VIPoma: Difference between revisions

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	VIPoma;
	Pancreatic vipoma. Electron microscopy of a pancreatic VIPoma. Abundant secretory granules of variable size, shape, and density in a pancreatic tumor with WDHA syndrome. Abundant PP-and a few VIP-immunoreactive cells (inset) were detected by light microscopic immunohistochemistry of the same tumor (X28.000). ; Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

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Latest revision as of 18:07, 23 September 2023

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]Madhu Sigdel M.B.B.S.[3] Parminder Dhingra, M.D. [4]

Synonyms and keywords: VIPomas ; watery diarrhea with hypokalemic alkalosis; WDHA syndrome; watery diarrhea hypokalemia achlorhydria syndrome; pancreatic cholera syndrome; Verner-Morrison syndrome; non-beta pancreatic islet cell tumor; diarrheogenic islet cell tumor; VIP-secreting tumor; vasoactive intestinal polypeptide secreting tumor, pancreatic VIPoma

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating VIPoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Treatment

Case Studies

Case #1

Template:WikiDoc Sources

@@ Line 4: / Line 4: @@
    Image          = Pancreatic vipoma.jpg|
    Caption        = Pancreatic vipoma. Electron microscopy of a pancreatic VIPoma. Abundant secretory granules of variable size, shape, and density in a pancreatic tumor with WDHA syndrome. Abundant PP-and a few VIP-immunoreactive cells (inset) were detected by light microscopic immunohistochemistry of the same tumor (X28.000). <br> <small> [http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology] </small>|
-  DiseasesDB     = 13877 |
-  ICD10          = {{ICD10|C|25|4|c|15}} or {{ICD10|E|16|8|e|15}} |
-  ICD9           = |
-  ICDO           = 8155/3 |
-  OMIM           = |
-  MedlinePlus    = 000228 |
-  MeshID         = D003969 |
 }}
-'''For patient information, click [[Jaundice (patient information)|here]]'''
+'''For patient information, click [[VIPoma (patient information)|here]]'''
-{{SI}}
+{{VIPoma}}
-{{CMG}}
+{{CMG}}; {{AE}}{{Homa}}{{MSI}} {{PSD}}
-==Overview==
+{{SK}} [[VIPomas]][[Watery diarrhea with hypokalemic alkalosis|; watery diarrhea with hypokalemic alkalosis]]; [[WDHA syndrome]]; [[watery diarrhea hypokalemia achlorhydria syndrome]]; [[pancreatic cholera syndrome]]; [[Verner-Morrison syndrome|Verner-Morrison syndrome;]] [[non-beta pancreatic islet cell tumor]]; [[diarrheogenic islet cell tumor]]; [[VIP-secreting tumor]]; [[vasoactive intestinal polypeptide secreting tumor]], [[pancreatic VIPoma]]
-A '''VIPoma''' (also known as '''[[Verner Morrison syndrome]]''', after the physicians who first described it <ref>Verner, J. V., and Morrison, A. B. Islet cell tumor and a syndrome of refractory watery diarrhea and hypokalemia. ''Am J Med'' 1958; '''374''': 1958.</ref>) is a rare (1 per 10'000'000 per year) [[endocrine]] [[tumor]], usually (about 90%) originating in the [[pancreas]], which produces [[vasoactive intestinal peptide]] (VIP).
+==[[VIPoma overview|Overview]]==
-* A syndrome caused by non-β islet-cell tumors.
+==[[VIPoma historical perspective|Historical Perspective]]==
-* It may be associated with multiple endocrine neoplasia.
-The massive amounts of VIP in turn cause profound and chronic '''w'''atery '''d'''[[diarrhea|iarrhea]] and resultant  [[dehydration]], '''h'''[[hypokalemia|ypokalemia]], '''a'''[[achlorhydria|chlorhydria]] (hence '''WDHA-syndrome''', or '''pancreatic cholera syndrome'''), acidosis, [[vasodilation]] ([[flushing (physiology)|flushing]] and [[hypotension]]), [[hypercalcemia]] and [[hyperglycemia]].<ref>Mansour JC, Chen H. Pancreatic endocrine tumors. ''J Surg Res'' 2004; '''120''': 139-61. PMID 15172200</ref>
