Renal amyloidosis history and symptoms: Difference between revisions
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{{CMG}}; {{AE}}[[User:Okamal|Omer Kamal, M.D.]] [Mailto:okamal@bidmc.harvard.edu|2] | {{CMG}}; {{AE}}[[User:Okamal|Omer Kamal, M.D.]] [Mailto:okamal@bidmc.harvard.edu|2] | ||
==Overview== | ==Overview== | ||
The | The hallmark symptoms of renal amyloidosis is [[proteinuria]] and [[hematuria]]. Other symptoms include edema, numbness or tingling in hands or feet. Common symptoms of renal amyloidosis include swelling of ankles and legs, severe fatigue, weakness, shortness of breath, diarrhea with blood, constipation, unintentional and significant weight loss. | ||
==History and | ==History == | ||
* | Patients with renal amyloidosis may have a positive history of <ref name="pmid23704299">{{cite journal |vauthors=Said SM, Sethi S, Valeri AM, Leung N, Cornell LD, Fidler ME, Herrera Hernandez L, Vrana JA, Theis JD, Quint PS, Dogan A, Nasr SH |title=Renal amyloidosis: origin and clinicopathologic correlations of 474 recent cases |journal=Clin J Am Soc Nephrol |volume=8 |issue=9 |pages=1515–23 |date=September 2013 |pmid=23704299 |pmc=3805078 |doi=10.2215/CJN.10491012 |url=}}</ref><ref name="pmid24497558">{{cite journal |vauthors=Mahmood S, Palladini G, Sanchorawala V, Wechalekar A |title=Update on treatment of light chain amyloidosis |journal=Haematologica |volume=99 |issue=2 |pages=209–21 |date=February 2014 |pmid=24497558 |pmc=3912950 |doi=10.3324/haematol.2013.087619 |url=}}</ref> | ||
* Idiopathic ( Primary (AL) amyloidosis | |||
* Amyloidosis secondary to: | |||
*[[ | ** [[Tuberculosis|TB]] | ||
*[[ | ** [[Familial mediterranean fever|Familial mediterranean fever (FMF)]] | ||
** [[Rheumatoid arthritis|Rheumatoid arthritis (RA)]] | |||
** [[Multiple myeloma]] | |||
*.Hereditary amyloidosis due to amyloidogenic [[Mutation|mutations]]: | |||
** [[Transthyretin|Transthyretin (TTR)]] (most common [[inherited]] [[mutation]]) | |||
** [[Fibrinogen]] | |||
** [[Apolipoprotein A1]] | |||
** [[Apolipoprotein A2]] | |||
** [[Lysozyme]] | |||
** [[Gelsolin]] [[Gene|genes]] | |||
== Symptoms == | |||
===Common Symptoms=== | ===Common Symptoms=== | ||
Common symptoms of | Common symptoms of renal amyloidosis include:<ref name="pmid7848315">{{cite journal |vauthors=Helin HJ, Korpela MM, Mustonen JT, Pasternack AI |title=Renal biopsy findings and clinicopathologic correlations in rheumatoid arthritis |journal=Arthritis Rheum. |volume=38 |issue=2 |pages=242–7 |date=February 1995 |pmid=7848315 |doi= |url=}}</ref><ref name="pmid4688790">{{cite journal |vauthors=Triger DR, Joekes AM |title=Renal amyloidosis--a fourteen-year follow-up |journal=Q. J. Med. |volume=42 |issue=165 |pages=15–40 |date=January 1973 |pmid=4688790 |doi= |url=}}</ref> | ||
* Swelling of ankles and legs<ref name="pmid7848315">{{cite journal |vauthors=Helin HJ, Korpela MM, Mustonen JT, Pasternack AI |title=Renal biopsy findings and clinicopathologic correlations in rheumatoid arthritis |journal=Arthritis Rheum. |volume=38 |issue=2 |pages=242–7 |date=February 1995 |pmid=7848315 |doi= |url=}}</ref> | * Swelling of ankles and legs<ref name="pmid7848315">{{cite journal |vauthors=Helin HJ, Korpela MM, Mustonen JT, Pasternack AI |title=Renal biopsy findings and clinicopathologic correlations in rheumatoid arthritis |journal=Arthritis Rheum. |volume=38 |issue=2 |pages=242–7 |date=February 1995 |pmid=7848315 |doi= |url=}}</ref> | ||
* Severe fatigue | * Severe fatigue | ||
Latest revision as of 15:33, 9 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D. [2]
Overview
The hallmark symptoms of renal amyloidosis is proteinuria and hematuria. Other symptoms include edema, numbness or tingling in hands or feet. Common symptoms of renal amyloidosis include swelling of ankles and legs, severe fatigue, weakness, shortness of breath, diarrhea with blood, constipation, unintentional and significant weight loss.
History
Patients with renal amyloidosis may have a positive history of [1][2]
- Idiopathic ( Primary (AL) amyloidosis
- Amyloidosis secondary to:
- .Hereditary amyloidosis due to amyloidogenic mutations:
Symptoms
Common Symptoms
Common symptoms of renal amyloidosis include:[3][4]
- Swelling of ankles and legs[3]
- Severe fatigue
- Weakness
- Shortness of breath
- Diarrhea with blood
- Constipation
- Unintentional, significant weight loss
Less Common Symptoms
Less common symptoms of [disease name] include
- Numbness or tingling in hands or feet (carpal tunnel syndrome)
References
- ↑ Said SM, Sethi S, Valeri AM, Leung N, Cornell LD, Fidler ME, Herrera Hernandez L, Vrana JA, Theis JD, Quint PS, Dogan A, Nasr SH (September 2013). "Renal amyloidosis: origin and clinicopathologic correlations of 474 recent cases". Clin J Am Soc Nephrol. 8 (9): 1515–23. doi:10.2215/CJN.10491012. PMC 3805078. PMID 23704299.
- ↑ Mahmood S, Palladini G, Sanchorawala V, Wechalekar A (February 2014). "Update on treatment of light chain amyloidosis". Haematologica. 99 (2): 209–21. doi:10.3324/haematol.2013.087619. PMC 3912950. PMID 24497558.
- ↑ 3.0 3.1 Helin HJ, Korpela MM, Mustonen JT, Pasternack AI (February 1995). "Renal biopsy findings and clinicopathologic correlations in rheumatoid arthritis". Arthritis Rheum. 38 (2): 242–7. PMID 7848315.
- ↑ Triger DR, Joekes AM (January 1973). "Renal amyloidosis--a fourteen-year follow-up". Q. J. Med. 42 (165): 15–40. PMID 4688790.