P2RX6: Difference between revisions

VALUE_ERROR (nil)
Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

VisualWikitext

Latest revision as of 17:25, 7 September 2017

P2X purinoceptor 6 is a protein that in humans is encoded by the P2RX6 gene.^[1]^[2]^[3]^[4]

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.^[4]

References

↑ Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T (Sep 1997). "Cloning of P2XM, a novel human P2X receptor gene regulated by p53". Cancer Res. 57 (15): 3281–7. PMID 9242461.
↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
↑ Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G (Sep 1996). "Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels". J Neurosci. 16 (8): 2495–507. PMID 8786426.
↑ ^4.0 ^4.1 "Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor".

Khakh BS, Burnstock G, Kennedy C, et al. (2001). "International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits". Pharmacol. Rev. 53 (1): 107–18. PMID 11171941.
Soto F, Garcia-Guzman M, Karschin C, Stühmer W (1996). "Cloning and tissue distribution of a novel P2X receptor from rat brain". Biochem. Biophys. Res. Commun. 223 (2): 456–60. doi:10.1006/bbrc.1996.0915. PMID 8670303.
Glass R, Loesch A, Bodin P, Burnstock G (2002). "P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells". Cell. Mol. Life Sci. 59 (5): 870–81. doi:10.1007/s00018-002-8474-y. PMID 12088286.
Maguire PB, Wynne KJ, Harney DF, et al. (2003). "Identification of the phosphotyrosine proteome from thrombin activated platelets". Proteomics. 2 (6): 642–8. doi:10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I. PMID 12112843.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Barrera NP, Ormond SJ, Henderson RM, et al. (2005). "Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize". J. Biol. Chem. 280 (11): 10759–65. doi:10.1074/jbc.M412265200. PMID 15657042.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

P2RXL1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[pmid9242461-1] Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T (Sep 1997). "Cloning of P2XM, a novel human P2X receptor gene regulated by p53". Cancer Res. 57 (15): 3281–7. PMID 9242461.

[pmid10591208-2] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.

[pmid8786426-3] Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G (Sep 1996). "Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels". J Neurosci. 16 (8): 2495–507. PMID 8786426.

[entrez-4] 4.0 ^4.1 "Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor".

