Fanconi anemia risk factors: Difference between revisions
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==Overview== | ==Overview== | ||
The major risk factor for Fanconi anemia is genetic inheritance. It is inherited in an autosomal recessive pattern. | |||
==Risk factors== | ==Risk factors== | ||
There are no particular risk factors for Fanconi anemia. This is a genetic disorder that is caused by a mutation in genes involved in DNA damage response. Patients with Fanconi anemia are more susceptible to malignancy such as [[acute myeloid leukemia]], and a risk factor for development of malignancies includes exposure to radiation and carcinogens.<ref name="pmid23333482">{{cite journal| author=Romick-Rosendale LE, Lui VW, Grandis JR, Wells SI| title=The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma. | journal=Mutat Res | year= 2013 | volume= 743-744 | issue= | pages= 78-88 | pmid=23333482 | doi=10.1016/j.mrfmmm.2013.01.001 | pmc=3661751 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23333482 }} </ref> | The major risk factor for Fanconi anemia is genetic inheritance. It is inherited in an autosomal recessive pattern, meaning that both parents must harbor the gene mutation to have an affected child. There are no other particular risk factors for Fanconi anemia. This is a genetic disorder that is caused by a mutation in genes involved in DNA damage response. Patients with Fanconi anemia are more susceptible to malignancy such as [[acute myeloid leukemia]], and a risk factor for development of malignancies includes exposure to radiation and carcinogens.<ref name="pmid23333482">{{cite journal| author=Romick-Rosendale LE, Lui VW, Grandis JR, Wells SI| title=The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma. | journal=Mutat Res | year= 2013 | volume= 743-744 | issue= | pages= 78-88 | pmid=23333482 | doi=10.1016/j.mrfmmm.2013.01.001 | pmc=3661751 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23333482 }} </ref> | ||
==References== | ==References== | ||
Latest revision as of 16:58, 4 May 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shyam Patel [2]
Overview
The major risk factor for Fanconi anemia is genetic inheritance. It is inherited in an autosomal recessive pattern.
Risk factors
The major risk factor for Fanconi anemia is genetic inheritance. It is inherited in an autosomal recessive pattern, meaning that both parents must harbor the gene mutation to have an affected child. There are no other particular risk factors for Fanconi anemia. This is a genetic disorder that is caused by a mutation in genes involved in DNA damage response. Patients with Fanconi anemia are more susceptible to malignancy such as acute myeloid leukemia, and a risk factor for development of malignancies includes exposure to radiation and carcinogens.[1]
References
- ↑ Romick-Rosendale LE, Lui VW, Grandis JR, Wells SI (2013). "The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma". Mutat Res. 743-744: 78–88. doi:10.1016/j.mrfmmm.2013.01.001. PMC 3661751. PMID 23333482.