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{{B-cell lymphoma}}
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==Overview==
==Overview==
 
The hallmark of Hodgkin's lymphoma is painless supra-diaphragmatic [[lymphadenopathy]]. A positive history of [[B symptoms]] (unexplained profound weight loss, high fevers, and drenching night sweats) is suggestive of Hodgkin's lymphoma. The hallmark of non-Hodgkin lymphomas is peripheral lymphadenopathy. Patients usually have different presentations depending on the subtype, the location of involvement, and the grade of the tumor. Although episodes of waxing and waning lymphadenopathy might be seen in low-grade lymphoma, B symptoms are more likely to present in patients with a high-grade variant of non-Hodgkin lymphoma.
==History and Symptoms==
B-cell lymphomas include both [[Hodgkin's lymphoma]]s and most [[Non-Hodgkin lymphomas]].
*The hallmark of Hodgkin's lymphoma is painless supra-diaphragmatic [[lymphadenopathy]]. A positive history of [[B symptoms]] (unexplained profound weight loss, high fevers, and drenching night sweats) is suggestive of Hodgkin's lymphoma.<ref name="pmid29763144">{{cite journal |vauthors=Kaseb H, Babiker HM |title= |journal= |volume= |issue= |pages= |date= |pmid=29763144 |doi= |url=}}</ref><ref name="pmid26541251">{{cite journal |vauthors=Ansell SM |title=Hodgkin Lymphoma: Diagnosis and Treatment |journal=Mayo Clin Proc |volume=90 |issue=11 |pages=1574–83 |date=November 2015 |pmid=26541251 |doi=10.1016/j.mayocp.2015.07.005 |url=}}</ref>
*The hallmark of non-Hodgkin lymphomas is peripheral lymphadenopathy. Patients usually have different presentations depending on the subtype, the location of involvement, and the grade of the tumor. Although episodes of waxing and waning lymphadenopathy might be seen in low-grade lymphoma, B symptoms are more likely to present in patients with a high-grade variant of non-Hodgkin lymphoma.<ref name="pmid32644754">{{cite journal |vauthors=Sapkota S, Shaikh H |title= |journal= |volume= |issue= |pages= |date= |pmid=32644754 |doi= |url=}}</ref><ref name="pmid28153383">{{cite journal |vauthors=Armitage JO, Gascoyne RD, Lunning MA, Cavalli F |title=Non-Hodgkin lymphoma |journal=Lancet |volume=390 |issue=10091 |pages=298–310 |date=July 2017 |pmid=28153383 |doi=10.1016/S0140-6736(16)32407-2 |url=}}</ref>
===History===
*Patients with Hodgkins's lymphoma may have a positive history of:<ref name="pmid29763144">{{cite journal |vauthors=Kaseb H, Babiker HM |title= |journal= |volume= |issue= |pages= |date= |pmid=29763144 |doi= |url=}}</ref><ref name="pmid26541251">{{cite journal |vauthors=Ansell SM |title=Hodgkin Lymphoma: Diagnosis and Treatment |journal=Mayo Clin Proc |volume=90 |issue=11 |pages=1574–83 |date=November 2015 |pmid=26541251 |doi=10.1016/j.mayocp.2015.07.005 |url=}}</ref>
**Painless supra-diaphragmatic [[lymphadenopathy]] in one to two lymph node areas generally seen in patients with Hodgkin's lymphoma.
**[[B symptoms]] (unexplained profound weight loss, high fevers, and drenching night sweats) might be seen in up to 30% of patients and are usually more common in patients with advanced disease.
**Alcohol-related pain in lymph nodes
**Chronic [[pruritus]]
**Chest pain and shortness of breath might be seen in patients with [[mediastinal]] involvement.
*Patients with non-Hodgkin lymphoma may have a positive history of:<ref name="pmid32644754">{{cite journal |vauthors=Sapkota S, Shaikh H |title= |journal= |volume= |issue= |pages= |date= |pmid=32644754 |doi= |url=}}</ref><ref name="pmid28153383">{{cite journal |vauthors=Armitage JO, Gascoyne RD, Lunning MA, Cavalli F |title=Non-Hodgkin lymphoma |journal=Lancet |volume=390 |issue=10091 |pages=298–310 |date=July 2017 |pmid=28153383 |doi=10.1016/S0140-6736(16)32407-2 |url=}}</ref>
**Peripheral [[lymphadenopathy]]
**Episodes of waxing and waning lymphadenopathy
**[[B symptoms]], usually in patients with advanced disease
===Common Symptoms===
*Common symptoms of Hodgkins's lymphoma include:<ref name="urlHodgkin Lymphoma | Hodgkin Disease">{{cite web |url=https://www.cancer.org/cancer/hodgkin-lymphoma.html |title=Hodgkin Lymphoma &#124; Hodgkin Disease |format= |work= |accessdate=}}</ref><ref name="pmid29763144">{{cite journal |vauthors=Kaseb H, Babiker HM |title= |journal= |volume= |issue= |pages= |date= |pmid=29763144 |doi= |url=}}</ref
**[[Lymphadenopathy]]
**[[B symptoms]]:
***Unexplained weight loss >10% of total body weight within the past 6 months
***High fevers
***Drenching night sweats
**Chronic [[pruritus]]
**Fatigue
**Enlargement of [[mediastinal]] lymph nodes might present with:
***Chest pain
***Shortness of breath
*Common symptoms of non-Hodgkin lymphoma include:<ref name="pmid32644754">{{cite journal |vauthors=Sapkota S, Shaikh H |title= |journal= |volume= |issue= |pages= |date= |pmid=32644754 |doi= |url=}}</ref><ref name="urlSigns and Symptoms of Non-Hodgkin Lymphoma">{{cite web |url=https://www.cancer.org/cancer/non-hodgkin-lymphoma/detection-diagnosis-staging/signs-symptoms.html |title=Signs and Symptoms of Non-Hodgkin Lymphoma |format= |work= |accessdate=}}</ref>
**Peripheral [[lymphadenopathy]]
**[[B symptoms]]
===Less Common Symptoms===
*Less common symptoms of [[non-Hodgkin lymphoma]] include:<ref name="pmid32644754">{{cite journal |vauthors=Sapkota S, Shaikh H |title= |journal= |volume= |issue= |pages= |date= |pmid=32644754 |doi= |url=}}</ref><ref name="urlSigns and Symptoms of Non-Hodgkin Lymphoma">{{cite web |url=https://www.cancer.org/cancer/non-hodgkin-lymphoma/detection-diagnosis-staging/signs-symptoms.html |title=Signs and Symptoms of Non-Hodgkin Lymphoma |format= |work= |accessdate=}}</ref>
**Skin rashes
**Fatigue
**[[Pruritus]]
**Malaise
**Chest pain or pressure
**[[Fever of unknown origin]]
**Easy bruising or bleeding
**[[Ascites]]
**Effusions
**Primary [[gastrointestinal tract]] lymphoma might present with:
***Nausea and vomiting
***Abdominal swelling
***Early satiety
**Primary [[central nervous system]] lymphoma might present with:
***Headaches
***[[Spinal cord]] compression features
***Lethargy
***[[Focal neurologic signs]]
***[[Seizures]]
***[[Paralysis]]
==References==
==References==
{{Reflist|2}}