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''P2X purinoceptor 6''' is a [[protein]] that in humans is encoded by the ''P2RX6'' [[gene]].<ref name="pmid9242461">{{cite journal | vauthors = Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T | title = Cloning of P2XM, a novel human P2X receptor gene regulated by p53 | journal = Cancer Res | volume = 57 | issue = 15 | pages = 3281–7 |date=Sep 1997 | pmid = 9242461 | pmc =  | doi =  }}</ref><ref name="pmid10591208">{{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP| title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 |date=Dec 1999 | pmid = 10591208 | pmc =  | doi = 10.1038/990031 |display-authors=etal}}</ref><ref name="pmid8786426">{{cite journal | vauthors = Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G | title = Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels | journal = J Neurosci | volume = 16 | issue = 8 | pages = 2495–507 |date=Sep 1996 | pmid = 8786426 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9127| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Purinergic receptor P2X, ligand-gated ion channel, 3
- | HGNCid = 8534
- | Symbol = P2RX3
- | AltSymbols =; MGC129956; P2X3
- | OMIM = 600843
- | ECnumber =
- | Homologene = 1922
-  | MGIid = 1097160
-  | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004931 |text = ATP-gated cation channel activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
- | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
-  | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 5024
-    | Hs_Ensembl =
-    | Hs_RefseqProtein = XP_001126192
-    | Hs_RefseqmRNA = XM_001126192
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr =
-    | Hs_GenLoc_start =
-    | Hs_GenLoc_end =
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 228139
-    | Mm_Ensembl = ENSMUSG00000027071
-    | Mm_RefseqmRNA = NM_145526
-    | Mm_RefseqProtein = NP_663501
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 2
-    | Mm_GenLoc_start = 84797391
-    | Mm_GenLoc_end = 84836673
-    | Mm_Uniprot = Q3UR32
-  }}
-}}
-{{CMG}}
-'''Purinergic receptor P2X, ligand-gated ion channel, 3''', also known as '''P2RX3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5024| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.<ref name="entrez">{{cite web | title = Entrez Gene: P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5024| accessdate = }}</ref>
+| summary_text = The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.<ref name="entrez">{{cite web | title = Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9127| accessdate = }}</ref>
 }}
@@ Line 62: / Line 12: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 68: / Line 18: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=North RA |title=Molecular physiology of P2X receptors. |journal=Physiol. Rev. |volume=82 |issue= 4 |pages= 1013-67 |year= 2002 |pmid= 12270951 |doi= 10.1152/physrev.00015.2002 }}
+*{{cite journal   |vauthors=Khakh BS, Burnstock G, Kennedy C, etal |title=International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. |journal=Pharmacol. Rev. |volume=53 |issue= 1 |pages= 107–18 |year= 2001 |pmid= 11171941 |doi=  }}
-*{{cite journal  | author=Jarvis MF |title=Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain. |journal=Expert Opin. Ther. Targets |volume=7 |issue= 4 |pages= 513-22 |year= 2005 |pmid= 12885270 |doi= 10.1517/14728222.7.4.513 }}
+*{{cite journal  | vauthors=Soto F, Garcia-Guzman M, Karschin C, Stühmer W |title=Cloning and tissue distribution of a novel P2X receptor from rat brain. |journal=Biochem. Biophys. Res. Commun. |volume=223 |issue= 2 |pages= 456–60 |year= 1996 |pmid= 8670303 |doi= 10.1006/bbrc.1996.0915 }}
-*{{cite journal  | author=Kennedy C, Leff P |title=Painful connection for ATP. |journal=Nature |volume=377 |issue= 6548 |pages= 385-6 |year= 1995 |pmid= 7566110 |doi= 10.1038/377385a0 }}
+*{{cite journal  | vauthors=Glass R, Loesch A, Bodin P, Burnstock G |title=P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells. |journal=Cell. Mol. Life Sci. |volume=59 |issue= 5 |pages= 870–81 |year= 2002 |pmid= 12088286 |doi=10.1007/s00018-002-8474-y  }}
-*{{cite journal  | author=Lewis C, Neidhart S, Holy C, ''et al.'' |title=Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. |journal=Nature |volume=377 |issue= 6548 |pages= 432-5 |year= 1995 |pmid= 7566120 |doi= 10.1038/377432a0 }}
+*{{cite journal   |vauthors=Maguire PB, Wynne KJ, Harney DF, etal |title=Identification of the phosphotyrosine proteome from thrombin activated platelets. |journal=Proteomics |volume=2 |issue= 6 |pages= 642–8 |year= 2003 |pmid= 12112843 |doi= 10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I }}
-*{{cite journal  | author=Garcia-Guzman M, Soto F, Gomez-Hernandez JM, ''et al.'' |title=Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. |journal=Mol. Pharmacol. |volume=51 |issue= 1 |pages= 109-18 |year= 1997 |pmid= 9016352 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Garcia-Guzman M, Stühmer W, Soto F |title=Molecular characterization and pharmacological properties of the human P2X3 purinoceptor. |journal=Brain Res. Mol. Brain Res. |volume=47 |issue= 1-2 |pages= 59-66 |year= 1997 |pmid= 9221902 |doi=  }}
+*{{cite journal   |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84  | pmc=545604 }}
-*{{cite journal  | author=Cook SP, McCleskey EW |title=ATP, pain and a full bladder. |journal=Nature |volume=407 |issue= 6807 |pages= 951-2 |year= 2000 |pmid= 11069162 |doi= 10.1038/35039648 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Barrera NP, Ormond SJ, Henderson RM, etal |title=Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize. |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10759–65 |year= 2005 |pmid= 15657042 |doi= 10.1074/jbc.M412265200 }}
-*{{cite journal  | author=Renton T, Yiangou Y, Baecker PA, ''et al.'' |title=Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp. |journal=Journal of orofacial pain |volume=17 |issue= 3 |pages= 245-50 |year= 2003 |pmid= 14520770 |doi=  }}
+*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
-*{{cite journal  | author=Mason HS, Bourke S, Kemp PJ |title=Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species. |journal=Mol. Pharmacol. |volume=66 |issue= 6 |pages= 1525-35 |year= 2005 |pmid= 15331767 |doi= 10.1124/mol.104.000851 }}
-*{{cite journal  | author=Fabbretti E, Sokolova E, Masten L, ''et al.'' |title=Identification of negative residues in the P2X3 ATP receptor ectodomain as structural determinants for desensitization and the Ca2+-sensing modulatory sites. |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53109-15 |year= 2005 |pmid= 15475563 |doi= 10.1074/jbc.M409772200 }}
-*{{cite journal  | author=Brown DA, Yule DI |title=Protein kinase C regulation of P2X3 receptors is unlikely to involve direct receptor phosphorylation. |journal=Biochim. Biophys. Acta |volume=1773 |issue= 2 |pages= 166-75 |year= 2007 |pmid= 17052768 |doi= 10.1016/j.bbamcr.2006.09.020 }}
 }}
 {{refend}}
 == External links ==
-* {{MeshName|P2RX3+protein,+human}}
+* {{MeshName|P2RXL1+protein,+human}}
 {{NLM content}}
 {{Ligand-gated ion channels}}
+{{Purinergics}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
 [[Category:Ion channels]]
-{{WH}}
-{{WS}}
+{{membrane-protein-stub}}

P2RX6: Difference between revisions

Latest revision as of 17:25, 7 September 2017

Contents

See also

References

Further reading

External links

Navigation menu