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{{PBB|geneid=3359}}
{{Infobox_gene}}
'''5-hydroxytryptamine receptor 3A''' is a [[protein]] that in humans is encoded by the ''HTR3A'' [[gene]].<ref name="pmid8530095">{{cite journal | author = Weiss B, Mertz A, Schrock E, Koenen M, Rappold G | title = Assignment of a human homolog of the mouse Htr3 receptor gene to chromosome 11q23.1-q23.2 | journal = Genomics | volume = 29 | issue = 1 | pages = 304–5 | year = 1996 | month = Feb | pmid = 8530095 | pmc =  | doi = 10.1006/geno.1995.1254 }}</ref><ref name="pmid12867984">{{cite journal | author = Kelley SP, Dunlop JI, Kirkness EF, Lambert JJ, Peters JA | title = A cytoplasmic region determines single-channel conductance in 5-HT3 receptors | journal = Nature | volume = 424 | issue = 6946 | pages = 321–4 | year = 2003 | month = Jul | pmid = 12867984 | pmc =  | doi = 10.1038/nature01788 }}</ref>
'''5-hydroxytryptamine receptor 3A''' is a [[protein]] that in humans is encoded by the ''HTR3A'' [[gene]].<ref name="pmid8530095">{{cite journal |vauthors=Weiss B, Mertz A, Schrock E, Koenen M, Rappold G | title = Assignment of a human homolog of the mouse Htr3 receptor gene to chromosome 11q23.1-q23.2 | journal = Genomics | volume = 29 | issue = 1 | pages = 304–5 |date=Feb 1996 | pmid = 8530095 | pmc =  | doi = 10.1006/geno.1995.1254 }}</ref><ref name="pmid12867984">{{cite journal |vauthors=Kelley SP, Dunlop JI, Kirkness EF, Lambert JJ, Peters JA | title = A cytoplasmic region determines single-channel conductance in 5-HT3 receptors | journal = Nature | volume = 424 | issue = 6946 | pages = 321–4 |date=Jul 2003 | pmid = 12867984 | pmc =  | doi = 10.1038/nature01788 }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The product of this gene belongs to the [[ligand-gated ion channel]] receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: HTR3A 5-hydroxytryptamine (serotonin) receptor 3A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3359| accessdate = }}</ref>
| summary_text = The product of this gene belongs to the [[ligand-gated ion channel]] receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. The A subunit is the only one that can be expressed alone and forms homomers with a very low single channel conductance of 0.6pS. When combined with the B subunit and expressed as a heteromer, the single channel conductance increases immensely. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: HTR3A 5-hydroxytryptamine (serotonin) receptor 3A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3359| accessdate = }}</ref>
}}
}}


