Renal amyloidosis risk factors: Difference between revisions
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{{Renal Amyloidosis}} | {{Renal Amyloidosis}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} [[User:Okamal|Omer Kamal, M.D.]] [Mailto:okamal@bidmc.harvard.edu| <nowiki>[2]</nowiki>] | ||
==Overview== | ==Overview== | ||
Common risk factors in the development of renal amyloidosis include genetic mutations such as heterozygous [[mutations]] in the genes for [[lysozyme]], [[apolipoprotein AI]], [[Apolipoprotein A2|apolipoprotein AII]], or fibrinogen A alpha-chain. | |||
==Risk Factors== | ==Risk Factors== | ||
The most potent risk factor in the development of renal amyloidosis are genetic mutations which include:<ref name="pmid19790131">{{cite journal |vauthors=Obici L, Raimondi S, Lavatelli F, Bellotti V, Merlini G |title=Susceptibility to AA amyloidosis in rheumatic diseases: a critical overview |journal=Arthritis Rheum. |volume=61 |issue=10 |pages=1435–40 |date=October 2009 |pmid=19790131 |doi=10.1002/art.24735 |url=}}</ref><ref name="pmid10036584">{{cite journal |vauthors=Booth DR, Booth SE, Gillmore JD, Hawkins PN, Pepys MB |title=SAA1 alleles as risk factors in reactive systemic AA amyloidosis |journal=Amyloid |volume=5 |issue=4 |pages=262–5 |date=December 1998 |pmid=10036584 |doi= |url=}}</ref> | |||
*SAA1 gene mutaions | |||
*[[Point mutations]] in the ''[[apoAI]]'' gene | |||
*[[Point mutations]] in the ''apoAII'' gene | |||
The most potent risk factor in the development of | *Heterozygous mutations in the genes for [[lysozyme]], [[apolipoprotein AI]], [[Apolipoprotein A2|apolipoprotein AII]],, or fibrinogen A alpha-chain | ||
* | |||
* | |||
* | |||
==References== | ==References== | ||
Latest revision as of 18:20, 2 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D. [2]
Overview
Common risk factors in the development of renal amyloidosis include genetic mutations such as heterozygous mutations in the genes for lysozyme, apolipoprotein AI, apolipoprotein AII, or fibrinogen A alpha-chain.
Risk Factors
The most potent risk factor in the development of renal amyloidosis are genetic mutations which include:[1][2]
- SAA1 gene mutaions
- Point mutations in the apoAI gene
- Point mutations in the apoAII gene
- Heterozygous mutations in the genes for lysozyme, apolipoprotein AI, apolipoprotein AII,, or fibrinogen A alpha-chain
References
- ↑ Obici L, Raimondi S, Lavatelli F, Bellotti V, Merlini G (October 2009). "Susceptibility to AA amyloidosis in rheumatic diseases: a critical overview". Arthritis Rheum. 61 (10): 1435–40. doi:10.1002/art.24735. PMID 19790131.
- ↑ Booth DR, Booth SE, Gillmore JD, Hawkins PN, Pepys MB (December 1998). "SAA1 alleles as risk factors in reactive systemic AA amyloidosis". Amyloid. 5 (4): 262–5. PMID 10036584.