SERPINB4: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Serpin B4''' is a [[protein]] that in humans is encoded by the ''SERPINB4'' [[gene]].<ref name="pmid7724531">{{cite journal | vauthors = Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA | title = A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene | journal = Proc Natl Acad Sci U S A | volume = 92 | issue = 8 | pages = 3147–51 |date=May 1995 | pmid = 7724531 | pmc = 42122 | doi =10.1073/pnas.92.8.3147 }}</ref><ref name="pmid14630915">{{cite journal | vauthors = Sakata Y, Arima K, Takai T, Sakurai W, Masumoto K, Yuyama N, Suminami Y, Kishi F, Yamashita T, Kato T, Ogawa H, Fujimoto K, Matsuo Y, Sugita Y, Izuhara K | title = The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1 | journal = J Biol Chem | volume = 279 | issue = 7 | pages = 5081–7 |date=Feb 2004 | pmid = 14630915 | pmc =  | doi = 10.1074/jbc.M311585200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6318| accessdate = }}</ref>  
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Serpin peptidase inhibitor, clade B (ovalbumin), member 4
| HGNCid = 10570
| Symbol = SERPINB4
| AltSymbols =; SCCA1; LEUPIN; PI11; SCCA-2; SCCA2
| OMIM = 600518
| ECnumber =
| Homologene = 74456
| MGIid = 3573933
| GeneAtlas_image1 = PBB_GE_SERPINB4_209720_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SERPINB4_209719_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_SERPINB4_210413_x_at_tn.png
  | Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}}  
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0030162 |text = regulation of proteolysis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6318
    | Hs_Ensembl = ENSG00000057149
    | Hs_RefseqProtein = NP_002965
    | Hs_RefseqmRNA = NM_002974
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 59455474
    | Hs_GenLoc_end = 59462470
    | Hs_Uniprot = P48594
    | Mm_EntrezGene = 20248
    | Mm_Ensembl =   
    | Mm_RefseqmRNA = NM_009126
    | Mm_RefseqProtein = NP_033152
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Serpin peptidase inhibitor, clade B (ovalbumin), member 4''', also known as '''SERPINB4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6318| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Line 60: Line 12:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
Line 66: Line 18:
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Barnes RC, Worrall DM |title=Identification of a novel human serpin gene; cloning sequencing and expression of leupin. |journal=FEBS Lett. |volume=373 |issue= 1 |pages= 61-5 |year= 1995 |pmid= 7589435 |doi= }}
*{{cite journal  | vauthors =Barnes RC, Worrall DM |title=Identification of a novel human serpin gene; cloning sequencing and expression of leupin. |journal=FEBS Letters |volume=373 |issue= 1 |pages= 61–5 |year= 1995 |pmid= 7589435 |doi=10.1016/0014-5793(95)01015-7}}
*{{cite journal  | author=Schneider SS, Schick C, Fish KE, ''et al.'' |title=A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 8 |pages= 3147-51 |year= 1995 |pmid= 7724531 |doi= }}
*{{cite journal  | vauthors =Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal   |vauthors=Bartuski AJ, Kamachi Y, Schick C |display-authors=etal |title=A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases |journal=Genomics |volume=54 |issue= 2 |pages= 297–306 |year= 1999 |pmid= 9828132 |doi= 10.1006/geno.1998.5586}}
*{{cite journal | author=Bartuski AJ, Kamachi Y, Schick C, ''et al.'' |title=A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases. |journal=Genomics |volume=54 |issue= 2 |pages= 297-306 |year= 1999 |pmid= 9828132 |doi= 10.1006/geno.1998.5586 }}
*{{cite journal   |vauthors=Sakaguchi Y, Kishi F, Murakami A |display-authors=etal |title=Structural analysis of human SCC antigen 2 promoter |journal=Biochim. Biophys. Acta |volume=1444 |issue= 1 |pages= 111–6 |year= 1999 |pmid= 9931463 |doi=10.1016/s0167-4781(98)00259-0}}
