TAP2: Difference between revisions

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{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''TAP2''' is a [[gene]] in humans that encodes the [[protein]] '''Antigen peptide transporter 2'''.<ref name="pmid1529427">{{cite journal | vauthors = Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T | title = Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system | journal = Tissue Antigens | volume = 39 | issue = 4 | pages = 161–73 | date = Oct 1992 | pmid = 1529427 | pmc =  | doi = 10.1111/j.1399-0039.1992.tb01932.x }}</ref><ref name="pmid1946428">{{cite journal | vauthors = Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T | title = Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region | journal = Proc Natl Acad Sci U S A | volume = 88 | issue = 22 | pages = 10094–8 | date = Dec 1991 | pmid = 1946428 | pmc = 52874 | doi = 10.1073/pnas.88.22.10094 }}</ref><ref name="pmid16395595">{{cite journal | vauthors = Hahn Y, Lee B | title = Human-specific nonsense mutations identified by genome sequence comparisons | journal = Hum Genet | volume = 119 | issue = 1–2 | pages = 169–78 | date = Feb 2006 | pmid = 16395595 | pmc =  | doi = 10.1007/s00439-005-0125-6 }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
| HGNCid = 44
| Symbol = TAP2
| AltSymbols =; ABC18; ABCB3; APT2; D6S217E; PSF2; RING11
| OMIM = 170261
| ECnumber =
| Homologene = 37323
| MGIid = 98484
| GeneAtlas_image1 = PBB_GE_TAP2_204769_s_at_tn.png
  | GeneAtlas_image2 = PBB_GE_TAP2_204770_at_tn.png
| GeneAtlas_image3 = PBB_GE_TAP2_208428_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004409 |text = homoaconitate hydratase activity}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0015198 |text = oligopeptide transporter activity}} {{GNF_GO|id=GO:0015433 |text = peptide antigen-transporting ATPase activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0042288 |text = MHC class I protein binding}} {{GNF_GO|id=GO:0042301 |text = phosphate binding}} {{GNF_GO|id=GO:0042605 |text = peptide antigen binding}} {{GNF_GO|id=GO:0042626 |text = ATPase activity, coupled to transmembrane movement of substances}} {{GNF_GO|id=GO:0046980 |text = tapasin binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005788 |text = endoplasmic reticulum lumen}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042825 |text = TAP complex}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006857 |text = oligopeptide transport}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0015833 |text = peptide transport}} {{GNF_GO|id=GO:0019885 |text = antigen processing and presentation of endogenous peptide antigen via MHC class I}} {{GNF_GO|id=GO:0046967 |text = cytosol to ER transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6891
    | Hs_Ensembl = ENSG00000204267
    | Hs_RefseqProtein = NP_000535
    | Hs_RefseqmRNA = NM_000544
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 32897588
    | Hs_GenLoc_end = 32914525
    | Hs_Uniprot = Q03519
    | Mm_EntrezGene = 21355
    | Mm_Ensembl = ENSMUSG00000024339
    | Mm_RefseqmRNA = NM_011530
    | Mm_RefseqProtein = NP_035660
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 33814426
    | Mm_GenLoc_end = 33826594
    | Mm_Uniprot = Q3TXM1
  }}
}}
{{CMG}}
__NOTOC__


== Function ==


==Overview==
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.  ABC proteins transport various [[molecule]]s across extra- and intra-cellular membranes.  ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).  This protein is a member of the MDR/TAP subfamily.  Members of the MDR/TAP subfamily are involved in multidrug resistance.  This gene is located 7 kb telomeric to gene family member ABCB2 ([[TAP1]]).  The protein encoded by this gene is involved in [[antigen presentation]].  This protein forms a heterodimer with ABCB2 in order to transport peptides from the [[cytoplasm]] to the [[endoplasmic reticulum]].  Mutations in this gene may be associated with [[ankylosing spondylitis]], insulin-dependent [[diabetes mellitus]], [[schizophrenia]],<ref>{{cite journal | vauthors = Yu H | title = Protein-interaction-network-based analysis for genome-wide association analysis of schizophrenia in Han Chinese population. }}</ref> and [[celiac disease]].  Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.<ref>{{cite web | title = Entrez Gene: TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6891| accessdate = }}</ref>


