Uveitis differential diagnosis: Difference between revisions

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Latest revision as of 00:37, 30 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Tarek Nafee, M.D. [2]

Overview

Uveitis must be differentiated from other diseases that cause conjunctival injection, eye pain, photophobia, or visual disturbance. Masquerade syndromes, which are ophthalmic disorders that clinically present as either an anterior or posterior uveitis but are not primarily inflammatory, must be differentiated from uveitis. As uveitis manifests in a variety of clinical etiologies, differentiation must also be established in accordance with the particular subtype.^[1]^[2]^[3]^[4]

Differential Diagnosis

Uveitis must be differentiated from other diseases that cause conjunctival injection, eye pain, photophobia, or visual disturbance. Masquerade syndromes, which are ophthalmic disorders that clinically present as either an anterior or posterior uveitis but are not primarily inflammatory, must be differentiated from uveitis. As uveitis manifests in a variety of clinical etiologies, differentiation must also be established in accordance with the particular subtype.^[1]^[2]^[3]^[4]

Differentiating Uveitis from Other Diseases

Uveitis must be differentiated from other diseases that cause conjunctival injection, eye pain, photophobia, or visual disturbance, and include:^[5]^[6]^[7]

Corneal ulceration
Conjunctivitis
Closed angle glaucoma
Corneal abrasion
Ulcerative keratitis
Herpes keratitis
Intraocular foreign body
Episcleritis or scleritis
Endophthalmitis
Radiation-induced keratitis

Masquerade syndromes

Masquerade syndromes are ophthalmic disorders that clinically present as either an anterior or posterior uveitis, but are not primarily inflammatory. The following are some of the most common:^[4]

Anterior segment

Posterior segment

References

↑ ^1.0 ^1.1 Prior-Español Á, Martínez-Morillo M, Holgado-Pérez S, Juega FJ (2016). "Differential diagnosis of acute bilateral uveitis in the rheumatologist's office". Reumatol Clin. 12 (3): 174–175. doi:10.1016/j.reuma.2015.05.012. PMID 26187650.
↑ ^2.0 ^2.1 Guly CM, Forrester JV (2010). "Investigation and management of uveitis". BMJ. 341: c4976. doi:10.1136/bmj.c4976. PMID 20943722.
↑ ^3.0 ^3.1 American Academy of Ophthalmology EyeWiki (2015)http://eyewiki.aao.org/Category:Uveitis
↑ ^4.0 ^4.1 ^4.2 Rothova A, Ooijman F, Kerkhoff F, Van Der Lelij A, Lokhorst HM (2001). "Uveitis masquerade syndromes". Ophthalmology. 108 (2): 386–99. PMID 11158819.
↑ Dart JK (1986). "Eye disease at a community health centre". Br Med J (Clin Res Ed). 293 (6560): 1477–80. PMC 1342247. PMID 3099921.
↑ Leibowitz HM (2000). "The red eye". N Engl J Med. 343 (5): 345–51. doi:10.1056/NEJM200008033430507. PMID 10922425.
↑ University of Michigan Eyes Have it (2009)http://kellogg.umich.edu/theeyeshaveit/red-eye/

Template:WH Template:WS

[pmid26187650-1] 1.0 ^1.1 Prior-Español Á, Martínez-Morillo M, Holgado-Pérez S, Juega FJ (2016). "Differential diagnosis of acute bilateral uveitis in the rheumatologist's office". Reumatol Clin. 12 (3): 174–175. doi:10.1016/j.reuma.2015.05.012. PMID 26187650.

[pmid20943722-2] 2.0 ^2.1 Guly CM, Forrester JV (2010). "Investigation and management of uveitis". BMJ. 341: c4976. doi:10.1136/bmj.c4976. PMID 20943722.

[eyewikiuveitis-3] 3.0 ^3.1 American Academy of Ophthalmology EyeWiki (2015)http://eyewiki.aao.org/Category:Uveitis

[pmid11158819-4] 4.0 ^4.1 ^4.2 Rothova A, Ooijman F, Kerkhoff F, Van Der Lelij A, Lokhorst HM (2001). "Uveitis masquerade syndromes". Ophthalmology. 108 (2): 386–99. PMID 11158819.

[pmid3099921-5] Dart JK (1986). "Eye disease at a community health centre". Br Med J (Clin Res Ed). 293 (6560): 1477–80. PMC 1342247. PMID 3099921.

[pmid10922425-6] Leibowitz HM (2000). "The red eye". N Engl J Med. 343 (5): 345–51. doi:10.1056/NEJM200008033430507. PMID 10922425.

[umichredeye-7] University of Michigan Eyes Have it (2009)http://kellogg.umich.edu/theeyeshaveit/red-eye/

