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{{Infobox_gene}}
{{PBB_Controls
'''Nuclear inhibitor of protein phosphatase 1''' is an [[enzyme]] that in humans is encoded by the ''PPP1R8'' [[gene]].<ref name="pmid7524097">{{cite journal |vauthors=Wang M, Cohen SN | title = ard-1: a human gene that reverses the effects of temperature-sensitive and deletion mutations in the Escherichia coli rne gene and encodes an activity producing RNase E-like cleavages | journal = Proc Natl Acad Sci USA | volume = 91 | issue = 22 | pages = 10591–5 |date=November 1994 | pmid = 7524097 | pmc = 45067 | doi =10.1073/pnas.91.22.10591  | bibcode =1994PNAS...9110591W }}</ref><ref name="pmid8473324">{{cite journal |vauthors=Mishima K, Tsuchiya M, Nightingale MS, Moss J, Vaughan M | title = ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain | journal = J Biol Chem | volume = 268 | issue = 12 | pages = 8801–7 |date=May 1993 | pmid = 8473324 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPP1R8 protein phosphatase 1, regulatory (inhibitor) subunit 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5511| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PPP1R8_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2jpe.
| PDB = {{PDB2|2jpe}}
| Name = Protein phosphatase 1, regulatory (inhibitor) subunit 8
| HGNCid = 9296
| Symbol = PPP1R8
| AltSymbols =; ARD1; ARD-1; NIPP-1; NIPP1; PRO2047
| OMIM = 602636
| ECnumber =
| Homologene = 8555
| MGIid = 2140494
| GeneAtlas_image1 = PBB_GE_PPP1R8_207830_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0004865 |text = type 1 serine/threonine specific protein phosphatase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008599 |text = protein phosphatase type 1 regulator activity}} {{GNF_GO|id=GO:0008995 |text = ribonuclease E activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0006401 |text = RNA catabolic process}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5511
    | Hs_Ensembl = ENSG00000117751
    | Hs_RefseqProtein = NP_002704
    | Hs_RefseqmRNA = NM_002713
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 28029876
    | Hs_GenLoc_end = 28050774
    | Hs_Uniprot = Q12972
    | Mm_EntrezGene = 100336
    | Mm_Ensembl = ENSMUSG00000028882
    | Mm_RefseqmRNA = NM_146154
    | Mm_RefseqProtein = NP_666266
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 132099005
    | Mm_GenLoc_end = 132115196
    | Mm_Uniprot = Q8R3G1
  }}
}}
'''Protein phosphatase 1, regulatory (inhibitor) subunit 8''', also known as '''PPP1R8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R8 protein phosphatase 1, regulatory (inhibitor) subunit 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5511| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R8 protein phosphatase 1, regulatory (inhibitor) subunit 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5511| accessdate = }}</ref>
| summary_text = This gene, through alternative splicing, encodes three different [[isoforms]]. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.<ref name="entrez" />
}}
}}
==Interactions==
PPP1R8 has been shown to [[Protein-protein interaction|interact]] with [[PPP1CA]],<ref name=pmid12788942>{{cite journal |last=Jin |first=Qiming |authorlink= |author2=van Eynde Aleyde |author3=Beullens Monique |author4=Roy Nivedita |author5=Thiel Gerald |author6=Stalmans Willy |author7=Bollen Mathieu  |date=August 2003  |title=The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor |journal=J. Biol. Chem. |volume=278 |issue=33 |pages=30677–85 |publisher= |location = United States| issn = 0021-9258| pmid = 12788942 |doi = 10.1074/jbc.M302273200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10637318>{{cite journal |doi=10.1093/nar/28.3.678 |last=Ajuh |first=P M |authorlink= |author2=Browne G J |author3=Hawkes N A |author4=Cohen P T |author5=Roberts S G |author6=Lamond A I  |date=February 2000  |title=Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex |journal=Nucleic Acids Res. |volume=28 |issue=3 |pages=678–86 |publisher= |location = ENGLAND| issn = | pmid = 10637318 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=102561 }}</ref> [[Histone deacetylase 2]],<ref name=pmid12788942/> [[SF3B1]]<ref name=pmid12105215>{{cite journal |last=Boudrez |first=An |authorlink= |author2=Beullens Monique |author3=Waelkens Etienne |author4=Stalmans Willy |author5=Bollen Mathieu  |date=August 2002  |title=Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1 |journal=J. Biol. Chem. |volume=277 |issue=35 |pages=31834–41 |publisher= |location = United States| issn = 0021-9258| pmid = 12105215 |doi = 10.1074/jbc.M204427200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[EED (protein)|EED]] <ref name=pmid12788942/> and the EZH2 domain of [[PRC2]].<ref name="pmid30305391">{{cite journal |vauthors=Ferreira M, Verbinnen I, Fardilha M, Van Eynde A, Bollen M |title=The deletion of the protein phosphatase 1 regulator NIPP1 in testis causes hyperphosphorylation and degradation of the histone methyltransferase EZH2 |journal=J. Biol. Chem. |volume=293 |issue=47 |pages=18031–18039 |date=November 2018 |pmid=30305391 |doi=10.1074/jbc.AC118.005577 |url=}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Van Eynde A, Wera S, Beullens M, ''et al.'' |title=Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing. |journal=J. Biol. Chem. |volume=270 |issue= 47 |pages= 28068-74 |year= 1996 |pmid= 7499293 |doi=  }}
