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{{Endometrial hyperplasia}}
{{Endometrial hyperplasia}}
{{CMG}}{{AE}} {{Badria}} ,  {{STM}}
{{CMG}}{{AE}} {{Swathi}}


==Overview==
==Overview==
Women of all age groups may develop endometrial hyperplasia.However, endometrial hyperplasia is more common in [[postmenopausal]] women.
[[Female|Women]] of all [[age]] groups may [[Development|develop]] [[endometrial]] [[Hyperplasia|hyperplasia.]]  However, [[endometrial]] [[hyperplasia]] is more common in [[postmenopausal]] [[women]].


==Epidemiology and Demographics==
==Epidemiology and Demographics==
===Incidence===
*The [[incidence]] [[endometrial hyperplasia]] is approximately 133 per 100,000 [[Female|woman]] per [[year]] worldwide. <ref name="pmid19393600">{{cite journal |vauthors=Reed SD, Newton KM, Clinton WL, Epplein M, Garcia R, Allison K, Voigt LF, Weiss NS |title=Incidence of endometrial hyperplasia |journal=Am. J. Obstet. Gynecol. |volume=200 |issue=6 |pages=678.e1–6 |date=June 2009 |pmid=19393600 |pmc=2692753 |doi=10.1016/j.ajog.2009.02.032 |url=}}</ref>
===Age===
===Age===
*Women of all age groups may develop endometrial hyperplasia.<ref name=lk>Endometrial Hyperplasia. Radiopedia. http://radiopaedia.org/articles/endometrial-hyperplasia-1 Accessed on March 9, 2016</ref>.
*The [[Incidence (epidemiology)|incidence]] of [[endometrial]] [[Hyperplasia|hyperplasia]] increases with [[age]]; the [[median]] [[age]] at [[diagnosis]] is 50-54 [[Year|years]].<ref name="pmid19393600">{{cite journal |vauthors=Reed SD, Newton KM, Clinton WL, Epplein M, Garcia R, Allison K, Voigt LF, Weiss NS |title=Incidence of endometrial hyperplasia |journal=Am. J. Obstet. Gynecol. |volume=200 |issue=6 |pages=678.e1–6 |date=June 2009 |pmid=19393600 |pmc=2692753 |doi=10.1016/j.ajog.2009.02.032 |url=}}</ref>
*However, endometrial hyperplasia is more common in [[postmenopausal]] women.
* The [[Incidence (epidemiology)|incidence]] of atypical [[hyperplasia]] is greatest in 60–64 year [[Old age|old]] [[women]].<ref name="pmid19393600">{{cite journal |vauthors=Reed SD, Newton KM, Clinton WL, Epplein M, Garcia R, Allison K, Voigt LF, Weiss NS |title=Incidence of endometrial hyperplasia |journal=Am. J. Obstet. Gynecol. |volume=200 |issue=6 |pages=678.e1–6 |date=June 2009 |pmid=19393600 |pmc=2692753 |doi=10.1016/j.ajog.2009.02.032 |url=}}</ref>


Most patients (75%) with endometrial cancer present with postmenopausal bleeding; however, only 10% of women with postmenopausal bleeding have endometrial carcinoma.28 The remaining women with postmenopausal bleeding have atrophic or inactive endometrium or benign endometrial conditions such as polyps. The clinical predictive model proposed by Feldman and colleagues30 (i.e., 70 years of age or older, diabetes, nulliparity, and postmenopausal status) is not predictive enough to distinguish between women with perimenopausal or postmenopausal bleeding at low versus high endometrial carcinoma risk.31 The traditional risk indicators associated with EIN/carcinoma are shown in Table 2. Most of the indicators are estrogen related, either from endogenous or exogenous sources. In women with these risk factors, the relative risk of developing carcinoma is 1.2–35.32 Experience also suggests that a significant proportion of patients fail to have these risk indicators but develop endometrial carcinoma. In these cases, either the disease may not be hormone related, or hyperestrogenism is metabolically inapparent. In a literature review, 74% of patients with adenocarcinoma of the endometrium were not obese, 58% were not nulliparous, 22% experienced menopause before age 49 years, and 43–89% were not exposed to hormone replacement therapy (HRT).33 It seems that the only constant endometrial carcinoma risk indicator is age. In women aged 65 years or older, endometrial cancer is generally aggressive and has a high mortality rate (75%) compared with that (15%) in the younger age group with hormone-related cancer.34
===Race===
*There is no [[racial]] predilection to [[endometrial hyperplasia]].
===Gender===
*[[endometrial hyperplasia]] affects [[women]].


==References==
==References==

Latest revision as of 11:18, 8 May 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Swathi Venkatesan, M.B.B.S.[2]

Overview

Women of all age groups may develop endometrial hyperplasia. However, endometrial hyperplasia is more common in postmenopausal women.

Epidemiology and Demographics

Incidence

Age

Race

Gender

References

  1. 1.0 1.1 1.2 Reed SD, Newton KM, Clinton WL, Epplein M, Garcia R, Allison K, Voigt LF, Weiss NS (June 2009). "Incidence of endometrial hyperplasia". Am. J. Obstet. Gynecol. 200 (6): 678.e1–6. doi:10.1016/j.ajog.2009.02.032. PMC 2692753. PMID 19393600.

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