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@@ Line 1: / Line 1: @@
 __NOTOC__
+{{Uveitis}}
+{{CMG}}; {{AE}}{{TarekNafee}}
-{{Uveitis}}
+== Overview ==
+Uveitis must be differentiated from other diseases that cause [[conjunctival injection]], [[eye pain]], [[photophobia]], or [[visual disturbance]]. Masquerade syndromes, which are ophthalmic disorders that clinically present as either an anterior or posterior uveitis but are not primarily inflammatory, must be differentiated from uveitis. As uveitis manifests in a variety of clinical etiologies, differentiation must also be established in accordance with the particular subtype.<ref name="pmid26187650">{{cite journal| author=Prior-Español Á, Martínez-Morillo M, Holgado-Pérez S, Juega FJ| title=Differential diagnosis of acute bilateral uveitis in the rheumatologist's office. | journal=Reumatol Clin | year= 2016 | volume= 12 | issue= 3 | pages= 174-175 | pmid=26187650 | doi=10.1016/j.reuma.2015.05.012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26187650  }} </ref><ref name="pmid20943722">{{cite journal| author=Guly CM, Forrester JV| title=Investigation and management of uveitis. | journal=BMJ | year= 2010 | volume= 341 | issue=  | pages= c4976 | pmid=20943722 | doi=10.1136/bmj.c4976 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20943722  }} </ref><ref name=eyewikiuveitis>American Academy of Ophthalmology EyeWiki (2015)http://eyewiki.aao.org/Category:Uveitis</ref><ref name="pmid11158819">{{cite journal| author=Rothova A, Ooijman F, Kerkhoff F, Van Der Lelij A, Lokhorst HM| title=Uveitis masquerade syndromes. | journal=Ophthalmology | year= 2001 | volume= 108 | issue= 2 | pages= 386-99 | pmid=11158819 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11158819  }} </ref>
+== Differential Diagnosis ==
+Uveitis must be differentiated from other diseases that cause [[conjunctival injection]], [[eye pain]], [[photophobia]], or [[visual disturbance]]. Masquerade syndromes, which are ophthalmic disorders that clinically present as either an anterior or posterior uveitis but are not primarily inflammatory, must be differentiated from uveitis. As uveitis manifests in a variety of clinical etiologies, differentiation must also be established in accordance with the particular subtype.<ref name="pmid26187650">{{cite journal| author=Prior-Español Á, Martínez-Morillo M, Holgado-Pérez S, Juega FJ| title=Differential diagnosis of acute bilateral uveitis in the rheumatologist's office. | journal=Reumatol Clin | year= 2016 | volume= 12 | issue= 3 | pages= 174-175 | pmid=26187650 | doi=10.1016/j.reuma.2015.05.012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26187650  }} </ref><ref name="pmid20943722">{{cite journal| author=Guly CM, Forrester JV| title=Investigation and management of uveitis. | journal=BMJ | year= 2010 | volume= 341 | issue=  | pages= c4976 | pmid=20943722 | doi=10.1136/bmj.c4976 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20943722  }} </ref><ref name=eyewikiuveitis>American Academy of Ophthalmology EyeWiki (2015)http://eyewiki.aao.org/Category:Uveitis</ref><ref name="pmid11158819">{{cite journal| author=Rothova A, Ooijman F, Kerkhoff F, Van Der Lelij A, Lokhorst HM| title=Uveitis masquerade syndromes. | journal=Ophthalmology | year= 2001 | volume= 108 | issue= 2 | pages= 386-99 | pmid=11158819 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11158819  }} </ref>
+=== Differentiating Uveitis from Other Diseases ===
+Uveitis must be differentiated from other diseases that cause [[conjunctival injection]], [[eye pain]], [[photophobia]], or [[visual disturbance]], and include:<ref name="pmid3099921">{{cite journal| author=Dart JK| title=Eye disease at a community health centre. | journal=Br Med J (Clin Res Ed) | year= 1986 | volume= 293 | issue= 6560 | pages= 1477-80 | pmid=3099921 | doi= | pmc=1342247 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3099921  }} </ref><ref name="pmid10922425">{{cite journal| author=Leibowitz HM| title=The red eye. | journal=N Engl J Med | year= 2000 | volume= 343 | issue= 5 | pages= 345-51 | pmid=10922425 | doi=10.1056/NEJM200008033430507 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10922425  }} </ref><ref name=umichredeye>University of Michigan Eyes Have it (2009)http://kellogg.umich.edu/theeyeshaveit/red-eye/</ref>
+* Corneal ulceration
+* [[Conjunctivitis]]
+* [[Closed angle glaucoma]]
+* [[Corneal abrasion]]
+* [[Ulcerative keratitis]]
+* Herpes keratitis
+* Intraocular [[foreign body]]
+* [[Episcleritis]] or [[scleritis]]
+* [[Endophthalmitis]]
+* Radiation-induced [[keratitis]]
-Please help WikiDoc by adding content here.  It's easy!  Click  [[Help:How to Edit a Page|here]]  to learn about editing.
+=== Masquerade syndromes ===
+Masquerade syndromes are ophthalmic disorders that clinically present as either an anterior or posterior uveitis, but are not primarily inflammatory. The following are some of the most common:<ref name="pmid11158819">{{cite journal| author=Rothova A, Ooijman F, Kerkhoff F, Van Der Lelij A, Lokhorst HM| title=Uveitis masquerade syndromes. | journal=Ophthalmology | year= 2001 | volume= 108 | issue= 2 | pages= 386-99 | pmid=11158819 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11158819  }} </ref>
+* '''Anterior segment'''
+:* Intraocular [[foreign body]]
+:* [[Juvenile xanthogranuloma]]
+:* [[Leukemia]]
+:* [[Malignant]] [[melanoma]]
+:* [[Retinoblastoma]]
+:* [[Retinal detachment]]
+* '''Posterior segment'''
+:* [[Lymphoma]]
+:* [[Malignant]] [[melanoma]]
+:* [[Multiple sclerosis]]
+:* Reticulum cell [[sarcoma]]
+:* [[Retinitis pigmentosa]]
+:* [[Retinoblastoma]]
+:*[[Syphilis]]
 == References ==
-{{reflist|2}}
+{{Reflist|2}}
 {{WH}}
+{{WS}}
-{{WS}}
+[[Category:Ophthalmology]]
+[[Category:FinalQCRequired]]
+[[Category:Emergency mdicine]]
+[[Category:Disease]]
+[[Category:Up-To-Date]]
+[[Category:Infectious disease]]