*{{cite journal   |vauthors=Van Eynde A, Wera S, Beullens M, etal |title=Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing. |journal=J. Biol. Chem. |volume=270 |issue= 47 |pages= 28068–74 |year= 1996 |pmid= 7499293 |doi=10.1074/jbc.270.47.28068 }}
*{{cite journal  | author=Wang M, Cohen SN |title=ard-1: a human gene that reverses the effects of temperature-sensitive and deletion mutations in the Escherichia coli rne gene and encodes an activity producing RNase E-like cleavages. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 22 |pages= 10591-5 |year= 1994 |pmid= 7524097 |doi=  }}
*{{cite journal  |vauthors=Claverie-Martin F, Wang M, Cohen SN |title=ARD-1 cDNA from human cells encodes a site-specific single-strand endoribonuclease that functionally resembles Escherichia coli RNase E. |journal=J. Biol. Chem. |volume=272 |issue= 21 |pages= 13823–8 |year= 1997 |pmid= 9153239 |doi=10.1074/jbc.272.21.13823 }}
*{{cite journal | author=Mishima K, Tsuchiya M, Nightingale MS, ''et al.'' |title=ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain. |journal=J. Biol. Chem. |volume=268 |issue= 12 |pages= 8801-7 |year= 1993 |pmid= 8473324 |doi=  }}
*{{cite journal   |vauthors=Vulsteke V, Beullens M, Waelkens E, etal |title=Properties and phosphorylation sites of baculovirus-expressed nuclear inhibitor of protein phosphatase-1 (NIPP-1). |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 32972–8 |year= 1998 |pmid= 9407077 |doi=10.1074/jbc.272.52.32972 }}
*{{cite journal | author=Claverie-Martin F, Wang M, Cohen SN |title=ARD-1 cDNA from human cells encodes a site-specific single-strand endoribonuclease that functionally resembles Escherichia coli RNase E. |journal=J. Biol. Chem. |volume=272 |issue= 21 |pages= 13823-8 |year= 1997 |pmid= 9153239 |doi=  }}
*{{cite journal   |vauthors=Van Eynde A, Pérez-Callejón E, Schoenmakers E, etal |title=Organization and alternate splice products of the gene encoding nuclear inhibitor of protein phosphatase-1 (NIPP-1). |journal=Eur. J. Biochem. |volume=261 |issue= 1 |pages= 291–300 |year= 1999 |pmid= 10103062 |doi=10.1046/j.1432-1327.1999.00272.x }}
*{{cite journal | author=Vulsteke V, Beullens M, Waelkens E, ''et al.'' |title=Properties and phosphorylation sites of baculovirus-expressed nuclear inhibitor of protein phosphatase-1 (NIPP-1). |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 32972-8 |year= 1998 |pmid= 9407077 |doi=  }}
*{{cite journal   |vauthors=Jin Q, Beullens M, Jagiello I, etal |title=Mapping of the RNA-binding and endoribonuclease domains of NIPP1, a nuclear targeting subunit of protein phosphatase 1. | series=342 |journal=Biochem. J. |volume=( Pt 1) |issue= 1|pages= 13–9 |year= 1999 |pmid= 10432294 |doi=10.1042/0264-6021:3420013  | pmc=1220430 }}
*{{cite journal | author=Van Eynde A, Pérez-Callejón E, Schoenmakers E, ''et al.'' |title=Organization and alternate splice products of the gene encoding nuclear inhibitor of protein phosphatase-1 (NIPP-1). |journal=Eur. J. Biochem. |volume=261 |issue= 1 |pages= 291-300 |year= 1999 |pmid= 10103062 |doi=  }}
*{{cite journal   |vauthors=Chang AC, Sohlberg B, Trinkle-Mulcahy L, etal |title=Alternative splicing regulates the production of ARD-1 endoribonuclease and NIPP-1, an inhibitor of protein phosphatase-1, as isoforms encoded by the same gene. |journal=Gene |volume=240 |issue= 1 |pages= 45–55 |year= 2000 |pmid= 10564811 |doi=10.1016/S0378-1119(99)00435-7 }}
*{{cite journal | author=Jin Q, Beullens M, Jagiello I, ''et al.'' |title=Mapping of the RNA-binding and endoribonuclease domains of NIPP1, a nuclear targeting subunit of protein phosphatase 1. |journal=Biochem. J. |volume=342 ( Pt 1) |issue= |pages= 13-9 |year= 1999 |pmid= 10432294 |doi= }}
*{{cite journal   |vauthors=Boudrez A, Beullens M, Groenen P, etal |title=NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25411–7 |year= 2000 |pmid= 10827081 |doi= 10.1074/jbc.M001676200 }}
