Monoclonal gammopathy of undetermined significance other diagnostic studies: Difference between revisions
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{{ Monoclonal gammopathy of undetermined significance }} | {{Monoclonal gammopathy of undetermined significance}} | ||
{{CMG}} | {{CMG}}; {{AE}} {{OK}} | ||
==Overview== | |||
The [[protein electrophoresis]] test should be repeated annually, and if there is any concern for a rise in the level of monoclonal protein, then prompt referral to a [[haematologist]] is required. A [[bone marrow biopsy]] should be performed. | |||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Protein Electrophoresis=== | ===Protein Electrophoresis=== | ||
The [[protein electrophoresis]] test should be repeated annually, and if there is any concern for a rise in the level of monoclonal protein, then prompt referral to a [[haematologist]] is required. | The [[protein electrophoresis]] test should be repeated annually, and if there is any concern for a rise in the level of monoclonal protein, then prompt referral to a [[haematologist]] is required.<ref name="pmid19399286">{{cite journal |vauthors=Jang ST, Sohn IS, Jin ES, Cho JM, Kim CJ, Lim SJ |title=A case of cardiac dysfunction associated with monoclonal gammopathy of undetermined significance |journal=J. Korean Med. Sci. |volume=24 |issue=2 |pages=354–6 |date=April 2009 |pmid=19399286 |pmc=2672144 |doi=10.3346/jkms.2009.24.2.354 |url=}}</ref><ref name="pmid23859528">{{cite journal |vauthors=Mangiacavalli S, Cocito F, Pochintesta L, Pascutto C, Ferretti V, Varettoni M, Zappasodi P, Pompa A, Landini B, Cazzola M, Corso A |title=Monoclonal gammopathy of undetermined significance: a new proposal of workup |journal=Eur. J. Haematol. |volume=91 |issue=4 |pages=356–60 |date=October 2013 |pmid=23859528 |doi=10.1111/ejh.12172 |url=}}</ref> | ||
===Bone Marrow Biopsy=== | ===Bone Marrow Biopsy=== | ||
A [[bone marrow biopsy]] should be performed because a diagnosis of MGUS requires the presence of less than 10% clonal plasma cells.<ref name="pmid19399286">{{cite journal |vauthors=Jang ST, Sohn IS, Jin ES, Cho JM, Kim CJ, Lim SJ |title=A case of cardiac dysfunction associated with monoclonal gammopathy of undetermined significance |journal=J. Korean Med. Sci. |volume=24 |issue=2 |pages=354–6 |date=April 2009 |pmid=19399286 |pmc=2672144 |doi=10.3346/jkms.2009.24.2.354 |url=}}</ref><ref name="pmid23859528">{{cite journal |vauthors=Mangiacavalli S, Cocito F, Pochintesta L, Pascutto C, Ferretti V, Varettoni M, Zappasodi P, Pompa A, Landini B, Cazzola M, Corso A |title=Monoclonal gammopathy of undetermined significance: a new proposal of workup |journal=Eur. J. Haematol. |volume=91 |issue=4 |pages=356–60 |date=October 2013 |pmid=23859528 |doi=10.1111/ejh.12172 |url=}}</ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Latest revision as of 03:49, 3 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]
Overview
The protein electrophoresis test should be repeated annually, and if there is any concern for a rise in the level of monoclonal protein, then prompt referral to a haematologist is required. A bone marrow biopsy should be performed.
Other Diagnostic Studies
Protein Electrophoresis
The protein electrophoresis test should be repeated annually, and if there is any concern for a rise in the level of monoclonal protein, then prompt referral to a haematologist is required.[1][2]
Bone Marrow Biopsy
A bone marrow biopsy should be performed because a diagnosis of MGUS requires the presence of less than 10% clonal plasma cells.[1][2]
References
- ↑ 1.0 1.1 Jang ST, Sohn IS, Jin ES, Cho JM, Kim CJ, Lim SJ (April 2009). "A case of cardiac dysfunction associated with monoclonal gammopathy of undetermined significance". J. Korean Med. Sci. 24 (2): 354–6. doi:10.3346/jkms.2009.24.2.354. PMC 2672144. PMID 19399286.
- ↑ 2.0 2.1 Mangiacavalli S, Cocito F, Pochintesta L, Pascutto C, Ferretti V, Varettoni M, Zappasodi P, Pompa A, Landini B, Cazzola M, Corso A (October 2013). "Monoclonal gammopathy of undetermined significance: a new proposal of workup". Eur. J. Haematol. 91 (4): 356–60. doi:10.1111/ejh.12172. PMID 23859528.