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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Miyake A, Mochizuki S, Takemoto Y, Akuzawa S |title=Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species. |journal=Mol. Pharmacol. |volume=48 |issue= 3 |pages= 407–16 |year= 1995 |pmid= 7565620 |doi=  }}
*{{cite journal  |vauthors=Miyake A, Mochizuki S, Takemoto Y, Akuzawa S |title=Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species. |journal=Mol. Pharmacol. |volume=48 |issue= 3 |pages= 407–16 |year= 1995 |pmid= 7565620 |doi=  }}
*{{cite journal | author=Uetz P, Abdelatty F, Villarroel A, ''et al.'' |title=Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11. |journal=FEBS Lett. |volume=339 |issue= 3 |pages= 302–6 |year= 1994 |pmid= 8112471 |doi=10.1016/0014-5793(94)80435-4  }}
*{{cite journal   |vauthors=Uetz P, Abdelatty F, Villarroel A, etal |title=Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11. |journal=FEBS Lett. |volume=339 |issue= 3 |pages= 302–6 |year= 1994 |pmid= 8112471 |doi=10.1016/0014-5793(94)80435-4  }}
*{{cite journal | author=Belelli D, Balcarek JM, Hope AG, ''et al.'' |title=Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit. |journal=Mol. Pharmacol. |volume=48 |issue= 6 |pages= 1054–62 |year= 1996 |pmid= 8848005 |doi=  }}
*{{cite journal   |vauthors=Belelli D, Balcarek JM, Hope AG, etal |title=Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit. |journal=Mol. Pharmacol. |volume=48 |issue= 6 |pages= 1054–62 |year= 1996 |pmid= 8848005 |doi=  }}
*{{cite journal  | author=Brüss M, Göthert M, Hayer M, Bönisch H |title=Molecular cloning of alternatively spliced human 5-HT3 receptor cDNAs. |journal=Ann. N. Y. Acad. Sci. |volume=861 |issue=  |pages= 234–5 |year= 1999 |pmid= 9928262 |doi=10.1111/j.1749-6632.1998.tb10196.x  }}
*{{cite journal  |vauthors=Brüss M, Göthert M, Hayer M, Bönisch H |title=Molecular cloning of alternatively spliced human 5-HT3 receptor cDNAs. |journal=Ann. N. Y. Acad. Sci. |volume=861 |issue=  |pages= 234–5 |year= 1999 |pmid= 9928262 |doi=10.1111/j.1749-6632.1998.tb10196.x  }}
*{{cite journal | author=Davies PA, Pistis M, Hanna MC, ''et al.'' |title=The 5-HT3B subunit is a major determinant of serotonin-receptor function. |journal=Nature |volume=397 |issue= 6717 |pages= 359–63 |year= 1999 |pmid= 9950429 |doi= 10.1038/16941 }}
*{{cite journal   |vauthors=Davies PA, Pistis M, Hanna MC, etal |title=The 5-HT3B subunit is a major determinant of serotonin-receptor function. |journal=Nature |volume=397 |issue= 6717 |pages= 359–63 |year= 1999 |pmid= 9950429 |doi= 10.1038/16941 }}
*{{cite journal  | author=Brüss M, Eucker T, Göthert M, Bönisch H |title=Exon-intron organization of the human 5-HT3A receptor gene. |journal=Neuropharmacology |volume=39 |issue= 2 |pages= 308–15 |year= 2000 |pmid= 10670426 |doi=10.1016/S0028-3908(99)00116-1  }}
*{{cite journal  |vauthors=Brüss M, Eucker T, Göthert M, Bönisch H |title=Exon-intron organization of the human 5-HT3A receptor gene. |journal=Neuropharmacology |volume=39 |issue= 2 |pages= 308–15 |year= 2000 |pmid= 10670426 |doi=10.1016/S0028-3908(99)00116-1  }}
*{{cite journal | author=Marazziti D, Betti L, Giannaccini G, ''et al.'' |title=Distribution of [3H]GR65630 binding in human brain postmortem. |journal=Neurochem. Res. |volume=26 |issue= 3 |pages= 187–90 |year= 2002 |pmid= 11495540 |doi=10.1023/A:1010939530412  }}
*{{cite journal   |vauthors=Marazziti D, Betti L, Giannaccini G, etal |title=Distribution of [3H]GR65630 binding in human brain postmortem. |journal=Neurochem. Res. |volume=26 |issue= 3 |pages= 187–90 |year= 2002 |pmid= 11495540 |doi=10.1023/A:1010939530412  }}
*{{cite journal  | author=Spier AD, Lummis SC |title=Immunological characterization of 5-HT3 receptor transmembrane topology. |journal=J. Mol. Neurosci. |volume=18 |issue= 3 |pages= 169–78 |year= 2003 |pmid= 12059035 |doi=10.1385/JMN:18:3:169  }}
*{{cite journal  |vauthors=Spier AD, Lummis SC |title=Immunological characterization of 5-HT3 receptor transmembrane topology. |journal=J. Mol. Neurosci. |volume=18 |issue= 3 |pages= 169–78 |year= 2003 |pmid= 12059035 |doi=10.1385/JMN:18:3:169  }}
*{{cite journal | author=Boyd GW, Low P, Dunlop JI, ''et al.'' |title=Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins. |journal=Mol. Cell. Neurosci. |volume=21 |issue= 1 |pages= 38–50 |year= 2002 |pmid= 12359150 |doi=10.1006/mcne.2002.1160  }}
*{{cite journal   |vauthors=Boyd GW, Low P, Dunlop JI, etal |title=Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins. |journal=Mol. Cell. Neurosci. |volume=21 |issue= 1 |pages= 38–50 |year= 2002 |pmid= 12359150 |doi=10.1006/mcne.2002.1160  }}
*{{cite journal | author=Hapfelmeier G, Haseneder R, Lampadius K, ''et al.'' |title=Cloned human and murine serotonin(3A) receptors expressed in human embryonic kidney 293 cells display different single-channel kinetics. |journal=Neurosci. Lett. |volume=335 |issue= 1 |pages= 44–8 |year= 2003 |pmid= 12457738 |doi=10.1016/S0304-3940(02)01156-4  }}
*{{cite journal   |vauthors=Hapfelmeier G, Haseneder R, Lampadius K, etal |title=Cloned human and murine serotonin(3A) receptors expressed in human embryonic kidney 293 cells display different single-channel kinetics. |journal=Neurosci. Lett. |volume=335 |issue= 1 |pages= 44–8 |year= 2003 |pmid= 12457738 |doi=10.1016/S0304-3940(02)01156-4  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Pick H, Preuss AK, Mayer M, ''et al.'' |title=Monitoring expression and clustering of the ionotropic 5HT3 receptor in plasma membranes of live biological cells. |journal=Biochemistry |volume=42 |issue= 4 |pages= 877–84 |year= 2003 |pmid= 12549905 |doi= 10.1021/bi026576d }}
*{{cite journal   |vauthors=Pick H, Preuss AK, Mayer M, etal |title=Monitoring expression and clustering of the ionotropic 5HT3 receptor in plasma membranes of live biological cells |journal=Biochemistry |volume=42 |issue= 4 |pages= 877–84 |year= 2003 |pmid= 12549905 |doi= 10.1021/bi026576d }}
*{{cite journal | author=Choi S, Lee JH, Oh S, ''et al.'' |title=Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes. |journal=Mol. Cells |volume=15 |issue= 1 |pages= 108–13 |year= 2003 |pmid= 12661769 |doi=  }}
*{{cite journal   |vauthors=Choi S, Lee JH, Oh S, etal |title=Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes |journal=Mol. Cells |volume=15 |issue= 1 |pages= 108–13 |year= 2003 |pmid= 12661769 |doi=  }}
*{{cite journal | author=Boyd GW, Doward AI, Kirkness EF, ''et al.'' |title=Cell surface expression of 5-hydroxytryptamine type 3 receptors is controlled by an endoplasmic reticulum retention signal. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 27681–7 |year= 2003 |pmid= 12750374 |doi= 10.1074/jbc.M304938200 }}
*{{cite journal   |vauthors=Boyd GW, Doward AI, Kirkness EF, etal |title=Cell surface expression of 5-hydroxytryptamine type 3 receptors is controlled by an endoplasmic reticulum retention signal |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 27681–7 |year= 2003 |pmid= 12750374 |doi= 10.1074/jbc.M304938200 }}
*{{cite journal | author=Sun H, Hu XQ, Moradel EM, ''et al.'' |title=Modulation of 5-HT3 receptor-mediated response and trafficking by activation of protein kinase C. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34150–7 |year= 2003 |pmid= 12791692 |doi= 10.1074/jbc.M303584200 }}
*{{cite journal   |vauthors=Sun H, Hu XQ, Moradel EM, etal |title=Modulation of 5-HT3 receptor-mediated response and trafficking by activation of protein kinase C |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34150–7 |year= 2003 |pmid= 12791692 |doi= 10.1074/jbc.M303584200 }}
*{{cite journal  | author=Maksay G, Bikádi Z, Simonyi M |title=Binding interactions of antagonists with 5-hydroxytryptamine3A receptor models. |journal=J. Recept. Signal Transduct. Res. |volume=23 |issue= 2-3 |pages= 255–70 |year= 2004 |pmid= 14626451 |doi=10.1081/RRS-120025568  }}
*{{cite journal  |vauthors=Maksay G, Bikádi Z, Simonyi M |title=Binding interactions of antagonists with 5-hydroxytryptamine3A receptor models |journal=J. Recept. Signal Transduct. Res. |volume=23 |issue= 2–3 |pages= 255–70 |year= 2004 |pmid= 14626451 |doi=10.1081/RRS-120025568  }}
*{{cite journal | author=Kaiser R, Tremblay PB, Sezer O, ''et al.'' |title=Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonists. |journal=Pharmacogenetics |volume=14 |issue= 5 |pages= 271–8 |year= 2004 |pmid= 15115912 |doi=10.1097/00008571-200405000-00001  }}
*{{cite journal   |vauthors=Kaiser R, Tremblay PB, Sezer O, etal |title=Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonists |journal=Pharmacogenetics |volume=14 |issue= 5 |pages= 271–8 |year= 2004 |pmid= 15115912 |doi=10.1097/00008571-200405000-00001  }}
*{{cite journal | author=Panicker S, Cruz H, Arrabit C, ''et al.'' |title=Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28149–58 |year= 2004 |pmid= 15131114 |doi= 10.1074/jbc.M403545200 }}
*{{cite journal   |vauthors=Panicker S, Cruz H, Arrabit C, etal |title=Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28149–58 |year= 2004 |pmid= 15131114 |doi= 10.1074/jbc.M403545200 }}
}}
}}
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{{refend}}
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{{NLM content}}
{{NLM content}}
{{transmembranereceptor-stub}}
 
