Endometrial hyperplasia: Difference between revisions

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Latest revision as of 15:34, 3 May 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Swathi Venkatesan, M.B.B.S.[2]

Synonyms and keywords: Benign endometrial hyperplasia; Simple non-atypical endometrial hyperplasia; Complex non-atypical endometrial hyperplasia; Simple endometrial hyperplasia without atypia; Complex endometrial hyperplasia without atypia; Complex atypical endometrial hyperplasia; Simple atypical endometrial hyperplasia

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Endometrial Hyperplasia From Other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Treatment

Medical Therapy | Surgery | Primary Prevention

Case Studies

Case #1

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-{{Infobox_Disease |
+__NOTOC__
-  Name           = Endometrial hyperplasia |
+{{Endometrial hyperplasia}}
-  Image          = |
+{{CMG}} {{Swathi}}
-  Caption        = |
-  DiseasesDB     = 4263|
-  ICD10          = N85.0|
-  ICD9           = {{ICD9|621.3}}|
-  ICDO           = |
-  OMIM           = |
-  MedlinePlus    = |
-  eMedicineSubj  = |
-  eMedicineTopic = |
-  eMedicine_mult = |
-  MeshID         = |
-}}
-{{SI}}
-{{CMG}}
-==Overview==
+{{SK}} Benign endometrial hyperplasia; Simple non-atypical endometrial hyperplasia; Complex non-atypical endometrial hyperplasia; Simple endometrial hyperplasia without atypia; Complex endometrial hyperplasia without atypia; Complex atypical endometrial hyperplasia; Simple atypical endometrial hyperplasia
-'''Endometrial hyperplasia''' is a condition of excessive proliferation of the cells of the [[endometrium]], or inner lining of the [[uterus]]. Most cases of endometrial hyperplasia result from high levels of [[estrogen]]s, combined with insufficient levels of the [[progestagen|progesterone-like]] hormones which ordinarily counteract estrogen's proliferative effects on this tissue. This may occur in a number of settings, including [[polycystic ovary syndrome]] and certain formulations of [[estrogen replacement therapy]]. Endometrial hyperplasia is a significant risk factor for the development of [[endometrial cancer]] so careful monitoring and treatment of women with this disorder is essential.
-==Classification==
+==[[Endometrial hyperplasia overview|Overview]]==
-Like other [[hyperplasia|hyperplastic]] disorders, endometrial hyperplasia initially represents a [[physiology|physiological]] response of endometrial tissue to the growth-promoting actions of [[estrogen]]. However, the gland-forming cells of a hyperplastic endometrium may also undergo changes over time which predispose them to [[cancer]]ous transformation. Several [[microscopic|histopathology]] subtypes of endometrial hyperplasia are recognisable to the [[pathology|pathologist]], with different therapeutic and [[prognosis|prognostic]] implications.<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref>
-*Endometrial hyperplasia (simple or complex) - Irregularity and cystic expansion of glands (simple) or crowding and budding of glands (complex) without worrisome changes in the appearance of individual gland cells. In one study, 1.6% of patients diagnosed with these abnormalities eventually developed endometrial cancer.<ref name="Kurman">{{cite journal |author=Kurman RJ, Kaminski PF, Norris HJ |title=The behavior of endometrial hyperplasia. A long-term study of "untreated" hyperplasia in 170 patients |journal=Cancer |volume=56 |issue=2 |pages=403-12 |year=1985 |pmid=4005805 |doi=}}</ref>
+==[[Endometrial hyperplasia historical perspective|Historical Perspective]]==
+==[[Endometrial hyperplasia classification|Classification]]==