*{{cite journal | author=Sakaguchi Y, Kishi F, Murakami A, ''et al.'' |title=Structural analysis of human SCC antigen 2 promoter. |journal=Biochim. Biophys. Acta |volume=1444 |issue= 1 |pages= 111-6 |year= 1999 |pmid= 9931463 |doi= }}
*{{cite journal   |vauthors=Cataltepe S, Gornstein ER, Schick C |display-authors=etal |title=Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas |journal=J. Histochem. Cytochem. |volume=48 |issue= 1 |pages= 113–22 |year= 2000 |pmid= 10653592 |doi=10.1177/002215540004800112}}
*{{cite journal | author=Cataltepe S, Gornstein ER, Schick C, ''et al.'' |title=Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas. |journal=J. Histochem. Cytochem. |volume=48 |issue= 1 |pages= 113-22 |year= 2000 |pmid= 10653592 |doi= }}
*{{cite journal   |vauthors=Luke C, Schick C, Tsu C |display-authors=etal |title=Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage |journal=Biochemistry |volume=39 |issue= 24 |pages= 7081–91 |year= 2000 |pmid= 10852705 |doi=10.1021/bi000050g}}
*{{cite journal | author=Luke C, Schick C, Tsu C, ''et al.'' |title=Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage. |journal=Biochemistry |volume=39 |issue= 24 |pages= 7081-91 |year= 2000 |pmid= 10852705 |doi= }}
*{{cite journal   |vauthors=Uemura Y, Pak SC, Luke C |display-authors=etal |title=Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells |journal=Int. J. Cancer |volume=89 |issue= 4 |pages= 368–77 |year= 2000 |pmid= 10956412 |doi=10.1002/1097-0215(20000720)89:4<368::AID-IJC9>3.0.CO;2-6}}
*{{cite journal | author=Uemura Y, Pak SC, Luke C, ''et al.'' |title=Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. |journal=Int. J. Cancer |volume=89 |issue= 4 |pages= 368-77 |year= 2000 |pmid= 10956412 |doi=  }}
*{{cite journal   |vauthors=Hamada K, Shinomiya H, Asano Y |display-authors=etal |title=Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter |journal=Biochim. Biophys. Acta |volume=1518 |issue= 1–2 |pages= 124–31 |year= 2001 |pmid= 11267667 |doi=  10.1016/s0167-4781(01)00174-9}}
*{{cite journal | author=Hamada K, Shinomiya H, Asano Y, ''et al.'' |title=Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter. |journal=Biochim. Biophys. Acta |volume=1518 |issue= 1-2 |pages= 124-31 |year= 2001 |pmid= 11267667 |doi= }}
*{{cite journal   |vauthors=Takeda A, Kajiya A, Iwasawa A |display-authors=etal |title=Aberrant expression of serpin squamous cell carcinoma antigen 2 in human tumor tissues and cell lines: evidence of protection from tumor necrosis factor-mediated apoptosis |journal=Biol. Chem. |volume=383 |issue= 7–8 |pages= 1231–6 |year= 2003 |pmid= 12437110 |doi=10.1515/BC.2002.136}}
*{{cite journal | author=Takeda A, Kajiya A, Iwasawa A, ''et al.'' |title=Aberrant expression of serpin squamous cell carcinoma antigen 2 in human tumor tissues and cell lines: evidence of protection from tumor necrosis factor-mediated apoptosis. |journal=Biol. Chem. |volume=383 |issue= 7-8 |pages= 1231-6 |year= 2003 |pmid= 12437110 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH |display-authors=etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gariboldi M, Peissel B, Fabbri A |display-authors=etal |title=SCCA2-like serpins mediate genetic predisposition to skin tumors |journal=Cancer Res. |volume=63 |issue= 8 |pages= 1871–5 |year= 2003 |pmid= 12702576 |doi=}}
*{{cite journal | author=Gariboldi M, Peissel B, Fabbri A, ''et al.'' |title=SCCA2-like serpins mediate genetic predisposition to skin tumors. |journal=Cancer Res. |volume=63 |issue= 8 |pages= 1871-5 |year= 2003 |pmid= 12702576 |doi=  }}
*{{cite journal   |vauthors=Pontisso P, Calabrese F, Benvegnù L |display-authors=etal |title=Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma |journal=Br. J. Cancer |volume=90 |issue= 4 |pages= 833–7 |year= 2004 |pmid= 14970861 |doi= 10.1038/sj.bjc.6601543 | pmc=2410161}}
