Haff disease differential diagnosis: Difference between revisions
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Haff disease causes rhabdomyolysis and must be differentiated from other causes of rhabdomyolysis, which may be categorized as physical, non-physical, and genetic factors. Physical factors include trauma, excessive muscular activity, status epilepticus, high-grade fever, heatstroke, and electric shock. Non-physical factors include medications, infections, drugs, and electrolyte abnormalities. Genetic factors consist of autoimmune diseases, metabolic diseases, and various inherited conditions.<br /> | Haff disease causes rhabdomyolysis and must be differentiated from other causes of rhabdomyolysis, which may be categorized as physical, non-physical, and genetic factors. Physical factors include trauma, excessive muscular activity, status epilepticus, high-grade fever, heatstroke, and electric shock. Non-physical factors include medications, infections, drugs, and electrolyte abnormalities. Genetic factors consist of autoimmune diseases, metabolic diseases, and various inherited conditions.<br /> | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Haff disease is known to cause '''rhabdomyolysis''', and therefore, it should be differentiated from other causes of rhabdomyolysis. There are numerous etiologies of rhabdomyolysis and they may be categorized based on the physical, non-physical and genetic factors.<ref name="pmid25678154">{{cite journal| author=Nance JR, Mammen AL| title=Diagnostic evaluation of rhabdomyolysis. | journal=Muscle Nerve | year= 2015 | volume= 51 | issue= 6 | pages= 793-810 | pmid=25678154 | doi=10.1002/mus.24606 | pmc=4437836 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25678154 }} </ref> | Haff disease is known to cause '''rhabdomyolysis''', and therefore, it should be differentiated from other causes of rhabdomyolysis. There are numerous etiologies of rhabdomyolysis and they may be categorized based on the physical, non-physical, and genetic factors.<ref name="pmid25678154">{{cite journal| author=Nance JR, Mammen AL| title=Diagnostic evaluation of rhabdomyolysis. | journal=Muscle Nerve | year= 2015 | volume= 51 | issue= 6 | pages= 793-810 | pmid=25678154 | doi=10.1002/mus.24606 | pmc=4437836 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25678154 }} </ref> | ||
===Physical factors=== | ===Physical factors=== | ||
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*Medication (e.g., [[AIDS antiretroviral drugs|anti-retrovirals]], [[anti-histamine|anti-histamines]], [[Antipsychotics|anti-psychotics]], [[antidepressants]], and [[statins]]) | *Medication (e.g., [[AIDS antiretroviral drugs|anti-retrovirals]], [[anti-histamine|anti-histamines]], [[Antipsychotics|anti-psychotics]], [[antidepressants]], and [[statins]]) | ||
*[[Infection]] (bacterial | *[[Infection]] (bacterial and viral) | ||
*Drugs (e.g., [[alcohol]], [[heroin]], [[cocaine]], [[methamphetamine]], [[Ecstasy (drug)|ecstasy]], and [[Lysergic acid diethylamide|LSD]]) | *Drugs (e.g., [[alcohol]], [[heroin]], [[cocaine]], [[methamphetamine]], [[Ecstasy (drug)|ecstasy]], and [[Lysergic acid diethylamide|LSD]]) | ||
*Electrolyte abnormalities (e.g., [[hypokalemia]], [[hypophosphatemia]], [[hyponatremia]], and [[hypernatremia]]) | *Electrolyte abnormalities (e.g., [[hypokalemia]], [[hypophosphatemia]], [[hyponatremia]], and [[hypernatremia]]) | ||
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[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Syndromes]] | [[Category:Syndromes]] | ||
[[Category: | [[Category:Up to Date]] | ||
Latest revision as of 20:38, 27 April 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S
Overview
Haff disease causes rhabdomyolysis and must be differentiated from other causes of rhabdomyolysis, which may be categorized as physical, non-physical, and genetic factors. Physical factors include trauma, excessive muscular activity, status epilepticus, high-grade fever, heatstroke, and electric shock. Non-physical factors include medications, infections, drugs, and electrolyte abnormalities. Genetic factors consist of autoimmune diseases, metabolic diseases, and various inherited conditions.
Differential Diagnosis
Haff disease is known to cause rhabdomyolysis, and therefore, it should be differentiated from other causes of rhabdomyolysis. There are numerous etiologies of rhabdomyolysis and they may be categorized based on the physical, non-physical, and genetic factors.[1]
Physical factors
- Trauma
- Excessive muscular activity
- Status epilepticus
- High-grade fever
- Heat stroke
- Electric shock
Non-physical factors
- Medication (e.g., anti-retrovirals, anti-histamines, anti-psychotics, antidepressants, and statins)
- Infection (bacterial and viral)
- Drugs (e.g., alcohol, heroin, cocaine, methamphetamine, ecstasy, and LSD)
- Electrolyte abnormalities (e.g., hypokalemia, hypophosphatemia, hyponatremia, and hypernatremia)
Genetic factors
- Autoimmune diseases (e.g., polymyositis and dermatomyositis)
- Metabolic diseases (e.g., diabetes, thyroid dysfunction, primary hyperaldosteronism, primary adrenal insufficiency, central diabetes insipidus, postpartum hypernatremia, and pituitary dysfunction).
- Inherited conditions (e.g., glycogen storage disorders, fatty acid oxidation disorders, mitochondrial myopathies, muscular dystrophies, and RYR1- related myopathies)
References
- ↑ Nance JR, Mammen AL (2015). "Diagnostic evaluation of rhabdomyolysis". Muscle Nerve. 51 (6): 793–810. doi:10.1002/mus.24606. PMC 4437836. PMID 25678154.