Feline sarcoma oncogene: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Tyrosine-protein kinase Fes/Fps''' also known as '''proto-oncogene c-Fes/Fps''' is an [[enzyme]] that in humans is encoded by the ''FES'' [[gene]].<ref name="pmid1870997">{{cite journal | vauthors = Bowden DW, Akots G, Rothschild CB | title = An insertion deletion polymorphism associated with C-FES | journal = Nucleic Acids Research | volume = 19 | issue = 15 | pages = 4311 | date = Aug 1991 | pmid = 1870997 | pmc = 328602 | doi = 10.1093/nar/19.15.4311 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FES feline sarcoma oncogene| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2242| accessdate = }}</ref> FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals.<ref>{{cite journal | vauthors = Craig AW | title = FES/FER kinase signaling in hematopoietic cells and leukemias | journal = Frontiers in Bioscience | volume = 17 | pmid = 22201778 | year=2012 | pages=861–75 | doi=10.2741/3961}}</ref>
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== Function ==
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has [[tyrosine protein kinase|tyrosine-specific protein kinase]] activity and that activity is required for maintenance of [[cellular transformation]]. Its chromosomal location has linked it to a specific translocation event identified in patients with [[acute promyelocytic leukemia]] but it is also involved in normal [[hematopoiesis]]. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.<ref name="entrez" />
{{GNF_Protein_box
| image = PBB_Protein_FES_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wqu.
| PDB = {{PDB2|1wqu}}, {{PDB2|2dcr}}
| Name = Feline sarcoma oncogene
| HGNCid = 3657
| Symbol = FES
| AltSymbols =; FPS
| OMIM = 190030
| ECnumber = 
| Homologene = 37563
| MGIid = 95514
| GeneAtlas_image1 = PBB_GE_FES_205418_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2242
    | Hs_Ensembl = ENSG00000182511
    | Hs_RefseqProtein = NP_001996
    | Hs_RefseqmRNA = NM_002005
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 89228713
    | Hs_GenLoc_end = 89240010
    | Hs_Uniprot = P07332
    | Mm_EntrezGene = 14159
    | Mm_Ensembl = ENSMUSG00000053158
    | Mm_RefseqmRNA = XM_981464
    | Mm_RefseqProtein = XP_986558
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 80251268
    | Mm_GenLoc_end = 80261449
    | Mm_Uniprot = Q3TD20
  }}
}}
'''Feline sarcoma oncogene''', also known as '''FES''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FES feline sarcoma oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2242| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text = This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.<ref name="entrez">{{cite web | title = Entrez Gene: FES feline sarcoma oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2242| accessdate = }}</ref>
}}


==References==
Feline sarcoma oncogene has been shown to [[Protein-protein interaction|interact]] with [[BCAR1]]<ref name=pmid8999909>{{cite journal | vauthors = Jücker M, McKenna K, da Silva AJ, Rudd CE, Feldman RA | title = The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling | journal = The Journal of Biological Chemistry | volume = 272 | issue = 4 | pages = 2104–9 | date = Jan 1997 | pmid = 8999909 | doi = 10.1074/jbc.272.4.2104 }}</ref> and [[BCR gene]].<ref name=pmid10706130>{{cite journal | vauthors = Lionberger JM, Smithgall TE | title = The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl | journal = Cancer Research | volume = 60 | issue = 4 | pages = 1097–103 | date = Feb 2000 | pmid = 10706130 }}</ref><ref name=pmid7529874>{{cite journal | vauthors = Maru Y, Peters KL, Afar DE, Shibuya M, Witte ON, Smithgall TE | title = Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS | journal = Molecular and Cellular Biology | volume = 15 | issue = 2 | pages = 835–42 | date = Feb 1995 | pmid = 7529874 | pmc = 231961 }}</ref>
{{reflist|2}}
 