{{Ligand-gated ion channels}}
{{Ligand-gated ion channels}}
[[Category:Neurotransmitters]]
[[Category:Ion channels]]
[[Category:Ionotropic receptors]]
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[[Category:Ion channels]]
[[Category:Serotonin receptors]]
{{transmembranereceptor-stub}}

Latest revision as of 14:11, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

5-hydroxytryptamine receptor 3A is a protein that in humans is encoded by the HTR3A gene.[1][2]

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. The A subunit is the only one that can be expressed alone and forms homomers with a very low single channel conductance of 0.6pS. When combined with the B subunit and expressed as a heteromer, the single channel conductance increases immensely. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

See also

References

  1. ↑ Weiss B, Mertz A, Schrock E, Koenen M, Rappold G (Feb 1996). "Assignment of a human homolog of the mouse Htr3 receptor gene to chromosome 11q23.1-q23.2". Genomics. 29 (1): 304–5. doi:10.1006/geno.1995.1254. PMID 8530095.
  2. ↑ Kelley SP, Dunlop JI, Kirkness EF, Lambert JJ, Peters JA (Jul 2003). "A cytoplasmic region determines single-channel conductance in 5-HT3 receptors". Nature. 424 (6946): 321–4. doi:10.1038/nature01788. PMID 12867984.
  3. ↑ "Entrez Gene: HTR3A 5-hydroxytryptamine (serotonin) receptor 3A".

