POEMS syndrome diagnostic criteria: Difference between revisions
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Created page with "__NOTOC__ {{POEMS syndrome}} {{CMG}} ==Overview== ==Diagnostic Criteria== A 2003 study<ref name=Dispenzieri>Dispenzieri A, Kyle RA, Lacy MQ, Rajkumar SV, Therneau TM, Larson..." |
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__NOTOC__ | __NOTOC__ | ||
{{POEMS syndrome}} | {{POEMS syndrome}} | ||
{{CMG}} | {{CMG}} {{AE}} {{HK}} | ||
==Overview== | == Overview == | ||
According to the The International Myeloma Working Group, the diagnosis of POEMS syndrome may be established if both mandatory criteria, one major and one minor criteria are fulfilled. Mandatory criteria include presence of [[polyneuropathy]] and a [[Monoclonal antibody|monoclonal]] [[plasma cell]] proliferative disorder. Major criteria include presence of sclerotic [[bone]] lesions or mixed sclerotic/lytic lesions, presence of [[Castleman's disease]] and elevated [[serum]] [[VEGF]] levels. Minor criteria include presence of [[organomegaly]], extravascular volume overload, [[endocrinopathy]], [[skin]] changes, [[papilledema]], [[thrombocytosis]] and [[polycythemia]]. | |||
==Diagnostic Criteria== | ==Diagnostic Criteria== | ||
According to the The International Myeloma Working Group, the diagnosis of POEMS syndrome may be established if '''both mandatory criteria, at least one major and at least one minor criteria are fulfilled'''. The following table enlists the mandatory, major and minor criteria required for the diagnosis of POEMS syndrome:<ref name="urlIMWG | International Myeloma Working Group (IMWG) Criteria for the Diagnosis of Multiple Myeloma">{{cite web |url=http://imwg.myeloma.org/international-myeloma-working-group-imwg-criteria-for-the-diagnosis-of-multiple-myeloma/ |title=IMWG | International Myeloma Working Group (IMWG) Criteria for the Diagnosis of Multiple Myeloma |format= |work= |accessdate=}}</ref> | |||
* | {| class="wikitable" | ||
** Sclerotic bone lesions | |+ | ||
* | ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Mandatory Criteria | ||
** [[Organomegaly]] ([[splenomegaly]], [[hepatomegaly]] or [[lymphadenopathy]]) | ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Major Criteria | ||
* | ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Minor Criteria | ||
* | |- | ||
** | | | ||
** [[ | * [[Polyneuropathy]] | ||
* A [[Monoclonal gammopathy|monoclonal]] [[plasma cell]] proliferative disorder | |||
| | |||
* Sclerotic [[bone]] lesions or mixed sclerotic/lytic lesions | |||
* [[Castleman's disease]] | |||
* Elevated [[VEGF]] levels | |||
| | |||
* [[Organomegaly]] ([[splenomegaly]], [[hepatomegaly]] or [[lymphadenopathy]]) | |||
* Extra-vascular volume overload ([[peripheral edema]], [[ascites]], [[pleural effusion]]) | |||
* [[Endocrinopathy]]: | |||
** [[Adrenal gland|Adrenal]] | |||
** [[Thyroid]] | |||
** [[Pituitary]] | |||
** [[Gonadal]] | |||
** [[Parathyroid gland|Parathyroid]] | |||
** [[Pancreatic]] disorders excluding [[diabetes mellitus]] and [[hypothyroidism]] | |||
* [[Skin]] changes: | |||
** [[Hyperpigmentation]] | |||
** [[Hypertrichosis]] | |||
** [[Angioma|Glomeruloid hemangiomata]] | |||
** [[Plethora]] | |||
** [[Acrocyanosis]] | |||
** [[Flushing]] | |||
** [[Leukonychia]] | |||
* [[Papilledema]] | |||
* [[Thrombocytosis]] | |||
* [[Polycythemia]] | |||
|} | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Needs overview]] | |||
[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
[[Category:Neurological disorders]] | [[Category:Neurological disorders]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
[[Category:Syndromes]] | [[Category:Syndromes]] | ||
[[Category: | [[Category:Disease]] | ||
[[es:Síndrome POEMS]] | [[es:Síndrome POEMS]] | ||
Latest revision as of 01:28, 6 February 2019
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POEMS syndrome Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
According to the The International Myeloma Working Group, the diagnosis of POEMS syndrome may be established if both mandatory criteria, one major and one minor criteria are fulfilled. Mandatory criteria include presence of polyneuropathy and a monoclonal plasma cell proliferative disorder. Major criteria include presence of sclerotic bone lesions or mixed sclerotic/lytic lesions, presence of Castleman's disease and elevated serum VEGF levels. Minor criteria include presence of organomegaly, extravascular volume overload, endocrinopathy, skin changes, papilledema, thrombocytosis and polycythemia.
Diagnostic Criteria
According to the The International Myeloma Working Group, the diagnosis of POEMS syndrome may be established if both mandatory criteria, at least one major and at least one minor criteria are fulfilled. The following table enlists the mandatory, major and minor criteria required for the diagnosis of POEMS syndrome:[1]
| Mandatory Criteria | Major Criteria | Minor Criteria |
|---|---|---|
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