*{{cite journal | author=Chang AC, Sohlberg B, Trinkle-Mulcahy L, ''et al.'' |title=Alternative splicing regulates the production of ARD-1 endoribonuclease and NIPP-1, an inhibitor of protein phosphatase-1, as isoforms encoded by the same gene. |journal=Gene |volume=240 |issue= 1 |pages= 45-55 |year= 2000 |pmid= 10564811 |doi=  }}
*{{cite journal   |vauthors=Jagiello I, Van Eynde A, Vulsteke V, etal |title=Nuclear and subnuclear targeting sequences of the protein phosphatase-1 regulator NIPP1. | series=113 |journal=J. Cell Sci. |volume=Pt 21 |issue= |pages= 3761–8 |year= 2001 |pmid= 11034904 |doi=  }}
*{{cite journal | author=Boudrez A, Beullens M, Groenen P, ''et al.'' |title=NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25411-7 |year= 2000 |pmid= 10827081 |doi= 10.1074/jbc.M001676200 }}
*{{cite journal   |vauthors=Beullens M, Vulsteke V, Van Eynde A, etal |title=The C-terminus of NIPP1 (nuclear inhibitor of protein phosphatase-1) contains a novel binding site for protein phosphatase-1 that is controlled by tyrosine phosphorylation and RNA binding. | series=352 |journal=Biochem. J. |volume=Pt 3 |issue= |pages= 651–8 |year= 2001 |pmid= 11104670 |doi= | pmc=1221501  }}
*{{cite journal  | author=Jagiello I, Van Eynde A, Vulsteke V, ''et al.'' |title=Nuclear and subnuclear targeting sequences of the protein phosphatase-1 regulator NIPP1. |journal=J. Cell. Sci. |volume=113 Pt 21 |issue= |pages= 3761-8 |year= 2001 |pmid= 11034904 |doi=  }}
*{{cite journal  |vauthors=Trinkle-Mulcahy L, Sleeman JE, Lamond AI |title=Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells. |journal=J. Cell Sci. |volume=114 |issue= Pt 23 |pages= 4219–28 |year= 2002 |pmid= 11739654 |doi=  }}
*{{cite journal  | author=Beullens M, Vulsteke V, Van Eynde A, ''et al.'' |title=The C-terminus of NIPP1 (nuclear inhibitor of protein phosphatase-1) contains a novel binding site for protein phosphatase-1 that is controlled by tyrosine phosphorylation and RNA binding. |journal=Biochem. J. |volume=352 Pt 3 |issue= |pages= 651-8 |year= 2001 |pmid= 11104670 |doi= }}
*{{cite journal  |vauthors=Beullens M, Bollen M |title=The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19855–60 |year= 2002 |pmid= 11909864 |doi= 10.1074/jbc.M200847200 }}
*{{cite journal | author=Trinkle-Mulcahy L, Sleeman JE, Lamond AI |title=Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4219-28 |year= 2002 |pmid= 11739654 |doi= }}
*{{cite journal   |vauthors=Boudrez A, Beullens M, Waelkens E, etal |title=Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31834–41 |year= 2002 |pmid= 12105215 |doi= 10.1074/jbc.M204427200 }}
*{{cite journal | author=Beullens M, Bollen M |title=The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19855-60 |year= 2002 |pmid= 11909864 |doi= 10.1074/jbc.M200847200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Boudrez A, Beullens M, Waelkens E, ''et al.'' |title=Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31834-41 |year= 2002 |pmid= 12105215 |doi= 10.1074/jbc.M204427200 }}
*{{cite journal   |vauthors=Ammosova T, Jerebtsova M, Beullens M, etal |title=Nuclear protein phosphatase-1 regulates HIV-1 transcription. |journal=J. Biol. Chem. |volume=278 |issue= 34 |pages= 32189–94 |year= 2003 |pmid= 12788939 |doi= 10.1074/jbc.M300521200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Jin Q, van Eynde A, Beullens M, etal |title=The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor. |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 30677–85 |year= 2003 |pmid= 12788942 |doi= 10.1074/jbc.M302273200 }}
*{{cite journal | author=Ammosova T, Jerebtsova M, Beullens M, ''et al.'' |title=Nuclear protein phosphatase-1 regulates HIV-1 transcription. |journal=J. Biol. Chem. |volume=278 |issue= 34 |pages= 32189-94 |year= 2003 |pmid= 12788939 |doi= 10.1074/jbc.M300521200 }}
*{{cite journal   |vauthors=Vulsteke V, Beullens M, Boudrez A, etal |title=Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1. |journal=J. Biol. Chem. |volume=279 |issue= 10 |pages= 8642–7 |year= 2004 |pmid= 14699119 |doi= 10.1074/jbc.M311466200 }}
*{{cite journal | author=Jin Q, van Eynde A, Beullens M, ''et al.'' |title=The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor. |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 30677-85 |year= 2003 |pmid= 12788942 |doi= 10.1074/jbc.M302273200 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104  | pmc=442148 }}
*{{cite journal | author=Vulsteke V, Beullens M, Boudrez A, ''et al.'' |title=Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1. |journal=J. Biol. Chem. |volume=279 |issue= 10 |pages= 8642-7 |year= 2004 |pmid= 14699119 |doi= 10.1074/jbc.M311466200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=5511}}
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Latest revision as of 00:44, 6 December 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene.[1][2][3]

