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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''FK506-binding protein 2''' is a [[protein]] that in humans is encoded by the ''FKBP2'' [[gene]].<ref name="pmid1713687">{{cite journal | vauthors = Jin YJ, Albers MW, Lane WS, Bierer BE, Schreiber SL, Burakoff SJ | title = Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 88 | issue = 15 | pages = 6677–81  | date = Sep 1991 | pmid = 1713687 | pmc = 52151 | doi = 10.1073/pnas.88.15.6677 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FKBP2 FK506 binding protein 2, 13kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2286| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_FKBP2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2pbc.
| PDB = {{PDB2|2pbc}}
| Name = FK506 binding protein 2, 13kDa
| HGNCid = 3718
| Symbol = FKBP2
| AltSymbols =; PPIase; FKBP-13
| OMIM = 186946
| ECnumber = 
| Homologene = 40604
| MGIid = 95542
| GeneAtlas_image1 = PBB_GE_FKBP2_203391_at_tn.png
| Function = {{GNF_GO|id=GO:0003755 |text = peptidyl-prolyl cis-trans isomerase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005528 |text = FK506 binding}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2286
    | Hs_Ensembl = ENSG00000173486
    | Hs_RefseqProtein = NP_004461
    | Hs_RefseqmRNA = NM_004470
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 63764989
    | Hs_GenLoc_end = 63768262
    | Hs_Uniprot = P26885
    | Mm_EntrezGene = 14227
    | Mm_Ensembl = ENSMUSG00000056629
    | Mm_RefseqmRNA = NM_008020
    | Mm_RefseqProtein = NP_032046
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 7044781
    | Mm_GenLoc_end = 7047474
    | Mm_Uniprot = Q3TND1
  }}
}}
'''FK506 binding protein 2, 13kDa''', also known as '''FKBP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FKBP2 FK506 binding protein 2, 13kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2286| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The [[protein]] encoded by this gene is a member of the [[immunophilin]] protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a [[cis-trans]] prolyl [[isomerase]] that binds the immunosuppressants FK506 and [[rapamycin]]. It is thought to function as an [[Endoplasmic reticulum|ER]] chaperone and may also act as a component of membrane cytoskeletal scaffolds. This gene has two alternatively spliced transcript variants that encode the same isoform. Multiple [[polyadenylation]] sites have been described for this gene, but the full length nature of this gene has not been determined.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. This gene has two alternatively spliced transcript variants that encode the same isoform. Multiple polyadenylation sites have been described for this gene, but the full length nature of this gene has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: FKBP2 FK506 binding protein 2, 13kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2286| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
FKBP2 has been shown to [[Protein-protein interaction|interact]] with [[ARFGEF1]]<ref name=pmid12606707>{{cite journal | vauthors = Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M | title = Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 5 | pages = 2322–7  | date = Mar 2003 | pmid = 12606707 | pmc = 151339 | doi = 10.1073/pnas.2628047100 }}</ref> and [[EPB41L2]].<ref name=pmid9531554>{{cite journal | vauthors = Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH | title = The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1 | journal = J. Cell Biol. | volume = 141 | issue = 1 | pages = 143–53  | date = Apr 1998 | pmid = 9531554 | pmc = 2132710 | doi = 10.1083/jcb.141.1.143 }}</ref>
 
