Acute megakaryoblastic leukemia differential diagnosis: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Acute megakaryoblastic leukemia}} | {{Acute megakaryoblastic leukemia}} | ||
{{CMG}}; {{AE}} | |||
==Overview== | |||
==Differentiating acute megakaryoblastic leukemia from other Diseases== | |||
Distinguishing features from other subtypes of AML are following: | Distinguishing features from other subtypes of AML are following: | ||
* Thrombocytopenia is more common and severe in AMKL compared with myelodysplastic syndrome (MDS). Blast cells in the bone marrow are <30% in MDS versus >30% in AMKL.<ref name="ZipurskyThorner1994">{{cite journal|last1=Zipursky|first1=A.|last2=Thorner|first2=P.|last3=De Harven|first3=E.|last4=Christensen|first4=H.|last5=Doyle|first5=J.|title=Myelodysplasia and acute megakaryoblastic leukemia in down's syndrome|journal=Leukemia Research|volume=18|issue=3|year=1994|pages=163–171|issn=01452126|doi=10.1016/0145-2126(94)90111-2}}</ref> | *[[Thrombocytopenia]] is more common and severe in AMKL compared with [[myelodysplastic syndrome]] (MDS). Blast cells in the bone marrow are <30% in MDS versus >30% in AMKL.<ref name="ZipurskyThorner1994">{{cite journal|last1=Zipursky|first1=A.|last2=Thorner|first2=P.|last3=De Harven|first3=E.|last4=Christensen|first4=H.|last5=Doyle|first5=J.|title=Myelodysplasia and acute megakaryoblastic leukemia in down's syndrome|journal=Leukemia Research|volume=18|issue=3|year=1994|pages=163–171|issn=01452126|doi=10.1016/0145-2126(94)90111-2}}</ref> | ||
* Presence of megakaryocytic specific antigens (CD41, CD61)<ref name="O Olatunji2018">{{cite journal|last1=O Olatunji|first1=Philip|title=A case of acute megakaryoblastic leukaemia (FAB M7), a rare type of acute myeloid leukemia (AML), in a teenager|journal=Malawi Medical Journal|volume=30|issue=4|year=2018|pages=298|issn=1995-7262|doi=10.4314/mmj.v30i4.15}}</ref> and markers (glycoprotein 1b) and platelets peroxidase | *Presence of megakaryocytic specific antigens ([[CD41,]] [[CD61]])<ref name="O Olatunji2018">{{cite journal|last1=O Olatunji|first1=Philip|title=A case of acute megakaryoblastic leukaemia (FAB M7), a rare type of acute myeloid leukemia (AML), in a teenager|journal=Malawi Medical Journal|volume=30|issue=4|year=2018|pages=298|issn=1995-7262|doi=10.4314/mmj.v30i4.15}}</ref> and markers ([[glycoprotein 1b]]) and platelets [[peroxidase]] activity. [[Karyotype]] analysis also helpful due to its complex and unusual karyotypic presentation (t(1;22)(p13;q13).<ref name="DöhnerEstey2010">{{cite journal|last1=Döhner|first1=Hartmut|last2=Estey|first2=Elihu H.|last3=Amadori|first3=Sergio|last4=Appelbaum|first4=Frederick R.|last5=Büchner|first5=Thomas|last6=Burnett|first6=Alan K.|last7=Dombret|first7=Hervé|last8=Fenaux|first8=Pierre|last9=Grimwade|first9=David|last10=Larson|first10=Richard A.|last11=Lo-Coco|first11=Francesco|last12=Naoe|first12=Tomoki|last13=Niederwieser|first13=Dietger|last14=Ossenkoppele|first14=Gert J.|last15=Sanz|first15=Miguel A.|last16=Sierra|first16=Jorge|last17=Tallman|first17=Martin S.|last18=Löwenberg|first18=Bob|last19=Bloomfield|first19=Clara D.