*{{cite journal | author=Sakata Y, Arima K, Takai T, ''et al.'' |title=The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5081-7 |year= 2004 |pmid= 14630915 |doi= 10.1074/jbc.M311585200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA |display-authors=etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928}}
*{{cite journal | author=Pontisso P, Calabrese F, Benvegnù L, ''et al.'' |title=Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma. |journal=Br. J. Cancer |volume=90 |issue= 4 |pages= 833-7 |year= 2004 |pmid= 14970861 |doi= 10.1038/sj.bjc.6601543 }}
*{{cite journal   |vauthors=Ray R, Choi M, Zhang Z |display-authors=etal |title=Uteroglobin suppresses SCCA gene expression associated with allergic asthma |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 9761–4 |year= 2005 |pmid= 15677460 |doi= 10.1074/jbc.C400581200}}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T |display-authors=etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209}}
*{{cite journal | author=Ray R, Choi M, Zhang Z, ''et al.'' |title=Uteroglobin suppresses SCCA gene expression associated with allergic asthma. |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 9761-4 |year= 2005 |pmid= 15677460 |doi= 10.1074/jbc.C400581200 }}
*{{cite journal   |vauthors=Sueoka K, Nawata S, Nakagawa T |display-authors=etal |title=Tumor-associated serpin, squamous cell carcinoma antigen stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines |journal=Int. J. Oncol. |volume=27 |issue= 5 |pages= 1345–53 |year= 2005 |pmid= 16211231 |doi=10.3892/ijo.27.5.1345}}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y |display-authors=etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Research |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129}}
*{{cite journal  | author=Sueoka K, Nawata S, Nakagawa T, ''et al.'' |title=Tumor-associated serpin, squamous cell carcinoma antigen stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines. |journal=Int. J. Oncol. |volume=27 |issue= 5 |pages= 1345-53 |year= 2005 |pmid= 16211231 |doi= }}
*{{cite journal  | vauthors =Katagiri C, Nakanishi J, Kadoya K, Hibino T |title=Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase |journal=J. Cell Biol. |volume=172 |issue= 7 |pages= 983–90 |year= 2006 |pmid= 16549498 |doi= 10.1083/jcb.200508064  | pmc=2063756}}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Katagiri C, Nakanishi J, Kadoya K, Hibino T |title=Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase. |journal=J. Cell Biol. |volume=172 |issue= 7 |pages= 983-90 |year= 2006 |pmid= 16549498 |doi= 10.1083/jcb.200508064 }}
}}
}}
{{refend}}
{{refend}}


==External links==
==External links==
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=I04.009 I04.009]
* {{MeshName|SERPINB4+protein,+human}}
* {{MeshName|SERPINB4+protein,+human}}


{{protein-stub}}
{{gene-18-stub}}
{{Serpins}}
{{Serpins}}
[[Category:Serine protease inhibitors]]
[[Category:Serine protease inhibitors]]
{{WikiDoc Sources}}
 
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

Latest revision as of 06:09, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serpin B4 is a protein that in humans is encoded by the SERPINB4 gene.[1][2][3]


See also

References

  1. ↑ Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA (May 1995). "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene". Proc Natl Acad Sci U S A. 92 (8): 3147–51. doi:10.1073/pnas.92.8.3147. PMC 42122. PMID 7724531.
  2. ↑ Sakata Y, Arima K, Takai T, Sakurai W, Masumoto K, Yuyama N, Suminami Y, Kishi F, Yamashita T, Kato T, Ogawa H, Fujimoto K, Matsuo Y, Sugita Y, Izuhara K (Feb 2004). "The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1". J Biol Chem. 279 (7): 5081–7. doi:10.1074/jbc.M311585200. PMID 14630915.
  3. ↑ "Entrez Gene: SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4".

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=SERPINB4&oldid=1418482"