Fanconi anemia classification: Difference between revisions
Jump to navigation
Jump to search
Shyam Patel (talk | contribs) Created page with "__NOTOC__ {{Fanconi anemia}} {{CMG}} {{AE}} {{shyam}} ==Overview== There is no classification system for Fanconi anemia. ==Classification== There is no classification syste..." |
Shyam Patel (talk | contribs) |
||
| (One intermediate revision by the same user not shown) | |||
| Line 5: | Line 5: | ||
==Overview== | ==Overview== | ||
Fanconi anemia is currently classified by complementation group. | |||
==Classification== | ==Classification== | ||
Fanconi anemia is a heterogenous disease from a genetic standpoint. Fanconi anemia is currently classified by complementation group. The four subtypes of Fanconi anemia can be discerned by somatic cell hybridization studies.<ref name="pmid7662964">{{cite journal| author=Joenje H, Lo ten Foe JR, Oostra AB, van Berkel CG, Rooimans MA, Schroeder-Kurth T et al.| title=Classification of Fanconi anemia patients by complementation analysis: evidence for a fifth genetic subtype. | journal=Blood | year= 1995 | volume= 86 | issue= 6 | pages= 2156-60 | pmid=7662964 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7662964 }} </ref> This concept is based on the fact that at least four different genes function in concert to support normal hematopoiesis in healthy persons.<ref name="pmid7662964">{{cite journal| author=Joenje H, Lo ten Foe JR, Oostra AB, van Berkel CG, Rooimans MA, Schroeder-Kurth T et al.| title=Classification of Fanconi anemia patients by complementation analysis: evidence for a fifth genetic subtype. | journal=Blood | year= 1995 | volume= 86 | issue= 6 | pages= 2156-60 | pmid=7662964 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7662964 }} </ref> The four subclasses of Fanconi anemia are: | |||
*'''FA-A''' | |||
*'''FA-B''' | |||
*'''FA-C''': This class of Fanconi anemia is characterized by a gene that encodes for a protein with unknown function, though it is known to localize to the cytoplasm. Six variants have been found in ''FA-C'', and these are associated with disease.<ref name="pmid7662964">{{cite journal| author=Joenje H, Lo ten Foe JR, Oostra AB, van Berkel CG, Rooimans MA, Schroeder-Kurth T et al.| title=Classification of Fanconi anemia patients by complementation analysis: evidence for a fifth genetic subtype. | journal=Blood | year= 1995 | volume= 86 | issue= 6 | pages= 2156-60 | pmid=7662964 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7662964 }} </ref> Approximately 8% of people with Fanconi anemia belong to complementation group C. | |||
*'''FA-D''' | |||
==References== | ==References== | ||
Latest revision as of 04:23, 29 April 2019
|
Fanconi anemia Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Fanconi anemia classification On the Web |
|
American Roentgen Ray Society Images of Fanconi anemia classification |
|
Risk calculators and risk factors for Fanconi anemia classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shyam Patel [2]
Overview
Fanconi anemia is currently classified by complementation group.
Classification
Fanconi anemia is a heterogenous disease from a genetic standpoint. Fanconi anemia is currently classified by complementation group. The four subtypes of Fanconi anemia can be discerned by somatic cell hybridization studies.[1] This concept is based on the fact that at least four different genes function in concert to support normal hematopoiesis in healthy persons.[1] The four subclasses of Fanconi anemia are:
- FA-A
- FA-B
- FA-C: This class of Fanconi anemia is characterized by a gene that encodes for a protein with unknown function, though it is known to localize to the cytoplasm. Six variants have been found in FA-C, and these are associated with disease.[1] Approximately 8% of people with Fanconi anemia belong to complementation group C.
- FA-D