SERPINB3: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
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'''Serpin B3''' is a [[protein]] that in humans is encoded by the ''SERPINB3'' [[gene]].<ref name="pmid7724531">{{cite journal |vauthors=Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA | title = A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene | journal = Proc Natl Acad Sci U S A | volume = 92 | issue = 8 | pages = 3147–51 |date=May 1995 | pmid = 7724531 | pmc = 42122 | doi =10.1073/pnas.92.8.3147 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6317| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Serpin peptidase inhibitor, clade B (ovalbumin), member 3
| HGNCid = 10569
| Symbol = SERPINB3
| AltSymbols =; HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1; T4-A
| OMIM = 600517
| ECnumber =
| Homologene = 74584
| MGIid = 2683295
| GeneAtlas_image1 = PBB_GE_SERPINB3_209720_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SERPINB3_209719_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_SERPINB3_210413_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}}
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6317
    | Hs_Ensembl = ENSG00000206073
    | Hs_RefseqProtein = NP_008850
    | Hs_RefseqmRNA = NM_006919
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 59473412
    | Hs_GenLoc_end = 59480107
    | Hs_Uniprot = P29508
    | Mm_EntrezGene = 394252
    | Mm_Ensembl = ENSMUSG00000058017
    | Mm_RefseqmRNA = NM_201376
    | Mm_RefseqProtein = NP_958764
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 108905740
    | Mm_GenLoc_end = 108911027
    | Mm_Uniprot = 
  }}
}}
'''Serpin peptidase inhibitor, clade B (ovalbumin), member 3''', also known as '''SERPINB3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6317| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
 