==Further reading==
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Smithgall TE, Rogers JA, Peters KL, Li J, Briggs SD, Lionberger JM, Cheng H, Shibata A, Scholtz B, Schreiner S, Dunham N | title = The c-Fes family of protein-tyrosine kinases | journal = Critical Reviews in Oncogenesis | volume = 9 | issue = 1 | pages = 43–62 | year = 1998 | pmid = 9754447 | doi = 10.1615/critrevoncog.v9.i1.40 }}
| citations =
* {{cite journal | vauthors = Jiang H, Harris MB, Rothman P | title = IL-4/IL-13 signaling beyond JAK/STAT | journal = The Journal of Allergy and Clinical Immunology | volume = 105 | issue = 6 Pt 1 | pages = 1063–70 | date = Jun 2000 | pmid = 10856136 | doi = 10.1067/mai.2000.107604 }}
*{{cite journal | author=Smithgall TE, Rogers JA, Peters KL, ''et al.'' |title=The c-Fes family of protein-tyrosine kinases. |journal=Critical reviews in oncogenesis |volume=9 |issue= 1 |pages= 43-62 |year= 1998 |pmid= 9754447 |doi= }}
* {{cite journal | vauthors = Greer P | title = Closing in on the biological functions of Fps/Fes and Fer | journal = Nature Reviews Molecular Cell Biology | volume = 3 | issue = 4 | pages = 278–89 | date = Apr 2002 | pmid = 11994747 | doi = 10.1038/nrm783 }}
*{{cite journal | author=Jiang H, Harris MB, Rothman P |title=IL-4/IL-13 signaling beyond JAK/STAT. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 6 Pt 1 |pages= 1063-70 |year= 2000 |pmid= 10856136 |doi= }}
*{{cite journal | author=Greer P |title=Closing in on the biological functions of Fps/Fes and Fer. |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue= 4 |pages= 278-89 |year= 2002 |pmid= 11994747 |doi= 10.1038/nrm783 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=2242}}
{{Tyrosine kinases}}
{{Enzymes}}
{{Portal bar|Molecular and Cellular Biology|border=no}}
[[Category:Tyrosine kinases]]


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{{WikiDoc Sources}}

Latest revision as of 01:43, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene.[1][2] FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals.[3]

Function

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.[2]

Interactions

Feline sarcoma oncogene has been shown to interact with BCAR1[4] and BCR gene.[5][6]

References

  1. ↑ Bowden DW, Akots G, Rothschild CB (Aug 1991). "An insertion deletion polymorphism associated with C-FES". Nucleic Acids Research. 19 (15): 4311. doi:10.1093/nar/19.15.4311. PMC 328602. PMID 1870997.
  2. ↑ 2.0 2.1 "Entrez Gene: FES feline sarcoma oncogene".
  3. ↑ Craig AW (2012). "FES/FER kinase signaling in hematopoietic cells and leukemias". Frontiers in Bioscience. 17: 861–75. doi:10.2741/3961. PMID 22201778.
  4. ↑ Jücker M, McKenna K, da Silva AJ, Rudd CE, Feldman RA (Jan 1997). "The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling". The Journal of Biological Chemistry. 272 (4): 2104–9. doi:10.1074/jbc.272.4.2104. PMID 8999909.
  5. ↑ Lionberger JM, Smithgall TE (Feb 2000). "The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl". Cancer Research. 60 (4): 1097–103. PMID 10706130.
  6. ↑ Maru Y, Peters KL, Afar DE, Shibuya M, Witte ON, Smithgall TE (Feb 1995). "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS". Molecular and Cellular Biology. 15 (2): 835–42. PMC 231961. PMID 7529874.

Further reading

  • Smithgall TE, Rogers JA, Peters KL, Li J, Briggs SD, Lionberger JM, Cheng H, Shibata A, Scholtz B, Schreiner S, Dunham N (1998). "The c-Fes family of protein-tyrosine kinases". Critical Reviews in Oncogenesis. 9 (1): 43–62. doi:10.1615/critrevoncog.v9.i1.40. PMID 9754447.
  • Jiang H, Harris MB, Rothman P (Jun 2000). "IL-4/IL-13 signaling beyond JAK/STAT". The Journal of Allergy and Clinical Immunology. 105 (6 Pt 1): 1063–70. doi:10.1067/mai.2000.107604. PMID 10856136.
  • Greer P (Apr 2002). "Closing in on the biological functions of Fps/Fes and Fer". Nature Reviews Molecular Cell Biology. 3 (4): 278–89. doi:10.1038/nrm783. PMID 11994747.


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