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.[3]

Interactions

PPP1R8 has been shown to interact with PPP1CA,[4][5] Histone deacetylase 2,[4] SF3B1[6] EED [4] and the EZH2 domain of PRC2.[7]

References

  1. ↑ Wang M, Cohen SN (November 1994). "ard-1: a human gene that reverses the effects of temperature-sensitive and deletion mutations in the Escherichia coli rne gene and encodes an activity producing RNase E-like cleavages". Proc Natl Acad Sci USA. 91 (22): 10591–5. Bibcode:1994PNAS...9110591W. doi:10.1073/pnas.91.22.10591. PMC 45067. PMID 7524097.
  2. ↑ Mishima K, Tsuchiya M, Nightingale MS, Moss J, Vaughan M (May 1993). "ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain". J Biol Chem. 268 (12): 8801–7. PMID 8473324.
  3. ↑ 3.0 3.1 "Entrez Gene: PPP1R8 protein phosphatase 1, regulatory (inhibitor) subunit 8".
  4. ↑ 4.0 4.1 4.2 Jin, Qiming; van Eynde Aleyde; Beullens Monique; Roy Nivedita; Thiel Gerald; Stalmans Willy; Bollen Mathieu (August 2003). "The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor". J. Biol. Chem. United States. 278 (33): 30677–85. doi:10.1074/jbc.M302273200. ISSN 0021-9258. PMID 12788942.
  5. ↑ Ajuh, P M; Browne G J; Hawkes N A; Cohen P T; Roberts S G; Lamond A I (February 2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex". Nucleic Acids Res. ENGLAND. 28 (3): 678–86. doi:10.1093/nar/28.3.678. PMC 102561. PMID 10637318.
  6. ↑ Boudrez, An; Beullens Monique; Waelkens Etienne; Stalmans Willy; Bollen Mathieu (August 2002). "Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1". J. Biol. Chem. United States. 277 (35): 31834–41. doi:10.1074/jbc.M204427200. ISSN 0021-9258. PMID 12105215.
  7. ↑ Ferreira M, Verbinnen I, Fardilha M, Van Eynde A, Bollen M (November 2018). "The deletion of the protein phosphatase 1 regulator NIPP1 in testis causes hyperphosphorylation and degradation of the histone methyltransferase EZH2". J. Biol. Chem. 293 (47): 18031–18039. doi:10.1074/jbc.AC118.005577. PMID 30305391.

Further reading



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