-*Atypical endometrial hyperplasia (simple or complex) - Simple or complex architectural changes, with worrisome (''atypical'') changes in gland cells, including cell stratification, tufting, loss of nuclear polarity, enlarged nuclei, and an increase in [[mitosis|mitotic activity]]. These changes are similar to those seen in true cancer cells, but atypical hyperplasia does not show invasion into the connective tissues, the defining characteristic of cancer. The previously mentioned study found that 22% of patients with atypical hyperplasia eventually developed cancer.<ref name="Kurman">{{cite journal |author=Kurman RJ, Kaminski PF, Norris HJ |title=The behavior of endometrial hyperplasia. A long-term study of "untreated" hyperplasia in 170 patients |journal=Cancer |volume=56 |issue=2 |pages=403-12 |year=1985 |pmid=4005805 |doi=}}</ref>
+==[[Endometrial hyperplasia pathophysiology|Pathophysiology]]==
+==[[Endometrial hyperplasia causes|Causes]]==
+==[[Endometrial hyperplasia differential diagnosis|Differentiating Endometrial Hyperplasia From Other Diseases]]==
+==[[Endometrial hyperplasia epidemiology and demographics|Epidemiology and Demographics]]==
+==[[Endometrial hyperplasia epidemiology and demographics|Risk Factors]]==
+==[[Endometrial hyperplasia screening|Screening]]==
+==[[Endometrial hyperplasia natural history|Natural History, Complications and Prognosis]]==
 ==Diagnosis==
-Diagnosis of endometrial hyperplasia is typically performed though [[curettage]] of the uterine cavity to obtain endometrial tissue for histopathologic analysis. A workup for endometrial disease may be prompted by abnormal uterine bleeding, or the presence of atypical glandular cells on a [[pap smear]].<ref name="UTDOL-EH">[http://www.uptodateonline.com/utd/content/topic.do?topicKey=gen_gyne/13384&type=A&selectedTitle=1~22] Howard A Zacur, Robert L Giuntoli, II, Marcus Jurema, "Endometrial Hyperplasia" from UpToDate Online (accessed 5-26-07)</ref>
+[[Endometrial hyperplasia history and symptoms|History and Symptoms]] | [[Endometrial hyperplasia physical examination|Physical Examination]] | [[Endometrial hyperplasia laboratory findings|Laboratory Findings]] | [[Endometrial hyperplasia ct|CT]] | [[Endometrial hyperplasia MRI|MRI]] | [[Endometrial hyperplasia ultrasound|Ultrasound]] | [[Endometrial hyperplasia Other Imaging Findings|Other Imaging Findings]] | [[Endometrial hyperplasia Other Diagnostic Studies|Other Diagnostic Studies]]
 ==Treatment==
-Treatment of endometrial hyperplasia is individualized, and may include [[hormonal therapy (oncology)|hormonal therapy]], such as cyclic or continuous [[progestin]] therapy, or [[hysterectomy]].<ref name="UTDOL-EH">[http://www.uptodateonline.com/utd/content/topic.do?topicKey=gen_gyne/13384&type=A&selectedTitle=1~22] Howard A Zacur, Robert L Giuntoli, II, Marcus Jurema, "Endometrial Hyperplasia" from UpToDate Online (accessed 5-26-07)</ref>
+[[Endometrial hyperplasia medical therapy|Medical Therapy]] | [[Endometrial hyperplasia surgery|Surgery]] | [[Endometrial hyperplasia primary prevention|Primary Prevention]]
+==Case Studies==
+:[[Endometrial hyperplasia case study one|Case #1]]
+[[Category:Overview complete]]
-==References==
+[[Category:Disease]]
-{{reflist|2}}
+[[Category:Types of cancer]]
-{{SIB}}
-[[Category:Overview complete]]
-[[Category:Disease state]]
 [[Category:Gynecology]]
 [[Category:Oncology]]
 {{WikiDoc Help Menu}}
 {{WikiDoc Sources}}
+ [[Category:Up-To-Date]]
+[[Category:Oncology]]
+[[Category:Medicine]]
+[[Category:Gynecology]]
+[[Category:Surgery]]

Endometrial hyperplasia: Difference between revisions

Latest revision as of 15:34, 3 May 2019

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