|title=Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet|journal=Blood|volume=115|issue=3|year=2010|pages=453–474|issn=0006-4971|doi=10.1182/blood-2009-07-235358}}</ref><ref name="De MarchiAraki2019">{{cite journal|last1=De Marchi|first1=Federico|last2=Araki|first2=Marito|last3=Komatsu|first3=Norio|title=Molecular features, prognosis, and novel treatment options for pediatric acute megakaryoblastic leukemia|journal=Expert Review of Hematology|volume=12|issue=5|year=2019|pages=285–293|issn=1747-4086|doi=10.1080/17474086.2019.1609351}}</ref> | ||
=== Differential Diagnoses:<ref name="DöhnerEstey20105">{{cite journal|last1=Döhner|first1=Hartmut|last2=Estey|first2=Elihu H.|last3=Amadori|first3=Sergio|last4=Appelbaum|first4=Frederick R.|last5=Büchner|first5=Thomas|last6=Burnett|first6=Alan K.|last7=Dombret|first7=Hervé|last8=Fenaux|first8=Pierre|last9=Grimwade|first9=David|last10=Larson|first10=Richard A.|last11=Lo-Coco|first11=Francesco|last12=Naoe|first12=Tomoki|last13=Niederwieser|first13=Dietger|last14=Ossenkoppele|first14=Gert J.|last15=Sanz|first15=Miguel A.|last16=Sierra|first16=Jorge|last17=Tallman|first17=Martin S.|last18=Löwenberg|first18=Bob|last19=Bloomfield|first19=Clara D.|title=Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet|journal=Blood|volume=115|issue=3|year=2010|pages=453–474|issn=0006-4971|doi=10.1182/blood-2009-07-235358}}</ref> === | ===Differential Diagnoses:<ref name="DöhnerEstey20105">{{cite journal|last1=Döhner|first1=Hartmut|last2=Estey|first2=Elihu H.|last3=Amadori|first3=Sergio|last4=Appelbaum|first4=Frederick R.|last5=Büchner|first5=Thomas|last6=Burnett|first6=Alan K.|last7=Dombret|first7=Hervé|last8=Fenaux|first8=Pierre|last9=Grimwade|first9=David|last10=Larson|first10=Richard A.|last11=Lo-Coco|first11=Francesco|last12=Naoe|first12=Tomoki|last13=Niederwieser|first13=Dietger|last14=Ossenkoppele|first14=Gert J.|last15=Sanz|first15=Miguel A.|last16=Sierra|first16=Jorge|last17=Tallman|first17=Martin S.|last18=Löwenberg|first18=Bob|last19=Bloomfield|first19=Clara D.|title=Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet|journal=Blood|volume=115|issue=3|year=2010|pages=453–474|issn=0006-4971|doi=10.1182/blood-2009-07-235358}}</ref>=== | ||
==== Acute myeloid leukemia otherwise not specified as per WHO classification: ==== | ====[[Acute myeloid leukemia]] otherwise not specified as per WHO classification:==== | ||
# ''Acute myeloid leukemia with minimal differentiation'' | #''Acute myeloid leukemia with minimal differentiation'' | ||
# ''Acute myeloid leukemia without maturation'' | #''Acute myeloid leukemia without maturation'' | ||
# ''Acute myeloid leukemia with maturation'' | #''Acute myeloid leukemia with maturation'' | ||
# ''Acute myelomonocytic leukemia'' | #''Acute myelomonocytic leukemia'' | ||
# ''Acute monoblastic/monocytic leukemia'' | #''Acute monoblastic/monocytic leukemia'' | ||
# '' Acute erythroid leukemia'' | #'' Acute erythroid leukemia'' | ||
# ''Pure erythroid leukemia'' | #''Pure erythroid leukemia'' | ||
# ''Erythroleukemia, erythroid/myeloid'' | #''Erythroleukemia, erythroid/myeloid'' | ||
# '' Acute basophilic leukemia'' | #'' Acute basophilic leukemia'' | ||
# ''Acute panmyelosis with myelofibrosis (a.k.a acute myelofibrosis)'' | #''Acute panmyelosis with myelofibrosis (a.k.a acute myelofibrosis)'' | ||
'''Myeloid sarcoma''' | '''[[Myeloid sarcoma]]''' | ||