Further reading

  • Miyake A, Mochizuki S, Takemoto Y, Akuzawa S (1995). "Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species". Mol. Pharmacol. 48 (3): 407–16. PMID 7565620.
  • Uetz P, Abdelatty F, Villarroel A, et al. (1994). "Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11". FEBS Lett. 339 (3): 302–6. doi:10.1016/0014-5793(94)80435-4. PMID 8112471.
  • Belelli D, Balcarek JM, Hope AG, et al. (1996). "Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit". Mol. Pharmacol. 48 (6): 1054–62. PMID 8848005.
  • Brüss M, Göthert M, Hayer M, Bönisch H (1999). "Molecular cloning of alternatively spliced human 5-HT3 receptor cDNAs". Ann. N. Y. Acad. Sci. 861: 234–5. doi:10.1111/j.1749-6632.1998.tb10196.x. PMID 9928262.
  • Davies PA, Pistis M, Hanna MC, et al. (1999). "The 5-HT3B subunit is a major determinant of serotonin-receptor function". Nature. 397 (6717): 359–63. doi:10.1038/16941. PMID 9950429.
  • Brüss M, Eucker T, Göthert M, Bönisch H (2000). "Exon-intron organization of the human 5-HT3A receptor gene". Neuropharmacology. 39 (2): 308–15. doi:10.1016/S0028-3908(99)00116-1. PMID 10670426.
  • Marazziti D, Betti L, Giannaccini G, et al. (2002). "Distribution of [3H]GR65630 binding in human brain postmortem". Neurochem. Res. 26 (3): 187–90. doi:10.1023/A:1010939530412. PMID 11495540.
  • Spier AD, Lummis SC (2003). "Immunological characterization of 5-HT3 receptor transmembrane topology". J. Mol. Neurosci. 18 (3): 169–78. doi:10.1385/JMN:18:3:169. PMID 12059035.
  • Boyd GW, Low P, Dunlop JI, et al. (2002). "Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins". Mol. Cell. Neurosci. 21 (1): 38–50. doi:10.1006/mcne.2002.1160. PMID 12359150.
  • Hapfelmeier G, Haseneder R, Lampadius K, et al. (2003). "Cloned human and murine serotonin(3A) receptors expressed in human embryonic kidney 293 cells display different single-channel kinetics". Neurosci. Lett. 335 (1): 44–8. doi:10.1016/S0304-3940(02)01156-4. PMID 12457738.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Pick H, Preuss AK, Mayer M, et al. (2003). "Monitoring expression and clustering of the ionotropic 5HT3 receptor in plasma membranes of live biological cells". Biochemistry. 42 (4): 877–84. doi:10.1021/bi026576d. PMID 12549905.
  • Choi S, Lee JH, Oh S, et al. (2003). "Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes". Mol. Cells. 15 (1): 108–13. PMID 12661769.
  • Boyd GW, Doward AI, Kirkness EF, et al. (2003). "Cell surface expression of 5-hydroxytryptamine type 3 receptors is controlled by an endoplasmic reticulum retention signal". J. Biol. Chem. 278 (30): 27681–7. doi:10.1074/jbc.M304938200. PMID 12750374.
  • Sun H, Hu XQ, Moradel EM, et al. (2003). "Modulation of 5-HT3 receptor-mediated response and trafficking by activation of protein kinase C". J. Biol. Chem. 278 (36): 34150–7. doi:10.1074/jbc.M303584200. PMID 12791692.
  • Maksay G, Bikádi Z, Simonyi M (2004). "Binding interactions of antagonists with 5-hydroxytryptamine3A receptor models". J. Recept. Signal Transduct. Res. 23 (2–3): 255–70. doi:10.1081/RRS-120025568. PMID 14626451.
  • Kaiser R, Tremblay PB, Sezer O, et al. (2004). "Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonists". Pharmacogenetics. 14 (5): 271–8. doi:10.1097/00008571-200405000-00001. PMID 15115912.
  • Panicker S, Cruz H, Arrabit C, et al. (2004). "Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor". J. Biol. Chem. 279 (27): 28149–58. doi:10.1074/jbc.M403545200. PMID 15131114.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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