Microangiopathic hemolytic anemia laboratory findings: Difference between revisions
Jump to navigation
Jump to search
MydahSajid (talk | contribs) |
MydahSajid (talk | contribs) No edit summary |
||
| (5 intermediate revisions by the same user not shown) | |||
| Line 2: | Line 2: | ||
{{Microangiopathic hemolytic anemia}} | {{Microangiopathic hemolytic anemia}} | ||
{{CMG}} | {{CMG}} {{MSJ}} | ||
==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of [[microangiopathic hemolytic anemia]] include [[blood]] complete picture indicating [[hemolytic anemia]], low [[platelet]] count and [[renal]] derangements. Specific tests like [[bacteria]]l [[antigen]] detection, [[enzyme]] and [[antibody]] assays are done to diagnose underlying cause like [[hemolytic uremic syndrome]] and [[thrombotic thrombocytopenic purpura]]. | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
===Blood Tests=== | ===Blood Tests=== | ||
Laboratory findings consistent with the diagnosis of [[microangiopathic hemolytic anemia]] include<ref name="pmid28447417">{{cite journal| author=Kottke-Marchant K| title=Diagnostic approach to microangiopathic hemolytic disorders. | journal=Int J Lab Hematol | year= 2017 | volume= 39 Suppl 1 | issue= | pages= 69-75 | pmid=28447417 | doi=10.1111/ijlh.12671 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28447417 }} </ref>: | Laboratory findings consistent with the diagnosis of [[microangiopathic hemolytic anemia]] include<ref name="pmid28447417">{{cite journal| author=Kottke-Marchant K| title=Diagnostic approach to microangiopathic hemolytic disorders. | journal=Int J Lab Hematol | year= 2017 | volume= 39 Suppl 1 | issue= | pages= 69-75 | pmid=28447417 | doi=10.1111/ijlh.12671 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28447417 }} </ref>: | ||
* Normochromic normocytic [[anemia]] | * Normochromic normocytic [[anemia]] | ||
* [[Thrombocytopenia]] usually significant with [[platelet count]] less than 20,000/μL. | * [[Thrombocytopenia]] usually significant with [[platelet count]] less than 20,000/μL. | ||
| Line 16: | Line 16: | ||
* Raised [[red ce]] distribution width | * Raised [[red ce]] distribution width | ||
* Raised mean [[platelet]] volume | * Raised mean [[platelet]] volume | ||
* Decreased [[haptoglobin]] levels | |||
* Elevated unconjugated [[bilirubin]] level | |||
*Elevated [[lactate dehydrogenase]] | |||
* [[Red cell]] polychromasia, anisocytosis, and normochromic appearance with a lack of central [[pallor]]. | * [[Red cell]] polychromasia, anisocytosis, and normochromic appearance with a lack of central [[pallor]]. | ||
* As [[red blood cell]]s travel through these damaged vessels, they are shredded. The result is [[red cell]] fragmentation and intravascular [[hemolysis]]. Under the microscope, damaged [[red cell]]s have the appearance of [[schistocyte]]s. It includes helmet [[cell]]s, irregular projections, and crescent-shape. | * As [[red blood cell]]s travel through these damaged vessels, they are shredded. The result is [[red cell]] fragmentation and intravascular [[hemolysis]]. Under the microscope, damaged [[red cell]]s have the appearance of [[schistocyte]]s. It includes helmet [[cell]]s, irregular projections, and crescent-shape<ref name="pmid22081912">{{cite journal| author=Zini G, d'Onofrio G, Briggs C, Erber W, Jou JM, Lee SH | display-authors=etal| title=ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes. | journal=Int J Lab Hematol | year= 2012 | volume= 34 | issue= 2 | pages= 107-16 | pmid=22081912 | doi=10.1111/j.1751-553X.2011.01380.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22081912 }} </ref><ref name="pmid25882632">{{cite journal| author=Lesesve JF, Speyer E, Perol JP| title=Fragmented red cells reference range for the Sysmex XN®-series of automated blood cell counters. | journal=Int J Lab Hematol | year= 2015 | volume= 37 | issue= 5 | pages= 583-7 | pmid=25882632 | doi=10.1111/ijlh.12364 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25882632 }} </ref>. | ||
* [[Automated analyser]]s (the machines that perform routine [[full blood count]]s in most hospitals) are generally programmed to flag blood films that display red blood cell fragments or ''schistocytes''. | * [[Automated analyser]]s (the machines that perform routine [[full blood count]]s in most hospitals) are generally programmed to flag blood films that display red blood cell fragments or ''schistocytes''. | ||
* Raised [[urine]] urobilinogen level | |||
* Elevated [[plasma]] [[creatinine]] level | |||
* Proteinuria | |||
* Hematuria | |||
==References== | ==References== | ||
Latest revision as of 20:51, 21 January 2021
|
Microangiopathic hemolytic anemia Microchapters |
|
Differentiating Microangiopathic hemolytic anemia from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Microangiopathic hemolytic anemia laboratory findings On the Web |
|
American Roentgen Ray Society Images of Microangiopathic hemolytic anemia laboratory findings |
|
FDA on Microangiopathic hemolytic anemia laboratory findings |
|
Microangiopathic hemolytic anemia laboratory findings in the news |
|
Blogs on Microangiopathic hemolytic anemia laboratory findings |
|
Directions to Hospitals Treating Microangiopathic hemolytic anemia |
|
Risk calculators and risk factors for Microangiopathic hemolytic anemia laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Mydah Sajid, MD[2]
Overview
Laboratory findings consistent with the diagnosis of microangiopathic hemolytic anemia include blood complete picture indicating hemolytic anemia, low platelet count and renal derangements. Specific tests like bacterial antigen detection, enzyme and antibody assays are done to diagnose underlying cause like hemolytic uremic syndrome and thrombotic thrombocytopenic purpura.
Laboratory Findings
Blood Tests
Laboratory findings consistent with the diagnosis of microangiopathic hemolytic anemia include[1]:
- Normochromic normocytic anemia
- Thrombocytopenia usually significant with platelet count less than 20,000/μL.
- High reticulocyte count
- Raised red ce distribution width
- Raised mean platelet volume
- Decreased haptoglobin levels
- Elevated unconjugated bilirubin level
- Elevated lactate dehydrogenase
- Red cell polychromasia, anisocytosis, and normochromic appearance with a lack of central pallor.
- As red blood cells travel through these damaged vessels, they are shredded. The result is red cell fragmentation and intravascular hemolysis. Under the microscope, damaged red cells have the appearance of schistocytes. It includes helmet cells, irregular projections, and crescent-shape[2][3].
- Automated analysers (the machines that perform routine full blood counts in most hospitals) are generally programmed to flag blood films that display red blood cell fragments or schistocytes.
- Raised urine urobilinogen level
- Elevated plasma creatinine level
- Proteinuria
- Hematuria
References
- ↑ Kottke-Marchant K (2017). "Diagnostic approach to microangiopathic hemolytic disorders". Int J Lab Hematol. 39 Suppl 1: 69–75. doi:10.1111/ijlh.12671. PMID 28447417.
- ↑ Zini G, d'Onofrio G, Briggs C, Erber W, Jou JM, Lee SH; et al. (2012). "ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes". Int J Lab Hematol. 34 (2): 107–16. doi:10.1111/j.1751-553X.2011.01380.x. PMID 22081912.
- ↑ Lesesve JF, Speyer E, Perol JP (2015). "Fragmented red cells reference range for the Sysmex XN®-series of automated blood cell counters". Int J Lab Hematol. 37 (5): 583–7. doi:10.1111/ijlh.12364. PMID 25882632.