'''Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)''', also known as '''TAP2''', is a human [[gene]].
== See also ==
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.  ABC proteins transport various molecules across extra- and intra-cellular membranes.  ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).  This protein is a member of the MDR/TAP subfamily.  Members of the MDR/TAP subfamily are involved in multidrug resistance.  This gene is located 7 kb telomeric to gene family member ABCB2.  The protein encoded by this gene is involved in antigen presentation.  This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum.  Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.  Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.<ref>{{cite web | title = Entrez Gene: TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6891| accessdate = }}</ref>
}}
==See also==
* [[ATP-binding cassette transporter]]
* [[ATP-binding cassette transporter]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Townsend A, Trowsdale J | title = The transporters associated with antigen presentation | journal = Semin. Cell Biol. | volume = 4 | issue = 1 | pages = 53–61 | year = 1993 | pmid = 8453065 | doi = 10.1006/scel.1993.1007 }}
| citations =
* {{cite journal | vauthors = Beck S, Kelly A, Radley E, Khurshid F, Alderton RP, Trowsdale J | title = DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing | journal = J. Mol. Biol. | volume = 228 | issue = 2 | pages = 433–41 | year = 1992 | pmid = 1453454 | doi = 10.1016/0022-2836(92)90832-5 }}
*{{cite journal | author=Townsend A, Trowsdale J |title=The transporters associated with antigen presentation. |journal=Semin. Cell Biol. |volume=4 |issue= 1 |pages= 53-61 |year= 1993 |pmid= 8453065 |doi= }}
* {{cite journal | vauthors = Kelly A, Powis SH, Kerr LA, Mockridge I, Elliott T, Bastin J, Uchanska-Ziegler B, Ziegler A, Trowsdale J, Townsend A | title = Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex | journal = Nature | volume = 355 | issue = 6361 | pages = 641–4 | year = 1992 | pmid = 1538751 | doi = 10.1038/355641a0 }}
*{{cite journal | author=Beck S, Kelly A, Radley E, ''et al.'' |title=DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. |journal=J. Mol. Biol. |volume=228 |issue= 2 |pages= 433-41 |year= 1992 |pmid= 1453454 |doi= }}
* {{cite journal | vauthors = Colonna M, Bresnahan M, Bahram S, Strominger JL, Spies T | title = Allelic variants of the human putative peptide transporter involved in antigen processing | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 9 | pages = 3932–6 | year = 1992 | pmid = 1570316 | pmc = 525605 | doi = 10.1073/pnas.89.9.3932 }}
*{{cite journal  | author=Bodmer JG, Marsh SG, Albert ED, ''et al.'' |title=Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system. |journal=Tissue Antigens |volume=39 |issue= 4 |pages= 161-73 |year= 1992 |pmid= 1529427 |doi=  }}
* {{cite journal | vauthors = Powis SH, Mockridge I, Kelly A, Kerr LA, Glynne R, Gileadi U, Beck S, Trowsdale J | title = Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 4 | pages = 1463–7 | year = 1992 | pmid = 1741401 | pmc = 48471 | doi = 10.1073/pnas.89.4.1463 }}
*{{cite journal | author=Kelly A, Powis SH, Kerr LA, ''et al.'' |title=Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex. |journal=Nature |volume=355 |issue= 6361 |pages= 641-4 |year= 1992 |pmid= 1538751 |doi= 10.1038/355641a0 }}
* {{cite journal | vauthors = Trowsdale J, Hanson I, Mockridge I, Beck S, Townsend A, Kelly A | title = Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters | journal = Nature | volume = 348 | issue = 6303 | pages = 741–4 | year = 1991 | pmid = 2259383 | doi = 10.1038/348741a0 }}
*{{cite journal | author=Colonna M, Bresnahan M, Bahram S, ''et al.'' |title=Allelic variants of the human putative peptide transporter involved in antigen processing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 9 |pages= 3932-6 |year= 1992 |pmid= 1570316 |doi= }}
