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{{Infobox_gene}}
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'''Interferon beta''' is a [[protein]] that in humans is encoded by the ''IFNB1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IFNB1 interferon, beta 1, fibroblast| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3456| accessdate = }}</ref> The natural and [[recombinant protein]] forms have antiviral, antibacterial, and anticancer properties.<ref name ="genesource">{{cite web | title = IFNB1 recombinant protein| url = http://www.mybiosource.com/datasheet.php?products_id=232060| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_IFNB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1au1.
| PDB = {{PDB2|1au1}}
| Name = Interferon, beta 1, fibroblast
| HGNCid = 5434
| Symbol = IFNB1
| AltSymbols =; IFB; IFF; IFNB; MGC96956
| OMIM = 147640
| ECnumber = 
| Homologene = 1640
| MGIid = 107657
| GeneAtlas_image1 = PBB_GE_IFNB1_208173_at_tn.png
| Function = {{GNF_GO|id=GO:0005132 |text = interferon-alpha/beta receptor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006919 |text = caspase activation}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009615 |text = response to virus}} {{GNF_GO|id=GO:0030101 |text = natural killer cell activation}} {{GNF_GO|id=GO:0042100 |text = B cell proliferation}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}} {{GNF_GO|id=GO:0045089 |text = positive regulation of innate immune response}} {{GNF_GO|id=GO:0045343 |text = regulation of MHC class I biosynthetic process}} {{GNF_GO|id=GO:0046597 |text = negative regulation of virion penetration into host}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3456
    | Hs_Ensembl = ENSG00000171855
    | Hs_RefseqProtein = NP_002167
    | Hs_RefseqmRNA = NM_002176
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 21067104
    | Hs_GenLoc_end = 21067962
    | Hs_Uniprot = P01574
    | Mm_EntrezGene = 15977
    | Mm_Ensembl = ENSMUSG00000048806
    | Mm_RefseqmRNA = NM_010510
    | Mm_RefseqProtein = NP_034640
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 87993457
    | Mm_GenLoc_end = 87994005
    | Mm_Uniprot = Q0VE17
  }}
}}
'''Interferon, beta 1, fibroblast''', also known as '''IFNB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IFNB1 interferon, beta 1, fibroblast| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3456| accessdate = }}</ref>
 
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[[Interferon beta 1a]] (tradenames: Avonex and Rebif) and [[Interferon beta 1b]] (tradenames: Betaseron/Betaferon) are used as drugs.