+==[[VIPoma pathophysiology|Pathophysiology]]==
-==Symptoms and Signs==
+==[[VIPoma causes|Causes]]==
-The Major clinical features are prolonged watery [[diarrhea]] (fasting stool volume > 750 to 1000 mL/day)and symptoms of [[hypokalemia]] and [[dehydration]].
-Half of the patients have relatively constant [[diarrhea]] while the rest have alternating periods of severe and moderate [[diarrhea]].
-One third have diarrhea < 1yr before diagnosis ,but in 25%, diarrhea is present for 5 yr or more before diagnosis.
-[[Lethargy]], muscle weakness, [[nausea]], vomiting and crampy abdominal pain are frequent symptoms.
-[[Hyperkalemia]] and impaired [[glucose]] tolerance occur in < 50% of patients.
-During attacks of diarrhea, flushing similar to the [[carcinoid syndrome]] occur rarely.
-==Diagnosis==
+==[[VIPoma differential diagnosis|Differentiating VIPoma from other Diseases]]==
-Besides the clinical picture, [[fasting]] VIP [[blood plasma|plasma]] dosage may confirm the diagnosis, and [[CT scan]] and [[somatostatin]] receptor [[scintigraphy]] are used to localise the [[tumor]], which is usually [[metastasis|metastatic]] at presentation.
+==[[VIPoma epidemiology and demographics|Epidemiology and Demographics]]==
-==Treatment==
+==[[VIPoma risk factors|Risk Factors]]==
-Besides treating the [[water]] and [[electrolyte]] abnormalities, [[octreotide]] (a [[somatostatin]] analogue) can be used to temper symptoms. [[Surgery]] is the only curative option.
-==References==
+==[[VIPoma screening|Screening]]==
-<references/>
-==Additional Resources==
+==[[VIPoma natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
-^The MERCK MANUAL Of Diagnosis And Therapy
+==Diagnosis==
-<br>
+[[VIPoma history and symptoms|History and Symptoms]] | [[VIPoma physical examination|Physical Examination]] | [[VIPoma laboratory findings|Laboratory Findings]] | [[VIPoma x ray|X Ray]] | [[VIPoma CT|CT]] | [[VIPoma MRI|MRI]] | [[VIPoma echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[VIPoma other imaging findings|Other Imaging Findings]] |
+[[VIPoma other diagnostic studies|Other Diagnostic Studies]]
-[[Category:Endocrinology]]
+==Treatment==
-[[Category:Types of cancer]]
+[[VIPoma medical therapy|Medical Therapy]] | [[VIPoma surgery|Surgery]] | [[VIPoma primary prevention|Primary Prevention]] | [[VIPoma secondary prevention|Secondary Prevention]] | [[VIPoma cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[VIPoma future or investigational therapies|Future or Investigational Therapies]]
+==Case Studies==
-[[de:Verner-Morrison-Syndrom]]
+[[VIPoma case study one|Case #1]]
-[[pl:Guz wydzielający VIP]]
-{{Tumor morphology}}
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+[[Category:Medicine]]
+[[Category:Oncology]]
+[[Category:Up-To-Date]]
+[[Category:Endocrinology]]
+[[Category:Gastroenterology]]


VIPoma
Pancreatic vipoma. Electron microscopy of a pancreatic VIPoma. Abundant secretory granules of variable size, shape, and density in a pancreatic tumor with WDHA syndrome. Abundant PP-and a few VIP-immunoreactive cells (inset) were detected by light microscopic immunohistochemistry of the same tumor (X28.000). Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

VIPoma: Difference between revisions

Latest revision as of 18:07, 23 September 2023

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