| citations =
*{{cite journal  |vauthors=Suminami Y, Kishi F, Sekiguchi K, Kato H |title=Squamous cell carcinoma antigen is a new member of the serine protease inhibitors. |journal=Biochem. Biophys. Res. Commun. |volume=181 |issue= 1 |pages= 51–8 |year= 1992 |pmid= 1958219 |doi=10.1016/S0006-291X(05)81380-4 }}
*{{cite journal  | author=Suminami Y, Kishi F, Sekiguchi K, Kato H |title=Squamous cell carcinoma antigen is a new member of the serine protease inhibitors. |journal=Biochem. Biophys. Res. Commun. |volume=181 |issue= 1 |pages= 51-8 |year= 1992 |pmid= 1958219 |doi=  }}
*{{cite journal  |vauthors=Mino-Miyagawa N, Kimura Y, Hamamoto K |title=Tumor-antigen 4. Its immunohistochemical distribution and tissue and serum concentrations in squamous cell carcinoma of the lung and esophagus. |journal=Cancer |volume=66 |issue= 7 |pages= 1505–12 |year= 1990 |pmid= 2208001 |doi=10.1002/1097-0142(19901001)66:7<1505::AID-CNCR2820660712>3.0.CO;2-V  }}
*{{cite journal  | author=Mino-Miyagawa N, Kimura Y, Hamamoto K |title=Tumor-antigen 4. Its immunohistochemical distribution and tissue and serum concentrations in squamous cell carcinoma of the lung and esophagus. |journal=Cancer |volume=66 |issue= 7 |pages= 1505-12 |year= 1990 |pmid= 2208001 |doi= }}
*{{cite journal  |vauthors=Mino N, Iio A, Hamamoto K |title=Availability of tumor-antigen 4 as a marker of squamous cell carcinoma of the lung and other organs. |journal=Cancer |volume=62 |issue= 4 |pages= 730–4 |year= 1988 |pmid= 2840187 |doi=10.1002/1097-0142(19880815)62:4<730::AID-CNCR2820620415>3.0.CO;2-W  }}
*{{cite journal  | author=Mino N, Iio A, Hamamoto K |title=Availability of tumor-antigen 4 as a marker of squamous cell carcinoma of the lung and other organs. |journal=Cancer |volume=62 |issue= 4 |pages= 730-4 |year= 1988 |pmid= 2840187 |doi= }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Schneider SS, Schick C, Fish KE, ''et al.'' |title=A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 8 |pages= 3147-51 |year= 1995 |pmid= 7724531 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal   |vauthors=Schick C, Pemberton PA, Shi GP, etal |title=Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis. |journal=Biochemistry |volume=37 |issue= 15 |pages= 5258–66 |year= 1998 |pmid= 9548757 |doi= 10.1021/bi972521d }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Cataltepe S, Gornstein ER, Schick C, etal |title=Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas. |journal=J. Histochem. Cytochem. |volume=48 |issue= 1 |pages= 113–22 |year= 2000 |pmid= 10653592 |doi= 10.1177/002215540004800112}}
*{{cite journal | author=Schick C, Pemberton PA, Shi GP, ''et al.'' |title=Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis. |journal=Biochemistry |volume=37 |issue= 15 |pages= 5258-66 |year= 1998 |pmid= 9548757 |doi= 10.1021/bi972521d }}
*{{cite journal   |vauthors=Uemura Y, Pak SC, Luke C, etal |title=Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. |journal=Int. J. Cancer |volume=89 |issue= 4 |pages= 368–77 |year= 2000 |pmid= 10956412 |doi=10.1002/1097-0215(20000720)89:4<368::AID-IJC9>3.0.CO;2-6 }}
*{{cite journal | author=Cataltepe S, Gornstein ER, Schick C, ''et al.'' |title=Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas. |journal=J. Histochem. Cytochem. |volume=48 |issue= 1 |pages= 113-22 |year= 2000 |pmid= 10653592 |doi=  }}
*{{cite journal   |vauthors=Hamada K, Shinomiya H, Asano Y, etal |title=Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter. |journal=Biochim. Biophys. Acta |volume=1518 |issue= 1-2 |pages= 124–31 |year= 2001 |pmid= 11267667 |doi=  10.1016/s0167-4781(01)00174-9}}
*{{cite journal | author=Uemura Y, Pak SC, Luke C, ''et al.'' |title=Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. |journal=Int. J. Cancer |volume=89 |issue= 4 |pages= 368-77 |year= 2000 |pmid= 10956412 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Hamada K, Shinomiya H, Asano Y, ''et al.'' |title=Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter. |journal=Biochim. Biophys. Acta |volume=1518 |issue= 1-2 |pages= 124-31 |year= 2001 |pmid= 11267667 |doi=  }}
*{{cite journal   |vauthors=Shimada H, Nabeya Y, Okazumi S, etal |title=Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma. |journal=Surgery |volume=133 |issue= 5 |pages= 486–94 |year= 2003 |pmid= 12773976 |doi= 10.1067/msy.2003.139 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Micke O, Bruns F, Schäfer U, etal |title=The clinical value of squamous cell carcinoma antigen in patients irradiated for locally advanced cancer of the head and neck. |journal=Anticancer Res. |volume=23 |issue= 2A |pages= 907–11 |year= 2003 |pmid= 12820321 |doi= }}
*{{cite journal | author=Shimada H, Nabeya Y, Okazumi S, ''et al.'' |title=Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma. |journal=Surgery |volume=133 |issue= 5 |pages= 486-94 |year= 2003 |pmid= 12773976 |doi= 10.1067/msy.2003.139 }}
*{{cite journal   |vauthors=Nawata S, Nakamura K, Hirakawa H, etal |title=Electrophoretic analysis of the cleaved form of serpin, squamous cell carcinoma antigen-1 in normal and malignant squamous epithelial tissues. |journal=Electrophoresis |volume=24 |issue= 14 |pages= 2277–82 |year= 2004 |pmid= 12874860 |doi= 10.1002/elps.200305501 }}
