of [[Hemophilia A]] and B include being of male sex and having a positive [[family history]] of the disease. | Risk factors for development of [[Hemophilia A]] and [[Hemophilia B|B]] include being of male sex and having a positive [[family history]] of the disease. | ||
It is of note that acquired forms of the disease occur in specific circumstances including Malignancies, Pregnancy, Autoimmune disorders, Certain medications; All of which could be considered as Hemophilia risk factor either. | It is of note that acquired forms of the disease occur in specific circumstances including Malignancies, Pregnancy, [[Autoimmune disorders]], Certain medications; All of which could be considered as Hemophilia risk factor either. | ||
==Risk Factors== | ==Risk Factors== | ||
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*Male sex | *Male sex | ||
*Family history of [[bleeding]]<ref>How Hemophilia is Inherited | Hemophilia | NCBDDD | CDC. Available at http://www.cdc.gov/ncbddd/hemophilia/inheritance-pattern.html. Accessed on Sept 20, 2016 </ref> | *Family history of [[bleeding]]<ref>How Hemophilia is Inherited | Hemophilia | NCBDDD | CDC. Available at http://www.cdc.gov/ncbddd/hemophilia/inheritance-pattern.html. Accessed on Sept 20, 2016 </ref> | ||
Best-studied risk factors of the acquired form of the disease include:<ref name="pmid22321904">{{cite journal| author=Knoebl P, Marco P, Baudo F, Collins P, Huth-Kühne A, Nemes L et al.| title=Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2). | journal=J Thromb Haemost | year= 2012 | volume= 10 | issue= 4 | pages= 622-31 | pmid=22321904 | doi=10.1111/j.1538-7836.2012.04654.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22321904 }}</ref> | Best-studied risk factors of the acquired form of the disease include:<ref name="pmid22321904">{{cite journal| author=Knoebl P, Marco P, Baudo F, Collins P, Huth-Kühne A, Nemes L et al.| title=Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2). | journal=J Thromb Haemost | year= 2012 | volume= 10 | issue= 4 | pages= 622-31 | pmid=22321904 | doi=10.1111/j.1538-7836.2012.04654.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22321904 }}</ref><ref name="pmid28470674">{{cite journal| author=Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA et al.| title=Acquired hemophilia A: Updated review of evidence and treatment guidance. | journal=Am J Hematol | year= 2017 | volume= 92 | issue= 7 | pages= 695-705 | pmid=28470674 | doi=10.1002/ajh.24777 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28470674 }}</ref><ref name="pmid20529258">Collins P, Baudo F, Huth-Kühne A, Ingerslev J, Kessler CM, Castellano ME et al. (2010) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=20529258 Consensus recommendations for the diagnosis and treatment of acquired hemophilia A.] ''BMC Res Notes'' 3 ():161. [http://dx.doi.org/10.1186/1756-0500-3-161 DOI:10.1186/1756-0500-3-161] PMID: [https://pubmed.gov/20529258 20529258]</ref> | ||
* Malignancies (mostly hematologic) | * Malignancies (mostly hematologic) | ||
* Pregnancy | * Pregnancy | ||
* Autoimmune disorders(Lupus erythematosus, Rheumatoid arthritis) | * Autoimmune disorders([[Systemic lupus erythematosus|Lupus erythematosus]], [[Rheumatoid arthritis]]) | ||
* Infections(Hepatitis C, AIDS) | * Infections([[Hepatitis C]], [[AIDS]]) | ||
* Certain Drugs consumption (e.g. Interferon-ą) | * Certain Drugs consumption (e.g. [[Interferon-alpha|Interferon-ą]]) | ||
* Dermatological conditions(Pemphigus, Psoriasis) | * Dermatological conditions([[Pemphigus]], [[Psoriasis]]) | ||
Of note, the majority of reported acquired cases of Hemophilia are about Hemophilia A type. It appears that, the same as | Of note, the majority of reported acquired cases of Hemophilia are about Hemophilia A type. It appears that, the same as [[hereditary]] form, acquired form of Hemophilia B is rarer than Hemophilia A too. | ||
The remaining cases of acquired Hemophilia are idiopathic or the underlying etiology is not known yet. | The remaining cases of acquired Hemophilia are idiopathic or the underlying etiology is not known yet. | ||
Latest revision as of 09:18, 29 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fahd Yunus, M.D. [2] Vahid Eidkhani, M.D.
Overview
Risk factors for development of Hemophilia A and B include being of male sex and having a positive family history of the disease.
It is of note that acquired forms of the disease occur in specific circumstances including Malignancies, Pregnancy, Autoimmune disorders, Certain medications; All of which could be considered as Hemophilia risk factor either.
Risk Factors
Common risk factors in the development of Hemophilia A are:
Best-studied risk factors of the acquired form of the disease include:[2][3][4]
- Malignancies (mostly hematologic)
- Pregnancy
- Autoimmune disorders(Lupus erythematosus, Rheumatoid arthritis)
- Infections(Hepatitis C, AIDS)
- Certain Drugs consumption (e.g. Interferon-ą)
- Dermatological conditions(Pemphigus, Psoriasis)
Of note, the majority of reported acquired cases of Hemophilia are about Hemophilia A type. It appears that, the same as hereditary form, acquired form of Hemophilia B is rarer than Hemophilia A too.
The remaining cases of acquired Hemophilia are idiopathic or the underlying etiology is not known yet.
References
- ↑ How Hemophilia is Inherited | Hemophilia | NCBDDD | CDC. Available at http://www.cdc.gov/ncbddd/hemophilia/inheritance-pattern.html. Accessed on Sept 20, 2016
- ↑ Knoebl P, Marco P, Baudo F, Collins P, Huth-Kühne A, Nemes L; et al. (2012). "Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2)". J Thromb Haemost. 10 (4): 622–31. doi:10.1111/j.1538-7836.2012.04654.x. PMID 22321904.
- ↑ Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA; et al. (2017). "Acquired hemophilia A: Updated review of evidence and treatment guidance". Am J Hematol. 92 (7): 695–705. doi:10.1002/ajh.24777. PMID 28470674.
- ↑ Collins P, Baudo F, Huth-Kühne A, Ingerslev J, Kessler CM, Castellano ME et al. (2010) Consensus recommendations for the diagnosis and treatment of acquired hemophilia A. BMC Res Notes 3 ():161. DOI:10.1186/1756-0500-3-161 PMID: 20529258