== References ==
{{Reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = DiLella AG, Hawkins A, Craig RJ, Schreiber SL, Griffin CA | title = Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13 | journal = Biochem. Biophys. Res. Commun. | volume = 189 | issue = 2 | pages = 819–23 | year = 1992 | pmid = 1281998 | doi = 10.1016/0006-291X(92)92276-4 }}
| citations =
* {{cite journal | vauthors = Hendrickson BA, Zhang W, Craig RJ, Jin YJ, Bierer BE, Burakoff S, DiLella AG | title = Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1 | journal = Gene | volume = 134 | issue = 2 | pages = 271–5 | year = 1993 | pmid = 7505249 | doi = 10.1016/0378-1119(93)90106-D }}
*{{cite journal | author=DiLella AG, Hawkins A, Craig RJ, ''et al.'' |title=Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13. |journal=Biochem. Biophys. Res. Commun. |volume=189 |issue= 2 |pages= 819-23 |year= 1993 |pmid= 1281998 |doi= }}
* {{cite journal | vauthors = Bush KT, Hendrickson BA, Nigam SK | title = Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum | journal = Biochem. J. | volume = 303 | issue = Pt 3 | pages = 705–8 | year = 1994 | pmid = 7526846 | pmc = 1137603 | doi =  10.1042/bj3030705}}
*{{cite journal  | author=Jin YJ, Albers MW, Lane WS, ''et al.'' |title=Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 15 |pages= 6677-81 |year= 1991 |pmid= 1713687 |doi=  }}
* {{cite journal | vauthors = Nigam SK, Jin YJ, Jin MJ, Bush KT, Bierer BE, Burakoff SJ | title = Localization of the FK506-binding protein, FKBP 13, to the lumen of the endoplasmic reticulum | journal = Biochem. J. | volume = 294 | issue = Pt 2 | pages = 511–5 | year = 1993 | pmid = 8373365 | pmc = 1134484 | doi =  10.1042/bj2940511}}
*{{cite journal | author=Hendrickson BA, Zhang W, Craig RJ, ''et al.'' |title=Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1. |journal=Gene |volume=134 |issue= 2 |pages= 271-5 |year= 1994 |pmid= 7505249 |doi= }}
* {{cite journal | vauthors = Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH | title = The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1 | journal = J. Cell Biol. | volume = 141 | issue = 1 | pages = 143–53 | year = 1998 | pmid = 9531554 | pmc = 2132710 | doi = 10.1083/jcb.141.1.143 }}
*{{cite journal | author=Bush KT, Hendrickson BA, Nigam SK |title=Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum. |journal=Biochem. J. |volume=303 ( Pt 3) |issue= |pages= 705-8 |year= 1994 |pmid= 7526846 |doi=  }}
* {{cite journal | vauthors = Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M | title = Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 5 | pages = 2322–7 | year = 2003 | pmid = 12606707 | pmc = 151339 | doi = 10.1073/pnas.2628047100 }}
*{{cite journal | author=Nigam SK, Jin YJ, Jin MJ, ''et al.'' |title=Localization of the FK506-binding protein, FKBP 13, to the lumen of the endoplasmic reticulum. |journal=Biochem. J. |volume=294 ( Pt 2) |issue= |pages= 511-5 |year= 1993 |pmid= 8373365 |doi=  }}
* {{cite journal | vauthors = Willingham S, Outeiro TF, DeVit MJ, Lindquist SL, Muchowski PJ | title = Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein | journal = Science | volume = 302 | issue = 5651 | pages = 1769–72 | year = 2003 | pmid = 14657499 | doi = 10.1126/science.1090389 }}
*{{cite journal | author=Walensky LD, Gascard P, Fields ME, ''et al.'' |title=The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1. |journal=J. Cell Biol. |volume=141 |issue= 1 |pages= 143-53 |year= 1998 |pmid= 9531554 |doi=  }}
* {{cite journal | vauthors = Won J, Kim M, Yi YW, Kim YH, Jung N, Kim TK | title = A magnetic nanoprobe technology for detecting molecular interactions in live cells | journal = Science | volume = 309 | issue = 5731 | pages = 121–5 | year = 2005 | pmid = 15994554 | doi = 10.1126/science.1112869 }}{{Retracted paper}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Padilla PI, Chang MJ, Pacheco-Rodriguez G, ''et al.'' |title=Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 5 |pages= 2322-7 |year= 2003 |pmid= 12606707 |doi= 10.1073/pnas.2628047100 }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY|authorlink13=Huda Zoghbi | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Willingham S, Outeiro TF, DeVit MJ, ''et al.'' |title=Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. |journal=Science |volume=302 |issue= 5651 |pages= 1769-72 |year= 2003 |pmid= 14657499 |doi= 10.1126/science.1090389 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Won J, Kim M, Yi YW, ''et al.'' |title=A magnetic nanoprobe technology for detecting molecular interactions in live cells. |journal=Science |volume=309 |issue= 5731 |pages= 121-5 |year= 2005 |pmid= 15994554 |doi= 10.1126/science.1112869 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
{{refend}}
{{refend}}


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[[Category:EC 5.2.1]]

Latest revision as of 15:08, 8 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

FK506-binding protein 2 is a protein that in humans is encoded by the FKBP2 gene.[1][2]

Function

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. This gene has two alternatively spliced transcript variants that encode the same isoform. Multiple polyadenylation sites have been described for this gene, but the full length nature of this gene has not been determined.[2]

Interactions

FKBP2 has been shown to interact with ARFGEF1[3] and EPB41L2.[4]

References

  1. ↑ Jin YJ, Albers MW, Lane WS, Bierer BE, Schreiber SL, Burakoff SJ (Sep 1991). "Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13". Proc. Natl. Acad. Sci. U.S.A. 88 (15): 6677–81. doi:10.1073/pnas.88.15.6677. PMC 52151. PMID 1713687.
  2. ↑ 2.0 2.1 "Entrez Gene: FKBP2 FK506 binding protein 2, 13kDa".
  3. ↑ Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M (Mar 2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2322–7. doi:10.1073/pnas.2628047100. PMC 151339. PMID 12606707.
  4. ↑ Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH (Apr 1998). "The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1". J. Cell Biol. 141 (1): 143–53. doi:10.1083/jcb.141.1.143. PMC 2132710. PMID 9531554.

Further reading


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