==References==
==References==
{{reflist|2}}
{{reflist}}
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==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Biron CA, Nguyen KB, Pien GC |title=Innate immune responses to LCMV infections: natural killer cells and cytokines. |journal=Curr. Top. Microbiol. Immunol. |volume=263 |issue=  |pages= 7-27 |year= 2002 |pmid= 11987821 |doi=  }}
*{{cite journal  |vauthors=Biron CA, Nguyen KB, Pien GC |title=Innate immune responses to LCMV infections: natural killer cells and cytokines. |journal=Curr. Top. Microbiol. Immunol. |volume=263 |issue=  |pages= 7–27 |year= 2002 |pmid= 11987821 |doi=  10.1007/978-3-642-56055-2_2}}
*{{cite journal | author=Conti L, Fantuzzi L, Del Cornò M, ''et al.'' |title=Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis. |journal=Immunobiology |volume=209 |issue= 1-2 |pages= 99-115 |year= 2005 |pmid= 15481145 |doi=  }}
*{{cite journal   |vauthors=Conti L, Fantuzzi L, Del Cornò M, etal |title=Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis. |journal=Immunobiology |volume=209 |issue= 1–2 |pages= 99–115 |year= 2005 |pmid= 15481145 |doi=10.1016/j.imbio.2004.02.008 }}
*{{cite journal | author=Bekisz J, Schmeisser H, Hernandez J, ''et al.'' |title=Human interferons alpha, beta and omega. |journal=Growth Factors |volume=22 |issue= 4 |pages= 243-51 |year= 2005 |pmid= 15621727 |doi= 10.1080/08977190400000833 }}
*{{cite journal   |vauthors=Bekisz J, Schmeisser H, Hernandez J, etal |title=Human interferons alpha, beta and omega |journal=Growth Factors |volume=22 |issue= 4 |pages= 243–51 |year= 2005 |pmid= 15621727 |doi= 10.1080/08977190400000833 }}
*{{cite journal  | author=Copeland KF |title=Modulation of HIV-1 transcription by cytokines and chemokines. |journal=Mini reviews in medicinal chemistry |volume=5 |issue= 12 |pages= 1093-101 |year= 2006 |pmid= 16375755 |doi=  }}
*{{cite journal  | author=Copeland KF |title=Modulation of HIV-1 transcription by cytokines and chemokines |journal=Mini Reviews in Medicinal Chemistry |volume=5 |issue= 12 |pages= 1093–101 |year= 2006 |pmid= 16375755 |doi=10.2174/138955705774933383 }}
*{{cite journal  | author=Silverman RH, Sengupta DN |title=Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes. |journal=J. Exp. Pathol. |volume=5 |issue= 2 |pages= 69-77 |year= 1991 |pmid= 1708818 |doi=  }}
*{{cite journal  |vauthors=Silverman RH, Sengupta DN |title=Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes |journal=J. Exp. Pathol. |volume=5 |issue= 2 |pages= 69–77 |year= 1991 |pmid= 1708818 |doi=  }}
*{{cite journal  | author=Flores I, Mariano TM, Pestka S |title=Human interferon omega (omega) binds to the alpha/beta receptor. |journal=J. Biol. Chem. |volume=266 |issue= 30 |pages= 19875-7 |year= 1991 |pmid= 1834641 |doi=  }}
*{{cite journal  |vauthors=Flores I, Mariano TM, Pestka S |title=Human interferon omega (omega) binds to the alpha/beta receptor |journal=J. Biol. Chem. |volume=266 |issue= 30 |pages= 19875–7 |year= 1991 |pmid= 1834641 |doi=  }}
*{{cite journal  | author=May LT, Sehgal PB |title=On the relationship between human interferon alpha 1 and beta 1 genes. |journal=J. Interferon Res. |volume=5 |issue= 3 |pages= 521-6 |year= 1985 |pmid= 2414376 |doi=  }}
*{{cite journal  |vauthors=May LT, Sehgal PB |title=On the relationship between human interferon alpha 1 and beta 1 genes |journal=J. Interferon Res. |volume=5 |issue= 3 |pages= 521–6 |year= 1985 |pmid= 2414376 |doi=  }}
*{{cite journal | author=Francois DT, Katona IM, June CH, ''et al.'' |title=Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens. |journal=Clin. Immunol. Immunopathol. |volume=48 |issue= 3 |pages= 297-306 |year= 1988 |pmid= 3135963 |doi= }}
*{{cite journal   |vauthors=Francois DT, Katona IM, June CH, etal |title=Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens |journal=Clin. Immunol. Immunopathol. |volume=48 |issue= 3 |pages= 297–306 |year= 1988 |pmid= 3135963 |doi=10.1016/0090-1229(88)90023-2  }}
*{{cite journal | author=Conradt HS, Egge H, Peter-Katalinic J, ''et al.'' |title=Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line. |journal=J. Biol. Chem. |volume=262 |issue= 30 |pages= 14600-5 |year= 1987 |pmid= 3667593 |doi=  }}
*{{cite journal   |vauthors=Conradt HS, Egge H, Peter-Katalinic J, etal |title=Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line |journal=J. Biol. Chem. |volume=262 |issue= 30 |pages= 14600–5 |year= 1987 |pmid= 3667593 |doi=  }}
*{{cite journal  | author=Blank KJ, McKernan LN, Murasko DM |title=Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation. |journal=J. Interferon Res. |volume=5 |issue= 1 |pages= 215-21 |year= 1985 |pmid= 3872918 |doi=  }}
*{{cite journal  |vauthors=Blank KJ, McKernan LN, Murasko DM |title=Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation |journal=J. Interferon Res. |volume=5 |issue= 1 |pages= 215–21 |year= 1985 |pmid= 3872918 |doi=  10.1089/jir.1985.5.215}}
*{{cite journal | author=Derynck R, Content J, DeClercq E, ''et al.'' |title=Isolation and structure of a human fibroblast interferon gene. |journal=Nature |volume=285 |issue= 5766 |pages= 542-7 |year= 1980 |pmid= 6157094 |doi=  }}