<br /> | <br /> | ||
==References== | ==References== | ||
Latest revision as of 14:09, 26 April 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Differentiating acute megakaryoblastic leukemia from other Diseases
Distinguishing features from other subtypes of AML are following:
- Thrombocytopenia is more common and severe in AMKL compared with myelodysplastic syndrome (MDS). Blast cells in the bone marrow are <30% in MDS versus >30% in AMKL.[1]
- Presence of megakaryocytic specific antigens (CD41, CD61)[2] and markers (glycoprotein 1b) and platelets peroxidase activity. Karyotype analysis also helpful due to its complex and unusual karyotypic presentation (t(1;22)(p13;q13).[3][4]
Differential Diagnoses:[5]
Acute myeloid leukemia otherwise not specified as per WHO classification:
- Acute myeloid leukemia with minimal differentiation
- Acute myeloid leukemia without maturation
- Acute myeloid leukemia with maturation
- Acute myelomonocytic leukemia
- Acute monoblastic/monocytic leukemia
- Acute erythroid leukemia
- Pure erythroid leukemia
- Erythroleukemia, erythroid/myeloid
- Acute basophilic leukemia
- Acute panmyelosis with myelofibrosis (a.k.a acute myelofibrosis)
References
- ↑ Zipursky, A.; Thorner, P.; De Harven, E.; Christensen, H.; Doyle, J. (1994). "Myelodysplasia and acute megakaryoblastic leukemia in down's syndrome". Leukemia Research. 18 (3): 163–171. doi:10.1016/0145-2126(94)90111-2. ISSN 0145-2126.
- ↑ O Olatunji, Philip (2018). "A case of acute megakaryoblastic leukaemia (FAB M7), a rare type of acute myeloid leukemia (AML), in a teenager". Malawi Medical Journal. 30 (4): 298. doi:10.4314/mmj.v30i4.15. ISSN 1995-7262.
- ↑ Döhner, Hartmut; Estey, Elihu H.; Amadori, Sergio; Appelbaum, Frederick R.; Büchner, Thomas; Burnett, Alan K.; Dombret, Hervé; Fenaux, Pierre; Grimwade, David; Larson, Richard A.; Lo-Coco, Francesco; Naoe, Tomoki; Niederwieser, Dietger; Ossenkoppele, Gert J.; Sanz, Miguel A.; Sierra, Jorge; Tallman, Martin S.; Löwenberg, Bob; Bloomfield, Clara D. (2010). "Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet". Blood. 115 (3): 453–474. doi:10.1182/blood-2009-07-235358. ISSN 0006-4971.
- ↑ De Marchi, Federico; Araki, Marito; Komatsu, Norio (2019). "Molecular features, prognosis, and novel treatment options for pediatric acute megakaryoblastic leukemia". Expert Review of Hematology. 12 (5): 285–293. doi:10.1080/17474086.2019.1609351. ISSN 1747-4086.
- ↑ Döhner, Hartmut; Estey, Elihu H.; Amadori, Sergio; Appelbaum, Frederick R.; Büchner, Thomas; Burnett, Alan K.; Dombret, Hervé; Fenaux, Pierre; Grimwade, David; Larson, Richard A.; Lo-Coco, Francesco; Naoe, Tomoki; Niederwieser, Dietger; Ossenkoppele, Gert J.; Sanz, Miguel A.; Sierra, Jorge; Tallman, Martin S.; Löwenberg, Bob; Bloomfield, Clara D. (2010). "Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet". Blood. 115 (3): 453–474. doi:10.1182/blood-2009-07-235358. ISSN 0006-4971.