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{{Infobox_gene}}
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'''Proto-oncogene tyrosine-protein kinase FER''' is an [[enzyme]] that in humans is encoded by the ''FER'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2241| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)
| HGNCid = 3655
| Symbol = FER
| AltSymbols =; TYK3
| OMIM = 176942
| ECnumber = 
| Homologene = 74300
| MGIid = 105917
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0046777 |text = protein amino acid autophosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2241
    | Hs_Ensembl = ENSG00000151422
    | Hs_RefseqProtein = NP_005237
    | Hs_RefseqmRNA = NM_005246
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 108111422
    | Hs_GenLoc_end = 108560441
    | Hs_Uniprot = P16591
    | Mm_EntrezGene = 14158
    | Mm_Ensembl = ENSMUSG00000000127
    | Mm_RefseqmRNA = NM_001037997
    | Mm_RefseqProtein = NP_001033086
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 63581484
    | Mm_GenLoc_end = 63824640
    | Mm_Uniprot = Q3TME9
  }}
}}
'''Fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)''', also known as '''FER''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2241| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors.<ref name="entrez">{{cite web | title = Entrez Gene: FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2241| accessdate = }}</ref>
| summary_text = Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors.<ref name="entrez" />
}}
}}
==Interactions==
FER (gene) has been shown to [[Protein-protein interaction|interact]] with [[TMF1]]<ref name=pmid9742951>{{cite journal |last=Schwartz |first=Y |authorlink= |author2=Ben-Dor I |author3=Navon A |author4=Motro B |author5=Nir U  |date=Sep 1998 |title=Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases |journal=FEBS Lett. |volume=434 |issue=3 |pages=339–45 |publisher= |location = NETHERLANDS| issn = 0014-5793| pmid = 9742951 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0014-5793(98)01003-5 }}</ref> and [[Cortactin]].<ref name=pmid9722593>{{cite journal |last=Kim |first=L |authorlink= |author2=Wong T W |date=Sep 1998 |title=Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER |journal=J. Biol. Chem. |volume=273 |issue=36 |pages=23542–8 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9722593 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.273.36.23542 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Greer P |title=Closing in on the biological functions of Fps/Fes and Fer. |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue= 4 |pages= 278-89 |year= 2002 |pmid= 11994747 |doi= 10.1038/nrm783 }}
*{{cite journal  | author=Greer P |title=Closing in on the biological functions of Fps/Fes and Fer |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue= 4 |pages= 278–89 |year= 2002 |pmid= 11994747 |doi= 10.1038/nrm783 }}
*{{cite journal  | author=Nishisho I, Nakamura Y, Miyoshi Y, ''et al.'' |title=Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. |journal=Science |volume=253 |issue= 5020 |pages= 665-9 |year= 1991 |pmid= 1651563 |doi= }}
*{{cite journal  |vauthors=Nishisho I, Nakamura Y, Miyoshi Y |title=Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients |journal=Science |volume=253 |issue= 5020 |pages= 665–9 |year= 1991 |pmid= 1651563 |doi=10.1126/science.1651563 |display-authors=etal|bibcode=1991Sci...253..665N }}
*{{cite journal | author=Warrington JA, Hall LV, Hinton LM, ''et al.'' |title=Radiation hybrid map of 13 loci on the long arm of chromosome 5. |journal=Genomics |volume=11 |issue= 3 |pages= 701-8 |year= 1992 |pmid= 1663488 |doi=  }}
*{{cite journal  |vauthors=Warrington JA, Hall LV, Hinton LM |title=Radiation hybrid map of 13 loci on the long arm of chromosome 5 |journal=Genomics |volume=11 |issue= 3 |pages= 701–8 |year= 1992 |pmid= 1663488 |doi=10.1016/0888-7543(91)90078-S |display-authors=etal}}
*{{cite journal  | author=Hao QL, Ferris DK, White G, ''et al.'' |title=Nuclear and cytoplasmic location of the FER tyrosine kinase. |journal=Mol. Cell. Biol. |volume=11 |issue= 2 |pages= 1180-3 |year= 1991 |pmid= 1990274 |doi=  }}
*{{cite journal  |vauthors=Hao QL, Ferris DK, White G |title=Nuclear and cytoplasmic location of the FER tyrosine kinase |journal=Mol. Cell. Biol. |volume=11 |issue= 2 |pages= 1180–3 |year= 1991 |pmid= 1990274 |doi=  | pmc=359807  |display-authors=etal}}