*{{cite journal   |vauthors=Derynck R, Content J, DeClercq E, etal |title=Isolation and structure of a human fibroblast interferon gene |journal=Nature |volume=285 |issue= 5766 |pages= 542–7 |year= 1980 |pmid= 6157094 |doi=10.1038/285542a0 }}
*{{cite journal  | author=Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M |title=The nucleotide sequence of human fibroblast interferon cDNA. |journal=Gene |volume=10 |issue= 1 |pages= 11-5 |year= 1980 |pmid= 6157601 |doi=  }}
*{{cite journal  |vauthors=Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M |title=The nucleotide sequence of human fibroblast interferon cDNA |journal=Gene |volume=10 |issue= 1 |pages= 11–5 |year= 1980 |pmid= 6157601 |doi=10.1016/0378-1119(80)90138-9 }}
*{{cite journal | author=Houghton M, Easton MA, Stewart AG, ''et al.'' |title=The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase. |journal=Nucleic Acids Res. |volume=8 |issue= 13 |pages= 2885-94 |year= 1981 |pmid= 6159580 |doi=  }}
*{{cite journal   |vauthors=Houghton M, Easton MA, Stewart AG, etal |title=The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase |journal=Nucleic Acids Res. |volume=8 |issue= 13 |pages= 2885–94 |year= 1981 |pmid= 6159580 |doi=10.1093/nar/8.13.2885  | pmc=324132 }}
*{{cite journal | author=Goeddel DV, Shepard HM, Yelverton E, ''et al.'' |title=Synthesis of human fibroblast interferon by E. coli. |journal=Nucleic Acids Res. |volume=8 |issue= 18 |pages= 4057-74 |year= 1981 |pmid= 6159584 |doi= }}
*{{cite journal   |vauthors=Goeddel DV, Shepard HM, Yelverton E, etal |title=Synthesis of human fibroblast interferon by E. coli |journal=Nucleic Acids Res. |volume=8 |issue= 18 |pages= 4057–74 |year= 1981 |pmid= 6159584 |doi=10.1093/nar/8.18.4057  | pmc=324219  }}
*{{cite journal | author=Houghton M, Stewart AG, Doel SM, ''et al.'' |title=The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers. |journal=Nucleic Acids Res. |volume=8 |issue= 9 |pages= 1913-31 |year= 1981 |pmid= 6159597 |doi= }}
*{{cite journal   |vauthors=Houghton M, Stewart AG, Doel SM, etal |title=The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers |journal=Nucleic Acids Res. |volume=8 |issue= 9 |pages= 1913–31 |year= 1981 |pmid= 6159597 |doi=10.1093/nar/8.9.1913  | pmc=324047  }}
*{{cite journal  | author=Wetzel R |title=Assignment of the disulphide bonds of leukocyte interferon. |journal=Nature |volume=289 |issue= 5798 |pages= 606-7 |year= 1981 |pmid= 6162107 |doi=  }}
*{{cite journal  | author=Wetzel R |title=Assignment of the disulphide bonds of leukocyte interferon |journal=Nature |volume=289 |issue= 5798 |pages= 606–7 |year= 1981 |pmid= 6162107 |doi=10.1038/289606a0 }}
*{{cite journal | author=Lawn RM, Adelman J, Franke AE, ''et al.'' |title=Human fibroblast interferon gene lacks introns. |journal=Nucleic Acids Res. |volume=9 |issue= 5 |pages= 1045-52 |year= 1981 |pmid= 6164984 |doi= }}
*{{cite journal   |vauthors=Lawn RM, Adelman J, Franke AE, etal |title=Human fibroblast interferon gene lacks introns |journal=Nucleic Acids Res. |volume=9 |issue= 5 |pages= 1045–52 |year= 1981 |pmid= 6164984 |doi=10.1093/nar/9.5.1045  | pmc=326735  }}
*{{cite journal  | author=Shepard HM, Leung D, Stebbing N, Goeddel DV |title=A single amino acid change in IFN-beta1 abolishes its antiviral activity. |journal=Nature |volume=294 |issue= 5841 |pages= 563-5 |year= 1982 |pmid= 6171735 |doi=  }}
*{{cite journal  |vauthors=Shepard HM, Leung D, Stebbing N, Goeddel DV |title=A single amino acid change in IFN-beta1 abolishes its antiviral activity |journal=Nature |volume=294 |issue= 5841 |pages= 563–5 |year= 1982 |pmid= 6171735 |doi=10.1038/294563a0 }}
*{{cite journal | author=Content J, De Wit L, Pierard D, ''et al.'' |title=Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=79 |issue= 9 |pages= 2768-72 |year= 1982 |pmid= 6178110 |doi=  }}
*{{cite journal   |vauthors=Content J, De Wit L, Pierard D, etal |title=Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=79 |issue= 9 |pages= 2768–72 |year= 1982 |pmid= 6178110 |doi=10.1073/pnas.79.9.2768  | pmc=346287 }}
*{{cite journal | author=Fiers W, Remaut E, Devos R, ''et al.'' |title=The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=299 |issue= 1094 |pages= 29-38 |year= 1983 |pmid= 6183692 |doi=  }}
*{{cite journal   |vauthors=Fiers W, Remaut E, Devos R, etal |title=The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells |journal=Philos. Trans. R. Soc. Lond. B Biol. Sci. |volume=299 |issue= 1094 |pages= 29–38 |year= 1983 |pmid= 6183692 |doi= 10.1098/rstb.1982.0103 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 07:34, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Interferon beta is a protein that in humans is encoded by the IFNB1 gene.[1] The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.[2]

Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.

References

  1. ↑ "Entrez Gene: IFNB1 interferon, beta 1, fibroblast".
  2. ↑ "IFNB1 recombinant protein".

{shfhfekg1215｝

Further reading

{jenfjw}



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