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'''Milk-alkali syndrome''' is [[hypercalcemia]] caused by repeated ingestion of [[calcium]] and absorbable [[alkali]] (such as [[calcium carbonate]], or [[milk]] and [[sodium bicarbonate]]).  If untreated, '''milk-alkali syndrome''' may lead to metastatic calcification and [[renal failure]]. 
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'''Pathophysiology'''<br />
'''For patient information page click [[{{PAGENAME}} (patient information)|here]]'''
Ingestion of over 2g of elemental [[calcium]] per day may lead to this disorder. When a large quantity of [[calcium]] is ingested and absorbed by the GI tract, [[hypercalcemia]] works to feedback on the [[parathyroid gland]] to inhibit production of [[PTH]].  This, in turn, leads to an increased absorption of [[bicarbonate]] in the [[kidney]], establishing [[metabolic alkalosis]].  Additionally, [[hypercalcemia]] produces a concentrating defect in the [[kidney]] which can be considered a form of nephrogenic [[diabetes insipidus]]. 
{{Infobox_Disease |
  Name          = {{PAGENAME}} |
  Image          = |
  Caption        = |
  DiseasesDB    = 8215 |
  ICD10          = |
  ICD9          = {{ICD9|275.42}} |
  ICDO          = |
  OMIM          = |
  MedlinePlus    = 000332 |
  MeshID        = |
}}
{{Milk-alkali syndrome}}
{{CMG}} {{SCC}} {{AE}} {{SHA}}


'''Clinical'''<br />
==[[Milk-alkali syndrome overview|Overview]]==
Effects due to [[hypercalcemia]] may be remembered by ''bones'', ''stones'', ''groans'' and ''psychiatric undertones''.  This means an increased risk of [[Kidney stones]], [[bone fractures]], [[anorexia (symptom)|anorexia]], [[vomiting]], [[constipation]] and a host of psychiatric effects, including weakness, fatigue and [[altered mental status]].  Thus, a level of [[serum]] [[calcium]] must be obtained, but a full workup must include total/ionized [[calcium]], [[human serum albumin|albumin]], [[phosphate]], [[PTH]], [[PTHrP]], [[vitamin D]] and [[TSH]].  In addition, evaluation of [[hypercalcemia]] must include an [[ECG]], which may show a short QT interval.<br />


'''REFERENCES'''<br />
==[[Milk-alkali syndrome historical perspective|Historical Perspective]]==
----
1. eMedicine.com - Milk-Alkali Syndrome ([http://www.emedicine.com/med/topic1477.htm]).


==[[Milk-alkali syndrome classification|Classification]]==
==[[Milk-alkali syndrome pathophysiology|Pathophysiology]]==
==[[Milk-alkali syndrome causes|Causes]]==
==[[Milk-alkali syndrome differential diagnosis|Differentiating Milk-alkali syndrome from other Diseases]]==
==[[Milk-alkali syndrome epidemiology and demographics|Epidemiology and Demographics]]==
==[[Milk-alkali syndrome risk factors|Risk Factors]]==
==[[Milk-alkali syndrome screening|Screening]]==
==[[Milk-alkali syndrome natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
==Diagnosis==
[[Milk-alkali syndrome diagnostic study of choice|Diagnostic Study of Choice]] |[[Milk-alkali syndrome history and symptoms|History and Symptoms]] | [[Milk-alkali syndrome physical examination|Physical Examination]] | [[Milk-alkali syndrome laboratory findings|Laboratory Findings]] |[[Milk-alkali syndrome electrocardiogram|Electrocardiogram]] |[[Milk-alkali syndrome x-ray|X-ray]] |[[Milk-alkali syndrome echocardiography and  ultrasound|Echocardiography and Ultrasound]] |  | [[Milk-alkali syndrome CT scan|CT Scan]] |[[Milk-alkali syndrome MRI|MRI]] | [[Milk-alkali syndrome other imaging findings|Other Imaging Findings]] | [[Milk-alkali syndrome other diagnostic studies|Other Diagnostic Studies]]
==Treatment==
[[Milk-alkali syndrome medical therapy|Medical Therapy]] | [[Milk-alkali syndrome surgery|Surgery]] | [[Milk-alkali syndrome primary prevention|Primary Prevention]] |[[Milk-alkali syndrome secondary prevention| Secondary Prevention]]|[[Milk-alkali syndrome cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Milk-alkali syndrome future or investigational therapies|Future or Investigational Therapies]]
{{Mineral metabolic pathology}}
[[Category:Electrolyte disturbances]]
[[Category:Calcium]]
[[Category:Urinary system]]
[[Category:Diseases and disorders]]
[[Category:Kidney diseases]]
[[Category:Urology]]
[[de:Burnett-Syndrom]]
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Latest revision as of 17:00, 13 July 2020


For patient information page click here

Milk-alkali syndrome
ICD-9 275.42
DiseasesDB 8215
MedlinePlus 000332

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Steven C. Campbell, M.D., Ph.D. Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Milk-alkali syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice |History and Symptoms | Physical Examination | Laboratory Findings |Electrocardiogram |X-ray |Echocardiography and Ultrasound | | CT Scan |MRI | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention|Cost-Effectiveness of Therapy | Future or Investigational Therapies

Template:Mineral metabolic pathology


de:Burnett-Syndrom


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