*{{cite journal  | author=Krolewski JJ, Lee R, Eddy R, ''et al.'' |title=Identification and chromosomal mapping of new human tyrosine kinase genes. |journal=Oncogene |volume=5 |issue= 3 |pages= 277-82 |year= 1990 |pmid= 2156206 |doi=  }}
*{{cite journal  |vauthors=Krolewski JJ, Lee R, Eddy R |title=Identification and chromosomal mapping of new human tyrosine kinase genes |journal=Oncogene |volume=5 |issue= 3 |pages= 277–82 |year= 1990 |pmid= 2156206 |doi=  |display-authors=etal}}
*{{cite journal  | author=Morris C, Heisterkamp N, Hao QL, ''et al.'' |title=The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q). |journal=Cytogenet. Cell Genet. |volume=53 |issue= 4 |pages= 196-200 |year= 1990 |pmid= 2209086 |doi= }}
*{{cite journal  |vauthors=Morris C, Heisterkamp N, Hao QL |title=The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q) |journal=Cytogenet. Cell Genet. |volume=53 |issue= 4 |pages= 196–200 |year= 1990 |pmid= 2209086 |doi=10.1159/000132929  |display-authors=etal}}
*{{cite journal  | author=Pawson T, Letwin K, Lee T, ''et al.'' |title=The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family. |journal=Mol. Cell. Biol. |volume=9 |issue= 12 |pages= 5722-5 |year= 1990 |pmid= 2685575 |doi=  }}
*{{cite journal  |vauthors=Pawson T, Letwin K, Lee T |title=The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family |journal=Mol. Cell. Biol. |volume=9 |issue= 12 |pages= 5722–5 |year= 1990 |pmid= 2685575 |doi=  | pmc=363745  |display-authors=etal}}
*{{cite journal  | author=Hao QL, Heisterkamp N, Groffen J |title=Isolation and sequence analysis of a novel human tyrosine kinase gene. |journal=Mol. Cell. Biol. |volume=9 |issue= 4 |pages= 1587-93 |year= 1989 |pmid= 2725517 |doi=  }}
*{{cite journal  |vauthors=Hao QL, Heisterkamp N, Groffen J |title=Isolation and sequence analysis of a novel human tyrosine kinase gene |journal=Mol. Cell. Biol. |volume=9 |issue= 4 |pages= 1587–93 |year= 1989 |pmid= 2725517 |doi= | pmc=362575 }}
*{{cite journal  | author=Brunati AM, Pinna LA |title=Characterization of four tyrosine protein kinases from the particulate fraction of rat spleen. |journal=Eur. J. Biochem. |volume=172 |issue= 2 |pages= 451-7 |year= 1988 |pmid= 3350007 |doi=  }}
*{{cite journal  |vauthors=Brunati AM, Pinna LA |title=Characterization of four tyrosine protein kinases from the particulate fraction of rat spleen |journal=Eur. J. Biochem. |volume=172 |issue= 2 |pages= 451–7 |year= 1988 |pmid= 3350007 |doi=10.1111/j.1432-1033.1988.tb13909.x }}
*{{cite journal  | author=Meggio F, Brunati AM, Pinna LA |title=Polycation-dependent, Ca2+-antagonized phosphorylation of calmodulin by casein kinase-2 and a spleen tyrosine protein kinase. |journal=FEBS Lett. |volume=215 |issue= 2 |pages= 241-6 |year= 1987 |pmid= 3472906 |doi=  }}
*{{cite journal  |vauthors=Meggio F, Brunati AM, Pinna LA |title=Polycation-dependent, Ca2+-antagonized phosphorylation of calmodulin by casein kinase-2 and a spleen tyrosine protein kinase |journal=FEBS Lett. |volume=215 |issue= 2 |pages= 241–6 |year= 1987 |pmid= 3472906 |doi=10.1016/0014-5793(87)80154-0 }}
*{{cite journal  | author=Kim L, Wong TW |title=The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors. |journal=Mol. Cell. Biol. |volume=15 |issue= 8 |pages= 4553-61 |year= 1995 |pmid= 7623846 |doi=  }}
*{{cite journal  |vauthors=Kim L, Wong TW |title=The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors |journal=Mol. Cell. Biol. |volume=15 |issue= 8 |pages= 4553–61 |year= 1995 |pmid= 7623846 |doi= | pmc=230695 }}
*{{cite journal  | author=Lee ST, Strunk KM, Spritz RA |title=A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. |journal=Oncogene |volume=8 |issue= 12 |pages= 3403-10 |year= 1993 |pmid= 8247543 |doi=  }}
*{{cite journal  |vauthors=Lee ST, Strunk KM, Spritz RA |title=A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes |journal=Oncogene |volume=8 |issue= 12 |pages= 3403–10 |year= 1993 |pmid= 8247543 |doi=  }}
*{{cite journal  | author=Kim L, Wong TW |title=Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23542-8 |year= 1998 |pmid= 9722593 |doi=  }}
*{{cite journal  |vauthors=Kim L, Wong TW |title=Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23542–8 |year= 1998 |pmid= 9722593 |doi=10.1074/jbc.273.36.23542 }}
*{{cite journal  | author=Rosato R, Veltmaat JM, Groffen J, Heisterkamp N |title=Involvement of the tyrosine kinase fer in cell adhesion. |journal=Mol. Cell. Biol. |volume=18 |issue= 10 |pages= 5762-70 |year= 1998 |pmid= 9742093 |doi=  }}