{{reflist|2}}
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Latest revision as of 18:01, 15 May 2022

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D[2]

Overview

The hallmark of Hodgkin's lymphoma is painless supra-diaphragmatic lymphadenopathy. A positive history of B symptoms (unexplained profound weight loss, high fevers, and drenching night sweats) is suggestive of Hodgkin's lymphoma. The hallmark of non-Hodgkin lymphomas is peripheral lymphadenopathy. Patients usually have different presentations depending on the subtype, the location of involvement, and the grade of the tumor. Although episodes of waxing and waning lymphadenopathy might be seen in low-grade lymphoma, B symptoms are more likely to present in patients with a high-grade variant of non-Hodgkin lymphoma.

History and Symptoms

B-cell lymphomas include both Hodgkin's lymphomas and most Non-Hodgkin lymphomas.

  • The hallmark of Hodgkin's lymphoma is painless supra-diaphragmatic lymphadenopathy. A positive history of B symptoms (unexplained profound weight loss, high fevers, and drenching night sweats) is suggestive of Hodgkin's lymphoma.[1][2]
  • The hallmark of non-Hodgkin lymphomas is peripheral lymphadenopathy. Patients usually have different presentations depending on the subtype, the location of involvement, and the grade of the tumor. Although episodes of waxing and waning lymphadenopathy might be seen in low-grade lymphoma, B symptoms are more likely to present in patients with a high-grade variant of non-Hodgkin lymphoma.[3][4]

History

  • Patients with Hodgkins's lymphoma may have a positive history of:[1][2]
    • Painless supra-diaphragmatic lymphadenopathy in one to two lymph node areas generally seen in patients with Hodgkin's lymphoma.
    • B symptoms (unexplained profound weight loss, high fevers, and drenching night sweats) might be seen in up to 30% of patients and are usually more common in patients with advanced disease.
    • Alcohol-related pain in lymph nodes
    • Chronic pruritus
    • Chest pain and shortness of breath might be seen in patients with mediastinal involvement.
  • Patients with non-Hodgkin lymphoma may have a positive history of:[3][4]
    • Peripheral lymphadenopathy
    • Episodes of waxing and waning lymphadenopathy
    • B symptoms, usually in patients with advanced disease

Common Symptoms

Less Common Symptoms

References

  1. ↑ 1.0 1.1 Kaseb H, Babiker HM. PMID 29763144. Missing or empty |title= (help)
  2. ↑ 2.0 2.1 Ansell SM (November 2015). "Hodgkin Lymphoma: Diagnosis and Treatment". Mayo Clin Proc. 90 (11): 1574–83. doi:10.1016/j.mayocp.2015.07.005. PMID 26541251.
  3. ↑ 3.0 3.1 3.2 Sapkota S, Shaikh H. PMID 32644754 Check |pmid= value (help). Missing or empty |title= (help)
  4. ↑ 4.0 4.1 Armitage JO, Gascoyne RD, Lunning MA, Cavalli F (July 2017). "Non-Hodgkin lymphoma". Lancet. 390 (10091): 298–310. doi:10.1016/S0140-6736(16)32407-2. PMID 28153383.
  5. ↑ "Hodgkin Lymphoma | Hodgkin Disease".
  6. ↑ 6.0 6.1 "Signs and Symptoms of Non-Hodgkin Lymphoma".


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