* {{cite journal | vauthors = de la Salle H, Hanau D, Fricker D, Urlacher A, Kelly A, Salamero J, Powis SH, Donato L, Bausinger H, Laforet M | title = Homozygous human TAP peptide transporter mutation in HLA class I deficiency | journal = Science | volume = 265 | issue = 5169 | pages = 237–41 | year = 1994 | pmid = 7517574 | doi = 10.1126/science.7517574 }}
*{{cite journal | author=Powis SH, Mockridge I, Kelly A, ''et al.'' |title=Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1463-7 |year= 1992 |pmid= 1741401 |doi= }}
* {{cite journal | vauthors = Cano P, Baxter-Lowe LA | title = Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain | journal = Tissue Antigens | volume = 45 | issue = 2 | pages = 139–42 | year = 1995 | pmid = 7792761 | doi = 10.1111/j.1399-0039.1995.tb02431.x }}
*{{cite journal  | author=Bahram S, Arnold D, Bresnahan M, ''et al.'' |title=Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 22 |pages= 10094-8 |year= 1991 |pmid= 1946428 |doi=  }}
* {{cite journal | vauthors = Roby KF, Fei K, Yang Y, Hunt JS | title = Expression of HLA class II-associated peptide transporter and proteasome genes in human placentas and trophoblast cell lines | journal = Immunology | volume = 83 | issue = 3 | pages = 444–8 | year = 1995 | pmid = 7835969 | pmc = 1415039 | doi =  }}
*{{cite journal | author=Trowsdale J, Hanson I, Mockridge I, ''et al.'' |title=Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters. |journal=Nature |volume=348 |issue= 6303 |pages= 741-4 |year= 1991 |pmid= 2259383 |doi= 10.1038/348741a0 }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=de la Salle H, Hanau D, Fricker D, ''et al.'' |title=Homozygous human TAP peptide transporter mutation in HLA class I deficiency. |journal=Science |volume=265 |issue= 5169 |pages= 237-41 |year= 1994 |pmid= 7517574 |doi= }}
* {{cite journal | vauthors = Singal DP, Ye M, Qiu X, D'Souza M | title = Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis | journal = Clin. Exp. Rheumatol. | volume = 12 | issue = 1 | pages = 29–33 | year = 1994 | pmid = 8162639 | doi =  }}
*{{cite journal | author=Cano P, Baxter-Lowe LA |title=Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain. |journal=Tissue Antigens |volume=45 |issue= 2 |pages= 139-42 |year= 1995 |pmid= 7792761 |doi= }}
* {{cite journal | vauthors = Powis SH, Tonks S, Mockridge I, Kelly AP, Bodmer JG, Trowsdale J | title = Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2 | journal = Immunogenetics | volume = 37 | issue = 5 | pages = 373–80 | year = 1993 | pmid = 8428770 | doi = 10.1007/BF00216802 }}
*{{cite journal | author=Roby KF, Fei K, Yang Y, Hunt JS |title=Expression of HLA class II-associated peptide transporter and proteasome genes in human placentas and trophoblast cell lines. |journal=Immunology |volume=83 |issue= 3 |pages= 444-8 |year= 1995 |pmid= 7835969 |doi=  }}
* {{cite journal | vauthors = Glynne R, Kerr LA, Mockridge I, Beck S, Kelly A, Trowsdale J | title = The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing | journal = Eur. J. Immunol. | volume = 23 | issue = 4 | pages = 860–6 | year = 1993 | pmid = 8458375 | doi = 10.1002/eji.1830230414 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Beck S, Abdulla S, Alderton RP, Glynne RJ, Gut IG, Hosking LK, Jackson A, Kelly A, Newell WR, Sanseau P, Radley E, Thorpe KL, Trowsdale J | title = Evolutionary dynamics of non-coding sequences within the class II region of the human MHC | journal = J. Mol. Biol. | volume = 255 | issue = 1 | pages = 1–13 | year = 1996 | pmid = 8568858 | doi = 10.1006/jmbi.1996.0001 }}
*{{cite journal | author=Singal DP, Ye M, Qiu X, D'Souza M |title=Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis. |journal=Clin. Exp. Rheumatol. |volume=12 |issue= 1 |pages= 29-33 |year= 1994 |pmid= 8162639 |doi=  }}