*{{cite journal  |vauthors=Rosato R, Veltmaat JM, Groffen J, Heisterkamp N |title=Involvement of the tyrosine kinase fer in cell adhesion |journal=Mol. Cell. Biol. |volume=18 |issue= 10 |pages= 5762–70 |year= 1998 |pmid= 9742093 |doi= | pmc=109162 }}
*{{cite journal  | author=Schwartz Y, Ben-Dor I, Navon A, ''et al.'' |title=Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases. |journal=FEBS Lett. |volume=434 |issue= 3 |pages= 339-45 |year= 1998 |pmid= 9742951 |doi=  }}
*{{cite journal  |vauthors=Schwartz Y, Ben-Dor I, Navon A |title=Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases |journal=FEBS Lett. |volume=434 |issue= 3 |pages= 339–45 |year= 1998 |pmid= 9742951 |doi=10.1016/S0014-5793(98)01003-5 |display-authors=etal}}
*{{cite journal  | author=Huang C, Liu J, Haudenschild CC, Zhan X |title=The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25770-6 |year= 1998 |pmid= 9748248 |doi= }}
*{{cite journal  |vauthors=Huang C, Liu J, Haudenschild CC, Zhan X |title=The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25770–6 |year= 1998 |pmid= 9748248 |doi=10.1074/jbc.273.40.25770  }}
*{{cite journal  | author=Corti C, Leclerc L'Hostis E, Quadroni M, ''et al.'' |title=Tyrosine phosphorylation modulates the interaction of calmodulin with its target proteins. |journal=Eur. J. Biochem. |volume=262 |issue= 3 |pages= 790-802 |year= 1999 |pmid= 10411641 |doi= }}
*{{cite journal  |vauthors=Corti C, Leclerc L'Hostis E, Quadroni M |title=Tyrosine phosphorylation modulates the interaction of calmodulin with its target proteins |journal=Eur. J. Biochem. |volume=262 |issue= 3 |pages= 790–802 |year= 1999 |pmid= 10411641 |doi=10.1046/j.1432-1327.1999.00441.x  |display-authors=etal}}
*{{cite journal  | author=Priel-Halachmi S, Ben-Dor I, Shpungin S, ''et al.'' |title=FER kinase activation of Stat3 is determined by the N-terminal sequence. |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28902-10 |year= 2000 |pmid= 10878010 |doi= 10.1074/jbc.M003402200 }}
*{{cite journal  |vauthors=Priel-Halachmi S, Ben-Dor I, Shpungin S |title=FER kinase activation of Stat3 is determined by the N-terminal sequence |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28902–10 |year= 2000 |pmid= 10878010 |doi= 10.1074/jbc.M003402200 |display-authors=etal}}
*{{cite journal  | author=Kapus A, Di Ciano C, Sun J, ''et al.'' |title=Cell volume-dependent phosphorylation of proteins of the cortical cytoskeleton and cell-cell contact sites. The role of Fyn and FER kinases. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 32289-98 |year= 2000 |pmid= 10921917 |doi= 10.1074/jbc.M003172200 }}
*{{cite journal  |vauthors=Kapus A, Di Ciano C, Sun J |title=Cell volume-dependent phosphorylation of proteins of the cortical cytoskeleton and cell-cell contact sites. The role of Fyn and FER kinases |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 32289–98 |year= 2000 |pmid= 10921917 |doi= 10.1074/jbc.M003172200 |display-authors=etal}}
*{{cite journal  | author=Orlovsky K, Ben-Dor I, Priel-Halachmi S, ''et al.'' |title=N-terminal sequences direct the autophosphorylation states of the FER tyrosine kinases in vivo. |journal=Biochemistry |volume=39 |issue= 36 |pages= 11084-91 |year= 2000 |pmid= 10998246 |doi=  }}
*{{cite journal  |vauthors=Orlovsky K, Ben-Dor I, Priel-Halachmi S |title=N-terminal sequences direct the autophosphorylation states of the FER tyrosine kinases in vivo |journal=Biochemistry |volume=39 |issue= 36 |pages= 11084–91 |year= 2000 |pmid= 10998246 |doi=10.1021/bi0005153 |display-authors=etal}}
}}
}}
{{refend}}
{{refend}}


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[[Category:Tyrosine kinases]]
 
 
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Latest revision as of 14:03, 23 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene.[1]

Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors.[1]

Interactions

FER (gene) has been shown to interact with TMF1[2] and Cortactin.[3]

References

  1. ↑ 1.0 1.1 "Entrez Gene: FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)".
  2. ↑ Schwartz, Y; Ben-Dor I; Navon A; Motro B; Nir U (Sep 1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. NETHERLANDS. 434 (3): 339–45. doi:10.1016/S0014-5793(98)01003-5. ISSN 0014-5793. PMID 9742951.
  3. ↑ Kim, L; Wong T W (Sep 1998). "Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER". J. Biol. Chem. UNITED STATES. 273 (36): 23542–8. doi:10.1074/jbc.273.36.23542. ISSN 0021-9258. PMID 9722593.

Further reading


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