*{{cite journal | author=Micke O, Bruns F, Schäfer U, ''et al.'' |title=The clinical value of squamous cell carcinoma antigen in patients irradiated for locally advanced cancer of the head and neck. |journal=Anticancer Res. |volume=23 |issue= 2A |pages= 907-11 |year= 2003 |pmid= 12820321 |doi= }}
*{{cite journal   |vauthors=Masumoto K, Sakata Y, Arima K, etal |title=Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1. |journal=J. Biol. Chem. |volume=278 |issue= 46 |pages= 45296–304 |year= 2003 |pmid= 12949073 |doi= 10.1074/jbc.M307741200 }}
*{{cite journal | author=Nawata S, Nakamura K, Hirakawa H, ''et al.'' |title=Electrophoretic analysis of the cleaved form of serpin, squamous cell carcinoma antigen-1 in normal and malignant squamous epithelial tissues. |journal=Electrophoresis |volume=24 |issue= 14 |pages= 2277-82 |year= 2004 |pmid= 12874860 |doi= 10.1002/elps.200305501 }}
*{{cite journal  |vauthors=Moore PL, Ong S, Harrison TJ |title=Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 46709–17 |year= 2004 |pmid= 12975381 |doi= 10.1074/jbc.M302842200 }}
*{{cite journal  | author=Masumoto K, Sakata Y, Arima K, ''et al.'' |title=Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1. |journal=J. Biol. Chem. |volume=278 |issue= 46 |pages= 45296-304 |year= 2003 |pmid= 12949073 |doi= 10.1074/jbc.M307741200 }}
*{{cite journal   |vauthors=Onishi A, Nakashiro K, Mihara M, etal |title=Basic and clinical studies on quantitative analysis of lymph node micrometastasis in oral cancer. |journal=Oncol. Rep. |volume=11 |issue= 1 |pages= 33–9 |year= 2004 |pmid= 14654899 |doi= 10.3892/or.11.1.33}}
*{{cite journal | author=Moore PL, Ong S, Harrison TJ |title=Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 46709-17 |year= 2004 |pmid= 12975381 |doi= 10.1074/jbc.M302842200 }}
*{{cite journal   |vauthors=Hirakawa H, Nawata S, Sueoka K, etal |title=Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line. |journal=Oncol. Rep. |volume=11 |issue= 2 |pages= 415–9 |year= 2004 |pmid= 14719077 |doi=  10.3892/or.11.2.415}}
*{{cite journal | author=Onishi A, Nakashiro K, Mihara M, ''et al.'' |title=Basic and clinical studies on quantitative analysis of lymph node micrometastasis in oral cancer. |journal=Oncol. Rep. |volume=11 |issue= 1 |pages= 33-9 |year= 2004 |pmid= 14654899 |doi=  }}
*{{cite journal   |vauthors=Pontisso P, Calabrese F, Benvegnù L, etal |title=Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma. |journal=Br. J. Cancer |volume=90 |issue= 4 |pages= 833–7 |year= 2004 |pmid= 14970861 |doi= 10.1038/sj.bjc.6601543 | pmc=2410161 }}
*{{cite journal | author=Hirakawa H, Nawata S, Sueoka K, ''et al.'' |title=Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line. |journal=Oncol. Rep. |volume=11 |issue= 2 |pages= 415-9 |year= 2004 |pmid= 14719077 |doi=  }}
*{{cite journal   |vauthors=Ruvoletto MG, Tono N, Carollo D, etal |title=Surface expression of squamous cell carcinoma antigen (SCCA) can be increased by the preS1(21-47) sequence of hepatitis B virus. |journal=J. Gen. Virol. |volume=85 |issue= Pt 3 |pages= 621–4 |year= 2004 |pmid= 14993646 |doi=10.1099/vir.0.19130-0  }}
*{{cite journal | author=Pontisso P, Calabrese F, Benvegnù L, ''et al.'' |title=Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma. |journal=Br. J. Cancer |volume=90 |issue= 4 |pages= 833-7 |year= 2004 |pmid= 14970861 |doi= 10.1038/sj.bjc.6601543 }}
*{{cite journal | last1 = Turato | first1 = C | last2 = Ruvoletto | first2 = MG | last3 = Biasiolo | first3 = A | display-authors = etal  | date = Mar 2009 | title = Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver disease | url = | journal = Dig Liver Dis. | volume = 41 | issue = 3| pages = 212–6 | doi=10.1016/j.dld.2008.06.001}}
*{{cite journal | author=Ruvoletto MG, Tono N, Carollo D, ''et al.'' |title=Surface expression of squamous cell carcinoma antigen (SCCA) can be increased by the preS1(21-47) sequence of hepatitis B virus. |journal=J. Gen. Virol. |volume=85 |issue= Pt 3 |pages= 621-4 |year= 2004 |pmid= 14993646 |doi= }}
}}
{{refend}}


==External links==
==External links==
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=I04.008 I04.008]
* {{MeshName|SERPINB3+protein,+human}}
* {{MeshName|SERPINB3+protein,+human}}


{{protein-stub}}
{{Serpins}}
{{Serpins}}
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[[Category:Serine protease inhibitors]]
[[Category:Serine protease inhibitors]]
{{WikiDoc Sources}}
 
 
{{gene-18-stub}}

Latest revision as of 09:02, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serpin B3 is a protein that in humans is encoded by the SERPINB3 gene.[1][2]


See also

References

  1. ↑ Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA (May 1995). "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene". Proc Natl Acad Sci U S A. 92 (8): 3147–51. doi:10.1073/pnas.92.8.3147. PMC 42122. PMID 7724531.
  2. ↑ "Entrez Gene: SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3".

Further reading

External links


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