* {{cite journal | vauthors = Ahn K, Meyer TH, Uebel S, Sempé P, Djaballah H, Yang Y, Peterson PA, Früh K, Tampé R | title = Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47 | journal = EMBO J. | volume = 15 | issue = 13 | pages = 3247–55 | year = 1996 | pmid = 8670825 | pmc = 451885 | doi =  }}
*{{cite journal | author=Powis SH, Tonks S, Mockridge I, ''et al.'' |title=Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2. |journal=Immunogenetics |volume=37 |issue= 5 |pages= 373-80 |year= 1993 |pmid= 8428770 |doi= }}
* {{cite journal | vauthors = Pattanakitsakul S, Takeuchi F, Nabeta H, Nakano K, Kuwata S, Yanagisawa M, Shibata Y, Ito K | title = A novel TAP 2 gene RFLP observed in a Japanese | journal = Tissue Antigens | volume = 47 | issue = 4 | pages = 353–5 | year = 1996 | pmid = 8773329 | doi = 10.1111/j.1399-0039.1996.tb02567.x }}
*{{cite journal | author=Glynne R, Kerr LA, Mockridge I, ''et al.'' |title=The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing. |journal=Eur. J. Immunol. |volume=23 |issue= 4 |pages= 860-6 |year= 1993 |pmid= 8458375 |doi= }}
* {{cite journal | vauthors = Lewis JW, Neisig A, Neefjes J, Elliott T | title = Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP | journal = Curr. Biol. | volume = 6 | issue = 7 | pages = 873–83 | year = 1997 | pmid = 8805302 | doi = 10.1016/S0960-9822(02)00611-5 }}
*{{cite journal | author=Beck S, Abdulla S, Alderton RP, ''et al.'' |title=Evolutionary dynamics of non-coding sequences within the class II region of the human MHC. |journal=J. Mol. Biol. |volume=255 |issue= 1 |pages= 1-13 |year= 1996 |pmid= 8568858 |doi= 10.1006/jmbi.1996.0001 }}
*{{cite journal | author=Ahn K, Meyer TH, Uebel S, ''et al.'' |title=Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47. |journal=EMBO J. |volume=15 |issue= 13 |pages= 3247-55 |year= 1996 |pmid= 8670825 |doi=  }}
*{{cite journal | author=Pattanakitsakul S, Takeuchi F, Nabeta H, ''et al.'' |title=A novel TAP 2 gene RFLP observed in a Japanese. |journal=Tissue Antigens |volume=47 |issue= 4 |pages= 353-5 |year= 1996 |pmid= 8773329 |doi= }}
*{{cite journal | author=Lewis JW, Neisig A, Neefjes J, Elliott T |title=Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP. |journal=Curr. Biol. |volume=6 |issue= 7 |pages= 873-83 |year= 1997 |pmid= 8805302 |doi= }}
}}
{{refend}}
{{refend}}


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{{NLM content}}
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{{Membrane transport proteins}}
{{ABC transporters}}
 
[[Category:ABC transporters]]
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Latest revision as of 11:34, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2.[1][2][3]

Function

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2 (TAP1). The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, schizophrenia,[4] and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.[5]

See also

References

  1. ↑ Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T (Oct 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens. 39 (4): 161–73. doi:10.1111/j.1399-0039.1992.tb01932.x. PMID 1529427.
  2. ↑ Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T (Dec 1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc Natl Acad Sci U S A. 88 (22): 10094–8. doi:10.1073/pnas.88.22.10094. PMC 52874. PMID 1946428.
  3. ↑ Hahn Y, Lee B (Feb 2006). "Human-specific nonsense mutations identified by genome sequence comparisons". Hum Genet. 119 (1–2): 169–78. doi:10.1007/s00439-005-0125-6. PMID 16395595.
  4. ↑ Yu H. "Protein-interaction-network-based analysis for genome-wide association analysis of schizophrenia in Han Chinese population".
  5. ↑ "Entrez Gene: TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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